SRL neurology & neurosurgery最新文献

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Post-Exertional Malaise in Patients with ME and CFS with Comorbid Fibromyalgia. 合并纤维肌痛的 ME 和 CFS 患者的劳累后不适。

SRL neurology & neurosurgery

Pub Date : 2017-01-01 Epub Date: 2017-03-10

Stephanie L McManimen, Leonard A Jason

Background: Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) share some similar symptoms with fibromyalgia (FM). Prior research has found increased illness severity when patients have FM that is comorbid with ME and CFS. For example, post-exertional malaise (PEM) has been shown to be more severe in those with comorbid FM. However, PEM can be separated into two factors, Muscle and General PEM. It is unknown if the more severe PEM findings in comorbid FM are due to the Muscle or General PEM factor.

Purpose: The purpose of this study was to determine if the PEM differences seen between patients with and without comorbid FM exist for the Muscle or General PEM factors.

Method: An international convenience sample was collected via an online questionnaire. The questionnaire assessed the frequency and severity of several PEM-related symptoms. Additionally, participants provided information regarding the course and characteristics of their illness.

Results: Participants that indicated a comorbid diagnosis of FM displayed significantly more frequent and severe PEM symptoms in the Muscle and General PEM factors. The FM group also indicated significantly worse physical functioning compared to the group without comorbid FM.

Discussion: The secondary diagnosis of FM in addition to ME and CFS appears to amplify the PEM symptomatology and worsen patients' physical functioning. The findings of this study have notable implications on the inclusion of patients with comorbid FM in ME and CFS research studies.

背景：肌痛性脑脊髓炎（ME）和慢性疲劳综合征（CFS）与纤维肌痛（FM）有一些相似的症状。先前的研究发现，当纤维肌痛与肌痛性脑脊髓炎和慢性疲劳综合征并发时，患者的病情会更加严重。例如，研究表明，合并有纤维肌痛的患者的劳累后乏力（PEM）症状更为严重。然而，运动后乏力可分为两个因素，即肌肉和全身运动后乏力。目的：本研究旨在确定合并和不合并 FM 患者的 PEM 差异是否存在于肌肉或全身 PEM 因素：方法：通过在线问卷调查的方式收集国际样本。该调查问卷评估了几种 PEM 相关症状的频率和严重程度。此外，参与者还提供了有关其病程和特征的信息：结果：在肌肉和一般 PEM 因素中，合并有 FM 诊断的参与者表现出的 PEM 症状明显更频繁、更严重。与没有合并 FM 的组别相比，FM 组的身体功能也明显较差：讨论：除 ME 和 CFS 外，FM 的辅助诊断似乎会放大 PEM 症状，并使患者的身体功能恶化。这项研究的结果对将合并有FM的患者纳入ME和CFS研究具有重要意义。

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