首页 > 最新文献

Alcohol (Fayetteville, N.Y.)最新文献

英文 中文
Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking. 操作性乙醇自我给药行为无法预测连续进入家笼饮酒的性别差异。
Pub Date : 2024-08-30 DOI: 10.1016/j.alcohol.2024.08.004
Hye Jean Yoon, Marie A Doyle, Megan E Altemus, Rishik Bethi, Sofia H Lago, Danny G Winder, Erin S Calipari

Understanding sex differences in disease prevalence is critical to public health, particularly in the context of alcohol use disorder (AUD). The goal of this study was to understand sex differences in ethanol drinking behavior and define the precise conditions under which sex differences emerge. Consistent with prior work, C57BL/6J females drank more than males under continuous access two-bottle choice conditions. However, using ethanol self-administration - where an operant response results in access to an ethanol sipper for a fixed time period - we found no sex differences in operant response rates or ethanol consumption (volume per body weight consumed, as well as lick behavior). This remained true across a wide range of parameters including acquisition, when the ethanol sipper access period was manipulated, and when the concentration of the ethanol available was scaled. The only sex differences observed were in total ethanol consumption, which was explained by differences in body weight between males and females, rather than by sex differences in motivation to drink. Using dimensionality reduction approaches, we found that drinking behavior in the operant context did not cluster by sex, but rather clustered by high and low drinking phenotypes. Interestingly, these high and low drinking phenotypes in the operant context showed no correlation with those same categorizations in the home cage context within the same animals. These data underscore the complexity of sex differences in ethanol consumption, highlighting the important role that drinking conditions/context plays in the expression of these differences.

了解疾病流行的性别差异对公共卫生至关重要,尤其是在酒精使用障碍(AUD)方面。本研究的目的是了解乙醇饮酒行为的性别差异,并确定出现性别差异的确切条件。与之前的研究结果一致,在连续获得两瓶乙醇的选择条件下,C57BL/6J雌性饮酒量高于雄性。然而,在乙醇自我给药条件下--即操作反应导致在固定时间内获得乙醇啜饮器--我们发现操作反应率或乙醇消耗量(单位体重消耗量以及舔食行为)没有性别差异。这一点在包括习得、乙醇啜饮器使用时间的调整以及乙醇浓度的调整等一系列参数中都没有改变。唯一观察到的性别差异出现在乙醇总消耗量上,其原因是雄性和雌性之间体重的差异,而不是饮酒动机的性别差异。通过降维方法,我们发现操作情境中的饮酒行为并不按性别分组,而是按高饮酒表型和低饮酒表型分组。有趣的是,这些在操作情境中的高饮酒表型和低饮酒表型与同一动物在家养笼情境中的高饮酒表型和低饮酒表型没有相关性。这些数据强调了乙醇消费中性别差异的复杂性,突出了饮酒条件/情境在这些差异表达中的重要作用。
{"title":"Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.","authors":"Hye Jean Yoon, Marie A Doyle, Megan E Altemus, Rishik Bethi, Sofia H Lago, Danny G Winder, Erin S Calipari","doi":"10.1016/j.alcohol.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.08.004","url":null,"abstract":"<p><p>Understanding sex differences in disease prevalence is critical to public health, particularly in the context of alcohol use disorder (AUD). The goal of this study was to understand sex differences in ethanol drinking behavior and define the precise conditions under which sex differences emerge. Consistent with prior work, C57BL/6J females drank more than males under continuous access two-bottle choice conditions. However, using ethanol self-administration - where an operant response results in access to an ethanol sipper for a fixed time period - we found no sex differences in operant response rates or ethanol consumption (volume per body weight consumed, as well as lick behavior). This remained true across a wide range of parameters including acquisition, when the ethanol sipper access period was manipulated, and when the concentration of the ethanol available was scaled. The only sex differences observed were in total ethanol consumption, which was explained by differences in body weight between males and females, rather than by sex differences in motivation to drink. Using dimensionality reduction approaches, we found that drinking behavior in the operant context did not cluster by sex, but rather clustered by high and low drinking phenotypes. Interestingly, these high and low drinking phenotypes in the operant context showed no correlation with those same categorizations in the home cage context within the same animals. These data underscore the complexity of sex differences in ethanol consumption, highlighting the important role that drinking conditions/context plays in the expression of these differences.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol-exacerbates post-traumatic stress psychiatric behavior and its neuropathological sequalae in experimental mice: preventive effects of morin. 酒精会加剧实验小鼠的创伤后应激精神病行为及其神经病理学后果:吗啉的预防作用。
Pub Date : 2024-07-31 DOI: 10.1016/j.alcohol.2024.07.009
Benneth Ben-Azu, Pere-Ebi Y Toloyai, Adaeze Adebesin, Vivian O Ojiokor, Olusegun G Adebayo, Aliance Romain Fokoua, Goodes E Moke, Elo J Ejukolemu, Ife-Oluwa O Akpojevughe, Abdulkareem M Abdulkadir, Ephraim Okwuchi

