K M Sujata, Poonam Chauhan, Nidhi Verma, Rekha Garg Solanki, Ashok Kumar
Today, there is a huge need for highly efficient and sustainable energy resources to tackle environmental degradation and energy crisis. We have analyzed the electronic, mechanical and thermoelectric (TE) characteristics of two-dimensional (2D) BiSbTeX2 (X = S, Se and Te) and Janus BiSbTeXY (X/Y = S, Se and Te) monolayers by implementing first principles simulations. These monolayers' dynamic stability and thermal stability have been demonstrated through phonon dispersion spectra and ab initio molecular dynamics (AIMD) simulations, respectively. The band structure of these monolayers can be tuned by applying uniaxial and biaxial strains. The investigated lattice thermal conductivity (κl) for these monolayers lies between 0.23 and 0.37 W m-1 K-1 at 300 K. For a more precise calculation of the scattering rate, we implemented electron-phonon coupling (EPC) and spin-orbit coupling effects to calculate the transport properties. For p(n)-type carriers, the power factor of these monolayers is predicted to be as high as 2.08 × 10-3 W m-1 K-2 and (0.47 × 10-3 W m-1 K-2) at 300 K. The higher thermoelectric figure of merit (ZT) of p-type carriers at 300 K is obtained because of their very low value of κl and high power factor. Our theoretical investigation predicts that these monolayers can be potential candidates for fabricating highly efficient thermoelectric power generators.
{"title":"Two-dimensional BiSbTeX<sub>2</sub> (X = S, Se, Te) and their Janus monolayers as efficient thermoelectric materials.","authors":"K M Sujata, Poonam Chauhan, Nidhi Verma, Rekha Garg Solanki, Ashok Kumar","doi":"10.1039/d4cp02750g","DOIUrl":"https://doi.org/10.1039/d4cp02750g","url":null,"abstract":"<p><p>Today, there is a huge need for highly efficient and sustainable energy resources to tackle environmental degradation and energy crisis. We have analyzed the electronic, mechanical and thermoelectric (TE) characteristics of two-dimensional (2D) BiSbTeX<sub>2</sub> (X = S, Se and Te) and Janus BiSbTeXY (X/Y = S, Se and Te) monolayers by implementing first principles simulations. These monolayers' dynamic stability and thermal stability have been demonstrated through phonon dispersion spectra and <i>ab initio</i> molecular dynamics (AIMD) simulations, respectively. The band structure of these monolayers can be tuned by applying uniaxial and biaxial strains. The investigated lattice thermal conductivity (<i>κ</i><sub>l</sub>) for these monolayers lies between 0.23 and 0.37 W m<sup>-1</sup> K<sup>-1</sup> at 300 K. For a more precise calculation of the scattering rate, we implemented electron-phonon coupling (EPC) and spin-orbit coupling effects to calculate the transport properties. For p(n)-type carriers, the power factor of these monolayers is predicted to be as high as 2.08 × 10<sup>-3</sup> W m<sup>-1</sup> K<sup>-2</sup> and (0.47 × 10<sup>-3</sup> W m<sup>-1</sup> K<sup>-2</sup>) at 300 K. The higher thermoelectric figure of merit (<i>ZT</i>) of p-type carriers at 300 K is obtained because of their very low value of <i>κ</i><sub>l</sub> and high power factor. Our theoretical investigation predicts that these monolayers can be potential candidates for fabricating highly efficient thermoelectric power generators.</p>","PeriodicalId":99,"journal":{"name":"Physical Chemistry Chemical Physics","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ammonia and urea represent two important chemicals that have contributed to the rapid development of humanity. However, their industrial production requires harsh conditions, consuming excessive energy and resulting in significant greenhouse gas emission. Therefore, there is growing interest in the electrocatalytic synthesis of ammonia and urea as it can be carried out under ambient conditions. Recently, atomic catalysts (ACs) have gained increased attention for their superior catalytic properties, being able to outperform their micro and nano counterparts. This review examines the advantages and disadvantages of ACs and summarises the advancement of ACs in the electrocatalytic synthesis of ammonia and urea. The focus is on two types of AC - single-atom catalysts (SACs) and diatom catalysts (DACs). SACs offer various advantages, including the 100% atom utilization that allows for low material mass loading, suppression of competitive reactions such as hydrogen evolution reaction (HER), and alternative reaction pathways allowing for efficient synthesis of ammonia and urea. DACs inherit these advantages, possessing further benefits of synergistic effects between the two catalytic centers at close proximity, particularly matching the NN bond for N2 reduction and boosting C-N coupling for urea synthesis. DACs also possess the ability to break the linear scaling relation of adsorption energy of reactants and intermediates, allowing for tuning of intermediate adsorption energies. Finally, possible future research directions using ACs are proposed.
