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Return on Investment from the Prevention of Orphan Diseases in Kuwait 科威特预防孤儿病的投资回报
Pub Date : 2022-03-25 DOI: 10.55085/aph.2022.637
S. Abuhadida, L. Bastaki, Buthina Bash, Barrak Alhindal
Spinal Muscular Atrophy type 1 and RPE65 mutation-associated Inherited Retinal dystrophy are two well-known Orphan diseases for expensive Orphan drugs. Being inheritable disorders, they can be prevented through a program that includes Premarital Genetic Screening to detect the defective gene carriers followed by Preimplantation Genetic Diagnosis to identify healthy gametes and In Vitro Fertilization. We developed a stochastic financial model to assess the Return on Investment over five years of implementing a prevention program to tackle these conditions from the financial perspective of the Ministry of Health in Kuwait. The ROI from the prevention program was shown to be highly cost-saving, with a probabilistic average of 9,710,311 USD (2,930,727 KWD). Every 1 USD or KWD spent on prevention would return 1.5 USD or KWD in savings. Meanwhile, not implementing the prevention program could cost the MOH a probabilistic average of 71,431,037 USD (21,555,325 KWD) within the same period. The findings of this study strongly support the adoption and implementation of the prevention program from the financial perspective of the MOH.
1型脊髓性肌萎缩症和RPE65突变相关的遗传性视网膜营养不良是两种众所周知的孤儿病,需要昂贵的孤儿药。作为遗传性疾病,它们可以通过一个项目来预防,包括婚前遗传筛查,以检测有缺陷的基因携带者,然后是植入前遗传学诊断,以识别健康的配子和体外受精。我们开发了一个随机财务模型,从科威特卫生部的财务角度评估实施一项预防方案的五年投资回报,以解决这些问题。该预防项目的投资回报率被证明是非常节省成本的,概率平均为9,710,311美元(2,930,727 KWD)。在预防上每花费1美元或金元,可节省1.5美元或金元。与此同时,不实施预防计划可能会使卫生部在同一时期平均损失71,431,037美元(21,555,325千瓦时)。本研究结果有力地支持卫生部从财政角度采用和实施预防方案。
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引用次数: 1
Knowledge, Attitudes and Preventive Practices towards COVID-19 among Bangladeshi Students: An Online Based Cross-sectional Study 孟加拉国学生对COVID-19的知识、态度和预防措施:一项基于在线的横断面研究
Pub Date : 2022-03-10 DOI: 10.55085/aph.2022.630
M. H. Banna, Satyajit Kundu, A. Sayeed, Keith Brazendale, M. Begum, B. Ahinkorah, J. Okyere, M. Khan
This study sought to assess the level of knowledge, attitude, and practice (KAP) toward COVID-19 among Bangladeshi students. An online-based cross-sectional study was conducted in late April 2020 among 904 Bangladeshi students using a Snowball sampling technique. Data collected were analyzed using descriptive statistics, independent sample t-tests, and analysis of variance (ANOVA) test. Multiple linear regression was employed to calculate the associations between KAP scores and other demographic variables. The mean COVID-19 knowledge score was 14.45 (SD: 1.72; range: 7-17), indicating a moderate level of knowledge. The mean scores for attitudes and practices were 2.45 (SD: 1.13; range: 0-6) and 4.58 (SD: 0.71; range: 1-5), indicating negative attitudes and reasonable practices toward COVID-19, respectively. Students enrolled at the undergraduate level or higher and from urban areas were associated with higher knowledge and practice scores. Students who read scientific articles as their main source of COVID-19 information were more knowledgeable than their peers. Students who participated in online training/courses about COVID-19 were significantly associated with higher KAP scores. The negative attitude of students reported in this study indicates the need for government and policymakers to ensure more targeted awareness campaigns are implemented to enhance public confidence and participation in COVID-19 preventive measures.
