Disorders of phagocyte (primarily PMN) function have been reviewed according to the processes exhibited chronologically as the cell responds to microbial invasion, namely, adherence, Chemotaxis, phagocytosis, and killing. Emphasis has been placed on those functional disorders that have at least a partial biochemical explanation and that result in increased susceptibility to infection.
It has become increasingly more apparent that la-bearing accessory cells are important in regulating the function of mature T lymphocytes as well as the maturation of immature T lymphocytes in the thymus. The experiments reviewed here have focused on the ontogeny of la-bearing macrophages in the peritoneal cavity, spleen, and thymus. In the former two sites, la-bearing macrophages appear late in ontogeny. This makes the neonate and fetus vulnerable to infection, but may also offer the immune system a critical mechanism for inducing self-tolerance. The delayed ontogenesis of la-bearing macrophages at these two sites is regulated by high concentrations of PGE2 as well as alpha-fetoprotein. On the other hand, la-bearing thymic macrophages are present early in ontogeny and may contribute to the expansion and maturation of appropriate T lymphocyte clones early in development.
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