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Is Cardiac Surgery Safe in Patients with Previous Liver Transplantation? A Narrative Review 曾接受过肝移植的患者接受心脏手术安全吗?叙述性综述
Pub Date : 2024-02-05 DOI: 10.33140/jsc.03.01.03
Background Liver transplant patients have increased risk of developing cardiovascular disease and the outcome of these patients following cardiac surgery has been reported in small series of patients. The aim of this review was to examine and report safety outcomes of liver transplant patients undergoing cardiac surgery. Methods Literature review was conducted using three databases from inception to June 2023. Multiple search terms were used and limited to English language. Nine relevant articles were included. Outcomes of interest were short-term mortality, long-term survival, liver graft failure, major morbidity and infection in liver transplant recipients undergoing cardiac surgery. Results Cardiac risk factors (diabetes mellitus, hypertension, hyperlipidemia) were prevalent in liver transplant patients. 30-days mortality ranged across the studies from zero to 23.8%. 1-year survival ranged from 74-91% and 5-years survival ranged from 33-69%. Commonest causes of death were cardiac and sepsis. Predictors of mortality were preoperative encephalopathy, pulmonary hypertension, blood transfusion and postoperative increase in creatinine and bilirubin levels. Liver allograft rejection ranged from zero to 4.7% with no predictors reported. Liver dysfunction was seen in 33-46% of patients, and all were transient with recovery at the time of hospital discharge. Major morbidities were commonly reported and included respiratory and renal failure. Infection rates ranged from zero to 38% and the most common reported sites were pneumonia, sepsis, and surgical site infections. Conclusion Cardiac surgery can be performed in liver transplant patients with good short- and long-term results and acceptable morbidities.
背景 肝移植患者罹患心血管疾病的风险较高,而这些患者在接受心脏手术后的疗效仅在小范围内有所报道。本综述旨在研究和报告接受心脏手术的肝移植患者的安全结果。方法 使用三个数据库进行文献综述,时间从开始到 2023 年 6 月。使用了多个检索词,并仅限于英语。共纳入九篇相关文章。关注的结果包括接受心脏手术的肝移植受者的短期死亡率、长期存活率、肝移植失败、主要发病率和感染。结果 肝移植患者普遍存在心脏风险因素(糖尿病、高血压、高脂血症)。各项研究的 30 天死亡率从零到 23.8%不等。1年存活率为74-91%,5年存活率为33-69%。最常见的死亡原因是心脏病和败血症。死亡率的预测因素包括术前脑病、肺动脉高压、输血以及术后肌酐和胆红素水平升高。肝脏异体移植排斥反应从零到4.7%不等,没有报告预测因素。33%-46%的患者出现肝功能异常,所有患者均为一过性肝功能异常,出院时即可恢复。常见的主要病症包括呼吸衰竭和肾衰竭。感染率从零到 38% 不等,最常见的感染部位是肺炎、败血症和手术部位感染。结论 肝移植患者可进行心脏手术,短期和长期效果良好,发病率可接受。
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引用次数: 0
The Prevalence of Multidrug-Resistant Organisms in Patients with Surgical Site Infections in Riyadh, Saudi Arabia: A Cross-sectional Study at a Tertiary Care Hospital 沙特阿拉伯利雅得手术部位感染患者耐多药病原体的流行情况:一家三级医院的横断面研究
Pub Date : 2023-10-20 DOI: 10.33140/jsc.02.01.08
Background: Multidrug-resistant (MDR) infections are a threat in patients undergoing surgery. This study was undertaken to determine the prevalence and possible predictors of MDR infections over a two-year period in patients with surgical site infection (SSI) at a tertiary care hospital in Riyadh, Saudi Arabia. Methods: We conducted a cross-sectional study from April 2016 to April 2018 by reviewing hospital records of patients with a diagnosis of SSI based on a physician report and laboratory findings. The isolation of MDR organisms (MDRO) from SSI was the primary outcome variable as well as other risk factors. Results: SSI was diagnosed in 55 out of 77 patients under study, with MDRO prevalence rate of 44%. Previous antibiotic use and hospitalization in the last 90 days were strongly associated with developing MDRO infection often due to ESBL producing Gram-negative bacterial pathogens. Superficial and deep incisional SSI were more frequent in patients compared to organ/space SSI. History of diabetes mellitus, duration of surgery and bacterial colonization at other body site also increased the likelihood of MDRO. Factors such as trauma, obesity, general anesthesia, and wound types were not found to increase the risk for MDRO. Conclusions: Our study identified recent antibiotic use and hospitalization as major risk factors for MDRO surgical site infections. Other predisposing factors include diabetes mellitus, duration of surgery and bacterial colonization. MDRO isolated include E. coli and Pseudomonas aeruginosa. Bacterial pathogens harboring multiple resistant mechanisms can complicate SSI adversely affecting clinical outcomes following routine surgical procedures.