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are very prevalent and co-occurring. It is unclear how alcohol exacerbates PTSD predicaments owing to less characterized pathophysiological mechanisms. Also, studies on pharmacological agents that can effectively reverse PTSD-AUD comorbidity have, to date, been scarce. Hence, we designed a methodological approach to investigate the pathophysiological mechanisms and pharmacological outcomes of morin, a neuroprotective flavonoid in mice. After 7 days of PTSD following single-prolonged stress (SPS) induction in mice, the PTSD mice were exposed to intermittent binge ethanol administration using ethanol (2g/kg, oral gavage) every other day, alongside daily morin (50 and 100mg/kg) or fluoxetine (10mg/kg) from days 8-21. The consequences of PTSD-AUD behavior, hypothalamic-pituitary-adrenal-axis (HPA-axis) dysfunction, neurochemistry, oxidative/nitrergic stress, and inflammation were evaluated in the prefrontal-cortex (PFC), striatum, and hippocampus of mice. The exacerbated anxiety-like behavior, and spatial/non-spatial memory deficits, with general depressive phenotypes and social stress susceptibility by SPS-ethanol interaction, were alleviated by morin and fluoxetine, evidenced by reduced corticosterone release and adrenal hypertrophy. SPS-ethanol exacerbates dopamine, serotonin, and glutamic acid decarboxylase alterations, and monoamine oxidase-B and acetylcholinesterase hyperactivities in the striatum, PFC, and hippocampus, respectively, which were prevented by morin. Compared to SPS-ethanol aggravation, morin prevented TNF-α, and IL-6 release, malondialdehyde and nitrite levels, with improved antioxidant (glutathione, superoxide-dismutase, catalase) levels in the hippocampus, PFC, and striatum. Overall, these findings suggest that AUD exacerbated PTSD might be primarily connected, among other mechanisms, with aggravated HPA-axis dysfunction, upregulated neurochemical degradative enzymes, enhancement of oxidative/nitrergic stress and neuroinflammation, stereo-selectively in the mice brains, which morin abated via the preventive mechanisms.

创伤后应激障碍(PTSD)和酒精使用障碍(AUD)非常普遍,并且同时存在。由于病理生理机制尚不明确,酒精如何加剧创伤后应激障碍的困境尚不清楚。此外,迄今为止,有关能有效逆转 PTSD-AUD 并发症的药理药剂的研究还很少。因此,我们设计了一种方法来研究小鼠神经保护类黄酮 Morin 的病理生理机制和药理结果。小鼠在单次长期应激(SPS)诱导后出现7天的创伤后应激障碍,在第8-21天期间,每隔一天用乙醇(2克/千克,口服)给小鼠间歇性狂饮乙醇,同时每天给小鼠服用吗啉(50和100毫克/千克)或氟西汀(10毫克/千克)。对小鼠前额皮质、纹状体和海马的创伤后应激障碍-AUD行为、下丘脑-垂体-肾上腺轴(HPA轴)功能障碍、神经化学、氧化/硝酸应激和炎症的后果进行了评估。通过减少皮质酮释放和肾上腺肥大,莫林和氟西汀可减轻小鼠因 SPS-乙醇相互作用而加剧的焦虑样行为、空间/非空间记忆缺陷、一般抑郁表型和社会应激易感性。SPS-乙醇会加剧多巴胺、5-羟色胺和谷氨酸脱羧酶的改变,以及纹状体、前足叶和海马中单胺氧化酶-B和乙酰胆碱酯酶的亢进,而吗啉可以防止这些改变。与 SPS-乙醇加重相比,吗啉能防止 TNF-α 和 IL-6 的释放、丙二醛和亚硝酸盐水平的升高,并能改善海马、前脑功能区和纹状体的抗氧化剂(谷胱甘肽、超氧化物歧化酶、过氧化氢酶)水平。总之,这些研究结果表明,AUD 加剧创伤后应激障碍的主要机制可能与 HPA 轴功能障碍加剧、神经化学降解酶上调、氧化/硝能应激和神经炎症增强有关。
{"title":"Alcohol-exacerbates post-traumatic stress psychiatric behavior and its neuropathological sequalae in experimental mice: preventive effects of morin.","authors":"Benneth Ben-Azu, Pere-Ebi Y Toloyai, Adaeze Adebesin, Vivian O Ojiokor, Olusegun G Adebayo, Aliance Romain Fokoua, Goodes E Moke, Elo J Ejukolemu, Ife-Oluwa O Akpojevughe, Abdulkareem M Abdulkadir, Ephraim Okwuchi","doi":"10.1016/j.alcohol.2024.07.009","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.07.009","url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are very prevalent and co-occurring. It is unclear how alcohol exacerbates PTSD predicaments owing to less characterized pathophysiological mechanisms. Also, studies on pharmacological agents that can effectively reverse PTSD-AUD comorbidity have, to date, been scarce. Hence, we designed a methodological approach to investigate the pathophysiological mechanisms and pharmacological outcomes of morin, a neuroprotective flavonoid in mice. After 7 days of PTSD following single-prolonged stress (SPS) induction in mice, the PTSD mice were exposed to intermittent binge ethanol administration using ethanol (2g/kg, oral gavage) every other day, alongside daily morin (50 and 100mg/kg) or fluoxetine (10mg/kg) from days 8-21. The consequences of PTSD-AUD behavior, hypothalamic-pituitary-adrenal-axis (HPA-axis) dysfunction, neurochemistry, oxidative/nitrergic stress, and inflammation were evaluated in the prefrontal-cortex (PFC), striatum, and hippocampus of mice. The exacerbated anxiety-like behavior, and spatial/non-spatial memory deficits, with general depressive phenotypes and social stress susceptibility by SPS-ethanol interaction, were alleviated by morin and fluoxetine, evidenced by reduced corticosterone release and adrenal hypertrophy. SPS-ethanol exacerbates dopamine, serotonin, and glutamic acid decarboxylase alterations, and monoamine oxidase-B and acetylcholinesterase hyperactivities in the striatum, PFC, and hippocampus, respectively, which were prevented by morin. Compared to SPS-ethanol aggravation, morin prevented TNF-α, and IL-6 release, malondialdehyde and nitrite levels, with improved antioxidant (glutathione, superoxide-dismutase, catalase) levels in the hippocampus, PFC, and striatum. Overall, these findings suggest that AUD exacerbated PTSD might be primarily connected, among other mechanisms, with aggravated HPA-axis dysfunction, upregulated neurochemical degradative enzymes, enhancement of oxidative/nitrergic stress and neuroinflammation, stereo-selectively in the mice brains, which morin abated via the preventive mechanisms.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coping-strategies as a mediator between emotional disorders and problematic alcohol use. 应对策略是情绪失调与酗酒问题之间的中介。
Pub Date : 2024-07-27 DOI: 10.1016/j.alcohol.2024.07.008
Celia Antuña-Camblor, Gabriel Esteller Collado, Joel Juarros-Basterretxea, Roger Muñoz-Navarro, Francisco Javier Rodríguez-Díaz

