Pub Date : 2026-01-08DOI: 10.1016/j.gande.2026.01.002
John Peacey , Laila Sheikh , George Hopkins , Patrick Walsh
Gastroduodenal intussusception is an extremely rare condition in adults, often associated with a pathological lead point such as a tumour. Given the paucity of case reports, it is generally difficult to diagnose efficiently and there is minimal evidence to guide surgical management. We present a unique case of idiopathic gastroduodenal intussusception without an associated lead point, successfully treated with Roux-en-Y gastric bypass.
{"title":"Intermittent gastroduodenal intussusception: A rare indication for an elective Roux-en-Y gastric bypass","authors":"John Peacey , Laila Sheikh , George Hopkins , Patrick Walsh","doi":"10.1016/j.gande.2026.01.002","DOIUrl":"10.1016/j.gande.2026.01.002","url":null,"abstract":"<div><div>Gastroduodenal intussusception is an extremely rare condition in adults, often associated with a pathological lead point such as a tumour. Given the paucity of case reports, it is generally difficult to diagnose efficiently and there is minimal evidence to guide surgical management. We present a unique case of idiopathic gastroduodenal intussusception without an associated lead point, successfully treated with Roux-en-Y gastric bypass.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 2","pages":"Pages 83-85"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.gande.2026.01.001
Meenakshi Sundari Rajendran , Rajkumar Prabhakaran , Padma Malini Ravi
Background
Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been implicated in colorectal cancer (CRC) risk, though the mechanisms remain unclear. This study examines the impact of MSG consumption on the expression of MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) proteins in rat colon tissues, which plays crucial role in DNA mismatch repair.
Materials and methods
The study employed male Wistar rats divided into four groups of six rats each: a control group, a group with N,N-dimethylhydrazine (DMH)-induced CRC (s.c.), and two experimental groups administered different doses (20,000 and 30,000 mg/kg body weight/day) of MSG orally for four weeks. Immunohistochemistry (IHC) was used to assess MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) protein expression levels in colon tissues.
Results
IHC results indicate a dose-dependent reduction in both MLH1 and MSH2 protein expressions in rats exposed to MSG. The reduced MLH1 and MSH2 expressions observed in MSG-exposed rats mirror patterns seen in DMH-induced CRC models, suggesting a potential mechanistic link between MSG intake and CRC development through microsatellite instability (MSI) pathways.
Conclusions
The study reveals that MSG affects MLH1 and MSH2 protein expressions, which are vital for DNA mismatch repair, highlighting a potential mechanism by which MSG may influence microsatellite instability and CRC development. These findings underscore the need for further research to clarify the implications of MSG consumption for CRC risk and to identify potential molecular targets and dietary recommendations for prevention.
{"title":"Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer","authors":"Meenakshi Sundari Rajendran , Rajkumar Prabhakaran , Padma Malini Ravi","doi":"10.1016/j.gande.2026.01.001","DOIUrl":"10.1016/j.gande.2026.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been implicated in colorectal cancer (CRC) risk, though the mechanisms remain unclear. This study examines the impact of MSG consumption on the expression of MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) proteins in rat colon tissues, which plays crucial role in DNA mismatch repair.</div></div><div><h3>Materials and methods</h3><div>The study employed male Wistar rats divided into four groups of six rats each: a control group, a group with N,N-dimethylhydrazine (DMH)-induced CRC (s.c.), and two experimental groups administered different doses (20,000 and 30,000 mg/kg body weight/day) of MSG orally for four weeks. Immunohistochemistry (IHC) was used to assess MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) protein expression levels in colon tissues.</div></div><div><h3>Results</h3><div>IHC results indicate a dose-dependent reduction in both MLH1 and MSH2 protein expressions in rats exposed to MSG. The reduced MLH1 and MSH2 expressions observed in MSG-exposed rats mirror patterns seen in DMH-induced CRC models, suggesting a potential mechanistic link between MSG intake and CRC development through microsatellite instability (MSI) pathways.</div></div><div><h3>Conclusions</h3><div>The study reveals that MSG affects MLH1 and MSH2 protein expressions, which are vital for DNA mismatch repair, highlighting a potential mechanism by which MSG may influence microsatellite instability and CRC development. These findings underscore the need for further research to clarify the implications of MSG consumption for CRC risk and to identify potential molecular targets and dietary recommendations for prevention.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 2","pages":"Pages 69-77"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.gande.2025.12.003
Deepika Pandey, Shivani Ghildiyal
Objective
The study aimed to evaluate the antiulcer activity of a 50 % hydroalcoholic extract of Launaea nudicaulis (L.) Hook.f (LN) using two experimental rat models: aspirin-induced gastric ulcer and aspirin plus pylorus ligation-induced gastric ulcer.
