Pub Date : 2011-06-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2011.06.014
Yi Fu, Xin-yan Zhang, M. Cui, Xian-min Liu, Fangxiang Mou
Objective To study the protective effects of aldioxa tablets on ethanol-induced gastric mucosal lesions in rats,and explore the potential pathogenesis.Methods Sixty healthy male Wistar rats were randomly divided into five groups: injury group,control group,sucralfate protective group,aluminium hydroxide protective group and aldioxa protective group.The three protective groups were treated with sucralfate,aluminium hydroxide and aldioxa tablets respectively before to induce gastric mucosal injury.Then the ulcer index,epithelial damage scoring,blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured,and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope.Results Compared with injury group,the ulcer index and epithelial damage scoring of gastric mucosa significantly decreased in aldioxa protective group(P=0.000,P=0.000),the blood flow of gastric mucosa significantly increased in aldioxa protective group(P=0.000),prostaglandin E2 and nitric oxide concentration of gastric mucosa significantly increased in aldioxa protective group(P=0.000,P=0.001).Conclusion The data revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosa injury induced by ethanol,and the increase in blood flow,prostaglandin E2 and nitric oxide concentration maybe contribute to the protective effects.
{"title":"Protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rats","authors":"Yi Fu, Xin-yan Zhang, M. Cui, Xian-min Liu, Fangxiang Mou","doi":"10.3760/CMA.J.ISSN.1008-1372.2011.06.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2011.06.014","url":null,"abstract":"Objective To study the protective effects of aldioxa tablets on ethanol-induced gastric mucosal lesions in rats,and explore the potential pathogenesis.Methods Sixty healthy male Wistar rats were randomly divided into five groups: injury group,control group,sucralfate protective group,aluminium hydroxide protective group and aldioxa protective group.The three protective groups were treated with sucralfate,aluminium hydroxide and aldioxa tablets respectively before to induce gastric mucosal injury.Then the ulcer index,epithelial damage scoring,blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured,and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope.Results Compared with injury group,the ulcer index and epithelial damage scoring of gastric mucosa significantly decreased in aldioxa protective group(P=0.000,P=0.000),the blood flow of gastric mucosa significantly increased in aldioxa protective group(P=0.000),prostaglandin E2 and nitric oxide concentration of gastric mucosa significantly increased in aldioxa protective group(P=0.000,P=0.001).Conclusion The data revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosa injury induced by ethanol,and the increase in blood flow,prostaglandin E2 and nitric oxide concentration maybe contribute to the protective effects.","PeriodicalId":10056,"journal":{"name":"Chinese Journal of Gastroenterology and Hepatology","volume":"118 1","pages":"772-775"},"PeriodicalIF":0.0,"publicationDate":"2011-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79623406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-01-01DOI: 10.1142/9789814329668_0029
N. Lizhi
Cryosurgery is an important modality for treatment of unresectable hepatocellular carcinoma (HCC). There are different forms of cryosurgery for HCC which are intraoperative cryoablation with or without excision, laparoscopic liver cryosurgery, and percutaneous liver cryoablation under guiding of ultrasonography or CT. As a local therapy, cryoablation carries certain advantages over other forms of treatment:it is able to destroy only the tumor tissue in liver while sparing more noninvolved tissues; because of the warming effect of flowing blood in the large blood vessels, tumors close to these vessel system can safely undergo cryoablation; liver cryoablation is more effective than surgical resection in treating multiple tumors in the liver. Cryosurgery with combination of transarterial chemoembolization (TACE), alcohol injection or 125iodine seed implantation has a complementary efficacy. Clinically, cryosurgery for HCC is performed according to the following principles:tumors in liver 5 cm,≤3 in number, may be performed intraoperative or percutaneous cryosurgery; tumor in liver 5 cm,should receive TACE, and then percutaneous cryosurgery; tumor in liver 5 cm with irregular margin, may be given intraoperative or percutaneous cryosurgery, and then alcohol injection or 125iodine seed implantation in the margin of tumor.
{"title":"Cryosurgery for hepatocellular carcinoma","authors":"N. Lizhi","doi":"10.1142/9789814329668_0029","DOIUrl":"https://doi.org/10.1142/9789814329668_0029","url":null,"abstract":"Cryosurgery is an important modality for treatment of unresectable hepatocellular carcinoma (HCC). There are different forms of cryosurgery for HCC which are intraoperative cryoablation with or without excision, laparoscopic liver cryosurgery, and percutaneous liver cryoablation under guiding of ultrasonography or CT. As a local therapy, cryoablation carries certain advantages over other forms of treatment:it is able to destroy only the tumor tissue in liver while sparing more noninvolved tissues; because of the warming effect of flowing blood in the large blood vessels, tumors close to these vessel system can safely undergo cryoablation; liver cryoablation is more effective than surgical resection in treating multiple tumors in the liver. Cryosurgery with combination of transarterial chemoembolization (TACE), alcohol injection or 125iodine seed implantation has a complementary efficacy. Clinically, cryosurgery for HCC is performed according to the following principles:tumors in liver 5 cm,≤3 in number, may be performed intraoperative or percutaneous cryosurgery; tumor in liver 5 cm,should receive TACE, and then percutaneous cryosurgery; tumor in liver 5 cm with irregular margin, may be given intraoperative or percutaneous cryosurgery, and then alcohol injection or 125iodine seed implantation in the margin of tumor.","PeriodicalId":10056,"journal":{"name":"Chinese Journal of Gastroenterology and Hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86447903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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