Pub Date : 2020-12-25DOI: 10.12970/2310-9971.2020.08.03
D. I. Kozusny-Andreani, R. Ramos, R. Zângaro, Luis Viotto, Camila Viotto
{"title":"Treatment of Diabetic Lower Limb Wounds with Ozonized Sunflower Oil and Collagenase","authors":"D. I. Kozusny-Andreani, R. Ramos, R. Zângaro, Luis Viotto, Camila Viotto","doi":"10.12970/2310-9971.2020.08.03","DOIUrl":"https://doi.org/10.12970/2310-9971.2020.08.03","url":null,"abstract":"","PeriodicalId":91903,"journal":{"name":"Journal of endocrinology and diabetes mellitus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42396439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-31DOI: 10.12970/2310-9971.2018.06.04
N. Haraj, S. Lezar, F. Louda, S. Aziz, A. Chadli
{"title":"Lymphocytic Hypophysitis: Case Report","authors":"N. Haraj, S. Lezar, F. Louda, S. Aziz, A. Chadli","doi":"10.12970/2310-9971.2018.06.04","DOIUrl":"https://doi.org/10.12970/2310-9971.2018.06.04","url":null,"abstract":"","PeriodicalId":91903,"journal":{"name":"Journal of endocrinology and diabetes mellitus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49192896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-05DOI: 10.12970/2310-9971.2018.06.03
D. Cheța, V. Chirilă, N. Paulescu
{"title":"Bariatric Surgery and its Place in Modern Diabetology","authors":"D. Cheța, V. Chirilă, N. Paulescu","doi":"10.12970/2310-9971.2018.06.03","DOIUrl":"https://doi.org/10.12970/2310-9971.2018.06.03","url":null,"abstract":"","PeriodicalId":91903,"journal":{"name":"Journal of endocrinology and diabetes mellitus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45537524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.12970/2310-9971.2018.06.02
S. Bellouk, S. Aziz, A. Chadli
Introduction : Relationship between diabetes and the (OH) vitamin D status raises several controversies; The aim of our study is to evaluate Vitamin D status in Moroccan type 2 diabetic women (DT2) by comparing it with a non-diabetic group (T). Secondary purpose was to establish relationships between Vitamine D status and T2D patients various metabolic, clinical and therapeutic parameters. Materials and Methods : This a cross-sectional case-control study including 110 patients with a Vitamin D dose (60 DT2 / 50 controls> 30 years). We excluded patients with a disease involving phosphocalcic metabolism or receiving Vitamin D supplementation or advanced renal or hepatic failure. Variables studied in the DT2 group were age, diabetes duration, glycemic equilibrium, BMI, degenerative complications, antidiabetic treatment, the menopause and vitamin D. Results were compared to a non-diabetic control group according to age, BMI and menopausal status. Results : Mean age was 51.5 ± 10.95 (DT2) vs 48.9 ± 11.2 years (T). Mean DT2 BMI was 32.1 vs 27.7 Kg / m 2 . Mean diabetes duration was 7.13 years with mean HBA1c at 9.17%. Hypovitaminosis D was present in 85% DT2, these results were comparable to the control group (84%). Mean level of Vitamin D was lower in the DT2 group: 17 ± 10.6 vs 22.2 ± 11.4 ng / ml (p = 0.005). 39% of TD2 were deficient vs 23% (T) p 35kg / m 2 (p= 0.003) with no significant relationship to age or menopausal status. In the DT2 group, there was a negative correlation between serum vitamin D levels and diabetes duration and BMI. Without relationship with HbA1c, degenerative complications or antidiabetic treatment. Conclusion : Hypovitaminosis D is as frequent in the diabetic population as in non-diabetic patients with lower rates and high prevalence in obese patients with ancient diabetes.