背景:耐多药(MDR)感染是手术患者面临的一个威胁。本研究旨在确定沙特阿拉伯利雅得一家三级医院手术部位感染(SSI)患者两年内 MDR 感染的发生率和可能的预测因素。研究方法我们在 2016 年 4 月至 2018 年 4 月期间进行了一项横断面研究,根据医生报告和实验室结果,查阅了诊断为 SSI 患者的住院记录。从 SSI 中分离出 MDR 菌(MDRO)是主要结果变量,其他风险因素也是主要结果变量。结果:在 77 位接受研究的患者中,55 位确诊为 SSI,MDRO 感染率为 44%。既往使用抗生素和过去90天内住院与MDRO感染密切相关,MDRO感染通常是由产生ESBL的革兰氏阴性细菌病原体引起的。与器官/空间 SSI 相比,浅表和深部切口 SSI 患者的发病率更高。糖尿病史、手术持续时间和其他身体部位的细菌定植也增加了感染 MDRO 的可能性。外伤、肥胖、全身麻醉和伤口类型等因素并未增加MDRO的风险。结论:我们的研究发现,近期使用抗生素和住院是MDRO手术部位感染的主要风险因素。其他易感因素包括糖尿病、手术持续时间和细菌定植。分离出的 MDRO 包括大肠杆菌和铜绿假单胞菌。细菌病原体具有多重耐药机制,可使 SSI 复杂化,对常规外科手术后的临床效果产生不利影响。
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引用次数: 0
Bouveret Syndrome : The Rare Challenging Case of the Day 布维雷综合征:当今罕见的挑战性病例
Pub Date : 2023-07-25 DOI: 10.33140/jsc.02.01.06
Case Report, Sabrine Soua¹, Mohamed Ghanem¹, Mohamed Morched Abdesselem², Mohamed Riadh Bouali¹, Sabrine Soua
Bouveret syndrome is an extremely rare disease. We report the case of a 54-year-old man who presented to our department with acute vomiting. An upper digestive endoscopy was first done, revealing an enclaved gallstone in the second duodenum. Crosssectional imaging was then performed to confirm the correct diagnosis of Bouveret's syndrome. Through a medline incision, cholecystectomy and extraction of the gallstone were done and the patient was discharged seven days after the operation with a good clinical outcome.
布维雷综合征是一种极为罕见的疾病。我们报告了一例因急性呕吐到我科就诊的 54 岁男性病例。首先进行了上消化道内窥镜检查,发现第二十二指肠内有一块包膜状胆结石。随后进行了横断面成像,以确诊布瓦雷综合征。患者术后七天出院,临床疗效良好。
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引用次数: 0
A Cross-Sectional Study Investigating the Tools and Resources Australian Medical Students Used to Support Their Mental Health During Covid-19 一项横断面研究,调查澳大利亚医科学生在科维德-19 期间用于支持其心理健康的工具和资源
Pub Date : 2023-06-05 DOI: 10.33140/jsc.02.01.03
Background The mental health of medical students is notoriously poor, and with the additional challenges posed by the COVID-19 pandemic, there has never been greater concern for the wellbeing of the current cohort. This cross-sectional study investigates the impact of lockdown coping strategies used by Australian medical students during the COVID-19 pandemic on their mental health improvement, including connecting with family and friends, exercise, using social media, and various other interests. Methods An anonymous questionnaire was shared in 2021 with medical students from all years via Facebook and General Practice Student Network’s communications during the COVID-19 pandemic. The impact of a variety of lockdown coping strategies utilized by participants was assessed using SPSS. Results There were 283 participants in this study, 69.6% of whom were females, 54.9% in their pre-clinical years, and 70.5% between the ages of 18-24. The results showed that nearly 80% of participants credited their mental health improvement to peri-lockdown strategies. The logistic regression analysis demonstrated that reading (non-medical books) and spending more time with family were the most notable peri-lockdown strategies associated with mental health improvement. Interestingly, some participants reported that some coping strategies decreased productivity, including TV shows and movies. Conclusions Our study found that lockdown coping strategies played an essential role in the improvement and maintenance of medical students’ mental health during the COVID-19 pandemic. In particular, strategies that allowed students to socialize and engage in non-academic activities allowed them to cope with mental stressors more effectively
