Ochnaflavone is a naturally occurring biflavonoid mainly isolated from Ochna integerrima, manifests health benefits encompassing antidiabetic, anticancer, anti-cardiovascular, and anti-inflammatory activities. However, most bioactivity research has focused on in vitro experiments, rather than in vivo disease models, toxicological assessments, and human clinical trials. Moreover, a comprehensive review of the pharmacological aspects of ochnaflavone is conspicuously lacking. Thus, this review provides a concise and comprehensive summary of existing knowledge on the chemical structure, plant origin, physical properties, biotransformations, and multifaceted biological activities of ochnaflavone along with an in-depth exploration of the complex molecular mechanisms behind these activities, including signaling pathways and gene expression regulation, with the aim of promoting future theoretical needs for ochnaflavone in clinical trials and providing comprehensive insights into the research and application of this valuable natural compound.
{"title":"Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone","authors":"Shiye Lin, Abirami Ramu Ganesan, Celia Vargas-De-La-Cruz, Jaime Ortiz-Viedma, Jianbo Xiao","doi":"10.1002/fpf2.12011","DOIUrl":"10.1002/fpf2.12011","url":null,"abstract":"<p>Ochnaflavone is a naturally occurring biflavonoid mainly isolated from <i>Ochna integerrima</i>, manifests health benefits encompassing antidiabetic, anticancer, anti-cardiovascular, and anti-inflammatory activities. However, most bioactivity research has focused on in vitro experiments, rather than in vivo disease models, toxicological assessments, and human clinical trials. Moreover, a comprehensive review of the pharmacological aspects of ochnaflavone is conspicuously lacking. Thus, this review provides a concise and comprehensive summary of existing knowledge on the chemical structure, plant origin, physical properties, biotransformations, and multifaceted biological activities of ochnaflavone along with an in-depth exploration of the complex molecular mechanisms behind these activities, including signaling pathways and gene expression regulation, with the aim of promoting future theoretical needs for ochnaflavone in clinical trials and providing comprehensive insights into the research and application of this valuable natural compound.</p>","PeriodicalId":100565,"journal":{"name":"Future Postharvest and Food","volume":"1 1","pages":"47-60"},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fpf2.12011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The exponential growth of the global population, coupled with issues of insufficient and imbalanced nutrition, as well as a surge in health-related problems, has compelled individuals to seek innovative and alternative food sources while optimizing existing resources. Microalgae have been a staple source of livelihood and essential nourishment for people in various regions worldwide. Their rich content of proteins, essential amino acids, carbohydrates, lipids, vitamins, and minerals necessary for nutrition, has made them a fundamental source of sustenance. Spirulina platensis (S. platensis), a single-celled, filamentous, prokaryotic microalgae, has long been recognized as a valuable natural food source, with historical usage dating back to ancient times. On the other hand, Phaeodactylum tricornutum (P. tricornutum), although a freshwater species, belongs to the Pennateae group of single-celled eukaryotic diatoms and exhibits adaptability to marine environments. S. platensis and P. tricornutum have recently gained attention due to their abundant bioactive compounds, including carotenoids and phenolic acids. These bioactive compounds are known for their potential health benefits, including anticancer, antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, and hypocholesterolemic properties. This review examines the bioactive compounds produced by S. platensis and P. tricornutum, their impacts on human health, and their promising applications within the food industry.
全球人口的指数式增长,加上营养不足和失衡问题,以及与健康有关的问题激增,迫使人们在优化现有资源的同时,寻求创新的替代食物来源。微藻一直是世界各地人们的主要生活来源和必需营养品。微藻富含蛋白质、必需氨基酸、碳水化合物、脂类、维生素和营养所需的矿物质,是人们的基本营养来源。螺旋藻(S. platensis)是一种单细胞、丝状、原核微生物藻类,长期以来一直被认为是一种宝贵的天然食物来源,其历史可追溯到古代。另一方面,Phaeodactylum tricornutum(P. tricornutum)虽然是淡水物种,但属于单细胞真核硅藻的彭氏藻(Pennateae)类,具有适应海洋环境的能力。S. platensis 和 P. tricornutum 最近因其丰富的生物活性化合物(包括类胡萝卜素和酚酸)而备受关注。这些生物活性化合物具有潜在的健康益处,包括抗癌、抗氧化、抗炎、神经保护、肝脏保护和降胆固醇等特性。本综述探讨了 S. platensis 和 P. tricornutum 产生的生物活性化合物、它们对人类健康的影响以及在食品工业中的应用前景。
{"title":"Spirulina platensis and Phaeodactylum tricornutum as sustainable sources of bioactive compounds: Health implications and applications in the food industry","authors":"Türkan Uzlaşır, Serkan Selli, Hasim Kelebek","doi":"10.1002/fpf2.12008","DOIUrl":"https://doi.org/10.1002/fpf2.12008","url":null,"abstract":"<p>The exponential growth of the global population, coupled with issues of insufficient and imbalanced nutrition, as well as a surge in health-related problems, has compelled individuals to seek innovative and alternative food sources while optimizing existing resources. Microalgae have been a staple source of livelihood and essential nourishment for people in various regions worldwide. Their rich content of proteins, essential amino acids, carbohydrates, lipids, vitamins, and minerals necessary for nutrition, has made them a fundamental source of sustenance. <i>Spirulina platensis (S. platensis)</i>, a single-celled, filamentous, prokaryotic microalgae, has long been recognized as a valuable natural food source, with historical usage dating back to ancient times. On the other hand, <i>Phaeodactylum tricornutum (P. tricornutum)</i>, although a freshwater species, belongs to the <i>Pennateae</i> group of single-celled eukaryotic diatoms and exhibits adaptability to marine environments. <i>S. platensis</i> and <i>P. tricornutum</i> have recently gained attention due to their abundant bioactive compounds, including carotenoids and phenolic acids. These bioactive compounds are known for their potential health benefits, including anticancer, antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, and hypocholesterolemic properties. This review examines the bioactive compounds produced by <i>S. platensis</i> and <i>P. tricornutum</i>, their impacts on human health, and their promising applications within the food industry.</p>","PeriodicalId":100565,"journal":{"name":"Future Postharvest and Food","volume":"1 1","pages":"34-46"},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fpf2.12008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140817223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Innovative agricultural solutions to global warming challenges are explored, focusing on the roles of genetic modification and lab-grown meats for a sustainable food future. This article underscores scientific advancements and future possibilities in food science to combat climate change impacts.