{"title":"Single and dual-atom catalysts towards electrosynthesis of ammonia and urea: a review.","authors":"Wenyu Luo, Jiawei Liu, Yue Hu, Qingyu Yan","doi":"10.1039/d4nr02387k","DOIUrl":"https://doi.org/10.1039/d4nr02387k","url":null,"abstract":"<p><p>Ammonia and urea represent two important chemicals that have contributed to the rapid development of humanity. However, their industrial production requires harsh conditions, consuming excessive energy and resulting in significant greenhouse gas emission. Therefore, there is growing interest in the electrocatalytic synthesis of ammonia and urea as it can be carried out under ambient conditions. Recently, atomic catalysts (ACs) have gained increased attention for their superior catalytic properties, being able to outperform their micro and nano counterparts. This review examines the advantages and disadvantages of ACs and summarises the advancement of ACs in the electrocatalytic synthesis of ammonia and urea. The focus is on two types of AC - single-atom catalysts (SACs) and diatom catalysts (DACs). SACs offer various advantages, including the 100% atom utilization that allows for low material mass loading, suppression of competitive reactions such as hydrogen evolution reaction (HER), and alternative reaction pathways allowing for efficient synthesis of ammonia and urea. DACs inherit these advantages, possessing further benefits of synergistic effects between the two catalytic centers at close proximity, particularly matching the NN bond for N<sub>2</sub> reduction and boosting C-N coupling for urea synthesis. DACs also possess the ability to break the linear scaling relation of adsorption energy of reactants and intermediates, allowing for tuning of intermediate adsorption energies. Finally, possible future research directions using ACs are proposed.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bipin Gaihre, Emily Camilleri, Maryam Tilton, Maria D Astudillo Potes, Xifeng Liu, Fabrice Lucien, Lichun Lu
LAPONITE®-based drug delivery systems offer many advantages due to the unique ionic and physical properties of LAPONITE®. The high ionicity and large surface area of LAPONITE® nanoparticles enable the intercalation and dissolution of biomolecules. In this study, we explored the potential of LAPONITE® as a carrier for FG-4592 to support angiogenesis and as a carrier for bone morphogenic protein-2 (BMP-2) to support osteogenesis. Interestingly, we found that LAPONITE® promoted the FG-4592 induced upregulation of vascular endothelial growth factor (VEGF) gene expression of human umbilical cord endothelial cells (HUVECs). Additionally, we observed that LAPONITE® could provide a sustained release of BMP-2 and significantly potentiate the osteogenic effects of BMP-2 on adipose derived mesenchymal stem cells (AMSCs). Overall, current findings on the LAPONITE®-drug/protein model system provide a unique way to potentiate the angiogenic activities of FG-4592 on HUVECs and osteogenic effects of BMP-2 on AMSCs for tissue engineering application. Future studies will be directed towards gaining a deeper understanding of these effects on a co-culture system of HUVECs and AMSCs.
