Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.11.005
Yuan-hang Dong, Chun-ying Jiang, W. Guo, Yanbo Zeng, Yiqi Du
Objective To compare the therapeutic value of transnasal gastroscopy and conventional gastroscopy for infective pancreatic necrosis(IPN) through percutaneous endoscopic necrosectomy(PEN). Methods A total of 24 IPN patients who received PEN for IPN from December 2015 to March 2019 were divided into the conventional gastroscopy group (n=15) and the transnasal gastroscopy group (n=9). The clinical therapeutic indicators such as vital signs, APACHE Ⅱ score changes, operation duration, difference in preoperative and postoperative volumes of peripancreatic necrosis and other indicators were compared between the two groups. Results There was no significant difference in the variation curve fitting of APACHE Ⅱ scores between the two groups (t=0.378, P=0.710). The operation time of the transnasal gastroscopy group was significantly shorter than that of the conventional gastroscopy group (119.7±47.4 min VS 172.8±56.2 min, P=0.018). Peripancreatic necrotic volume significantly decreased after operation in the transnasal gastroscopy group (404.03±170.73 mL VS 468.9±137.37 mL, P=0.002), and in the conventional gastroscopy group (499.44±227.17 mL VS 722.50±292.96 mL, P<0.001). There was no significant difference in the decrease extent in the conventional gastroscopy group and the transnasal gastroscopy group (223.06±212.92 mL VS 64.87±54.94 mL, P= 0.094). Conclusion On the condition of poor drainage of percutaneous catheter drainage, PEN can significantly reduce the range of necrotic lesions. Transnasal gastroscopy has the advantages in operation time in PEN and clearing deep abscess cavities over conventional gastroscopy. Key words: Pancreatitis; Percutaneous endoscopic necrosectomy; Infective pancreatic necrosis
目的比较经皮内镜下坏死切除术(PEN)经鼻胃镜与常规胃镜对感染性胰腺坏死(IPN)的治疗价值。方法将2015年12月至2019年3月接受PEN治疗的24例IPN患者分为常规胃镜组(n=15)和经鼻胃镜组(n=9)。比较两组患者的生命体征、APACHEⅡ评分变化、手术时间、术前和术后胰周坏死量的差异等临床治疗指标。结果两组APACHEⅡ评分变化曲线拟合无显著性差异(t=0.378,P=0.710),经鼻胃镜检查组手术时间明显短于常规胃镜检查组(119.7±47.4min VS 172.8±56.2min,P=0.018)经鼻胃镜检查组(404.03±170.73mL VS 468.9±137.37mL,P=0.002),常规胃镜检查组(499.44±227.17 mL VS 722.50±292.96 mL,P<0.001)。常规胃镜检查和经鼻胃镜检查组的下降幅度(223.06±212.92 mL VS 64.87±54.94 mL,P=0.094)无显著差异,PEN可以显著减少坏死病变的范围。与传统胃镜相比,经鼻胃镜在PEN手术时间和清除深脓肿腔方面具有优势。关键词:胰腺炎;经皮内镜尸检;感染性胰腺坏死
{"title":"A comparative study on transnasal gastroscopy and conventional gastroscopy for percutaneous endoscopic pancreatic necrosectomy","authors":"Yuan-hang Dong, Chun-ying Jiang, W. Guo, Yanbo Zeng, Yiqi Du","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.11.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.11.005","url":null,"abstract":"Objective \u0000To compare the therapeutic value of transnasal gastroscopy and conventional gastroscopy for infective pancreatic necrosis(IPN) through percutaneous endoscopic necrosectomy(PEN). \u0000 \u0000 \u0000Methods \u0000A total of 24 IPN patients who received PEN for IPN from December 2015 to March 2019 were divided into the conventional gastroscopy group (n=15) and the transnasal gastroscopy group (n=9). The clinical therapeutic indicators such as vital signs, APACHE Ⅱ score changes, operation duration, difference in preoperative and postoperative volumes of peripancreatic necrosis and other indicators were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no significant difference in the variation curve fitting of APACHE Ⅱ scores between the two groups (t=0.378, P=0.710). The operation time of the transnasal gastroscopy group was significantly shorter than that of the conventional gastroscopy group (119.7±47.4 min VS 172.8±56.2 min, P=0.018). Peripancreatic