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DELAYED REFERRAL FOR DIAGNOSTIC ENDOSCOPY IS A CONTRIBUTING FACTOR TO LATE GASTRIC CANCER DIAGNOSIS IN ZAMBIA. 在赞比亚,内镜诊断转诊延迟是导致胃癌诊断过晚的一个因素。
Pub Date : 2019-02-01
V Kayamba, P Kelly

There is evidence that 15 % of gastric cancer patients in Zambia survive more than one-year after diagnosis. The major contributing factor to these poor outcomes is late case detection. We set out to investigate the time course of gastric cancer diagnosis in Zambia. The study was conducted at the University Teaching Hospital, in Lusaka. Consenting patients presenting to the endoscopy unit were enrolled and their endoscopic findings recorded. An interviewer-administered questionnaire was used to collect information on basic characteristics, presenting symptoms and duration. We enrolled 388 patients, 92 (24%) of whom had gastric cancer. About two-thirds of the gastric cancers were located in the distal part of the stomach. The median time to endoscopic gastric cancer diagnosis was 12 weeks, IQR 4-32 weeks after the first health care consultation. This was despite gastric cancer patients seeking healthcare attention within a median of 2 weeks, IQR 0-4 weeks of noticing the symptoms. Patients presenting with persistent vomiting or evidence of blood loss had significantly shorter delays than those with abdominal pain (p<0.05 and p<0.001 respectively). Delayed referral for diagnostic endoscopy is a contributing factor to late gastric cancer diagnosis in Zambia. The delay is highest in patients presenting with abdominal pain.

有证据表明,赞比亚 15% 的胃癌患者在确诊后存活时间超过一年。导致这些不良后果的主要因素是病例发现较晚。我们着手调查赞比亚胃癌诊断的时间过程。研究在卢萨卡大学教学医院进行。征得同意的内镜检查患者被登记在册,他们的内镜检查结果也被记录在案。研究人员使用由访谈者填写的问卷收集有关基本特征、主要症状和病程的信息。我们共登记了 388 名患者,其中 92 人(24%)患有胃癌。约三分之二的胃癌位于胃的远端。内镜胃癌诊断的中位时间为首次就诊后 12 周,IQR 为 4-32 周。尽管胃癌患者在发现症状后2周(IQR为0-4周)内就开始就医,但这并不意味着胃癌患者在发现症状后2周(IQR为0-4周)内就开始就医。与腹痛患者相比,出现持续呕吐或失血症状的患者的就诊延迟时间明显更短(p
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