Background: Epidemiological studies reveal a high prevalence of alcohol use and comorbidity rates with emotional disorders. This study aims to explore the possible mediational effect of stress-coping strategies on the relationship between symptoms of emotional disorders and problematic alcohol use.

Methods: The sample included 1014 participants (33.82% male, 66.17% female) aged 18 to 75 years (M = 33.0, SD = 15.15). Three mediation analyzes were carried out, for depressive, anxious and somatization symptomatology measured with the LSB-50 in which they acted as an independent variable, the coping strategies of the CSQ as a mediating variable and the problematic alcohol use, measured with AUDIT, as a dependent variable. Additionally, sex, age, educational level, and socioeconomic status were entered as covariates.

Results: In all the models, problematic alcohol use was mediated by Problem-Solving Focus and Open Emotional Expression. However, while in depressive symptoms was a fully mediation, in anxious and somatization symptomatology was partially mediated.

Conclusions: The similarities found may be due to shared variance between emotional disorders. Interventions focused on Problem-Solving Focus could improve the emotional symptoms and the problematic alcohol use.

背景:流行病学研究显示,酒精使用的流行率很高,而且与情绪障碍的合并率也很高。本研究旨在探讨压力应对策略对情绪障碍症状与问题性饮酒之间关系的可能中介效应:样本包括 1014 名参与者(33.82% 为男性,66.17% 为女性),年龄在 18 岁至 75 岁之间(M = 33.0,SD = 15.15)。对以 LSB-50 测量的抑郁、焦虑和躯体化症状进行了三项中介分析,其中抑郁、焦虑和躯体化症状作为自变量,CSQ 的应对策略作为中介变量,以 AUDIT 测量的问题性饮酒作为因变量。此外,还将性别、年龄、教育程度和社会经济地位作为协变量:结果:在所有模型中,问题性饮酒都受到问题解决焦点和开放式情感表达的调节。然而,虽然抑郁症状是完全中介,但焦虑和躯体化症状却是部分中介:结论:所发现的相似性可能是由于情绪障碍之间存在共同的变异。结论:所发现的相似性可能是由于情绪障碍之间存在共同的变异。以 "关注问题解决 "为重点的干预措施可以改善情绪症状和酗酒问题。
{"title":"Coping-strategies as a mediator between emotional disorders and problematic alcohol use.","authors":"Celia Antuña-Camblor, Gabriel Esteller Collado, Joel Juarros-Basterretxea, Roger Muñoz-Navarro, Francisco Javier Rodríguez-Díaz","doi":"10.1016/j.alcohol.2024.07.008","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.07.008","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological studies reveal a high prevalence of alcohol use and comorbidity rates with emotional disorders. This study aims to explore the possible mediational effect of stress-coping strategies on the relationship between symptoms of emotional disorders and problematic alcohol use.</p><p><strong>Methods: </strong>The sample included 1014 participants (33.82% male, 66.17% female) aged 18 to 75 years (M = 33.0, SD = 15.15). Three mediation analyzes were carried out, for depressive, anxious and somatization symptomatology measured with the LSB-50 in which they acted as an independent variable, the coping strategies of the CSQ as a mediating variable and the problematic alcohol use, measured with AUDIT, as a dependent variable. Additionally, sex, age, educational level, and socioeconomic status were entered as covariates.</p><p><strong>Results: </strong>In all the models, problematic alcohol use was mediated by Problem-Solving Focus and Open Emotional Expression. However, while in depressive symptoms was a fully mediation, in anxious and somatization symptomatology was partially mediated.</p><p><strong>Conclusions: </strong>The similarities found may be due to shared variance between emotional disorders. Interventions focused on Problem-Solving Focus could improve the emotional symptoms and the problematic alcohol use.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between sleep health, negative reinforcement learning, and alcohol use among South Florida college students with elevated internalizing symptoms. 南佛罗里达州内化症状加重的大学生睡眠健康、负强化学习和饮酒之间的关系。
Pub Date : 2024-04-27 DOI: 10.1016/j.alcohol.2024.04.006
Nathan A Sollenberger, Logan R Cummings, Josefina Freitag, Elisa M Trucco, Sthefany Gomez, Melanie Giraldo, Gabriela Muse, Aaron T Mattfeld, Dana L McMakin