{"title":"LAPONITE® nano-silicates potentiate the angiogenic effects of FG-4592 and osteogenic effects of BMP-2.","authors":"Bipin Gaihre, Emily Camilleri, Maryam Tilton, Maria D Astudillo Potes, Xifeng Liu, Fabrice Lucien, Lichun Lu","doi":"10.1039/d4bm00636d","DOIUrl":"10.1039/d4bm00636d","url":null,"abstract":"<p><p>LAPONITE®-based drug delivery systems offer many advantages due to the unique ionic and physical properties of LAPONITE®. The high ionicity and large surface area of LAPONITE® nanoparticles enable the intercalation and dissolution of biomolecules. In this study, we explored the potential of LAPONITE® as a carrier for FG-4592 to support angiogenesis and as a carrier for bone morphogenic protein-2 (BMP-2) to support osteogenesis. Interestingly, we found that LAPONITE® promoted the FG-4592 induced upregulation of vascular endothelial growth factor (VEGF) gene expression of human umbilical cord endothelial cells (HUVECs). Additionally, we observed that LAPONITE® could provide a sustained release of BMP-2 and significantly potentiate the osteogenic effects of BMP-2 on adipose derived mesenchymal stem cells (AMSCs). Overall, current findings on the LAPONITE®-drug/protein model system provide a unique way to potentiate the angiogenic activities of FG-4592 on HUVECs and osteogenic effects of BMP-2 on AMSCs for tissue engineering application. Future studies will be directed towards gaining a deeper understanding of these effects on a co-culture system of HUVECs and AMSCs.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuebin Ma, Kanaparedu P C Sekhar, Peiyu Zhang, Jiwei Cui
Injectable hydrogels, as a class of highly hydrated soft materials, are of interest for biomedicine due to their precise implantation and minimally invasive local drug delivery at the implantation site. The combination of in situ gelation ability and versatile therapeutic agent/cell loading capabilities makes injectable hydrogels ideal materials for drug delivery, tissue engineering, wound dressing and tumor treatment. In particular, the stimuli-responsive injectable hydrogels that can respond to different stimuli in and out of the body (e.g., temperature, pH, redox conditions, light, magnetic fields, etc.) have significant advantages in biomedicine. Here, we summarize the design strategies, advantages, and recent developments of stimuli-responsive injectable hydrogels in different biomedical fields. Challenges and future perspectives of stimuli-responsive injectable hydrogels are also discussed and the future steps necessary to fulfill the potential of these promising materials are highlighted.
{"title":"Advances in stimuli-responsive injectable hydrogels for biomedical applications.","authors":"Xuebin Ma, Kanaparedu P C Sekhar, Peiyu Zhang, Jiwei Cui","doi":"10.1039/d4bm00956h","DOIUrl":"10.1039/d4bm00956h","url":null,"abstract":"<p><p>Injectable hydrogels, as a class of highly hydrated soft materials, are of interest for biomedicine due to their precise implantation and minimally invasive local drug delivery at the implantation site. The combination of <i>in situ</i> gelation ability and versatile therapeutic agent/cell loading capabilities makes injectable hydrogels ideal materials for drug delivery, tissue engineering, wound dressing and tumor treatment. In particular, the stimuli-responsive injectable hydrogels that can respond to different stimuli in and out of the body (<i>e.g.</i>, temperature, pH, redox conditions, light, magnetic fields, <i>etc</i>.) have significant advantages in biomedicine. Here, we summarize the design strategies, advantages, and recent developments of stimuli-responsive injectable hydrogels in different biomedical fields. Challenges and future perspectives of stimuli-responsive injectable hydrogels are also discussed and the future steps necessary to fulfill the potential of these promising materials are highlighted.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bennehalli Basavaraju, Santhosh Nagaraja, Ashok R. Banagar, C. V. Srinivasa, B. T. Ramesh, Deden Ramdan and Muhammad Imam Ammarullah
The need for non-conventional natural fibres for synthesis of hybrid composites has gained momentum in the recent past. Taking into consideration this need, in the current study, hybrid composites were fabricated by reinforcing wood apple shell powder and coconut shell powder, in the resin with varying amounts of cenospheres (up to 20 wt% in increments of 5 wt%) to evaluate their mechanical and tribological properties. The densities of these composites were directly correlated with the quantity of additives utilized. Enhanced tensile and flexural properties were noted in composites containing 10 wt% cenospheres, along with 15 wt% wood apple shell powder and coconut shell powder, compared to other formulations. Dry sliding wear tests were performed at room temperature using a pin-on-disc apparatus, considering loading factors, travel distance, and speed. A hybrid composite consisting of 10 wt% cenospheres, subjected to a normal load of 10 N (1.02 kgf), and tested at a sliding speed of 1.5 m s−1 (90 m min−1) over a distance of 500 m, exhibited superior wear resistance compared to all other composite variations.
