Pub Date : 2019-03-22DOI: 10.35248/2684-124X.19.4.150
M. Matin, A. Asilian, Samaneh Mozafar Poor, Elaheh Haftbaradaran, A. Feily
Benign Cutaneous Lymphoid Hyperplasia (CLH) is a B-cell pseudolymphoma of an unknown origin. The face is the most affected site in CLH. This report presents the cases of 3 patients with CLH who were treated with rituximab. It is a hypothesis that rituximab is useful for treating resistant-to-relapsing forms of CLH that do not respond to previous therapies but must be checked with appropriate designs research.
{"title":"Treatment of Cutaneous Lymphoid Hyperplasia with Rituximab: A Case Report of 3 Patients","authors":"M. Matin, A. Asilian, Samaneh Mozafar Poor, Elaheh Haftbaradaran, A. Feily","doi":"10.35248/2684-124X.19.4.150","DOIUrl":"https://doi.org/10.35248/2684-124X.19.4.150","url":null,"abstract":"Benign Cutaneous Lymphoid Hyperplasia (CLH) is a B-cell pseudolymphoma of an unknown origin. The face is the most affected site in CLH. This report presents the cases of 3 patients with CLH who were treated with rituximab. \u0000 \u0000It is a hypothesis that rituximab is useful for treating resistant-to-relapsing forms of CLH that do not respond to previous therapies but must be checked with appropriate designs research.","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45733093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.35248/2684-124X.19.4.149
A. Hameed, N. Akhtar
Skin is the largest organ of the human body. It performs many functions like protection, acts as a physical, chemical and biological barrier, and also helps in the synthesis of vitamin D when exposed to UVB radiations. The color of the skin is usually determined by a pigment "The Melanin" which is present in the skin and is synthesized by melanocytes. The objective of the current review is to evaluate the effect of Melanin of Vitamin D synthesis. Different search databases like Google Scholar, Pubmed, Mendeley, and Scopus were being utilized to find the relation between the production of vitamin D in the skin and its level of pigmentation. If the level of melanin increases, the skin becomes darker in color and vice versa. Melanin secretion is increased when skin is exposed to UV radiations. Melanin has photoprotective action and protects the skin from harmful effects of ultraviolet radiations. High melanin level inhibits the production of vitamin D in the skin. Vitamin D is a prohormone that helps in the absorption of calcium from the gut. Deficiency of vitamin D leads to many threats.
{"title":"The Skin Melanin: An Inhibitor of Vitamin-D3 Biosynthesis: With Special Emphasis with Structure of Skin. A Mini Review","authors":"A. Hameed, N. Akhtar","doi":"10.35248/2684-124X.19.4.149","DOIUrl":"https://doi.org/10.35248/2684-124X.19.4.149","url":null,"abstract":"Skin is the largest organ of the human body. It performs many functions like protection, acts as a physical, chemical and biological barrier, and also helps in the synthesis of vitamin D when exposed to UVB radiations. The color of the skin is usually determined by a pigment \"The Melanin\" which is present in the skin and is synthesized by melanocytes. The objective of the current review is to evaluate the effect of Melanin of Vitamin D synthesis. \u0000 \u0000Different search databases like Google Scholar, Pubmed, Mendeley, and Scopus were being utilized to find the relation between the production of vitamin D in the skin and its level of pigmentation. If the level of melanin increases, the skin becomes darker in color and vice versa. Melanin secretion is increased when skin is exposed to UV radiations. Melanin has photoprotective action and protects the skin from harmful effects of ultraviolet radiations. High melanin level inhibits the production of vitamin D in the skin. Vitamin D is a prohormone that helps in the absorption of calcium from the gut. Deficiency of vitamin D leads to many threats.","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44305627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-24DOI: 10.35248/2684-124x.19.4.147
J. Saleh, Brooke Vasicek, J. Reserva, E. Lake, J. Speiser
Neutrophilic Eccrine Hidradenitis (NEH) is a rare inflammatory neutrophilic dermatosis that primarily affects eccrine sweat glands. Although it has been described in various malignancies and with therapeutic agents, it is most frequently associated with cytarabine-based induction chemotherapy for acute myelogenous leukemia. We report a rare case of NEH in a 63-year-old male with a medical history significant for primary CNS lymphoma. The patient was treated with high-dose thiotepa, busulfan, and cyclophosphamide (BuCy) followed by autologous stem cell transplantation, which was complicated by bacteremia and septic shock. Approximately three weeks after chemotherapy, he developed localized bright red, desquamating plaques on his bilateral outer hips, posterior upper thighs, and buttocks. Histological findings revealed neutrophils infiltrating and surrounding the eccrine glands accompanied by squamous syringometaplasia, apoptotic keratinocytes, and basovacuolar changes. This case serves to highlight that NEH should be considered in the differential diagnosis of erosive, erythematous plaques, especially in patients with lymphoproliferative tumors receiving high-dose chemotherapy, in order to provide appropriate clinical management.