Negative reinforcement is proposed to mediate associations between sleep and alcohol use, especially among people with depression and/or anxiety symptoms. Worse sleep (e.g., shorter duration, less efficiency, more irregular timing) exacerbates negative emotions, which alcohol may temporarily relieve. Not yet examined, we propose sleep indirectly impacts early stages of alcohol use via differences in negative reinforcement learning (NRL), since sleep impacts emotion, reward response, and learning. The current study aimed to replicate associations between sleep and alcohol use, test associations with NRL, and examine indirect associations between sleep health and alcohol use via NRL among 60 underage college students (ages 18-20 years, 77% female) varying in depression and anxiety symptoms. Participants wore Fitbit smartwatches and completed daily diaries measuring sleep and substance use for ∼14 days before completing two computer tasks assessing social (SNRL) and monetary (MNRL) negative reinforcement learning. Robust generalized linear models tested direct associations within the proposed model. SNRL performance was positively associated with alcohol use, but no other associations were observed. Statistical mediation models failed to indicate indirect effects of sleep on alcohol use via SNRL or MNRL performance. Post-hoc exploratory models examining depression and anxiety symptoms as moderators of direct associations indicated several interactions. Positive associations between sleep timing variability and alcohol use were weakened at higher anxiety symptom severity and stronger at higher depression symptom severity. The positive association between SNRL performance and alcohol use was also stronger at higher depression symptom severity. Among students with elevated depression symptoms, variable sleep timing and stronger SNRL performance were independently associated with more alcohol use, but indirect effects were not supported. Future research should replicate findings, confirm causality of interactions, and examine sleep timing and behavioral responses to negative social stimuli as targets for improving alcohol-related outcomes among underage college students with elevated depressive symptoms.

负强化被认为是睡眠与饮酒之间的中介作用,尤其是在有抑郁和/或焦虑症状的人群中。较差的睡眠(如持续时间较短、效率较低、时间较不规律)会加剧负面情绪,而酒精可能会暂时缓解负面情绪。由于睡眠会影响情绪、奖赏反应和学习,因此我们认为睡眠会通过负强化学习(NRL)的差异间接影响饮酒的早期阶段。目前的研究旨在复制睡眠与饮酒之间的关联,测试与 NRL 的关联,并通过 NRL 检验睡眠健康与饮酒之间的间接关联,研究对象为 60 名未成年大学生(18-20 岁,77% 为女性),他们的抑郁和焦虑症状各不相同。参与者佩戴 Fitbit 智能手表,在完成两项评估社交(SNRL)和金钱(MNRL)负强化学习的计算机任务之前,每天填写睡眠和药物使用日记,为期 14 天。稳健的广义线性模型检验了拟议模型中的直接关联。SNRL成绩与饮酒呈正相关,但未观察到其他关联。统计中介模型未能显示睡眠通过SNRL或MNRL表现对饮酒的间接影响。事后探索性模型将抑郁和焦虑症状作为直接关联的调节因素进行了研究,结果表明两者之间存在若干相互作用。焦虑症状严重程度越高,睡眠时间变异性与饮酒之间的正相关就越弱,而抑郁症状严重程度越高,两者之间的正相关就越强。在抑郁症状严重程度较高的情况下,SNRL 表现与饮酒之间的正相关也较强。在抑郁症状较重的学生中,睡眠时间不稳定和SNRL表现较强与饮酒较多独立相关,但间接效应不成立。未来的研究应复制研究结果,确认相互作用的因果关系,并研究睡眠时间和对负面社会刺激的行为反应,以此作为改善抑郁症状加重的未成年大学生与酒精相关的结果的目标。
{"title":"Associations between sleep health, negative reinforcement learning, and alcohol use among South Florida college students with elevated internalizing symptoms.","authors":"Nathan A Sollenberger, Logan R Cummings, Josefina Freitag, Elisa M Trucco, Sthefany Gomez, Melanie Giraldo, Gabriela Muse, Aaron T Mattfeld, Dana L McMakin","doi":"10.1016/j.alcohol.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.04.006","url":null,"abstract":"<p><p>Negative reinforcement is proposed to mediate associations between sleep and alcohol use, especially among people with depression and/or anxiety symptoms. Worse sleep (e.g., shorter duration, less efficiency, more irregular timing) exacerbates negative emotions, which alcohol may temporarily relieve. Not yet examined, we propose sleep indirectly impacts early stages of alcohol use via differences in negative reinforcement learning (NRL), since sleep impacts emotion, reward response, and learning. The current study aimed to replicate associations between sleep and alcohol use, test associations with NRL, and examine indirect associations between sleep health and alcohol use via NRL among 60 underage college students (ages 18-20 years, 77% female) varying in depression and anxiety symptoms. Participants wore Fitbit smartwatches and completed daily diaries measuring sleep and substance use for ∼14 days before completing two computer tasks assessing social (SNRL) and monetary (MNRL) negative reinforcement learning. Robust generalized linear models tested direct associations within the proposed model. SNRL performance was positively associated with alcohol use, but no other associations were observed. Statistical mediation models failed to indicate indirect effects of sleep on alcohol use via SNRL or MNRL performance. Post-hoc exploratory models examining depression and anxiety symptoms as moderators of direct associations indicated several interactions. Positive associations between sleep timing variability and alcohol use were weakened at higher anxiety symptom severity and stronger at higher depression symptom severity. The positive association between SNRL performance and alcohol use was also stronger at higher depression symptom severity. Among students with elevated depression symptoms, variable sleep timing and stronger SNRL performance were independently associated with more alcohol use, but indirect effects were not supported. Future research should replicate findings, confirm causality of interactions, and examine sleep timing and behavioral responses to negative social stimuli as targets for improving alcohol-related outcomes among underage college students with elevated depressive symptoms.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECTS OF ALCOHOL AND ITS PREVENTION STRATEGIES ON ADOLESCENT SCHOOL STUDENTS. 酒精对青少年学生的影响及其预防策略。
Pub Date : 2024-03-26 DOI: 10.1016/j.alcohol.2024.03.009
Emmanuel Janagan Johnson, Jessica Evangelin Emmanuel Janagan

Substance use continues to be recognized as one of the major health and social issues in the Caribbean. This study focusses on the risks and consequences of adolescent school student's exposure to alcohol and prevention strategies. Participants were selected from the age group of 13 to 19 years old, who are attending Secondary School. Five schools were chosen according to the prevalence of alcohol. Students were purposively selected from each school based on the recommendations from the school social workers. Students completed the Adolescent Drug Involvement Scale (ADIS) to understand the extent of involvement in alcohol use. The study recommends that there is a need for effective parenting where training in awareness, skills, and techniques around engaging young adolescent students with age-appropriate information on alcohol abuse can be disbursed and reinforced as they enter various stages of their development.