近年来,人们越来越需要用非常规天然纤维合成混合复合材料。考虑到这一需求,在当前的研究中,通过在树脂中添加不同量的仙人球(最高达 20 wt%,增量为 5 wt%)来增强木苹果壳粉和椰子壳粉,从而制成了混合复合材料,并对其机械和摩擦学性能进行了评估。这些复合材料的密度与添加剂的用量直接相关。与其他配方相比,含有 10 wt% 的仙人球以及 15 wt% 的木苹果壳粉和椰子壳粉的复合材料具有更强的拉伸和弯曲性能。考虑到加载因素、移动距离和速度,在室温下使用针盘装置进行了干滑动磨损测试。由 10 wt% 的仙人球组成的混合复合材料在承受 10 N(1.02 kgf)的正常载荷,并以 1.5 m s-1(90 m min-1)的滑动速度在 500 m 的距离上进行测试时,与所有其他复合材料变体相比,表现出更优异的耐磨性。
{"title":"Influence of suspended cenospheres on the mechanical characteristics and wear loss of natural fiber-reinforced hybrid composites: implications for biomedical applications and sustainable material management","authors":"Bennehalli Basavaraju, Santhosh Nagaraja, Ashok R. Banagar, C. V. Srinivasa, B. T. Ramesh, Deden Ramdan and Muhammad Imam Ammarullah","doi":"10.1039/D4RA06223J","DOIUrl":"https://doi.org/10.1039/D4RA06223J","url":null,"abstract":"<p >The need for non-conventional natural fibres for synthesis of hybrid composites has gained momentum in the recent past. Taking into consideration this need, in the current study, hybrid composites were fabricated by reinforcing wood apple shell powder and coconut shell powder, in the resin with varying amounts of cenospheres (up to 20 wt% in increments of 5 wt%) to evaluate their mechanical and tribological properties. The densities of these composites were directly correlated with the quantity of additives utilized. Enhanced tensile and flexural properties were noted in composites containing 10 wt% cenospheres, along with 15 wt% wood apple shell powder and coconut shell powder, compared to other formulations. Dry sliding wear tests were performed at room temperature using a pin-on-disc apparatus, considering loading factors, travel distance, and speed. A hybrid composite consisting of 10 wt% cenospheres, subjected to a normal load of 10 N (1.02 kgf), and tested at a sliding speed of 1.5 m s<small><sup>−1</sup></small> (90 m min<small><sup>−1</sup></small>) over a distance of 500 m, exhibited superior wear resistance compared to all other composite variations.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra06223j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shivani R. Bharucha, Mehul S. Dave, Sunil H. Chaki and Tushar A. Limbani
Due to their unique size-dependent properties, transition metal di-chalcogenide nanoparticles are trending in research for their potential to revolutionize next-generation electronics, energy storage, and catalytic processes. This study addresses the effect of temperature when synthesizing NbSe2 nanoparticles via the sonochemical method at three different temperatures, room temperature (R.T.), 70 °C, and 100 °C. Energy Dispersive X-ray Analysis (EDAX) confirmed the high purity of NbSe2, with the sample synthesized at 70 °C, displaying the accurate stoichiometric ratio. X-ray diffraction (XRD) analysis revealed that all samples maintained the hexagonal phase of NbSe2, with 70 °C exhibiting superior crystallinity due to their crystallite size, lowest dislocation density, and minimal internal strain. Thermogravimetric analysis (TGA) and differential thermogravimetric (DTG) analyses, demonstrated that the sample synthesized at 70 °C had the highest thermal stability, with the lowest total weight loss and most consistent mass loss behavior. Kinetic parameters were evaluated using the Kissinger–Akahira–Sunose (KAS) and Flynn–Wall–Ozawa (FWO) methods, determining activation energy (Ea), pre-exponential factor (A), change in activation enthalpy (ΔH*), change in activation entropy (ΔS*), and Gibbs free energy change (ΔG*). Also, the sample synthesized at 70 °C exhibited the highest Ea, indicating superior thermal stability and favorable reaction kinetics. The findings underscore the significant impact of synthesis temperature on the structural and thermal properties of NbSe2 nanoparticles, with the sample synthesized at 70 °C demonstrating optimal characteristics. This study provides valuable insights into temperature-dependent synthesis and the thermal behavior of NbSe2 nanoparticles, highlighting their potential in various technological applications.