Materials and methods
The hydroalcoholic extract of LN was prepared using Soxhlet extraction. Wistar rats were randomly divided into groups (6 animals per group) and treated with vehicle, LN extract at doses of 100, 200, and 400 mg/kg, or reference standards (omeprazole and sucralfate) for 7 days. Gastric ulceration was induced using aspirin or aspirin plus pylorus ligation models. Parameters such as ulcer index, total acidity, gastric juice volume, pH, Biochemical markers (SOD, TC, TP, TC:TP) and histopathological changes were evaluated. Statistical analysis was conducted using one-way ANOVA and post hoc, with significance ranging from P < 0.05 to P < 0.001.
Results
The hydroalcoholic extract of LN demonstrated dose-dependent antiulcer activity. At 400 mg/kg, the extract significantly reduced the ulcer index, total acidity, and gastric juice volume while increasing gastric pH compared to the control group. Biochemical markers showed a modest improvement with treatment and Histopathological analysis confirmed reduced gastric lesions and inflammation in treated groups.
Conclusion
The 50 % hydroalcoholic extract of LN exhibited potent antiulcer activity comparable to omeprazole and sucralfate, supporting its traditional use in gastrointestinal disorders.
{"title":"Evaluation of antiulcer activity of Launaea nudicaulis (L.) Hook.f (Gojihva) in experimental rat models","authors":"Deepika Pandey, Shivani Ghildiyal","doi":"10.1016/j.gande.2025.12.003","DOIUrl":"10.1016/j.gande.2025.12.003","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to evaluate the antiulcer activity of a 50 % hydroalcoholic extract of <em>Launaea nudicaulis</em> (L.) Hook.f (LN) using two experimental rat models: aspirin-induced gastric ulcer and aspirin plus pylorus ligation-induced gastric ulcer.</div></div><div><h3>Materials and methods</h3><div>The hydroalcoholic extract of LN was prepared using Soxhlet extraction. Wistar rats were randomly divided into groups (6 animals per group) and treated with vehicle, LN extract at doses of 100, 200, and 400 mg/kg, or reference standards (omeprazole and sucralfate) for 7 days. Gastric ulceration was induced using aspirin or aspirin plus pylorus ligation models. Parameters such as ulcer index, total acidity, gastric juice volume, pH, Biochemical markers (SOD, TC, TP, TC:TP) and histopathological changes were evaluated. Statistical analysis was conducted using one-way ANOVA and post hoc, with significance ranging from P < 0.05 to P < 0.001.</div></div><div><h3>Results</h3><div>The hydroalcoholic extract of LN demonstrated dose-dependent antiulcer activity. At 400 mg/kg, the extract significantly reduced the ulcer index, total acidity, and gastric juice volume while increasing gastric pH compared to the control group. Biochemical markers showed a modest improvement with treatment and Histopathological analysis confirmed reduced gastric lesions and inflammation in treated groups.</div></div><div><h3>Conclusion</h3><div>The 50 % hydroalcoholic extract of LN exhibited potent antiulcer activity comparable to omeprazole and sucralfate, supporting its traditional use in gastrointestinal disorders.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 1","pages":"Pages 55-67"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-25DOI: 10.1016/j.gande.2025.12.004
Dong Chen , Xingliang Yin , Peng Li , Jimin Wu , Zhiwei Hu
Introduction
Our previous data showed that the W-H fundoplication had a similar mid-term satisfaction rate and a lower mid-term dysphagia rate compared with the Nissen-Rossetti fundoplication. But the results are limited by its retrospective nature.
