Pub Date : 2024-01-11DOI: 10.14218/erhm.2023.00086
Swarup K. Chakrabarti, Dhrubajyoti Chattopadhyay
{"title":"Expanding Role of Epigenetics in Human Health and Disease","authors":"Swarup K. Chakrabarti, Dhrubajyoti Chattopadhyay","doi":"10.14218/erhm.2023.00086","DOIUrl":"https://doi.org/10.14218/erhm.2023.00086","url":null,"abstract":"","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and objectivesNo previous study has been conducted in Nigeria on the role of neutrophil elastase in predicting preterm birth. The present study aimed to determine the role of the neutrophil elastase test in predicting birth in women with preterm labor.
{"title":"Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour","authors":"George Uchenna Eleje, Uchenna Ifeanyi Nwagha, Ifeanyichukwu Uzoma Ezebialu, Emmanuel Onyebuchi Ugwu, Kingsley Emeka Ekwuazi, Joseph Ifeanyichukwu Ikechebelu, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke","doi":"10.14218/erhm.2023.00032","DOIUrl":"https://doi.org/10.14218/erhm.2023.00032","url":null,"abstract":"Background and objectivesNo previous study has been conducted in Nigeria on the role of neutrophil elastase in predicting preterm birth. The present study aimed to determine the role of the neutrophil elastase test in predicting birth in women with preterm labor.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"67 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136262261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-19DOI: 10.14218/erhm.2023.00045
Isobel Han Ying Griffith, Faisal Usman Qureshi, Revin Thomas
Takotsubo cardiomyopathy can masquerade as an acute coronary syndrome and present clinically with chest pain and dyspnea, electrocardiogram changes of cardiac ischemia and elevation of cardiac enzymes. Such changes are particularly relevant in cases where Takotsubo cardiomyopathy is associated with subarachnoid hemorrhage, and treatment of acute coronary syndrome with antiplatelet drugs is contraindicated. We describe a case of a 68-year-old woman, who developed ventricular changes consistent with Takotsubo cardiomyopathy following an aneurysmal subarachnoid hemorrhage. The patient presented with collapse and vomiting, initial workup revealed anterior ST-elevation electrocardiogram changes, increased troponin I, and a chest radiograph suggestive of acute cardiac failure. In light of this, the patient was managed initially as an acute coronary syndrome with antiplatelet medication. An echocardiogram showed acute left ventricular systolic dysfunction with apical ballooning. After 3 days of hospitalization, she became increasingly drowsy with a worsening headache. Computed tomography of the head revealed intracerebral hemorrhage and bilateral subarachnoid hemorrhage and computed tomography angiography demonstrated a 9 × 5 mm A2 aneurysm. She subsequently underwent embolization to treat the ruptured aneurysm. She recovered well neurologically, and subsequent cardiac imaging revealed a complete resolution of her prior issues.
Takotsubo心肌病可伪装成急性冠状动脉综合征，临床表现为胸痛、呼吸困难、心肌缺血心电图改变和心肌酶升高。这种改变在Takotsubo心肌病与蛛网膜下腔出血相关的病例中尤为重要，并且禁止使用抗血小板药物治疗急性冠状动脉综合征。我们描述了一个病例68岁的妇女，谁发展心室改变符合Takotsubo心肌病后动脉瘤性蛛网膜下腔出血。患者表现为虚脱和呕吐，初步检查显示前st段抬高心电图改变，肌钙蛋白I增高，胸片提示急性心力衰竭。鉴于此，患者最初作为急性冠状动脉综合征进行抗血小板药物治疗。超声心动图显示急性左心室收缩功能不全伴心尖球囊。住院3天后，她变得越来越困倦，头痛加剧。头部ct显示脑出血和双侧蛛网膜下腔出血，ct血管造影显示9 × 5 mm A2动脉瘤。她随后接受了栓塞治疗破裂的动脉瘤。她的神经系统恢复良好，随后的心脏成像显示她先前的问题完全解决了。
{"title":"Takotsubo Cardiomyopathy in Aneurysmal Subarachnoid Hemorrhage with an Atypical Clinical Presentation: A Case Report","authors":"Isobel Han Ying Griffith, Faisal Usman Qureshi, Revin Thomas","doi":"10.14218/erhm.2023.00045","DOIUrl":"https://doi.org/10.14218/erhm.2023.00045","url":null,"abstract":"Takotsubo cardiomyopathy can masquerade as an acute coronary syndrome and present clinically with chest pain and dyspnea, electrocardiogram changes of cardiac ischemia and elevation of cardiac enzymes. Such changes are particularly relevant in cases where Takotsubo cardiomyopathy is associated with subarachnoid hemorrhage, and treatment of acute coronary syndrome with antiplatelet drugs is contraindicated. We describe a case of a 68-year-old woman, who developed ventricular changes consistent with Takotsubo cardiomyopathy following an aneurysmal subarachnoid hemorrhage. The patient presented with collapse and vomiting, initial workup revealed anterior ST-elevation electrocardiogram changes, increased troponin I, and a chest radiograph suggestive of acute cardiac failure. In light of this, the patient was managed initially as an acute coronary syndrome with antiplatelet medication. An echocardiogram showed acute left ventricular systolic dysfunction with apical ballooning. After 3 days of hospitalization, she became increasingly drowsy with a worsening headache. Computed tomography of the head revealed intracerebral hemorrhage and bilateral subarachnoid hemorrhage and computed tomography angiography demonstrated a 9 × 5 mm A2 aneurysm. She subsequently underwent embolization to treat the ruptured aneurysm. She recovered well neurologically, and subsequent cardiac imaging revealed a complete resolution of her prior issues.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Newborns, with their low immune system, lack of self-care ability, and inability to express discomfort through language, face challenges during the treatment of diseases, especially during intravenous infusion treatments where extravasation can occur. The inability of nurses to immediately detect extravasation often leads to severe consequences, including disability and even death. This increases the pain and treatment costs for children and places a heavy burden on healthcare professionals, hospitals, and society. Neonatal infusion extravasation is widespread during intravenous infusion and is influenced by various factors. Therefore, this article aims to review the research progress on relevant influencing factors that cause neonatal infusion extravasation.
