{"title":"Young Investigator Award for Basic Science","authors":"","doi":"10.1093/eurjhf/hsr013","DOIUrl":"https://doi.org/10.1093/eurjhf/hsr013","url":null,"abstract":"","PeriodicalId":100499,"journal":{"name":"European Journal of Heart Failure Supplements","volume":"10 S1","pages":"S5-S6"},"PeriodicalIF":0.0,"publicationDate":"2011-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eurjhf/hsr013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71971538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Despite recent approaches, a profound understanding of pathophysio- logical abnormalities in heart failure with preserved ejection fraction (HFpEF) is still lacking. Purpose: Echocardiography provides the method of choice for diagnosis as well as progression assessment in patients with suspected HFpEF. Thus, the purpose of this exploratory study is to investigate long-term outcomes regarding echocardiographic and clinical parameters aiming to further characterize this barely described condition. Methods: A total number of 115 HFpEF patients (mean age 70.6 6 8.9 years, 66.1% females) were consecutively enrolled: medical history, physical examination, New York Heart Association (NYHA) functional class, 6-minute walking distance and rou- tine blood tests including serum NT-proBNP measurement were evaluated at baseline and follow-up visits. Furthermore, comprehensive transthoracic echocardiography (TTE) was performed at baseline and at mean 23.9 6 15.5 months of follow-up. Results: The present analysis suggests that HFpEF patients featured significant improvement in NYHA functional class ( (cid:2) III: 72.2% vs. 55.7%, p < 0.001) as well as a minor increase in 6-minute walking distance (mean 325.4 6 120.6 vs. 355.1 6 123.5 meters, p ¼ 0.756) at follow-up, whereas serum NT-proBNP levels (mean 2026.7 6 3301.5 vs. 2242.0 6 3976.9 pg/mL, p ¼ 0.265) remained consistent. Notably, TTE revealed global, yet not significant, enlargement of atrial and ventricular size over time (left Conclusions: Our work demonstrates deterioration of right ventricular function and worsening of tricuspid regurgitation over time. Although HFpEF is generally regarded as disease of the left ventricle, recent investigations provide strong evidence of right ventricular contribution to the overall impairment and mortality of these patients. can on of ablation may in and effects on may remodeling paroxysms of AF than in patients without paroxysms of AF (4,5 6 1,5 and 2,8 6 1,5 mm, h ¼ 0,001). The multivariate regression analysis demonstrated that EFT is an independent predictor of non-effective of radiofrequency ablation therapy of AF (OR ¼ 1,47, 95% CI 1,02-2,04, p ¼ 0,014). Conclusions: Epicardial fat in patients with non effectiveness of radiofrequency abla- tion is thicker than in patients with effect of this therapy. Greater thickness of epicardial fat is associated with higher risk of non effectiveness of radiofrequency ablation. Epicardial fat can influence on remodeling of the heart, that’s why in patients with metabolic syndrome recurrent paroxysms of atrial fibrillation were detected more often than in patients with atrial fibrillation and without metabolic syndrome. AIM:Tocompare left atrial (LA) mechanical function, assessed by two-dimensional echo- cardiography, in patients with essential hypertension with healthy controls. Methods: LA volumes were measured echocardiographically in 50 hypertensive patients and 50 age-matched healthy controls using biplane Simpson m
{"title":"Poster Session 5","authors":"","doi":"10.1093/eurjhf/hsr011","DOIUrl":"10.1093/eurjhf/hsr011","url":null,"abstract":"Background: Despite recent approaches, a profound understanding of pathophysio- logical abnormalities in heart failure with preserved ejection fraction (HFpEF) is still lacking. Purpose: Echocardiography provides the method of choice for diagnosis as well as progression assessment in patients with suspected HFpEF. Thus, the purpose of this exploratory study is to investigate long-term outcomes regarding echocardiographic and clinical parameters aiming to further characterize this barely described condition. Methods: A total number of 115 HFpEF patients (mean age 70.6 6 8.9 years, 66.1% females) were consecutively enrolled: medical history, physical examination, New York Heart Association (NYHA) functional class, 6-minute walking distance and rou- tine blood tests including serum NT-proBNP measurement were evaluated at baseline and follow-up visits. Furthermore, comprehensive transthoracic echocardiography (TTE) was performed at baseline and at mean 23.9 6 15.5 months of follow-up. Results: The present analysis suggests that HFpEF patients featured significant improvement in NYHA functional class ( (cid:2) III: 72.2% vs. 55.7%, p < 0.001) as well as a minor increase in 6-minute walking distance (mean 325.4 6 120.6 vs. 355.1 6 123.5 meters, p ¼ 0.756) at follow-up, whereas serum NT-proBNP levels (mean 2026.7 6 3301.5 vs. 2242.0 6 3976.9 pg/mL, p ¼ 0.265) remained consistent. Notably, TTE revealed global, yet not significant, enlargement of atrial and ventricular size over time (left Conclusions: Our work demonstrates deterioration of right ventricular function and worsening of tricuspid regurgitation over time. Although HFpEF is generally regarded as disease of the left ventricle, recent investigations provide strong evidence of right ventricular contribution to the overall impairment and mortality of these patients. can on of ablation may in and effects on may remodeling paroxysms of AF than in patients without paroxysms of AF (4,5 6 1,5 and 2,8 6 1,5 mm, h ¼ 0,001). The multivariate regression analysis demonstrated that EFT is an independent predictor of non-effective of radiofrequency ablation therapy of AF (OR ¼ 1,47, 95% CI 1,02-2,04, p ¼ 0,014). Conclusions: Epicardial fat in patients with non effectiveness of radiofrequency abla- tion is thicker than in patients with effect of this therapy. Greater thickness of epicardial fat is associated with higher risk of non effectiveness of radiofrequency ablation. Epicardial fat can influence on remodeling of the heart, that’s why in patients with metabolic syndrome recurrent paroxysms of atrial fibrillation were detected more often than in patients with atrial fibrillation and without metabolic syndrome. AIM:Tocompare left atrial (LA) mechanical function, assessed by two-dimensional echo- cardiography, in patients with essential hypertension with healthy controls. Methods: LA volumes were measured echocardiographically in 50 hypertensive patients and 50 age-matched healthy controls using biplane Simpson m","PeriodicalId":100499,"journal":{"name":"European Journal of Heart Failure Supplements","volume":"10 S1","pages":"S218-S263"},"PeriodicalIF":0.0,"publicationDate":"2011-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eurjhf/hsr011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60728151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Young Investigator Award for Clinical Research","authors":"","doi":"10.1093/eurjhf/hsr012","DOIUrl":"https://doi.org/10.1093/eurjhf/hsr012","url":null,"abstract":"","PeriodicalId":100499,"journal":{"name":"European Journal of Heart Failure Supplements","volume":"10 S1","pages":"S3-S4"},"PeriodicalIF":0.0,"publicationDate":"2011-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eurjhf/hsr012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71971539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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