Methods and analysis
We plan to conduct a multicenter, randomized controlled trial to compare the 1-year dysphagia rate and efficacy after laparoscopic hiatal hernia repair combined with Nissen-Rossetti or W-H fundoplication for proton pump inhibitor dependent gastroesophageal reflux disease patients. The primary endpoint is dysphagia rate at 1-year after the surgery, the secondary endpoints are perioperative and other 1-year outcomes. Intention-to-treat analysis will be used for the study results. For the primary endpoint, the chi-square test or Fisher's exact test will be used to compare the difference between the two groups, addressing whether the novel fundoplication technique can reduce the 1-year dysphagia rate. For categorical secondary endpoints, the chi-square test or Fisher's exact test will be used to compare differences; for continuous secondary endpoints, the t-test or non-parametric tests will be used to compare differences.
Ethics and dissemination
We have obtained ethical approval from all the three centers. Protocol changes will first be approved by the grant sponsor and communicated to the ethical boards and registry platform. Participating doctors will secure written informed consent from patients or surrogates. Anonymized data will be used in publications. Authors from the leading center will have access to the final dataset on the Resman platform. Data may be shared upon reasonable request.
Registration details
This study have registried in the Chinese Clinical Trial Registry (ChiCTR2400081762).
{"title":"Effect of laparoscopic W-H versus Nissen-Rossetti fundoplication for proton pump inhibitor dependent gastroesophageal reflux disease: A multicenter randomized controlled trial protocol","authors":"Dong Chen , Xingliang Yin , Peng Li , Jimin Wu , Zhiwei Hu","doi":"10.1016/j.gande.2025.12.004","DOIUrl":"10.1016/j.gande.2025.12.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Our previous data showed that the W-H fundoplication had a similar mid-term satisfaction rate and a lower mid-term dysphagia rate compared with the Nissen-Rossetti fundoplication. But the results are limited by its retrospective nature.</div></div><div><h3>Methods and analysis</h3><div>We plan to conduct a multicenter, randomized controlled trial to compare the 1-year dysphagia rate and efficacy after laparoscopic hiatal hernia repair combined with Nissen-Rossetti or W-H fundoplication for proton pump inhibitor dependent gastroesophageal reflux disease patients. The primary endpoint is dysphagia rate at 1-year after the surgery, the secondary endpoints are perioperative and other 1-year outcomes. Intention-to-treat analysis will be used for the study results. For the primary endpoint, the chi-square test or Fisher's exact test will be used to compare the difference between the two groups, addressing whether the novel fundoplication technique can reduce the 1-year dysphagia rate. For categorical secondary endpoints, the chi-square test or Fisher's exact test will be used to compare differences; for continuous secondary endpoints, the <em>t</em>-test or non-parametric tests will be used to compare differences.</div></div><div><h3>Ethics and dissemination</h3><div>We have obtained ethical approval from all the three centers. Protocol changes will first be approved by the grant sponsor and communicated to the ethical boards and registry platform. Participating doctors will secure written informed consent from patients or surrogates. Anonymized data will be used in publications. Authors from the leading center will have access to the final dataset on the Resman platform. Data may be shared upon reasonable request.</div></div><div><h3>Registration details</h3><div>This study have registried in the Chinese Clinical Trial Registry (ChiCTR2400081762).</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 2","pages":"Pages 78-82"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic alcohol use has a substantial effect on liver health and general morbidity, making it one of the world's main causes of liver disease. Recent studies highlight the pivotal role of the gut-liver axis in the onset and progression of liver disorders linked to alcohol consumption. This review explores the molecular insights of chronic liver damage caused by alcohol, with a focus on the gut-liver axis that includes microbial translocation, increased intestinal permeability, and alcohol-induced dysbiosis. It also looks at how prolonged alcohol use alter the liver metabolism, which accelerate the course of the illness. The study also covers microbiome therapeutic approaches, that attempt to modify the gut microbiome and liver function. This review takes into account the results from clinical trials and animal models to provide a thorough picture of the therapeutic promise and difficulties in this area. These findings provide a basis for further investigation and treatment approaches aimed at lessening the chronic effects of long-term alcohol use on liver function.