{"title":"Neutrophilic Eccrine Hidradenitis in a Primary CNS Lymphoma Patient Receiving High-Dose Chemotherap","authors":"J. Saleh, Brooke Vasicek, J. Reserva, E. Lake, J. Speiser","doi":"10.35248/2684-124x.19.4.147","DOIUrl":"https://doi.org/10.35248/2684-124x.19.4.147","url":null,"abstract":"Neutrophilic Eccrine Hidradenitis (NEH) is a rare inflammatory neutrophilic dermatosis that primarily affects eccrine sweat glands. Although it has been described in various malignancies and with therapeutic agents, it is most frequently associated with cytarabine-based induction chemotherapy for acute myelogenous leukemia. We report a rare case of NEH in a 63-year-old male with a medical history significant for primary CNS lymphoma. The patient was treated with high-dose thiotepa, busulfan, and cyclophosphamide (BuCy) followed by autologous stem cell transplantation, which was complicated by bacteremia and septic shock. Approximately three weeks after chemotherapy, he developed localized bright red, desquamating plaques on his bilateral outer hips, posterior upper thighs, and buttocks. Histological findings revealed neutrophils infiltrating and surrounding the eccrine glands accompanied by squamous syringometaplasia, apoptotic keratinocytes, and basovacuolar changes. This case serves to highlight that NEH should be considered in the differential diagnosis of erosive, erythematous plaques, especially in patients with lymphoproliferative tumors receiving high-dose chemotherapy, in order to provide appropriate clinical management.","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48344945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-14DOI: 10.35248/2684-124X.19.4.146
C. Kenny, Deptmer M Ashely, Sunghun Cho
One-day old infant girl, born at term, presents with blanching erythematous macules, vesicles and pustules scattered on her upper and lower extremities. These lesions progressed rapidly and began to coalesce and take on a linear configuration, even appearing on her trunk and face. A punch biopsy revealed eosinophilic spongiosis. Based on skin findings and histopathology this girl was diagnosed with Incontinentia pigmenti (IP) in accordance with the IP Diagnostic Criteria 2013. IP is a rare, X linked dominant genetic syndrome occurring in 1 of 50,000 births. IP presents with characteristic cutaneous lesions and in varying frequency, extracutaneous manifestations. The cutaneous manifestations appear in four progressive stages. The first stage consists of multifocal and coalescing erythematous macules and patches with overlying tense vesicles on the patient’s trunk and extremities. These lesions are distributed along Blashko lines. In stage two, the lesions become hyperkeratotic appearing similar to viral warts. The lesions in the third stage darken and become hyperpigmented. They may appear as swirled macules. In the final stage hypopigmentation of the lesion occurs. Cutaneous symptoms often do not require additional medical care. Extracutaneous findings include dental, neurologic, and ocular anomalies. Requiring increased frequency of follow up by specialists during early childhood.
{"title":"Newborn Girl with Rapidly Progressive Linearly Distributed Vesicles and Pustules","authors":"C. Kenny, Deptmer M Ashely, Sunghun Cho","doi":"10.35248/2684-124X.19.4.146","DOIUrl":"https://doi.org/10.35248/2684-124X.19.4.146","url":null,"abstract":"One-day old infant girl, born at term, presents with blanching erythematous macules, vesicles and pustules scattered on her upper and lower extremities. These lesions progressed rapidly and began to coalesce and take on a linear configuration, even appearing on her trunk and face. A punch biopsy revealed eosinophilic spongiosis. Based on skin findings and histopathology this girl was diagnosed with Incontinentia pigmenti (IP) in accordance with the IP Diagnostic Criteria 2013. IP is a rare, X linked dominant genetic syndrome occurring in 1 of 50,000 births. IP presents with characteristic cutaneous lesions and in varying frequency, extracutaneous manifestations. The cutaneous manifestations appear in four progressive stages. The first stage consists of multifocal and coalescing erythematous macules and patches with overlying tense vesicles on the patient’s trunk and extremities. These lesions are distributed along Blashko lines. In stage two, the lesions become hyperkeratotic appearing similar to viral warts. The lesions in the third stage darken and become hyperpigmented. They may appear as swirled macules. In the final stage hypopigmentation of the lesion occurs. Cutaneous symptoms often do not require additional medical care. Extracutaneous findings include dental, neurologic, and ocular anomalies. Requiring increased frequency of follow up by specialists during early childhood.","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42991605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2684-124x.19.4.148
P. Choudhary, H PatkiAnil, S. Tejaswini
Linear and Whorled Nevoid Hypermelanosis (LWNH) also known as ‘zebra-like pigmentation’ is characterized by linear and swirling streaks of hyperpigmentation along the Blaschko’s lines without preceding inflammation and atrophy. It is mainly located on trunk and limbs. The hyperpigmentation may be present at birth or may develop by early childhood. Hyperpigmentation may progress for one to two years before stabilization. The eyes, palms, soles and mucus membrane are usually not affected. LWNH generally occurs sporadically. Very rarely, familial cases have been described.