由于过渡金属二粲化物纳米粒子具有与尺寸相关的独特性质,它们有望彻底改变下一代电子学、能量存储和催化过程,因而成为研究的趋势。本研究探讨了在室温 (R.T.)、70 °C 和 100 °C 三种不同温度下通过超声化学方法合成 NbSe2 纳米粒子时温度的影响。能量色散 X 射线分析(EDAX)证实了 NbSe2 的高纯度,在 70 °C 下合成的样品显示出精确的化学计量比。X 射线衍射(XRD)分析表明,所有样品都保持了 NbSe2 的六方相,其中 70 °C 的样品因其晶粒大小、位错密度最低和内部应变最小而表现出更高的结晶度。热重分析 (TGA) 和差热重 (DTG) 分析表明,在 70 °C 下合成的样品具有最高的热稳定性、最低的总失重和最一致的质量损失行为。采用基辛格-阿卡希拉-苏诺塞(KAS)法和弗林-沃尔-奥泽(FWO)法评估了动力学参数,确定了活化能(Ea)、前指数因子(A)、活化焓变化(ΔH*)、活化熵变化(ΔS*)和吉布斯自由能变化(ΔG*)。此外,在 70 °C 下合成的样品表现出最高的 Ea,表明其具有卓越的热稳定性和有利的反应动力学。研究结果表明,合成温度对 NbSe2 纳米粒子的结构和热性能有显著影响,在 70 ℃ 下合成的样品具有最佳特性。这项研究为了解随温度变化的合成和 NbSe2 纳米粒子的热行为提供了宝贵的见解,凸显了它们在各种技术应用中的潜力。
{"title":"Thermal investigation of NbSe2 nanoparticles synthesized through a temperature-dependent sonochemical method","authors":"Shivani R. Bharucha, Mehul S. Dave, Sunil H. Chaki and Tushar A. Limbani","doi":"10.1039/D4RA05108D","DOIUrl":"https://doi.org/10.1039/D4RA05108D","url":null,"abstract":"<p >Due to their unique size-dependent properties, transition metal di-chalcogenide nanoparticles are trending in research for their potential to revolutionize next-generation electronics, energy storage, and catalytic processes. This study addresses the effect of temperature when synthesizing NbSe<small><sub>2</sub></small> nanoparticles <em>via</em> the sonochemical method at three different temperatures, room temperature (R.T.), 70 °C, and 100 °C. Energy Dispersive X-ray Analysis (EDAX) confirmed the high purity of NbSe<small><sub>2</sub></small>, with the sample synthesized at 70 °C, displaying the accurate stoichiometric ratio. X-ray diffraction (XRD) analysis revealed that all samples maintained the hexagonal phase of NbSe<small><sub>2</sub></small>, with 70 °C exhibiting superior crystallinity due to their crystallite size, lowest dislocation density, and minimal internal strain. Thermogravimetric analysis (TGA) and differential thermogravimetric (DTG) analyses, demonstrated that the sample synthesized at 70 °C had the highest thermal stability, with the lowest total weight loss and most consistent mass loss behavior. Kinetic parameters were evaluated using the Kissinger–Akahira–Sunose (KAS) and Flynn–Wall–Ozawa (FWO) methods, determining activation energy (<em>E</em><small><sub>a</sub></small>), pre-exponential factor (<em>A</em>), change in activation enthalpy (Δ<em>H</em>*), change in activation entropy (Δ<em>S</em>*), and Gibbs free energy change (Δ<em>G</em>*). Also, the sample synthesized at 70 °C exhibited the highest <em>E</em><small><sub>a</sub></small>, indicating superior thermal stability and favorable reaction kinetics. The findings underscore the significant impact of synthesis temperature on the structural and thermal properties of NbSe<small><sub>2</sub></small> nanoparticles, with the sample synthesized at 70 °C demonstrating optimal characteristics. This study provides valuable insights into temperature-dependent synthesis and the thermal behavior of NbSe<small><sub>2</sub></small> nanoparticles, highlighting their potential in various technological applications.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra05108d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaifali Dhingra, Vidit Gaur, Varsha Saini, Kajal Rana, Jayanta Bhattacharyya, Thomas Loho, Sudip Ray, Avinash Bajaj, Sampa Saha
Retraction of 'Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections' by Shaifali Dhingra et al., Biomater. Sci., 2022, 10, 3856-3877, https://doi.org/10.1039/D2BM00245K.