{"title":"Chronic alcohol and liver health: The gut-liver axis as a therapeutic target","authors":"Dakshina M. Nair, Leela Kakithakara Vajravelu, Poornima Baskar Vimala, Rahul Harikumar Lathakumari, Vishnupriya Paneerselvam, Jayaprakash Thulukanam","doi":"10.1016/j.gande.2025.12.002","DOIUrl":"10.1016/j.gande.2025.12.002","url":null,"abstract":"<div><div>Chronic alcohol use has a substantial effect on liver health and general morbidity, making it one of the world's main causes of liver disease. Recent studies highlight the pivotal role of the gut-liver axis in the onset and progression of liver disorders linked to alcohol consumption. This review explores the molecular insights of chronic liver damage caused by alcohol, with a focus on the gut-liver axis that includes microbial translocation, increased intestinal permeability, and alcohol-induced dysbiosis. It also looks at how prolonged alcohol use alter the liver metabolism, which accelerate the course of the illness. The study also covers microbiome therapeutic approaches, that attempt to modify the gut microbiome and liver function. This review takes into account the results from clinical trials and animal models to provide a thorough picture of the therapeutic promise and difficulties in this area. These findings provide a basis for further investigation and treatment approaches aimed at lessening the chronic effects of long-term alcohol use on liver function.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 1","pages":"Pages 38-47"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Systemic sclerosis (SSc) is an autoimmune disease characterized by diffuse organ fibrosis and nearly universal gastrointestinal (GIT) involvement, which impacts immune function, mucosal integrity, and metabolic balance. This systematic review aims to assess alterations in the gut microbiome of SSc patients compared to healthy controls and explore its relationship with disease severity and symptoms.
Method
A thorough search of PubMed, Google Scholar, and Cochrane was conducted from 2019 to 2024. After applying the inclusion criteria and quality assessments, seven studies were selected, comprising four cohort studies, one randomized controlled trial (RCT), and two systematic reviews.
Results
Studies demonstrated significant alterations in gut microbiota composition in SSc patients characterized by decrease in commensal genera (Faecalibacterium, Clostridium, Bacteroides, and Rikenella) and an increase in pathobiont genera (Fusobacterium, Prevotella, and γ-Proteobacteria). Almost all papers showed an increase in the genera lactcobacilli. Immunosuppressed SSc patients showed reduced diversity, suggesting medication-induced changes. Longitudinal characterization of the lower GIT microbiome in SSc for 1 year showed no significant change in GIT scores and bacterial composition at taxa level. Differences in gut bacteria were noted between Swedish and American cohorts, highlighting potential environmental influences. A cohort study found no significant improvement in GIT symptoms with a low-FODMAP diet.
Conclusion
Studies show a strong link between gut dysbiosis SSc, but limited data leaves many questions unanswered. The role of elevated lactobacilli in SSc remains unclear, and its association with symptom severity warrants further research. Investigating dietary interventions like Mediterranean, vegan, or carnivore diets could offer therapeutic benefits.
{"title":"A systematic review on gut microbiome and systemic sclerosis: Current evidence and future directions","authors":"Shravya Pingili , Lakshmi Sai Deepak Reddy Velugoti , Neha Bhanusali","doi":"10.1016/j.gande.2025.12.001","DOIUrl":"10.1016/j.gande.2025.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>Systemic sclerosis (SSc) is an autoimmune disease characterized by diffuse organ fibrosis and nearly universal gastrointestinal (GIT) involvement, which impacts immune function, mucosal integrity, and metabolic balance. This systematic review aims to assess alterations in the gut microbiome of SSc patients compared to healthy controls and explore its relationship with disease severity and symptoms.</div></div><div><h3>Method</h3><div>A thorough search of PubMed, Google Scholar, and Cochrane was conducted from 2019 to 2024. After applying the inclusion criteria and quality assessments, seven studies were selected, comprising four cohort studies, one randomized controlled trial (RCT), and two systematic reviews.</div></div><div><h3>Results</h3><div>Studies demonstrated significant alterations in gut microbiota composition in SSc patients characterized by decrease in commensal genera (Faecalibacterium, Clostridium, Bacteroides, and Rikenella) and an increase in pathobiont genera (Fusobacterium, Prevotella, and γ-Proteobacteria). Almost all papers showed an increase in the genera lactcobacilli. Immunosuppressed SSc patients showed reduced diversity, suggesting medication-induced changes. Longitudinal characterization of the lower GIT microbiome in SSc for 1 year showed no significant change in GIT scores and bacterial composition at taxa level. Differences in gut bacteria were noted between Swedish and American cohorts, highlighting potential environmental influences. A cohort study found no significant improvement in GIT symptoms with a low-FODMAP diet.</div></div><div><h3>Conclusion</h3><div>Studies show a strong link between gut dysbiosis SSc, but limited data leaves many questions unanswered. The role of elevated lactobacilli in SSc remains unclear, and its association with symptom severity warrants further research. Investigating dietary interventions like Mediterranean, vegan, or carnivore diets could offer therapeutic benefits.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 1","pages":"Pages 48-54"},"PeriodicalIF":0.0,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.gande.2025.11.001
Ignatius Bima Prasetya , Irsan Hasan , Rabbinu Rangga Pribadi , Dicky L. Tahapary
Introduction
Ramadan fasting is an annual obligation practiced by millions of Muslims worldwide. This practice is generally safe for healthy individuals, but the metabolic burden of this all-day fasting could cause serious health concerns for those with underlying medical conditions. Cirrhosis is a chronic progressive end-stage liver disease that has profound effect on the body's metabolism. However, the impact of Ramadan Fasting on patient with cirrhosis is still relatively unknown. The aim of this review is to summarize available evidences on the topic of Ramadan Fasting in patients with cirrhosis.