导论:糖尿病与(OH)维生素D状态的关系引起了一些争议;我们研究的目的是通过比较摩洛哥2型糖尿病女性(DT2)与非糖尿病组(T)的维生素D水平，以评估其水平。次要目的是建立维生素D水平与T2D患者各种代谢、临床和治疗参数之间的关系。材料和方法:这是一项横断面病例对照研究，包括110名服用维生素D剂量的患者(60名DT2 / 50名对照组，30岁)。我们排除了涉及磷钙代谢或接受维生素D补充或晚期肾或肝功能衰竭的患者。DT2组研究的变量包括年龄、糖尿病病程、血糖平衡、BMI、退行性并发症、抗糖尿病治疗、绝经和维生素d。根据年龄、BMI和绝经状态与非糖尿病对照组进行比较。结果:平均年龄分别为51.5±10.95 (DT2)和48.9±11.2岁(T)，平均DT2 BMI分别为32.1和27.7 Kg / m2。平均糖尿病病程为7.13年，平均HBA1c为9.17%。85%的DT2患者存在维生素D缺乏症，这些结果与对照组(84%)相当。DT2组维生素D的平均水平较低:17±10.6 vs 22.2±11.4 ng / ml (p = 0.005)。39%的TD2缺乏vs 23% (T) p 35kg / m2 (p= 0.003)，与年龄或绝经状态无显著关系。在DT2组中，血清维生素D水平与糖尿病持续时间和BMI呈负相关。与HbA1c、退行性并发症或降糖治疗无关。结论:糖尿病人群中维生素D缺乏症的发生率与非糖尿病患者相同，但发病率较低，肥胖合并古发糖尿病患者患病率较高。
{"title":"Hypovitaminosis D and Type 2 Diabetes: What Correlation? Control Case Study about 110 Cases","authors":"S. Bellouk, S. Aziz, A. Chadli","doi":"10.12970/2310-9971.2018.06.02","DOIUrl":"https://doi.org/10.12970/2310-9971.2018.06.02","url":null,"abstract":"Introduction : Relationship between diabetes and the (OH) vitamin D status raises several controversies; The aim of our study is to evaluate Vitamin D status in Moroccan type 2 diabetic women (DT2) by comparing it with a non-diabetic group (T). Secondary purpose was to establish relationships between Vitamine D status and T2D patients various metabolic, clinical and therapeutic parameters. Materials and Methods : This a cross-sectional case-control study including 110 patients with a Vitamin D dose (60 DT2 / 50 controls> 30 years). We excluded patients with a disease involving phosphocalcic metabolism or receiving Vitamin D supplementation or advanced renal or hepatic failure. Variables studied in the DT2 group were age, diabetes duration, glycemic equilibrium, BMI, degenerative complications, antidiabetic treatment, the menopause and vitamin D. Results were compared to a non-diabetic control group according to age, BMI and menopausal status. Results : Mean age was 51.5 ± 10.95 (DT2) vs 48.9 ± 11.2 years (T). Mean DT2 BMI was 32.1 vs 27.7 Kg / m 2 . Mean diabetes duration was 7.13 years with mean HBA1c at 9.17%. Hypovitaminosis D was present in 85% DT2, these results were comparable to the control group (84%). Mean level of Vitamin D was lower in the DT2 group: 17 ± 10.6 vs 22.2 ± 11.4 ng / ml (p = 0.005). 39% of TD2 were deficient vs 23% (T) p 35kg / m 2 (p= 0.003) with no significant relationship to age or menopausal status. In the DT2 group, there was a negative correlation between serum vitamin D levels and diabetes duration and BMI. Without relationship with HbA1c, degenerative complications or antidiabetic treatment. Conclusion : Hypovitaminosis D is as frequent in the diabetic population as in non-diabetic patients with lower rates and high prevalence in obese patients with ancient diabetes.","PeriodicalId":91903,"journal":{"name":"Journal of endocrinology and diabetes mellitus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45256503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.12970/2310-9971.2014.02.02.6
Scott Carlson, Jeevan K Prasain, Ning Peng, Yanying Dai, J Michael Wyss
Previous studies demonstrate that kudzu root extract and its major isoflavone (puerarin) improve glucose metabolism in animal models of insulin resistance and type 2 diabetes; however, these beneficial effects have not been investigated in normal glycemic mice. The present study investigates the effect of acute and chronic kudzu root extract supplementation on glucose tolerance in normoglycemic CD-1 mice. Male, adult CD-1 mice were fed a phytoestrogen-free diet containing 0.2% or 0.0% kudzu root extract for 6 weeks. Thereafter, they were acutely administered