在加勒比地区,使用药物仍然被认为是主要的健康和社会问题之一。本研究的重点是青少年学生接触酒精的风险和后果以及预防策略。研究对象选自 13 至 19 岁的中学生。根据酗酒的普遍程度选择了五所学校。根据学校社工的推荐,有目的地从每所学校挑选学生。学生们填写了青少年毒品参与量表(ADIS),以了解参与饮酒的程度。研究建议,有必要开展有效的亲职教育,在青少年学生进入不同的成长阶段时,对他们进行有关酗酒的意识、技能和技巧培训,让他们了解适合其年龄的信息。
{"title":"EFFECTS OF ALCOHOL AND ITS PREVENTION STRATEGIES ON ADOLESCENT SCHOOL STUDENTS.","authors":"Emmanuel Janagan Johnson, Jessica Evangelin Emmanuel Janagan","doi":"10.1016/j.alcohol.2024.03.009","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.03.009","url":null,"abstract":"<p><p>Substance use continues to be recognized as one of the major health and social issues in the Caribbean. This study focusses on the risks and consequences of adolescent school student's exposure to alcohol and prevention strategies. Participants were selected from the age group of 13 to 19 years old, who are attending Secondary School. Five schools were chosen according to the prevalence of alcohol. Students were purposively selected from each school based on the recommendations from the school social workers. Students completed the Adolescent Drug Involvement Scale (ADIS) to understand the extent of involvement in alcohol use. The study recommends that there is a need for effective parenting where training in awareness, skills, and techniques around engaging young adolescent students with age-appropriate information on alcohol abuse can be disbursed and reinforced as they enter various stages of their development.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gestational choline supplementation ameliorates T-maze reversal learning deficits induced by first trimester binge alcohol exposure in weanling lambs. 妊娠期胆碱补充剂可改善断奶羔羊在妊娠头三个月暴饮暴食导致的T迷宫逆转学习障碍。
Pub Date : 2024-03-12 DOI: 10.1016/j.alcohol.2024.03.007
S Washburn, K Nation, T Cudd, M Stanton, C Goodlett

In rodent models of fetal alcohol spectrum disorders (FASD), cognitive deficits are implicated in impaired T-maze spatial reversal learning. Rat studies have indicated supplemental administration of choline during the developmental period of alcohol exposure can ameliorate spatial reversal deficits. This study tested whether beneficial effects of prenatal choline supplementation could be confirmed in a sheep model of binge exposure in the first trimester equivalent. Two hypotheses were tested: 1) alcohol exposure would produce deficits in reversal of a T-maze position discrimination; and 2) gestational dietary supplementation of choline would ameliorate those deficits. Mated ewes were assigned to one of seven groups-a normal control (NC) group or one of six infusion treatment groups: saline control (SC; isotonic saline), saline control plus choline (SC-CH; isotonic saline plus choline, 10 mg/kg administered orally throughout each day of gestation), binge alcohol (BA; 1.75 g/kg alcohol per infusion day), binge alcohol plus choline (BA-CH; 1.75 g/kg/day alcohol plus choline), heavy binge alcohol (HBA; 2.5 g/kg/day alcohol), or heavy binge alcohol plus choline (HBA-CH; 2.5 g/kg/day alcohol plus choline). The alcohol infusions modeled a weekend binge drinking pattern over the first trimester-equivalent (gestational day 4-41). T-maze training began at 12 weeks of age, with daily sessions occurring 5 days/week. Lambs were given five days of habituation training, followed by five days of position discrimination training (3 trials per daily session, intertrial interval of 3 hours, reinforced side randomly assigned across subjects). Lambs were then given 10 days of training on the reversal task. There was no difference among groups during acquisition. Alcohol impaired reversal learning, and choline supplementation mitigated these deficits in the HBA-CH group. These results suggest that maternal dietary choline supplementation can ameliorate or prevent some impairments of executive function in a sheep model of FASD.