背景 医学生的心理健康状况不佳是众所周知的,而 COVID-19 大流行带来了更多的挑战,医学生的健康状况受到了前所未有的关注。本横断面研究调查了澳大利亚医科学生在 COVID-19 大流行期间使用的封锁应对策略对其心理健康改善的影响,包括与家人和朋友联系、锻炼、使用社交媒体以及其他各种兴趣。方法 2021 年,在 COVID-19 大流行期间,通过 Facebook 和全科医学学生网络的通信与各年级医学生分享了一份匿名问卷。使用 SPSS 评估了参与者使用的各种封锁应对策略的影响。结果 本研究共有 283 名参与者,其中 69.6% 为女性,54.9% 为临床前学生,70.5% 年龄在 18-24 岁之间。结果显示,近 80% 的参与者将其心理健康的改善归功于围封锁策略。逻辑回归分析表明,阅读(非医学书籍)和花更多时间与家人在一起是与心理健康改善相关的最显著的周边封锁策略。有趣的是,一些参与者表示一些应对策略会降低工作效率,其中包括电视节目和电影。结论 我们的研究发现,在 COVID-19 大流行期间,封锁应对策略在改善和维持医学生心理健康方面发挥了重要作用。特别是,允许学生社交和参与非学术活动的策略使他们能够更有效地应对心理压力。
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引用次数: 0
Prevalence of Surgical Site infections among Surgical operated patients in Zewditu Memorial Hospital. Addis Ababa Ethiopia December 2020. 泽迪都纪念医院手术患者手术部位感染的流行情况。2020年12月埃塞俄比亚亚的斯亚贝巴。
Pub Date : 2022-12-12 DOI: 10.33140/jsc.01.01.01
Background: Surgical site infections are the most common kinds of hospital-acquired infections. It's a common complication that can cause serious morbidity and mortality after surgery. It is also the major cause of extended hospital stays, accounting for up to 20% of hospital expenses. Methods and materials: A random sample of 144 surgical patients was analyzed utilizing a hospital-based retrospective cross-sectional study technique from January 1 to December 31, 2019. The information was acquired using a World Health Organization-developed modified standardized checklist for surgery safety and the national surveillance network for nosocomial infections. A rigorous random sampling strategy was used to choose study participants. Descriptive statistics such as frequency and percentage were used to describe the data. Result: A total of 13 of the 144 patients who were operated on had surgical site infections (9.02 percent). Elective surgical cases made up 102 (71%) of the total, while emergency surgical cases comprised 42 (29%). Preventive antibiotics were administered to the remaining 99 (69%) research participants, with 73 (73%) receiving ceftriaxone, 3% receiving ampicillin, and 23 (24%) receiving a combination of ceftriaxone and metronidazole. There were 13 cases of surgical site infections in all (9.02 percent). Six (46%) were superficial surgical site infections, four (31%) were deep surgical site infections, and three (23%) were organ space surgical site infections. 11 (84%) patients were treated with IV antibiotics and wound treatment, 1 (8%) cases with wound debridement, and the remaining 1 (8%) cases with laparotomy, antibiotics, and wound management. Conclusion: In this study area, surgical site infection is infrequent. The bulk of the population is made up of women. The use of prophylactic antibiotics and the age of the patients were both variables in the development of surgical site infections
背景:手术部位感染是最常见的医院获得性感染。这是一种常见的并发症,可导致手术后严重的发病率和死亡率。它也是延长住院时间的主要原因,占医院费用的20%。方法与材料:采用基于医院的回顾性横断面研究技术,随机抽取144例外科患者,于2019年1月1日至12月31日进行分析。这些信息是通过世界卫生组织制定的手术安全修订标准核对表和国家医院感染监测网络获得的。采用严格的随机抽样策略来选择研究参与者。使用频率和百分比等描述性统计来描述数据。结果:144例手术患者中有13例发生手术部位感染(9.02%)。择期手术病例102例(71%),急诊手术病例42例(29%)。其余99名(69%)研究参与者接受预防性抗生素治疗,其中73名(73%)接受头孢曲松治疗,3%接受氨苄西林治疗,23名(24%)接受头孢曲松和甲硝唑联合治疗。手术部位感染13例(9.02%)。手术部位浅表感染6例(46%),深部感染4例(31%),器官间隙感染3例(23%)。11例(84%)患者采用静脉注射抗生素和伤口处理,1例(8%)患者采用伤口清创,其余1例(8%)患者采用剖腹手术、抗生素和伤口处理。结论:本研究区手术部位感染少见。大部分人口是由妇女组成的。预防性抗生素的使用和患者的年龄都是手术部位感染发生的变量
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引用次数: 0
Characterizing and Controlling the Risk Factors in Manufacturing Dental Implants 牙种植体制造过程中危险因素的表征与控制
Pub Date : 2022-09-30 DOI: 10.33140/jsc.01.01.05
Researc H Article, Amirhossein Emamian, H. Ramezanpour, H. Yousefi, J. S. Care
