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Spondyloarthropathy associated with Crohn's disease treated with adalimumab 阿达木单抗治疗与克罗恩病相关的脊椎关节病
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60003-X
Maria Laura Annunziata, Michele Cicala
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引用次数: 0
Steroid-free remission and closure of recto-vaginal fistula using adalimumab in a Crohn's disease patient naïve to anti-tumour necrosis factor alpha antibodies 使用阿达木单抗治疗克罗恩病患者naïve对抗肿瘤坏死因子α抗体的无类固醇缓解和直肠阴道瘘闭合
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60010-7
Sara Onali, Francesca Zorzi, Emma Calabrese, Livia Biancone
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引用次数: 0
Adalimumab in a patient with steroid-dependent Crohn's disease 阿达木单抗在类固醇依赖型克罗恩病患者中的应用
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60013-2
Rosy Tambasco, Fernando Rizzello, Paolo Gionchetti, Massimo Campieri

We present the case of 51-year-old man with stricturing Crohn's disease of the jejunum and ileum who underwent jejunal resection and creation of a latero-lateral anastomosis. The patient had a history of steroid-dependent disease and was inappropriately treated with azathioprine, complicated by vertebral collapse. Adalimumab administered subcutaneously was used because of the persistence of active disease.

我们提出一例51岁的男子与狭窄的克罗恩病的空肠和回肠谁接受空肠切除术和创造一个左右侧吻合。患者有类固醇依赖病史，曾不恰当地使用硫唑嘌呤治疗，并发椎体塌陷。由于活动性疾病持续存在，使用皮下给药阿达木单抗。
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引用次数: 0
Long-term remission with adalimumab in steroid-dependent Crohn's disease patients with multiple drug intolerances 阿达木单抗治疗多种药物不耐受的类固醇依赖型克罗恩病患者的长期缓解
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60004-1
Fabrizio Bossa, Giuseppe Biscaglia, Antonio Merla, Fulvia Terracciano
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引用次数: 0
Adalimumab and perianal Crohn's disease: Case report 阿达木单抗与肛周克罗恩病:1例报告
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60011-9
Mariabeatrice Principi, Nicola De Tullio, Alfredo di Leo
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引用次数: 0
Prevention of post-surgical recurrence with adalimumab in a patient with complicated Crohn's disease 阿达木单抗预防合并克罗恩病患者术后复发
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60008-9
Giuseppe Costantino , Giuseppe Navarra , Luigi Familiari , Walter Fries
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引用次数: 0
Adalimumab and endoscopic dilatation in the treatment of inflammatory strictures due to Crohn's disease: A case report of a treatment-naïve patient 阿达木单抗和内镜扩张治疗克罗恩病引起的炎症性狭窄:treatment-naïve患者的病例报告
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60005-3
Rosamaria Bozzi , Pietro Schettino , Angelo Pezzullo , Domenico Cattaneo
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引用次数: 0
Adalimumab is effective in achieving clinical and endoscopic long-term deep remission: A case report 阿达木单抗在实现临床和内镜下长期深度缓解方面是有效的:一个病例报告
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60009-0
Gionata Fiorino , Alessandro Repici , Alberto Malesci , Silvio Danese

Anti-tumour necrosis factor-alpha has dramatically changed the natural history of Crohn's disease in the last decades. Adalimumab is effective in inducing and maintaining clinical remission as well as in inducing deep mucosal healing, which is a prognostic factor for further progression of the disease. Long-term treatment with adalimumab is considered safe and should be continued for at least 3 years in patients with aggressive long-standing Crohn's disease.

We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery.

在过去的几十年里，抗肿瘤坏死因子- α戏剧性地改变了克罗恩病的自然历史。阿达木单抗在诱导和维持临床缓解以及诱导深层粘膜愈合方面是有效的，这是疾病进一步进展的预后因素。长期使用阿达木单抗治疗被认为是安全的，对于侵袭性长期克罗恩病患者应持续使用至少3年。我们报告一例患有侵袭性和复杂的类固醇依赖性克罗恩病的61岁妇女，其临床和内窥镜长期深度缓解达3年，无需类固醇，住院或手术。
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引用次数: 0
Combined treatment with adalimumab and surgery in a patient with steroid-dependent Crohn's disease complicated by perianal disease 阿达木单抗联合手术治疗类固醇依赖型克罗恩病并发肛周疾病1例
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60012-0
Sara Renna , Ambrogio Orlando , Gaspare Solina , Mario Cottone
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引用次数: 0
The Italian clinical experience with adalimumab in Crohn's disease: Eleven clinical cases 意大利阿达木单抗治疗克罗恩病的临床经验:11例临床病例
Digestive and Liver Disease Supplements
Pub Date : 2010-12-01 DOI: 10.1016/S1594-5804(11)60002-8
Maria Laura Annunziata , Fabrizio Bossa , Rosamaria Bozzi , Flavio Caprioli , Andrea Cassinotti , Giuseppe Costantino , Gionata Fiorino , Sara Onali , Mariabeatrice Principi , Sara Renna , Rosy Tambasco
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引用次数: 0
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