在胎儿酒精谱系障碍(FASD)的啮齿类动物模型中,认知障碍与 T 迷宫空间倒转学习能力受损有关。大鼠研究表明,在酒精暴露的发育期补充胆碱可改善空间逆转缺陷。本研究测试了产前补充胆碱的益处是否能在绵羊妊娠头三个月暴饮暴食模型中得到证实。研究测试了两个假设:1)酒精暴露会导致T迷宫位置辨别的逆转缺陷;2)妊娠期膳食中补充胆碱会改善这些缺陷。交配母羊被分配到七个组中的一组--正常对照组(NC)或六个输液治疗组中的一组:生理盐水对照组(SC;等渗生理盐水)、生理盐水对照组加胆碱组(SC-CH;等渗生理盐水加胆碱,妊娠期每天口服 10 毫克/千克)、暴饮暴食酒精组(BA;每次输液 1.大剂量酒精(HBA;2.5 克/千克/天酒精)或大剂量酒精加胆碱(HBA-CH;2.5 克/千克/天酒精加胆碱)。酒精输注模拟了相当于妊娠头三个月(妊娠第 4-41 天)的周末酗酒模式。T 型迷宫训练从 12 周龄开始,每天训练 5 天/周。羔羊先接受5天的习惯性训练,然后进行5天的位置辨别训练(每天3次,每次间隔3小时,受试者随机分配强化侧)。然后对羔羊进行为期 10 天的反转任务训练。在习得过程中,各组之间没有差异。酒精会损害羔羊的逆转学习能力,而在 HBA-CH 组中,补充胆碱可减轻这些缺陷。这些结果表明,在绵羊 FASD 模型中,母体膳食胆碱补充剂可改善或预防某些执行功能障碍。
{"title":"Gestational choline supplementation ameliorates T-maze reversal learning deficits induced by first trimester binge alcohol exposure in weanling lambs.","authors":"S Washburn, K Nation, T Cudd, M Stanton, C Goodlett","doi":"10.1016/j.alcohol.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.03.007","url":null,"abstract":"<p><p>In rodent models of fetal alcohol spectrum disorders (FASD), cognitive deficits are implicated in impaired T-maze spatial reversal learning. Rat studies have indicated supplemental administration of choline during the developmental period of alcohol exposure can ameliorate spatial reversal deficits. This study tested whether beneficial effects of prenatal choline supplementation could be confirmed in a sheep model of binge exposure in the first trimester equivalent. Two hypotheses were tested: 1) alcohol exposure would produce deficits in reversal of a T-maze position discrimination; and 2) gestational dietary supplementation of choline would ameliorate those deficits. Mated ewes were assigned to one of seven groups-a normal control (NC) group or one of six infusion treatment groups: saline control (SC; isotonic saline), saline control plus choline (SC-CH; isotonic saline plus choline, 10 mg/kg administered orally throughout each day of gestation), binge alcohol (BA; 1.75 g/kg alcohol per infusion day), binge alcohol plus choline (BA-CH; 1.75 g/kg/day alcohol plus choline), heavy binge alcohol (HBA; 2.5 g/kg/day alcohol), or heavy binge alcohol plus choline (HBA-CH; 2.5 g/kg/day alcohol plus choline). The alcohol infusions modeled a weekend binge drinking pattern over the first trimester-equivalent (gestational day 4-41). T-maze training began at 12 weeks of age, with daily sessions occurring 5 days/week. Lambs were given five days of habituation training, followed by five days of position discrimination training (3 trials per daily session, intertrial interval of 3 hours, reinforced side randomly assigned across subjects). Lambs were then given 10 days of training on the reversal task. There was no difference among groups during acquisition. Alcohol impaired reversal learning, and choline supplementation mitigated these deficits in the HBA-CH group. These results suggest that maternal dietary choline supplementation can ameliorate or prevent some impairments of executive function in a sheep model of FASD.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burden of alcohol use and inclusion of alcohol use disorder medications in the essential medicine lists across 132 countries: An observational study. 132 个国家的酒精使用负担以及将酒精使用障碍药物纳入基本药物清单的情况:一项观察性研究。
Pub Date : 2024-02-27 DOI: 10.1016/j.alcohol.2024.02.007
Arpit Parmar, Dinesh Prasad Sahu, Priyamadhaba Behera

Harmful use of alcohol effects the health of the population. The treatment coverage of alcohol use disorders (AUD) varies among countries. The study aimed to determine the inclusion of AUD medicines in various national Essential Medicine Lists (EMLs) and its association with alcohol consumption. It was a secondary data analysis of alcohol consumptions and AUD related medicines in EML. Data were extracted from the WHO Global Essential Medicines database and the WHO Global Status Report on Alcohol and Health 2018. Data were extracted for 194 countries. Only 132 of 194 countries (68.0%) had EML, and among the 132 countries only 27.3% had included AUD medicines in their EML. Only 36 countries had included any of the AUD medicines in their EML. Disulfiram was included by 23 countries, while Acamprosate and Naltrexone was included by only four and 19 countries, respectively. Among the countries, 36.1% were from upper-middle income countries and 16.65 from low-income countries. The inclusion of AUD medicines in national EML was neither associated with alcohol consumption parameters nor the alcohol consumption related policy parameters. Considering the high prevalence of AUD and its complications, there is an urgent need to focus on including AUD medicines in national EML for making AUD treatment available and accessible across the world.

有害使用酒精会影响人们的健康。各国对酒精使用障碍(AUD)的治疗覆盖率各不相同。本研究旨在确定各国基本药物清单(EMLs)中包含的 AUD 药物及其与酒精消费的关系。这是一项关于酒精消费和 EML 中 AUD 相关药物的二手数据分析。数据提取自世卫组织全球基本药物数据库和《2018 年世卫组织全球酒精与健康状况报告》。共提取了 194 个国家的数据。在 194 个国家中,只有 132 个国家(68.0%)拥有 EML,而在这 132 个国家中,只有 27.3% 的国家将 AUD 药物纳入其 EML。只有 36 个国家在其 EML 中纳入了任何一种 AUD 药物。有 23 个国家将双硫仑纳入其中,而将阿坎酸和纳曲酮纳入其中的国家分别只有 4 个和 19 个。在这些国家中,36.1%来自中上收入国家,16.65%来自低收入国家。将 AUD 药物纳入国家 EML 既与酒精消费参数无关,也与酒精消费相关政策参数无关。考虑到 AUD 及其并发症的高发病率,迫切需要将 AUD 药物纳入国家 EML,以便在全球范围内提供 AUD 治疗。
{"title":"Burden of alcohol use and inclusion of alcohol use disorder medications in the essential medicine lists across 132 countries: An observational study.","authors":"Arpit Parmar, Dinesh Prasad Sahu, Priyamadhaba Behera","doi":"10.1016/j.alcohol.2024.02.007","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.02.007","url":null,"abstract":"<p><p>Harmful use of alcohol effects the health of the population. The treatment coverage of alcohol use disorders (AUD) varies among countries. The study aimed to determine the inclusion of AUD medicines in various national Essential Medicine Lists (EMLs) and its association with alcohol consumption. It was a secondary data analysis of alcohol consumptions and AUD related medicines in EML. Data were extracted from the WHO Global Essential Medicines database and the WHO Global Status Report on Alcohol and Health 2018. Data were extracted for 194 countries. Only 132 of 194 countries (68.0%) had EML, and among the 132 countries only 27.3% had included AUD medicines in their EML. Only 36 countries had included any of the AUD medicines in their EML. Disulfiram was included by 23 countries, while Acamprosate and Naltrexone was included by only four and 19 countries, respectively. Among the countries, 36.1% were from upper-middle income countries and 16.65 from low-income countries. The inclusion of AUD medicines in national EML was neither associated with alcohol consumption parameters nor the alcohol consumption related policy parameters. Considering the high prevalence of AUD and its complications, there is an urgent need to focus on including AUD medicines in national EML for making AUD treatment available and accessible across the world.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of factors related to problem drinking among the working population: The Japanese civil servants study. 日本公务员研究》(Japanese Civil Servants' Study):日本公务员研究》。
Pub Date : 2024-02-08 DOI: 10.1016/j.alcohol.2024.02.001
Takashi Shigeno, Takashi Tatsuse, Michikazu Sekine, Masaaki Yamada

