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Journal of infectious pulmonary diseases最新文献

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Bronchiolitis Obliterans Organizing Pneumonia on the Onset of Granulomatosis with Polyangiitis Associated with Orbital Involvement and Prostatic Carcinoma 肉芽肿合并多血管炎伴眼眶受累和前列腺癌发病时的组织性肺炎
Pub Date : 2018-01-01 DOI: 10.16966/2470-3176.134
Granulomatosis with Polyangiitis (GPA) is a systemic vasculitis characterized by upper and lower respiratory tract involvement with renal manifestations. Bronchiolitis Obliterans Organizing Pneumonia (BOOP) can be a misleading pulmonary manifestation especially in the onset of the disease, in the absence of the other major findings of GPA which can develop later during the follow up. Malignancy occurrence seems to be increased in GPA patients due to treatment but other authors reported an increase of preceding cancers too. We reported a case of BOOP in the onset of GPA associated with orbital pseudo tumor and prostatic cancer.
肉芽肿病合并多血管炎(GPA)是一种以上呼吸道和下呼吸道累及肾脏为特征的全身性血管炎。闭塞性毛细支气管炎组织肺炎(BOOP)可能是一种容易引起误解的肺部表现,特别是在疾病发病时,在没有其他主要的GPA表现的情况下,这些表现可能在随后的随访中出现。由于治疗,GPA患者的恶性肿瘤发生率似乎有所增加,但其他作者也报道了先前癌症的增加。我们报告了一例伴有眼窝假性肿瘤和前列腺癌的原发性原发性前列腺炎。
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引用次数: 0
A Novel in vivo System to Test Bronchodilators. 一种新的体内系统来测试支气管扩张剂。
Pub Date : 2017-03-01 Epub Date: 2017-02-03 DOI: 10.16966/2470-3176.120

The incidence and severity of asthma continue to rise worldwide. β-agonists are the most commonly prescribed therapeutic for asthma management but have less efficacy for some subsets of asthmatic patients and there are concerns surrounding the side effects from their long-term persistent use. The demand to develop novel asthma therapeutics highlights the need for a standardized approach to effectively screen and test potential bronchoprotective compounds using relevant in vivo animal models. Here we describe a validated method of testing potential therapeutic compounds for their fast-acting efficacy during the midst of an induced bronchoconstriction in a house dust mite challenged animal model.

哮喘的发病率和严重程度在世界范围内持续上升。β激动剂是哮喘治疗中最常用的处方药物,但对某些哮喘患者的疗效较差,并且长期持续使用会产生副作用。开发新型哮喘治疗药物的需求强调需要一种标准化的方法来有效地筛选和测试潜在的支气管保护化合物,使用相关的体内动物模型。在这里,我们描述了一种有效的方法来测试潜在的治疗化合物的快速作用功效,在一个室内尘螨挑战的动物模型中诱导支气管收缩。
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引用次数: 11
Cystic Fibrosis Mice Develop Spontaneous Chronic Bordetella Airway Infections. 囊性纤维化小鼠发生自发性慢性博德氏菌气道感染。
Pub Date : 2017-01-01 Epub Date: 2017-11-02 DOI: 10.16966/2470-3176.128
Chronic pulmonary disease and infection is the primary cause of morbidity and mortality in people with cystic fibrosis (CF). Though Pseudomonas aeruginosa, is most commonly found in the airways of individuals with CF, there is increasing appreciation for the diversity of the CF microbiome, including other taxa such as Bordetella. Here we describe the identification and impact of Bordetella pseudohinzii infection in CF mice, which previously have not been thought to develop spontaneous airway infections. We determined that CF mice are more susceptible to the B. pseudohinzii infections, and less able to resolve the infection than non-CF mice. Moreover, in both CF and non-CF mice, B. pseudohinzii infections lead to markedly reduced respiratory rates and a CF-specific immune response. These results establish the CF mouse model as an important tool for the study of CF-relevant infection and highlight the potential contribution of Bordetella to CF clinical pathology.
慢性肺部疾病和感染是囊性纤维化(CF)患者发病和死亡的主要原因。虽然铜绿假单胞菌最常见于CF患者的气道,但CF微生物群的多样性越来越受到重视,包括其他分类群,如博德特拉菌。在这里,我们描述了CF小鼠中伪氏杆菌感染的鉴定和影响,这种感染以前没有被认为会发生自发性气道感染。我们确定CF小鼠比非CF小鼠更容易感染pseudohinzii杆菌,并且解决感染的能力较差。此外,在CF和非CF小鼠中,伪氏螺旋体感染导致呼吸频率显著降低和CF特异性免疫反应。这些结果建立了CF小鼠模型作为CF相关感染研究的重要工具,并强调了博德特拉菌对CF临床病理的潜在贡献。
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引用次数: 9
Lethal Synergism between Influenza and Streptococcus pneumoniae 流感与肺炎链球菌的致死性协同作用
Pub Date : 2016-04-30 DOI: 10.16966/2470-3176.114
The devastating synergism of bacterial pneumonia with influenza viral infections left its mark on the world over the last century. Although the details of pathogenesis remain unclear, the synergism is related to a variety of factors including pulmonary epithelial barrier damage which exposes receptors that influence bacterial adherence and the triggering of an exaggerated innate immune response and cytokine storm, which further acts to worsen the injury. Several therapeutics and combination therapies of antibiotics, anti-inflammatories including corticosteroids and toll-like receptor modifiers, and anti-virals are being discussed. This mini review summarizes recent developments in unearthing the pathogenesis of the lethal synergism of pneumococcal co-infection following influenza, as well as addresses potential therapeutic options and combinations of therapies currently being evaluated.
细菌性肺炎与流感病毒感染的毁灭性协同作用在上个世纪给世界留下了印记。虽然发病机制的细节尚不清楚,但协同作用与多种因素有关,包括肺上皮屏障损伤,暴露影响细菌粘附的受体,以及触发夸大的先天免疫反应和细胞因子风暴,这进一步加重了损伤。目前正在讨论几种治疗方法和抗生素、抗炎药(包括皮质类固醇和toll样受体调节剂)和抗病毒药物的联合治疗。本综述总结了流感后肺炎球菌合并感染致死性增效作用发病机制的最新进展,并介绍了目前正在评估的潜在治疗方案和治疗组合。
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引用次数: 43
Neutrophils as Possible Therapeutic Targets in Severe Influenza Pneumonia 中性粒细胞作为重症流感肺炎可能的治疗靶点
Pub Date : 2016-01-01 DOI: 10.16966/2470-3176.115
Copyright: © Teluguakula N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Teluguakula Narasaraju, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA, E-mail: narasa@okstate.edu
版权所有:©Teluguakula N, et al。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。*通讯作者:Teluguakula Narasaraju,美国俄克拉荷马州立大学兽医健康科学中心,E-mail: narasa@okstate.edu
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引用次数: 1
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Journal of infectious pulmonary diseases
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