Wenna Shi, Hui Xue, Tianwei Du, Jun-Li Liu, Victor Ling, Yuzhuo Wang, Zhenwei Ma, Zu-Hua Gao
The human body possesses natural barriers, such as skin and mucosa, which limit the effective delivery of therapeutics and integration of medical devices to target tissues. Various strategies have been deployed to breach these barriers mechanically, chemically, or electronically. The development of various penetration enhancers (PEs) offers a promising solution due to their ability to increase tissue permeability using readily available reagents. However, existing PE-mediated delivery methods often rely on weak gel or liquid drug formulations, which are not ideal for sustained local delivery. Hydrogel adhesives that can seamlessly interface biological tissues with controlled drug delivery could potentially resolve these issues. Here, we demonstrate that tough adhesion between drug-laden hydrogels and biological tissue (e.g. skin and tumours) can lead to effective local delivery of drugs deep into targeted tissues by leveraging the enhanced tissue penetration mediated by PEs. The drug release profile of the hydrogel adhesives can be fine-tuned by further engineering the nanocomposite hydrogel matrix to elute chemotherapeutics from 2 weeks to 2 months. Using a 3D tumour spheroid model, we demonstrated that PEs increased the cancer-killing effectiveness of doxorubicin by facilitating its delivery into tumour microtissues. Therefore, the proposed tough bioadhesion and drug delivery strategy modulated by PEs holds promise as a platform technique to develop next-generation wearable and implantable devices for cancer management and regenerative medicine.
人体具有皮肤和粘膜等天然屏障,这些屏障限制了向目标组织有效输送治疗药物和整合医疗设备。人们采取了各种策略,通过机械、化学或电子手段来突破这些障碍。各种渗透促进剂(PE)的开发提供了一种很有前景的解决方案,因为它们能够利用现成的试剂增加组织的渗透性。然而,现有的以 PE 为媒介的给药方法通常依赖于弱凝胶或液体药物制剂,这对于持续的局部给药并不理想。水凝胶粘合剂能将生物组织与可控给药无缝衔接,有可能解决这些问题。在这里,我们证明了含药水凝胶与生物组织(如皮肤和肿瘤)之间的强力粘附可以利用聚乙烯介导的增强组织穿透力,将药物有效地局部输送到目标组织的深部。通过进一步设计纳米复合水凝胶基质,可对水凝胶粘合剂的药物释放曲线进行微调,使化疗药物的洗脱时间从 2 周延长至 2 个月。我们利用三维肿瘤球体模型证明,PE 可促进多柔比星向肿瘤微组织的递送,从而提高多柔比星的杀癌效果。因此,由聚乙烯调制的韧性生物粘附和药物输送策略有望成为开发下一代可穿戴和植入式癌症治疗和再生医学设备的平台技术。
{"title":"Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery.","authors":"Wenna Shi, Hui Xue, Tianwei Du, Jun-Li Liu, Victor Ling, Yuzhuo Wang, Zhenwei Ma, Zu-Hua Gao","doi":"10.1039/d4bm00807c","DOIUrl":"10.1039/d4bm00807c","url":null,"abstract":"<p><p>The human body possesses natural barriers, such as skin and mucosa, which limit the effective delivery of therapeutics and integration of medical devices to target tissues. Various strategies have been deployed to breach these barriers mechanically, chemically, or electronically. The development of various penetration enhancers (PEs) offers a promising solution due to their ability to increase tissue permeability using readily available reagents. However, existing PE-mediated delivery methods often rely on weak gel or liquid drug formulations, which are not ideal for sustained local delivery. Hydrogel adhesives that can seamlessly interface biological tissues with controlled drug delivery could potentially resolve these issues. Here, we demonstrate that tough adhesion between drug-laden hydrogels and biological tissue (<i>e.g.</i> skin and tumours) can lead to effective local delivery of drugs deep into targeted tissues by leveraging the enhanced tissue penetration mediated by PEs. The drug release profile of the hydrogel adhesives can be fine-tuned by further engineering the nanocomposite hydrogel matrix to elute chemotherapeutics from 2 weeks to 2 months. Using a 3D tumour spheroid model, we demonstrated that PEs increased the cancer-killing effectiveness of doxorubicin by facilitating its delivery into tumour microtissues. Therefore, the proposed tough bioadhesion and drug delivery strategy modulated by PEs holds promise as a platform technique to develop next-generation wearable and implantable devices for cancer management and regenerative medicine.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mathijs J Pals, Alexander Lindberg, Willem A Velema
Antibacterial resistance is a severe threat to modern medicine and human health. To stay ahead of constantly-evolving bacteria we need to expand our arsenal of effective antibiotics. As such, antisense therapy is an attractive approach. The programmability allows to in principle target any RNA sequence within bacteria, enabling tremendous selectivity. In this Tutorial Review we provide guidelines for devising effective antibacterial antisense agents and offer a concise perspective for future research. We will review the chemical architectures of antibacterial antisense agents with a special focus on the delivery and target selection for successful antisense design. This Tutorial Review will strive to serve as an essential guide for antibacterial antisense technology development.