Problem drinking affects not only the health of a population but also the productivity of a nation, especially if it is rampant among the working population. This study examines the association between problem drinking and work characteristics, work-family status, and social situations among the Japanese working population. Multivariable logistic regression analysis was performed on the basis of gender on 3136 participants (men: 65.1%, women: 34.9%) adopted from the Japanese Civil Servants Study in 2014 (response rate: 87.8%), to examine the factors related to problem drinking, after adjusting for frequency and quantity of drinking. Problem drinking was assessed using the Cutdown, Annoyed, Guilty, and Eye-opener (CAGE) questionnaire. The presence of problem drinking was found in 24.3% of men and 10.3% of women. The analysis showed that in men, poor work performance (OR: 1.34, 95% CI: 1.00-1.79), high family-to-work conflict (OR: 1.54, 95% CI: 1.14-2.09), and high work-to-family conflict (OR: 1.63, 95% CI: 1.14-2.34) were significantly associated with problem drinking, whereas in women, high work-to-family conflict (OR: 2.45, 95% CI: 1.21-4.95) was significantly associated with problem drinking. Although the number of close friends is negatively associated with problem drinking in women, the significance disappeared in the fully adjusted model. It can be concluded that it is important for both men and women to strike a balance between work and family life. Moreover, owing to gender differences, work performance may be important for men, and the presence of close friends may be important for women, in reducing the risk of problem drinking.

问题饮酒不仅会影响人口的健康,还会影响国家的生产力,尤其是在工作人口中肆虐的问题饮酒。本研究探讨了日本劳动人口中问题饮酒与工作特征、工作-家庭状况和社会状况之间的关系。在对饮酒频率和数量进行调整后,对2014年日本公务员研究中的3136名参与者(男性:65.1%,女性:34.9%)进行了基于性别的多变量逻辑回归分析(应答率:87.8%),以研究与问题饮酒相关的因素。问题饮酒采用 "沮丧、恼怒、内疚和开眼"(CAGE)问卷进行评估。结果发现,24.3%的男性和 10.3%的女性存在问题饮酒。分析表明,在男性中,低工作绩效(OR:1.34,95%CI:1.00-1.79)、高家庭与工作冲突(OR:1.54,95%CI:1.14-2.09)和高工作与家庭冲突(OR:1.63,95%CI:1.14-2.34)与问题饮酒显著相关,而在女性中,高工作与家庭冲突(OR:2.45,95%CI:1.21-4.95)与问题饮酒显著相关。虽然女性密友的数量与问题饮酒呈负相关,但在完全调整模型中,其显著性消失了。由此可以得出结论,在工作和家庭生活之间取得平衡对男性和女性都很重要。此外,由于性别差异,工作表现对男性来说可能很重要,而密友的存在对女性来说可能对降低问题饮酒的风险很重要。
{"title":"Examination of factors related to problem drinking among the working population: The Japanese civil servants study.","authors":"Takashi Shigeno, Takashi Tatsuse, Michikazu Sekine, Masaaki Yamada","doi":"10.1016/j.alcohol.2024.02.001","DOIUrl":"10.1016/j.alcohol.2024.02.001","url":null,"abstract":"<p><p>Problem drinking affects not only the health of a population but also the productivity of a nation, especially if it is rampant among the working population. This study examines the association between problem drinking and work characteristics, work-family status, and social situations among the Japanese working population. Multivariable logistic regression analysis was performed on the basis of gender on 3136 participants (men: 65.1%, women: 34.9%) adopted from the Japanese Civil Servants Study in 2014 (response rate: 87.8%), to examine the factors related to problem drinking, after adjusting for frequency and quantity of drinking. Problem drinking was assessed using the Cutdown, Annoyed, Guilty, and Eye-opener (CAGE) questionnaire. The presence of problem drinking was found in 24.3% of men and 10.3% of women. The analysis showed that in men, poor work performance (OR: 1.34, 95% CI: 1.00-1.79), high family-to-work conflict (OR: 1.54, 95% CI: 1.14-2.09), and high work-to-family conflict (OR: 1.63, 95% CI: 1.14-2.34) were significantly associated with problem drinking, whereas in women, high work-to-family conflict (OR: 2.45, 95% CI: 1.21-4.95) was significantly associated with problem drinking. Although the number of close friends is negatively associated with problem drinking in women, the significance disappeared in the fully adjusted model. It can be concluded that it is important for both men and women to strike a balance between work and family life. Moreover, owing to gender differences, work performance may be important for men, and the presence of close friends may be important for women, in reducing the risk of problem drinking.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139713537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating microRNA profiling identifies microRNAs linked to prediabetes associated with alcohol dependence syndrome. 循环微RNA分析确定了与酒精依赖综合征相关的糖尿病前期有关的微RNA。
Pub Date : 2024-01-22 DOI: 10.1016/j.alcohol.2024.01.003
Palaniswamy Ramaswamy, Athira S V, Pratibha Misra, V S Chauhan, Arka Adhvaryu, Anurodh Gupta, Ankita G, Sibin M K

Background: MicroRNAs are abundant in serum and have emerged as important regulators of gene expression, implicating them in a wide range of diseases. The purpose of this study was to discover and validate serum miRNAs in prediabetes associated with alcohol dependence syndrome (ADS).