Methods
Systematic searches were conducted in several databases up to December 2024. Search results were screened using predetermined criteria. Further risk-of-bias assessment was conducted using the ROBINS-I V2 tool.
Results
Four studies met the inclusion criteria and underwent a risk-of-bias assessment. Quality of included studies ranges from moderate to serious risk-of bias. Ramadan Fasting was associated with increased severity of Child-Pugh Classification. This increase was most likely caused by the increase in bilirubin level. This increase was especially prominent in decompensated cirrhosis. Included studies reported no significant impact of Ramadan Fasting on serum albumin, PT-INR, or AFP of cirrhosis patients. Studies on the effect of Ramadan Fasting on portal vein parameters and Upper Gastrointestinal Bleeding yielded inconclusive results.
Conclusion
Ramadan Fasting might be related with increase in Child-Pugh category of patients, especially in decompensated cirrhosis. Further research is needed to inform the best practice.
{"title":"The impact of Ramadan fasting on the health of cirrhosis patients: A systematic review of available evidences","authors":"Ignatius Bima Prasetya , Irsan Hasan , Rabbinu Rangga Pribadi , Dicky L. Tahapary","doi":"10.1016/j.gande.2025.11.001","DOIUrl":"10.1016/j.gande.2025.11.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Ramadan fasting is an annual obligation practiced by millions of Muslims worldwide. This practice is generally safe for healthy individuals, but the metabolic burden of this all-day fasting could cause serious health concerns for those with underlying medical conditions. Cirrhosis is a chronic progressive end-stage liver disease that has profound effect on the body's metabolism. However, the impact of Ramadan Fasting on patient with cirrhosis is still relatively unknown. The aim of this review is to summarize available evidences on the topic of Ramadan Fasting in patients with cirrhosis.</div></div><div><h3>Methods</h3><div>Systematic searches were conducted in several databases up to December 2024. Search results were screened using predetermined criteria. Further risk-of-bias assessment was conducted using the ROBINS-I V2 tool.</div></div><div><h3>Results</h3><div>Four studies met the inclusion criteria and underwent a risk-of-bias assessment. Quality of included studies ranges from moderate to serious risk-of bias. Ramadan Fasting was associated with increased severity of Child-Pugh Classification. This increase was most likely caused by the increase in bilirubin level. This increase was especially prominent in decompensated cirrhosis. Included studies reported no significant impact of Ramadan Fasting on serum albumin, PT-INR, or AFP of cirrhosis patients. Studies on the effect of Ramadan Fasting on portal vein parameters and Upper Gastrointestinal Bleeding yielded inconclusive results.</div></div><div><h3>Conclusion</h3><div>Ramadan Fasting might be related with increase in Child-Pugh category of patients, especially in decompensated cirrhosis. Further research is needed to inform the best practice.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"4 1","pages":"Pages 13-19"},"PeriodicalIF":0.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.gande.2025.10.001
Luwen Zhang , Yubing Shen , Wentao Gu , Peng Wu
Gastrointestinal diseases represent a significant global health challenge, with current diagnostic and management approaches constrained by the integration of heterogeneous multimodal data. This review synthesizes the development prospects of multimodal applications in gastroenterology. By summarizing recent literatures, we demonstrate how multimodal integration can facilitate gastrointestinal disease screening, enable more accurate staging, support treatment decision-making, and optimize clinical workflows. Feature-level fusion serves as the dominant technique in current implementations, while hybrid approaches combining multiple fusion levels are increasingly adopted to enhance flexibility in complex clinical scenarios. Despite these advances, retrospective performance does not guarantee clinical success. Persistent challenges, including data heterogeneity, modality incompleteness, and barriers to clinical translation, remain to be addressed. Overall, this review underscores the transformative potential of multimodal learning to advance precision gastroenterology through integrated diagnostic and therapeutic.