{"title":"Chemical strategies for antisense antibiotics.","authors":"Mathijs J Pals, Alexander Lindberg, Willem A Velema","doi":"10.1039/d4cs00238e","DOIUrl":"https://doi.org/10.1039/d4cs00238e","url":null,"abstract":"<p><p>Antibacterial resistance is a severe threat to modern medicine and human health. To stay ahead of constantly-evolving bacteria we need to expand our arsenal of effective antibiotics. As such, antisense therapy is an attractive approach. The programmability allows to in principle target any RNA sequence within bacteria, enabling tremendous selectivity. In this Tutorial Review we provide guidelines for devising effective antibacterial antisense agents and offer a concise perspective for future research. We will review the chemical architectures of antibacterial antisense agents with a special focus on the delivery and target selection for successful antisense design. This Tutorial Review will strive to serve as an essential guide for antibacterial antisense technology development.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":null,"pages":null},"PeriodicalIF":40.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We explore the dynamics of a tracer in an active particle harmonic chain, investigating the influence of interactions. Our analysis involves calculating mean-squared displacements (MSDs) and space-time correlations through Green's function techniques and numerical simulations. Depending on chain characteristics, i.e., different time scales determined by interaction stiffness and persistence of activity, tagged-particle MSDs exhibit ballistic, diffusive, and single-file diffusion (SFD) scaling over time, with crossovers explained by our analytic expressions. Our results reveal transitions in bulk particle displacement distributions from an early-time bimodal to late-time Gaussian, passing through regimes of unimodal distributions with finite support and negative excess kurtosis and longer-tailed distributions with positive excess kurtosis. The distributions exhibit data collapse, aligning with ballistic, diffusive, and SFD scaling in the appropriate time regimes. However, at much longer times, the distributions become Gaussian. Finally, we derive analytic expressions for steady-state static and dynamic two-point displacement correlations. We verify these from simulations and highlight the differences from the equilibrium results.
{"title":"Dynamical crossovers and correlations in a harmonic chain of active particles.","authors":"Subhajit Paul, Abhishek Dhar, Debasish Chaudhuri","doi":"10.1039/d4sm00350k","DOIUrl":"https://doi.org/10.1039/d4sm00350k","url":null,"abstract":"<p><p>We explore the dynamics of a tracer in an active particle harmonic chain, investigating the influence of interactions. Our analysis involves calculating mean-squared displacements (MSDs) and space-time correlations through Green's function techniques and numerical simulations. Depending on chain characteristics, <i>i.e.</i>, different time scales determined by interaction stiffness and persistence of activity, tagged-particle MSDs exhibit ballistic, diffusive, and single-file diffusion (SFD) scaling over time, with crossovers explained by our analytic expressions. Our results reveal transitions in bulk particle displacement distributions from an early-time bimodal to late-time Gaussian, passing through regimes of unimodal distributions with finite support and negative excess kurtosis and longer-tailed distributions with positive excess kurtosis. The distributions exhibit data collapse, aligning with ballistic, diffusive, and SFD scaling in the appropriate time regimes. However, at much longer times, the distributions become Gaussian. Finally, we derive analytic expressions for steady-state static and dynamic two-point displacement correlations. We verify these from simulations and highlight the differences from the equilibrium results.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}