本研究旨在评估孟加拉国学生对COVID-19的知识、态度和实践水平。2020年4月下旬,使用雪球抽样技术对904名孟加拉国学生进行了一项基于在线的横断面研究。收集的资料采用描述性统计、独立样本t检验和方差分析(ANOVA)检验进行分析。采用多元线性回归计算KAP得分与其他人口统计学变量之间的关系。平均COVID-19知识得分为14.45分(SD: 1.72;范围:7-17),表明知识水平中等。态度和行为的平均得分为2.45分(SD: 1.13;范围:0-6)和4.58 (SD: 0.71;范围:1-5),分别表示对COVID-19的负面态度和合理做法。来自城市地区的本科或更高水平的学生与更高的知识和实践分数相关。将阅读科学文章作为新冠肺炎信息主要来源的学生比同龄人更有知识。参加COVID-19在线培训/课程的学生与更高的KAP分数显著相关。本研究中报告的学生的消极态度表明,政府和政策制定者需要确保开展更有针对性的宣传活动,以增强公众对COVID-19预防措施的信心和参与。
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引用次数: 0
Health Policy and Systems Research in Sub-Saharan Africa during the COVID-19 Pandemic COVID-19大流行期间撒哈拉以南非洲的卫生政策和系统研究
Pub Date : 2022-01-28 DOI: 10.55085/aph.2022.609
E. Manirambona
Authors’ contributions The participation of each author corresponds to the criteria of authorship and contributorship emphasized in the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals of the International Committee of Medical Journal Editors. Indeed, all the authors have actively participated in the redaction, the revision of the manuscript, and provided approval for this final revised version.
每位作者的参与符合国际医学期刊编辑委员会《关于医学期刊学术工作的行为、报告、编辑和出版的建议》中强调的作者和贡献者的标准。的确,所有作者都积极参与了手稿的编校、修订,并对最终修订版提供了认可。
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引用次数: 3
Impact of Nyiragongo Volcanic Eruptions on the Resilience to the COVID-19 and Ebola in the Democratic Republic of the Congo 尼拉贡戈火山爆发对刚果民主共和国抵御COVID-19和埃博拉病毒能力的影响
Pub Date : 2022-01-25 DOI: 10.55085/aph.2022.592
E. Manirambona, Emmanuel Uwiringiyimana, Shuaibu Saidu Musa, Samuel Niyonkuru, Dawa Gyeltshen, Yusuff Adebayo Adebisi, Don Eliseo Lucero-Prisno, III
For decades, the Democratic Republic of the Congo (DRC) has been vulnerable to disasters. The most dangerous Nyiragongo volcanic eruption posed a threat to the country, particularly the city of Goma. The explosions on 22 May 2021 caused unfathomable damages, with loss of lives, properties, and the destruction of homes, displacing thousands of people, with thousands of children being left vulnerable as a result. Furthermore, it charred health and school infrastructures and decimated crops, an issue in the population where the COVID-19 has exacerbated the existing fragile health system. Importantly, these eruptions posed a challenge when DRC struggled to end COVID-19 and Ebola through surveillance, preventive measures, and vaccination. It is doubtless that priorities of the emergency have interrupted the surveillance system, thus increasing exposure to the COVID-19 and Ebola transmission. It is critical to provide basic needs to victims of the Nyiragongo volcanic eruptions in the aftermath of such a disaster. Local and global humanitarian organizations are needed to assist residents in relocating. Furthermore, appropriate and adjusted mitigation strategies will significantly prevent Ebola, COVID-19, and other infectious diseases. In this paper, we discuss the impacts of the volcanic eruption on population health and Ebola preparedness and response in the context of the global COVID-19 outbreak in the Democratic Republic of the Congo.
几十年来,刚果民主共和国(DRC)一直很容易受到灾害的影响。最危险的尼拉贡戈火山喷发对该国,特别是戈马市构成了威胁。2021年5月22日的爆炸造成了难以估量的损失,造成生命和财产损失,房屋被毁,数千人流离失所,数千名儿童因此处于弱势。此外,它烧毁了卫生和学校基础设施,摧毁了农作物,这是人口中的一个问题,COVID-19加剧了现有脆弱的卫生系统。重要的是,当刚果民主共和国努力通过监测、预防措施和疫苗接种来结束COVID-19和埃博拉病毒时,这些爆发构成了挑战。毫无疑问,紧急情况的优先事项中断了监测系统,从而增加了对COVID-19和埃博拉病毒传播的接触。在尼拉贡戈火山爆发后,向受害者提供基本需求至关重要。需要地方和全球人道主义组织协助居民搬迁。此外,适当和调整后的缓解战略将显著预防埃博拉、COVID-19和其他传染病。本文以刚果民主共和国2019冠状病毒病(COVID-19)全球疫情为背景,探讨了火山爆发对人口健康和埃博拉防范与应对的影响。
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引用次数: 1
Global, WHO Regional, and Continental Prevalence of Self-medication from 2000 to 2018: A Systematic Review and Meta-analysis 2000年至2018年全球、世卫组织区域和大陆自我药疗患病率:系统回顾和荟萃分析
Pub Date : 2022-01-18 DOI: 10.55085/aph.2022.585
Shabnam Ghasemyani, Mahshid Roohravan Benis, H. Hosseinifard, R. Jahangiri, A. Aryankhesal, Hosein Shabaninejad, S. Rafiei, A. Ghashghaee
