Forensic Science International Supplement Series最新文献

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A rare case of lethal methadone intoxication of a 3-week-old infant 一例罕见的致命美沙酮中毒的三周大的婴儿

Forensic Science International Supplement Series

Pub Date : 2009-12-01 DOI: 10.1016/j.fsisup.2009.07.008

M. Kobek , C.H. Jabłoński , J. Kulikowska , D. Pieśniak , C.Z. Chowaniec , Z. Gąszczyk-Ożarowski

The authors describe a rare case of lethal methadone intoxication of a 3-week-old infant. Born of a drug-addicted mother who was undergoing methadone substitution therapy, the newborn presented withdrawal symptoms and was immediately admitted to a paediatric ward where it was treated for 3 weeks, without administration of methadone. The infant died during bottle feeding within 24 h following discharge home.

A post-mortem examination was performed as well as histopathological, toxicological and genetic tests were carried out in order to establish the cause and mode of death.

The autopsy revealed obstruction of the lower air passages by stomach contents along with classical features of asphyxia. Toxicological tests revealed high concentrations of methadone and its metabolite in blood and urine as well as presence of methadone in stomach contents, and the DNA polymorphism analysis of the (sex-specific) amelogenin locus gave a negative result.

On the basis of the results of the post-mortem examination, the laboratory tests and the police investigation, it was concluded that the drug was ingested with the bottle milk, and the possibility of administration of methadone at the hospital or its ingestion with the breast milk was precluded. Though both the cause and mode of death were established, the public prosecutor discontinued proceedings in the case due to inability to find the perpetrator.

作者描述了一个罕见的致命的美沙酮中毒的3周大的婴儿。该新生儿的母亲吸毒成瘾，正在接受美沙酮替代治疗。该新生儿出现戒断症状，并立即被送入儿科病房，在那里接受了3周的治疗，未使用美沙酮。婴儿出院回家后24小时内死于奶瓶喂养。进行了尸检，并进行了组织病理学、毒理学和基因检测，以确定死因和死亡方式。尸检显示胃内容物阻塞下气道，伴有典型的窒息特征。毒理学试验显示，血液和尿液中含有高浓度的美沙酮及其代谢物，胃内容物中也含有美沙酮，而(性别特异性)淀粉原基因位点的DNA多态性分析结果为阴性。根据验尸、实验室化验和警方调查的结果，得出的结论是，该药物是随奶瓶一起摄入的，排除了在医院服用美沙酮或与母乳一起摄入的可能性。虽然死因和死亡方式都已确定，但由于无法找到肇事者，检察官停止了对此案的诉讼。

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引用次数: 4

Estimating the degree of ethanol intoxication from analysis of cerebro-cranial hematomas 从脑颅血肿分析判断乙醇中毒程度

Forensic Science International Supplement Series

Pub Date : 2009-12-01 DOI: 10.1016/j.fsisup.2009.09.002

M. Chowaniec, Cz. Chowaniec, A. Nowak, J. Nowicka, K. Droździok

314 cases of combined cerebro-cranial trauma and posttraumatic intracranial hematomas were identified of which ethanol was detected in 114 hematomas. The other investigative group was 103 hospitalized patients who had hematomas evacuated during neurosurgical procedures. In 62 of these cases ethanol was detected. Blood and urine samples were also collected and the alcohol concentration was determined in all specimens by GC and ADH. The ethanol elimination rate for autopsy and operative intracranial hematomas was approximately 0.07–0.08‰/h(±0.034‰/h). The elimination rate of ethanol from blood (β₆₀) was about two or three times greater as that from hematomas. Because of the different water content of intracranial hematomas from blood, it was necessary to adjust the ethanol concentration for water content. On the basis of the corrected ethanol concentrations and the elimination rates for both tissues it was possible to estimate the ethanol concentration at the time of injury. Intracranial hematomas are tissues of possible value in the determination of alcohol intoxication especially in alcoholism. Ethanol can be found in hematomas even after 72 h from head injury.

本文分析了314例颅脑外伤合并外伤后颅内血肿，其中114例血肿中检测到乙醇。另一组调查对象是103名在神经外科手术过程中有血肿排出的住院患者。其中62例检测到乙醇。同时采集血样和尿样，用气相色谱法和ADH法测定所有标本的酒精浓度。尸检和手术颅内血肿的乙醇消除率约为0.07-0.08‰/h(±0.034‰/h)。血液中乙醇的清除率(β60)大约是血肿的两到三倍。由于颅内血肿与血液含水量不同，需要对乙醇浓度进行调整。根据校正后的乙醇浓度和两种组织的消除率，可以估计出损伤时的乙醇浓度。颅内血肿是测定酒精中毒(尤其是酒精中毒)可能有价值的组织。颅脑损伤72小时后仍可在血肿中发现乙醇。

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引用次数: 0

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