Method: Serum samples from ADS patients with or without prediabetes and normoglycemic controls were subjected to microarray. Validation of identified candidate miRNAs was performed by RT-qPCR. Additionally, GO and KEGG pathway analyses were carried out to uncover target genes anticipated to be controlled by the candidate miRNAs.

Results: Notably, 198, and 172 miRNAs were differentially expressed in ADS-patients with or without prediabetes compared to healthy controls, and 7 miRNAs in ADS-patients with prediabetes compared to ADS-normoglycemic patients, respectively. Furthermore, hsa-miR-320b and hsa-miR-3135b were differentially expressed exclusively in ADS-patients with prediabetes, and this was further validated. Interestingly, GO and KEGG pathway analysis revealed that genes predicted to be modulated by the candidates were considerably enriched in numerous diabetes-related biological processes and pathways.

Conclusion: Our findings revealed that ADS-patients with or without prediabetes have different sets of miRNAs compared to normoglycemic healthy subjects. We propose serum hsa-miR-320b and hsa-miR-3135b as potential biomarkers for the diagnosis of prediabetes in ADS-patients.

背景:微RNA在血清中含量丰富,已成为基因表达的重要调控因子,与多种疾病有关。本研究旨在发现和验证与酒精依赖综合征(ADS)相关的糖尿病前期患者的血清 miRNA:方法:对伴有或不伴有糖尿病前期的 ADS 患者和血糖正常对照组的血清样本进行芯片分析。通过 RT-qPCR 验证已确定的候选 miRNA。此外,还进行了 GO 和 KEGG 通路分析,以发现候选 miRNAs 预期控制的靶基因:值得注意的是,与健康对照组相比,有糖尿病前期或无糖尿病前期的 ADS 患者分别有 198 和 172 个 miRNAs 有差异表达;与 ADS 正常血糖患者相比,有糖尿病前期的 ADS 患者分别有 7 个 miRNAs 有差异表达。此外,hsa-miR-320b和hsa-miR-3135b只在糖尿病前期ADS患者中有差异表达,这一点得到了进一步验证。有趣的是,GO 和 KEGG 通路分析表明,候选基因预测被调节的基因在许多与糖尿病相关的生物过程和通路中都有相当大的富集:我们的研究结果表明,与血糖正常的健康受试者相比,患有或不患有糖尿病前期的 ADS 患者具有不同的 miRNAs 组。我们建议将血清中的 hsa-miR-320b 和 hsa-miR-3135b 作为诊断 ADS 患者糖尿病前期的潜在生物标记物。
{"title":"Circulating microRNA profiling identifies microRNAs linked to prediabetes associated with alcohol dependence syndrome.","authors":"Palaniswamy Ramaswamy, Athira S V, Pratibha Misra, V S Chauhan, Arka Adhvaryu, Anurodh Gupta, Ankita G, Sibin M K","doi":"10.1016/j.alcohol.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.alcohol.2024.01.003","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs are abundant in serum and have emerged as important regulators of gene expression, implicating them in a wide range of diseases. The purpose of this study was to discover and validate serum miRNAs in prediabetes associated with alcohol dependence syndrome (ADS).</p><p><strong>Method: </strong>Serum samples from ADS patients with or without prediabetes and normoglycemic controls were subjected to microarray. Validation of identified candidate miRNAs was performed by RT-qPCR. Additionally, GO and KEGG pathway analyses were carried out to uncover target genes anticipated to be controlled by the candidate miRNAs.</p><p><strong>Results: </strong>Notably, 198, and 172 miRNAs were differentially expressed in ADS-patients with or without prediabetes compared to healthy controls, and 7 miRNAs in ADS-patients with prediabetes compared to ADS-normoglycemic patients, respectively. Furthermore, hsa-miR-320b and hsa-miR-3135b were differentially expressed exclusively in ADS-patients with prediabetes, and this was further validated. Interestingly, GO and KEGG pathway analysis revealed that genes predicted to be modulated by the candidates were considerably enriched in numerous diabetes-related biological processes and pathways.</p><p><strong>Conclusion: </strong>Our findings revealed that ADS-patients with or without prediabetes have different sets of miRNAs compared to normoglycemic healthy subjects. We propose serum hsa-miR-320b and hsa-miR-3135b as potential biomarkers for the diagnosis of prediabetes in ADS-patients.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of serum BDNF levels in alcohol withdrawal syndrome with and without other medical co-morbidities. 调查有无其他并发症的酒精戒断综合征患者的血清 BDNF 水平。
Pub Date : 2024-01-16 DOI: 10.1016/j.alcohol.2023.12.006
Marta Malinowska-Kubiak, Magda Malewska-Kasprzak
{"title":"Investigation of serum BDNF levels in alcohol withdrawal syndrome with and without other medical co-morbidities.","authors":"Marta Malinowska-Kubiak, Magda Malewska-Kasprzak","doi":"10.1016/j.alcohol.2023.12.006","DOIUrl":"https://doi.org/10.1016/j.alcohol.2023.12.006","url":null,"abstract":"","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Alcohol (Fayetteville, N.Y.)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1