Background: Nowadays, with regard to the availability of medicines and populations’ increased knowledge of medical sciences, self-medication has increased which is a challenging issue for the healthcare system. This study aimed to examine the prevalence of self-medication, comprehensively at a global level. In addition, effective factors in this regard, including the motives of self-medication, diversity of medicines used, the supply resources, and type of the resulted disease were evaluated.Materials: English language articles published during 2000-2018 were systematically searched in Embase, PubMed, Web of Science, and Scopus to find relevant research. Studies that met the inclusion criteria were evaluated independently by two researchers the relevant articles were examined based on the prevalence of the phenomenon and factors such as setting of study, common reasons for self-medication, and common drugs used.Results: From 951 primarily revealed articles, 69 papers were entered for the final analysis. Overall, 41620 individuals were included in the selected papers, 67% of whom (N=27890) had at least one experience of self-medication. Among the continents, Europe (Eastern) had the highest incidence rate of self-medication (74%, 95% CI, 56%-86%). In terms of supply resources, 71% of the subjects purchased drugs from pharmacies (95% CI, 61-80%). Regarding the condition that led to self-medication, 48% of the patients turned to self-medication due to neurological problems (95% CI, 40-55%). Among the causes of self-medication, “a previous history” and “minor nature of the disease” were the most common reasons for self-medication.Conclusion: According to the results of the study, the mean incidence of self-medication was higher in Eastern Europe and Asian countries, compared to other parts of the world. This could be a considerable note for policy-makers of this field. In general, self-medication can lead to short and long-term harmful consequences for the society and the healthcare systems, resulting in huge costs for countries.
背景:如今,关于药物的可用性和人口的医学科学知识的增加,自我药疗增加了,这是一个具有挑战性的问题,为医疗保健系统。本研究旨在全面调查全球范围内自我药疗的流行情况。此外,还评估了这方面的有效因素,包括自我用药的动机、使用药物的多样性、供应资源和所导致疾病的类型。资料:系统检索Embase、PubMed、Web of Science、Scopus等数据库2000-2018年间发表的英文论文,查找相关研究。符合纳入标准的研究由两名研究人员独立评估,相关文章根据现象的普遍性和研究环境、自我用药的常见原因、常用药物等因素进行检查。结果:951篇初查论文中,69篇被纳入最终分析。总体而言,入选论文共纳入41620人,其中67% (N=27890)至少有一次自我药物治疗的经历。在各大洲中,欧洲(东部)的自我药疗发生率最高(74%,95% CI, 56%-86%)。在供应资源方面,71%的受试者从药店购买药品(95% CI为61 ~ 80%)。对于导致自我药疗的情况,48%的患者由于神经问题而转向自我药疗(95% CI, 40-55%)。在自我药疗的原因中,“既往病史”和“疾病性质轻微”是最常见的原因。结论:根据研究结果,与世界其他地区相比,东欧和亚洲国家的自我药疗平均发生率更高。这对该领域的政策制定者来说可能是一个相当重要的注意事项。一般来说,自我药疗会给社会和卫生保健系统带来短期和长期的有害后果,给国家带来巨大的成本。
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引用次数: 8
Thirdhand Smoke Exposure in Homes with Children under 48 Months during the First Wave of the COVID-19 Pandemic Confinement in Barcelona (Spain) 西班牙巴塞罗那第一波COVID-19大流行隔离期间,有48个月以下儿童的家庭暴露于三手烟
Pub Date : 2022-01-01 DOI: 10.55085/aph.2022.617
Cristina Lidón-Moyano, Ana Díez-Izquierdo, Pia Cassanello, À. Cartanyà-Hueso, J. Martín-Sánchez, A. Balaguer, J. Martínez-Sánchez
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引用次数: 0
Financial Burden and Average Cost of COVID-19 per Patient Admitted to the Intensive Care Unit in Kuwait 科威特重症监护室收治的每位患者的经济负担和COVID-19平均费用
Pub Date : 2022-01-01 DOI: 10.55085/aph.2022.663
S. Abuhadida, S. Alzaid, Medhat Elshazely, Barrak Alhindal
Introduction: COVID-19 pandemic imposed a massive impact on constrained healthcare resources especially Intensive Care Units beds. Nevertheless, few studies have explored direct medical costs of ICU admissions and the financial burden associated with them. Aim: Our aim is to estimate the average direct medical cost of COVID-19 admitted to ICU per patient and per diem as well as the associated financial burden. Methods: A stochastic financial model was developed in accordance with Kuwait Task Force guidelines for COVID-19 management in ICU. Results: Our results showed the average cost of COVID-19 patients admitted in the ICU per patient and per diem to be 16,471 KWD (53,354 USD) and 1,643 KWD (5,422 USD) respectively. While the financial burden over one fiscal year amounted to 15,795,830 KWD (52,126,239 USD). Conclusion: This estimate can guide policy makers, researchers and financial analysts to follow a data driven decisions in planning and budgeting healthcare resources for this concurrent event or similar future events.