{"title":"Multimodal learning in gastrointestinal diseases","authors":"Luwen Zhang , Yubing Shen , Wentao Gu , Peng Wu","doi":"10.1016/j.gande.2025.10.001","DOIUrl":"10.1016/j.gande.2025.10.001","url":null,"abstract":"<div><div>Gastrointestinal diseases represent a significant global health challenge, with current diagnostic and management approaches constrained by the integration of heterogeneous multimodal data. This review synthesizes the development prospects of multimodal applications in gastroenterology. By summarizing recent literatures, we demonstrate how multimodal integration can facilitate gastrointestinal disease screening, enable more accurate staging, support treatment decision-making, and optimize clinical workflows. Feature-level fusion serves as the dominant technique in current implementations, while hybrid approaches combining multiple fusion levels are increasingly adopted to enhance flexibility in complex clinical scenarios. Despite these advances, retrospective performance does not guarantee clinical success. Persistent challenges, including data heterogeneity, modality incompleteness, and barriers to clinical translation, remain to be addressed. Overall, this review underscores the transformative potential of multimodal learning to advance precision gastroenterology through integrated diagnostic and therapeutic.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 251-258"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.gande.2025.10.003
Jiaqi Bo , Zishuai Liu , Yiran wang , Qingfeng Luo
The global burden of colorectal diseases is steadily increasing, nderscoring the importance of early diagnosis, accurate assessment, and timely treatment. Despite being the standard for screening and diagnosis, traditional endoscopy faces limitations such as missed lesions and operator variability. With the rapid advancement of artificial intelligence (AI), automated image analysis has shown considerable promise in enhancing diagnostic accuracy, procedural quality, and treatment efficiency.” This review summarizes the current applications of AI in colonoscopy, covering areas such as bowel preparation, polyp detection and characterization, and inflammatory bowel disease management, highlighting the impact of these technologies on clinical practice, aiming to provide a reference for clinical practice and research.
{"title":"Research progress on the application of artificial intelligence in colonoscopy","authors":"Jiaqi Bo , Zishuai Liu , Yiran wang , Qingfeng Luo","doi":"10.1016/j.gande.2025.10.003","DOIUrl":"10.1016/j.gande.2025.10.003","url":null,"abstract":"<div><div>The global burden of colorectal diseases is steadily increasing, nderscoring the importance of early diagnosis, accurate assessment, and timely treatment. Despite being the standard for screening and diagnosis, traditional endoscopy faces limitations such as missed lesions and operator variability. With the rapid advancement of artificial intelligence (AI), automated image analysis has shown considerable promise in enhancing diagnostic accuracy, procedural quality, and treatment efficiency.” This review summarizes the current applications of AI in colonoscopy, covering areas such as bowel preparation, polyp detection and characterization, and inflammatory bowel disease management, highlighting the impact of these technologies on clinical practice, aiming to provide a reference for clinical practice and research.</div></div>","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 263-270"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.gande.2025.10.002
Lianyong Li , Jun Cheng
{"title":"Beyond the scope: The evolution of smart digestive endoscopy centers","authors":"Lianyong Li , Jun Cheng","doi":"10.1016/j.gande.2025.10.002","DOIUrl":"10.1016/j.gande.2025.10.002","url":null,"abstract":"","PeriodicalId":100571,"journal":{"name":"Gastroenterology & Endoscopy","volume":"3 4","pages":"Pages 259-262"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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