kudzu root extract (75 mg/kg BW; oral) or vehicle followed by a glucose challenge (2 g/kg BW; oral). In control fed mice, the acute glucose challenge increased blood glucose ~300% after 30 minutes, and acute kudzu root extract administration significantly blunted this response by ~50%. In mice chronically fed a kudzu-supplemented diet, glucose tolerance was improved, and acute treatment caused no additional improvement. Irrespective of treatment, all mice were normoglycemic at the start of each glucose challenge. Administration of insulin resulted in a larger decrease in blood glucose in chronic kudzu-supplemented compared to control mice. Co-administration of phloridzin (a specific inhibitor of SGLT-mediated glucose uptake), improved glucose tolerance in acutely kudzu-treated mice but had no significant effect on glucose tolerance in chronically treated mice. These results indicate that both acute and chronic administration of kudzu root extract improves glucose tolerance in a normal glycemic mouse strain and that the effects of chronic kudzu feeding may be mediated, in part, by enhanced insulin sensitivity (chronic) and inhibition of sodium dependent glucose transport.
{"title":"Acute and Chronic Kudzu Improves Plasma Glucose Tolerance in Non-Diabetic CD-1 Mice.","authors":"Scott Carlson, Jeevan K Prasain, Ning Peng, Yanying Dai, J Michael Wyss","doi":"10.12970/2310-9971.2014.02.02.6","DOIUrl":"10.12970/2310-9971.2014.02.02.6","url":null,"abstract":"<p><p>Previous studies demonstrate that kudzu root extract and its major isoflavone (puerarin) improve glucose metabolism in animal models of insulin resistance and type 2 diabetes; however, these beneficial effects have not been investigated in normal glycemic mice. The present study investigates the effect of acute and chronic kudzu root extract supplementation on glucose tolerance in normoglycemic CD-1 mice. Male, adult CD-1 mice were fed a phytoestrogen-free diet containing 0.2% or 0.0% kudzu root extract for 6 weeks. Thereafter, they were acutely administered kudzu root extract (75 mg/kg BW; oral) or vehicle followed by a glucose challenge (2 g/kg BW; oral). In control fed mice, the acute glucose challenge increased blood glucose ~300% after 30 minutes, and acute kudzu root extract administration significantly blunted this response by ~50%. In mice chronically fed a kudzu-supplemented diet, glucose tolerance was improved, and acute treatment caused no additional improvement. Irrespective of treatment, all mice were normoglycemic at the start of each glucose challenge. Administration of insulin resulted in a larger decrease in blood glucose in chronic kudzu-supplemented compared to control mice. Co-administration of phloridzin (a specific inhibitor of SGLT-mediated glucose uptake), improved glucose tolerance in acutely kudzu-treated mice but had no significant effect on glucose tolerance in chronically treated mice. These results indicate that both acute and chronic administration of kudzu root extract improves glucose tolerance in a normal glycemic mouse strain and that the effects of chronic kudzu feeding may be mediated, in part, by enhanced insulin sensitivity (chronic) and inhibition of sodium dependent glucose transport.</p>","PeriodicalId":91903,"journal":{"name":"Journal of endocrinology and diabetes mellitus","volume":"2 ","pages":"70-77"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/08/nihms814315.PMC5330362.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34779350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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