导言:COVID-19大流行对有限的医疗资源,特别是重症监护病房床位造成了巨大影响。然而,很少有研究探讨ICU入院的直接医疗费用和与之相关的经济负担。目的:我们的目的是估计每个患者和每天入住ICU的COVID-19的平均直接医疗费用以及相关的经济负担。方法:根据科威特特别工作组ICU COVID-19管理指南建立随机财务模型。结果:我们的结果显示,COVID-19患者在ICU住院的平均费用为每名患者16,471 KWD(53,354美元)和每天1,643 KWD(5,422美元)。而一个财政年度的财政负担为15,795,830 KWD(52,126,239美元)。结论:这一估计可以指导政策制定者、研究人员和金融分析师根据数据驱动的决策来规划和预算医疗资源,以应对这一并发事件或类似的未来事件。
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引用次数: 0
The Effect of a Dedicated Lung Mass Clinic on Lung Nodule Follow Up. 肺肿块专科门诊对肺结节随访的影响。
Pub Date : 2022-01-01 Epub Date: 2022-05-09 DOI: 10.33552/aphe.2022.01.000524
Avnee J Kumar, Dena H Tran, Barathi Sivasailam, Zain Nagaria, Jigar Patel, Avelino C Verceles, Janaki Deepak

Introduction: With the increased use of computed tomography (CT) imaging, lung nodules are found yearly requiring tracking and guideline directed follow up imaging. We describe the structure of a clinic dedicated to lung nodule tracking, patient education and the outcomes of lung nodule follow up.

Methods: Patient electronic medical record charts were reviewed for lung nodules requiring tracking to determine if a follow up study was ordered, completed by the patient, and completed in an appropriate time frame. Patients were grouped based on referral to pulmonary clinic, lung mass clinic, or no subspecialty clinic. 700 CT reports were extracted from the electronic medical record of which 350 (50%) had lung nodules reported on CT, and 111 (15.9%) were lung nodules that additionally recommended discrete follow up in the radiologist report at the Veterans Health Administration hospital in Baltimore. Of these 111 patients, 95% were male and 5% were female. The mean age of the population was 66.3 ± 7.7 years.

Results and discussion: Patients seen in the lung mass clinic had a statistically significant higher rate of the follow up study being ordered by the provider. The lung mass clinic also had a higher percentage of patients who completed the study and completed the study within the recommended time frame, however, this was not statistically significant.

Conclusion: A dedicated lung mass clinic should be considered as a method of improving lung nodule tracking with the added benefit of patient education and multidisciplinary care.

简介:随着计算机断层扫描(CT)成像的使用增加,每年发现的肺结节需要跟踪和指导的随访成像。我们描述了一个诊所的结构,致力于肺结节跟踪,患者教育和肺结节随访的结果。方法:查看需要跟踪的肺结节患者电子病历图表,以确定是否安排了随访研究,由患者完成,并在适当的时间框架内完成。患者根据转诊到肺部诊所、肺肿块诊所或无亚专科诊所进行分组。从电子病历中提取700例CT报告,其中350例(50%)在CT上报告有肺结节,111例(15.9%)为肺结节,在巴尔的摩退伍军人健康管理医院的放射科医生报告中额外建议进行离散随访。111例患者中,95%为男性,5%为女性。人口平均年龄为66.3±7.7岁。结果和讨论:在肺肿块门诊就诊的患者接受医生要求的随访率有统计学意义上的提高。肺肿块诊所也有更高比例的患者完成了研究,并在推荐的时间框架内完成了研究,然而,这没有统计学意义。结论:应考虑设立专门的肺肿块门诊,以改善肺结节的跟踪,并增加患者教育和多学科护理的好处。
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引用次数: 0
A Description of lethal lead Intoxication in Dante’s Divine Comedy 但丁《神曲》中致命铅中毒的描写
Pub Date : 2022-01-01 DOI: 10.55085/aph.2022.665
K. Stamatiou, Andreas Stamatiou
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引用次数: 0
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Annals of public health & epidemiology
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