Background Subtractive manufacturing have been popular in dental implant production. In order to increase the survival rate of the dental implants, a comprehensive risk analysis has been performed in the technical documentation of the products. Purpose In this paper the most common risk factors categorized as implant-related, surgeon-related, patient-related, and maintenance-related risks in the manufacturing process, application, the long term usage and the so-called survival rate of dental implants are studied. Methods The importance of any of the potential risk factors which is directly or indirectly related to the product quality is assessed. In the evaluation stage, the factors are sorted based on their severity and probability of occurrence, brought to the risk criterion table. Proper measurement called as mitigations were used to standardize the risks to the acceptable criteria. The standardization could be through reducing the severity of the risk or through reducing the probability of its occurrence, or even both of them. Advancing from the hazardous situations was an expected aim for any of the risk factors. Results The equivalent risk assessment factors are compared in pre-mitigation and post-mitigation stages. The main aim was to see whether the risk level of the factors reduces to the acceptable or conditionally acceptable region. Falling in to the conditionally acceptable region makes the application of the product to be under sufficient warnings, which orders to take enough pre-cautions for the user or operator. For most of the risk factors, there was a concern that the measurements are able to only improve them in the frequency of occurrence, however, the results show that there are solutions to improve the severity as well. Conclusion Through this comprehensive study, the risk analysis file is completed however it can be even more complete, in the future, at this industry. In the further studies, discretizing the steps of severity or probability to finer steps, and ultimately converting them to a continuous form would be aimed.
减法生产在种植体生产中非常流行。为了提高种植体的成活率,在产品的技术文档中进行了全面的风险分析。目的研究牙种植体在制造过程、应用、长期使用和所谓的成活率中最常见的风险因素,包括种植体相关风险、外科相关风险、患者相关风险和维护相关风险。方法对直接或间接影响产品质量的潜在危险因素进行重要性评价。在评价阶段,根据影响因素的严重程度和发生概率对影响因素进行排序,纳入风险判据表。使用了称为缓解的适当度量来将风险标准化到可接受的标准。标准化可以通过降低风险的严重程度或通过降低其发生的概率,甚至两者兼而有之。从危险情况中前进是任何风险因素的预期目标。结果比较了缓解前阶段和缓解后阶段的等效风险评估因子。主要目的是观察这些因素的风险水平是否降低到可接受或有条件可接受的范围。落入有条件可接受的区域,使产品的应用受到足够的警告,这就要求用户或操作人员采取足够的预防措施。对于大多数风险因素,人们担心测量只能在发生的频率上改善它们,然而,结果表明也有改善严重性的解决方案。通过全面的研究,完成了风险分析文件,但在未来,这个行业的风险分析文件可以更加完整。在进一步的研究中,将严重性或概率的步骤离散为更精细的步骤,并最终将其转化为连续形式。
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引用次数: 0
Rehabilitation After Neurotrauma: A Commentary. 神经创伤后的康复:评论。
Pub Date : 2022-01-01 Epub Date: 2022-09-29
Matthew C Findlay, Sawyer Z Bauer, Diwas Gautam, Brandon Lucke-Wold

Rehabilitation following neurotrauma is an important component of recovery. The best outcomes involve multidisciplinary management. This involves medical therapies, functional therapies, and physical therapies. Speech therapy, physical therapy, and occupational therapy are crucial components. Emerging evidence has implicated the need for vision therapies and a focus on mental health. A seamless integration from inpatient to outpatient is validated. This can be at outpatient facilities or home care. The importance is a key point person for the patient.

神经创伤后的康复是恢复的重要组成部分。最佳的康复效果需要多学科的管理。这包括医疗疗法、功能疗法和物理疗法。言语治疗、物理治疗和职业治疗是关键的组成部分。新的证据表明,需要进行视力治疗并关注心理健康。从住院病人到门诊病人的无缝整合已得到验证。这可以在门诊设施或家庭护理中实现。重要的是,它是病人的关键联系人。
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引用次数: 0
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Journal of surgery care
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