Pub Date : 2019-01-01DOI: 10.21767/2471-304x-c1-009
Shaymaa M. Mohammed
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Pub Date : 2016-01-01Epub Date: 2016-04-10DOI: 10.21767/2471-304X.100014
D Berman, C Clinton, R Limb, E C Somers, V Romero, E Mozurkewich
Background: Long-term follow-up was completed in 84 mother-infant pairs of 118 women who completed a randomized controlled trial of prenatal supplementation with EPA- or DHA-rich fish oil or soy oil placebo. The goal of this study was to determine whether prenatal omega-3 fatty acid supplementation protects offspring against development of early childhood allergies.
Methods and findings: Assessment of childhood allergic/atopic disease among offspring at age 36 months was performed by maternal interview using the National Health Interview Survey (NHIS) questions for childhood digestive allergies, wheezing, eczema or skin allergy, and respiratory allergy. Multiple logistic regressions examined the association between prenatal supplementation and childhood outcomes, adjusted for covariates. Eczema was reported in 26/84 (31%) of offspring at age 36 months, and was significantly more prevalent in the omega-3 supplementation groups vs. placebo: EPA 13/31 (41.9%); DHA 10/26 (38.5%); placebo 3/27 (11.1%), p=0.019. Compared to placebo, EPA and DHA were associated with ≥5 times risk of offspring eczema [odds ratios (ORs): EPA 5.8 (95% CI 1.4-23.3); DHA 5.0 (95% CI 1.2-21.0)]. After adjusting for other potential risk factors (race, birth weight, vaginal/Cesarean delivery, and maternal eczema) the magnitudes of association for omega-3 supplementation increased: EPA OR 8.1 (95% CI 1.4-45.6); DHA OR 9.6 (95% CI 1.6-58.5). Maternal eczema was also significantly associated with offspring eczema in the adjusted model: OR 10.8 (95% CI 2.1-54.3).
Conclusion: Contrary to our hypothesis, acids supplementation compared to soy oil was associated with a substantial increase in risk of childhood eczema. This association was not observed on childhood respiratory or digestive outcomes. It is unclear if these findings were driven by unfavorable effects of omega-3s, or whether there may have been unanticipated protective effects of the soy-based placebo with regards to eczema.
背景:对84对118名妇女的母婴进行了长期随访，这些妇女完成了产前补充富含EPA或dha的鱼油或豆油安慰剂的随机对照试验。这项研究的目的是确定产前补充omega-3脂肪酸是否能保护后代免受儿童早期过敏的影响。方法和研究结果:对36月龄子代的儿童过敏/特应性疾病进行评估，采用全国健康访谈调查(NHIS)对儿童消化过敏、喘息、湿疹或皮肤过敏和呼吸道过敏进行母亲访谈。多重逻辑回归检验了产前补充与儿童结局之间的关系，并对协变量进行了调整。36个月大时，有26/84(31%)的后代出现湿疹，并且omega-3补充剂组比安慰剂组明显更普遍:EPA 13/31 (41.9%);Dha 10/26 (38.5%);安慰剂3/27 (11.1%)，p=0.019。与安慰剂相比，EPA和DHA与后代湿疹的风险相关≥5倍[比值比(or): EPA 5.8 (95% CI 1.4-23.3);Dha 5.0 (95% ci 1.2-21.0)]。在调整了其他潜在的危险因素(种族、出生体重、阴道/剖宫产和母亲湿疹)后，补充omega-3的相关性增加了:EPA OR 8.1 (95% CI 1.4-45.6);Dha或9.6 (95% ci 1.6-58.5)。在调整后的模型中，母亲湿疹与后代湿疹也显著相关:OR 10.8 (95% CI 2.1-54.3)。结论:与我们的假设相反，与豆油相比，补充酸与儿童湿疹风险的大幅增加有关。在儿童呼吸或消化方面没有观察到这种关联。目前尚不清楚这些发现是由ω -3的不利影响引起的，还是大豆安慰剂对湿疹有意想不到的保护作用。
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