{"title":"Factors Influencing Extravasation of Newborn Intravenous Infusions: A Review","authors":"Fang Huang, Lixuan Huang, Fengzhen Liao, Jiangping Huang, Jiaojiao Wei, Qun Liang, Zhenpeng Huang","doi":"10.14218/erhm.2023.00030","DOIUrl":"https://doi.org/10.14218/erhm.2023.00030","url":null,"abstract":"Newborns, with their low immune system, lack of self-care ability, and inability to express discomfort through language, face challenges during the treatment of diseases, especially during intravenous infusion treatments where extravasation can occur. The inability of nurses to immediately detect extravasation often leads to severe consequences, including disability and even death. This increases the pain and treatment costs for children and places a heavy burden on healthcare professionals, hospitals, and society. Neonatal infusion extravasation is widespread during intravenous infusion and is influenced by various factors. Therefore, this article aims to review the research progress on relevant influencing factors that cause neonatal infusion extravasation.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135855282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-19DOI: 10.14218/erhm.2023.00048
Ruby Srivastava
Artificial intelligence (AI) with machine learning tools are used to search, store, and analyze medical data to benefit both physicians and the health of patients in various ways. With the advancement in machine learning algorithms and bioinformatics techniques, AI has become an essential part of modern healthcare society. AI algorithms and deep learning applications support clinicians with managing health records, making diagnoses and clinical decisions, prescribing medication, determining mental health, and imaging analysis. Clinicians gain rapid access to information and research relevant to the needs of the patients. As some algorithms compete with and sometimes outperform clinicians, it is necessary to fully integrate this technology into daily medical practices. However, we must recognize the strengths and weaknesses of AI, and obtain the perspectives of experts outside the medical field to enable the inclusion of the ethical, philosophical, sociological, psychological, behavioral, and economical aspects of machine behavior when understanding the evolving interaction of machines with humans, so that it can be used for advantageous purposes. AI technology cannot be considered a replacement for physicians, rather it can act as multiple task-oriented device support to ease the burden on clinicians so that they can provide better care of life to patients at every level.
{"title":"Applications of Artificial Intelligence in Medicine","authors":"Ruby Srivastava","doi":"10.14218/erhm.2023.00048","DOIUrl":"https://doi.org/10.14218/erhm.2023.00048","url":null,"abstract":"Artificial intelligence (AI) with machine learning tools are used to search, store, and analyze medical data to benefit both physicians and the health of patients in various ways. With the advancement in machine learning algorithms and bioinformatics techniques, AI has become an essential part of modern healthcare society. AI algorithms and deep learning applications support clinicians with managing health records, making diagnoses and clinical decisions, prescribing medication, determining mental health, and imaging analysis. Clinicians gain rapid access to information and research relevant to the needs of the patients. As some algorithms compete with and sometimes outperform clinicians, it is necessary to fully integrate this technology into daily medical practices. However, we must recognize the strengths and weaknesses of AI, and obtain the perspectives of experts outside the medical field to enable the inclusion of the ethical, philosophical, sociological, psychological, behavioral, and economical aspects of machine behavior when understanding the evolving interaction of machines with humans, so that it can be used for advantageous purposes. AI technology cannot be considered a replacement for physicians, rather it can act as multiple task-oriented device support to ease the burden on clinicians so that they can provide better care of life to patients at every level.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135060917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2022-08-15DOI: 10.14218/erhm.2022.00086
Divine Nwafor, Joel Goeckeritz, Zahra Hasanpour, Caroline Davidson, Brandon Lucke-Wold
Traumatic brain injury (TBI) can contribute to extensive dysbiosis of the gastrointestinal system, leading to worsened outcomes. The importance of nutrition in recovery is underappreciated but highly important. In this focused review, we discuss the timing of nutritional interventions with supporting data. We highlight routes of administration that are important given the extent of injury often seen in TBI. The increased energy demands can be met through these approaches. Furthermore, patients need increased vitamins, minerals, and supplements. These interventions are constantly being refined. The current standards are reviewed with an emphasis on evidence-based practices.
{"title":"Nutritional Support Following Traumatic Brain Injury: A Comprehensive Review.","authors":"Divine Nwafor, Joel Goeckeritz, Zahra Hasanpour, Caroline Davidson, Brandon Lucke-Wold","doi":"10.14218/erhm.2022.00086","DOIUrl":"10.14218/erhm.2022.00086","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) can contribute to extensive dysbiosis of the gastrointestinal system, leading to worsened outcomes. The importance of nutrition in recovery is underappreciated but highly important. In this focused review, we discuss the timing of nutritional interventions with supporting data. We highlight routes of administration that are important given the extent of injury often seen in TBI. The increased energy demands can be met through these approaches. Furthermore, patients need increased vitamins, minerals, and supplements. These interventions are constantly being refined. The current standards are reviewed with an emphasis on evidence-based practices.</p>","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"8 3","pages":"236-247"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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