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Clinics in Immunology and Allergy
Pub Date : 1985-06-01 DOI: 10.1016/S0260-4639(22)00123-2
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引用次数: 0
Ontogeny of B Cells and Humoral Immune Functions B细胞的个体发生与体液免疫功能
Clinics in Immunology and Allergy
Pub Date : 1985-06-01 DOI: 10.1016/S0260-4639(22)00127-X
LARRY B. VOGLER, ALEXANDER R. LAWTON
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引用次数: 12
Macrophage Ontogeny: Implications for Host Defence, T-lymphocyte Differentiation, and the Acquisition of Self-tolerance 巨噬细胞个体发生:宿主防御、t淋巴细胞分化和获得自我耐受的意义
Clinics in Immunology and Allergy
Pub Date : 1985-06-01 DOI: 10.1016/S0260-4639(22)00128-1
CHRISTOPHER Y. LU, EMIL R. UNANUE

It has become increasingly more apparent that la-bearing accessory cells are important in regulating the function of mature T lymphocytes as well as the maturation of immature T lymphocytes in the thymus. The experiments reviewed here have focused on the ontogeny of la-bearing macrophages in the peritoneal cavity, spleen, and thymus. In the former two sites, la-bearing macrophages appear late in ontogeny. This makes the neonate and fetus vulnerable to infection, but may also offer the immune system a critical mechanism for inducing self-tolerance. The delayed ontogenesis of la-bearing macrophages at these two sites is regulated by high concentrations of PGE2 as well as alpha-fetoprotein. On the other hand, la-bearing thymic macrophages are present early in ontogeny and may contribute to the expansion and maturation of appropriate T lymphocyte clones early in development.

承载la的辅助细胞在调节胸腺成熟T淋巴细胞的功能以及未成熟T淋巴细胞的成熟中起着重要的作用，这一点越来越明显。本文综述的实验主要集中在腹腔、脾脏和胸腺中携带la的巨噬细胞的个体发生。在前两个部位，巨噬细胞在个体发育中出现较晚。这使得新生儿和胎儿容易受到感染，但也可能为免疫系统提供一个诱导自我耐受的关键机制。在这两个部位携带la的巨噬细胞的延迟个体形成是由高浓度的PGE2和甲胎蛋白调节的。另一方面，携带la的胸腺巨噬细胞在个体发育早期就存在，可能有助于发育早期适当T淋巴细胞克隆的扩张和成熟。
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引用次数: 8
Perspectives on the Genetics of the Gm System and its Role in Immune Response and Diseases 转基因系统遗传学及其在免疫反应和疾病中的作用的研究进展
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/s0260-4639(22)00204-3
J. Pandey, H. Fudenberg
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引用次数: 4
HLA-Gm Interactions: Clinical Implications HLA-Gm相互作用:临床意义
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/s0260-4639(22)00203-1
S. Whittingham, I. Mackay, J. Mathews
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引用次数: 6
Complement Polymorphism and Disease 补体多态性与疾病
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/S0260-4639(22)00205-5
M.J. HOBART, M.J. WALPORT, P.J. LACHMANN
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引用次数: 5
The Immunoglobulin Genes: Genetics, Biological and Clinical Significance 免疫球蛋白基因:遗传学、生物学和临床意义
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/s0260-4639(22)00202-x
E. van Loghem
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引用次数: 0
Prevention of Rhesus Immunization 预防恒河猴免疫
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/S0260-4639(22)00195-5
JOHN G. GORMAN, VINCENT J. FREDA, WILLIAM POLLACK
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引用次数: 2
Immunogenetics, Chemistry and Clinical Significance of Red Cell Antigens 红细胞抗原的免疫遗传学、化学及临床意义
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/S0260-4639(22)00194-3
FRED H. ALLEN Jr
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引用次数: 0
Molecular Genetics of the HLA System: New Tools for the Study of HLA and Disease HLA系统的分子遗传学:HLA与疾病研究的新工具
Clinics in Immunology and Allergy
Pub Date : 1984-10-01 DOI: 10.1016/s0260-4639(22)00200-6
J. Dausset, D. Cohen
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引用次数: 1
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