Pub Date : 2012-01-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2012.003
Li Sun, Jianfei Ma, Jing Zhu, Q. Guan, Jiang-min Feng, Lining Wang
Objective To observe the therapeutic effects of Shenxiong glucose injection in the patients with chronic kidney diseases.Methods Seventy-eight patients with chronic kidney disease were given intravenous glucose injection 200 ml,qd,for 2 weeks.The patients who were complicated with diabetes would be given insulin 2 U/100 ml.Before and after Shenxiong injection treatment,24 h urinary protein,blood urea nitrogen ( BUN),creatinine ( Cr),hemoglobin ( Hb),albumin ( ALB),hematocrit ( HCT),fiber fibrinogen (FIB),cholesterol (TC) and triglyceride (TG) were measured and compared.Results After 1 course of Shenxiong treatment,the serum BUN,Cr,FIB,24 h urinary protein,Hb and HCT ( [ 15.70 ± 3.62 ] mmol/L vs.[6.74 ± 1.56 ] mmol/L,[ 564 ± 65 ] μmol/Lvs.[ 189 ± 43 ] μmol/L,[ 0.08 ± 0.01 ] g/L vs.[ 0.04 ± 0.01 ] g/L,[7.96 ±3.45]g vs.[3.60 ± 1.92]g,[83.6 ±10.5]g/L vs.[79.5 ±8.7]g/L,[0.43 ±0.0] vs.[0.39 ±0.06 ] were decreased,and ALB ( 28.7 ± 8.6) vs.( 36.8 ± 6.2) was increased.The difference was statistically significant (t =3.1 1,2.98,3.04,2.82,2.02,2.23,P＜0.01 for all).TC and TG were not changed much after the treatment.Conclusion Shenxiong injection can improve the kidney function,lower Fibrinogen and urine protein,which may effectively slow down the progress of chronic kidney disease and improve the life quality. Key words: Chronic kidney disease; Shenxiong injection; Kidney function
目的观察参熊葡萄糖注射液对慢性肾病患者的治疗效果。方法78例慢性肾病患者静脉注射葡萄糖200 ml，每日1次，连续2周。合并糖尿病患者给予胰岛素2 U/100 ml，参雄注射液治疗前后测定尿蛋白、血尿素氮(BUN)、肌酐(Cr)、血红蛋白(Hb)、白蛋白(ALB)、红细胞压积(HCT)、纤维蛋白原(FIB)、胆固醇(TC)、甘油三酯(TG)等指标，并进行比较。结果参雄治疗1个疗程后，血清BUN、Cr、FIB、24 h尿蛋白、Hb、HCT分别为[15.70±3.62]mmol/L、[6.74±1.56]mmol/L、[564±65]μmol/Lvs。(189±43)μmol / L, g / L(0.08±0.01)和(0.04±0.01)g / L, g(7.96±3.45)和(3.60±1.92)g, g / L(83.6±10.5)和(79.5±8.7)g / L,(0.43±0.0)和(0.39±0.06)下降,和铝青铜(28.7±8.6)和(36.8±6.2)增加。差异有统计学意义(t =3.1 1、2.98、3.04、2.82、2.02、2.23,P均<0.01)。治疗后TC、TG变化不大。结论参熊注射液能改善肾功能，降低纤维蛋白原和尿蛋白，可有效延缓慢性肾病的进展，提高生活质量。关键词:慢性肾病;Shenxiong注射;肾脏功能
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