{"title":"Linear and Whorled Nevoid Hypermelanosis: A Rare Case Report","authors":"P. Choudhary, H PatkiAnil, S. Tejaswini","doi":"10.35248/2684-124x.19.4.148","DOIUrl":"https://doi.org/10.35248/2684-124x.19.4.148","url":null,"abstract":"Linear and Whorled Nevoid Hypermelanosis (LWNH) also known as ‘zebra-like pigmentation’ is characterized by linear and swirling streaks of hyperpigmentation along the Blaschko’s lines without preceding inflammation and atrophy. It is mainly located on trunk and limbs. The hyperpigmentation may be present at birth or may develop by early childhood. Hyperpigmentation may progress for one to two years before stabilization. The eyes, palms, soles and mucus membrane are usually not affected. LWNH generally occurs sporadically. Very rarely, familial cases have been described.","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70015984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2684-124X.19.4.151
Man, har Upasana, W. Yin, W. Bo, Song Ji Quan
Human Recombinant Granulocyte colony-stimulating factor is a hematopoietic growth factor; most commonly known to be used for chemotherapy-induced neutropenia for the mobilization of peripheral blood stem cells. A case of 43 years old lady, post radical mastectomy for breast cancer and one cycle of chemotherapy was encountered with the development of massive psoriasis-like eruptions all over the body including the scalp with adherent silvery scales after 10 days of administration of granulocyte colony-stimulating factor with the failure of remission even after months of treatment. Specific psoriasis signs were seen positive but the Biopsy and Reflectance Confocal Microscopy was inconclusive for the diagnosis of Psoriasis, therefore managed as an allergic drug eruption with immediate cessation of G-CSF administration. The rash improved significantly with no new appearances. However during follow up, the island of patches persisted on certain areas, which made it a not so clear case of a drug eruption because of its incomplete remission even after cessation of the drug. So we would like to present a case of G-CSF induced drug eruption coinciding with Psoriasis features suggestive of early presentation of Psoriasis. The main objective of this report is to analyze whether the eruptions caused by G-CSF is a drug eruption or an initiation towards the overall progression of Psoriasis.
{"title":"Failure of Remission of Granulocyte-Colony Stimulating Factor G-Csf Induced Drug Eruption Suggestive of Early Psoriasis-A Case Report and Literature Review","authors":"Man, har Upasana, W. Yin, W. Bo, Song Ji Quan","doi":"10.35248/2684-124X.19.4.151","DOIUrl":"https://doi.org/10.35248/2684-124X.19.4.151","url":null,"abstract":"Human Recombinant Granulocyte colony-stimulating factor is a hematopoietic growth factor; most commonly known to be used for chemotherapy-induced neutropenia for the mobilization of peripheral blood stem cells. A case of 43 years old lady, post radical mastectomy for breast cancer and one cycle of chemotherapy was encountered with the development of massive psoriasis-like eruptions all over the body including the scalp with adherent silvery scales after 10 days of administration of granulocyte colony-stimulating factor with the failure of remission even after months of treatment. Specific psoriasis signs were seen positive but the Biopsy and Reflectance Confocal Microscopy was inconclusive for the diagnosis of Psoriasis, therefore managed as an allergic drug eruption with immediate cessation of G-CSF administration. The rash improved significantly with no new appearances. However during follow up, the island of patches persisted on certain areas, which made it a not so clear case of a drug eruption because of its incomplete remission even after cessation of the drug. So we would like to present a case of G-CSF induced drug eruption coinciding with Psoriasis features suggestive of early presentation of Psoriasis. The main objective of this report is to analyze whether the eruptions caused by G-CSF is a drug eruption or an initiation towards the overall progression of Psoriasis.","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70015990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01Epub Date: 2019-04-08DOI: 10.35248/2684-124X.19.4.152
Daniel J Zinn, Olive Eckstein, Mary L Olsen, Carl E Allen, Kenneth L McClain
A patient with Multifocal Reticulohistiocytosis (MRH) of skin and joints failed treatment with etanercept, methotrexate, hydroxychloroquine, prednisone, bisphosphonates and hydroxyzine. Long term treatment with thalidomide led to marked improvement in joint and cutaneous manifestations.
{"title":"Thalidomide, A Rational Agent for Treatment of Multicentric Reticulohistiocytosis.","authors":"Daniel J Zinn, Olive Eckstein, Mary L Olsen, Carl E Allen, Kenneth L McClain","doi":"10.35248/2684-124X.19.4.152","DOIUrl":"https://doi.org/10.35248/2684-124X.19.4.152","url":null,"abstract":"<p><p>A patient with Multifocal Reticulohistiocytosis (MRH) of skin and joints failed treatment with etanercept, methotrexate, hydroxychloroquine, prednisone, bisphosphonates and hydroxyzine. Long term treatment with thalidomide led to marked improvement in joint and cutaneous manifestations.</p>","PeriodicalId":92997,"journal":{"name":"Dermatology case reports","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/24/nihms-1024550.PMC7289025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38036041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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