necrotic volume significantly decreased after operation in the transnasal gastroscopy group (404.03±170.73 mL VS 468.9±137.37 mL, P=0.002), and in the conventional gastroscopy group (499.44±227.17 mL VS 722.50±292.96 mL, P<0.001). There was no significant difference in the decrease extent in the conventional gastroscopy group and the transnasal gastroscopy group (223.06±212.92 mL VS 64.87±54.94 mL, P= 0.094). \u0000 \u0000 \u0000Conclusion \u0000On the condition of poor drainage of percutaneous catheter drainage, PEN can significantly reduce the range of necrotic lesions. Transnasal gastroscopy has the advantages in operation time in PEN and clearing deep abscess cavities over conventional gastroscopy. \u0000 \u0000 \u0000Key words: \u0000Pancreatitis; Percutaneous endoscopic necrosectomy; Infective pancreatic necrosis","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"815-820"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46105553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.11.002
J. Xiang, E. Linghu, Longsong Li, Xiangyao Wang, J. Zou, H. Du, Ping Tang, N. Chai
Objective To evaluate optical coherence tomography(OCT)for predicting invasion depth of early esophageal cancer(EEC) and to compare OCT and magnifying endoscopy-narrow band imaging (ME-NBI)in clinical performance. Methods Twenty-eight patients who were diagnosed with EEC and accepted OCT and ME-NBI before endoscopic submucosal dissection(ESD)were enrolled in this prospective study. On the basis of OCT and ME-NBI images, real-time prediction of EEC invasion depth was conducted. Postoperative pathological results were taken as golden standard to compare the accuracy of OCT and ME-NBI in evaluation of EEC invasion depth. The procedure time and incidence of complications during evaluation process were also analyzed. Results The overall accuracy of OCT and ME-NBI in predicting invasion depth of 28 EEC patients were 67.9% (19/28) and 75.0% (21/28) respectively, with no significant difference(P>0.05). The accuracy of OCT and ME-NBI in distinguishing lesions located in epithelium/lamina propria mucosa (EP/LPM) lesions were 78.9%(15/19) and 68.4% (13/19), with no significant difference(P>0.05). The procedure time of OCT was significantly shorter than that of ME-NBI (6.0±2.9 min VS 16.3±5.4 min, P<0.001). Conclusion The ability of OCT to predict invasion depth of EEC and distinguish lesions located in the EP/LPM is comparable with that of ME-NBI. Besides, OCT requires shorter procedure time for evaluation. Key words: Tomography, optical coherence; Esophageal neoplasm; Invasion depth; Magnifying endoscopy with narrow band imaging; Accuracy
目的探讨光学相干断层扫描(OCT)对早期食管癌(EEC)侵袭深度的预测价值,并比较OCT与放大内镜-窄带成像(ME-NBI)的临床应用价值。方法28例经内镜下粘膜下剥离术(ESD)前诊断为EEC并接受OCT和ME-NBI检查的患者进行前瞻性研究。在OCT和ME-NBI图像的基础上,实时预测脑电图侵袭深度。以术后病理结果为金标准,比较OCT与ME-NBI评价脑电图侵袭深度的准确性。并分析了手术时间和评估过程中并发症的发生率。结果OCT和ME-NBI预测28例脑电图患者侵深的总体准确率分别为67.9%(19/28)和75.0%(21/28),两者差异无统计学意义(P < 0.05)。OCT与ME-NBI区分上皮/固有层粘膜(EP/LPM)病变的准确率分别为78.9%(15/19)和68.4%(13/19),差异无统计学意义(P < 0.05)。OCT的手术时间明显短于ME-NBI(6.0±2.9 min VS 16.3±5.4 min, P<0.001)。结论OCT预测脑电图侵袭深度和区分EP/LPM病变的能力与ME-NBI相当。此外,OCT需要更短的程序时间进行评估。关键词:层析成像;光学相干;食管肿瘤;侵入深度;窄带放大内镜;精度
{"title":"A prospective study of optical coherence tomography for predicting invasion depth of early esophageal cancer","authors":"J. Xiang, E. Linghu, Longsong Li, Xiangyao Wang, J. Zou, H. Du, Ping Tang, N. Chai","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.11.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.11.002","url":null,"abstract":"Objective \u0000To evaluate optical coherence tomography(OCT)for predicting invasion depth of early esophageal cancer(EEC) and to compare OCT and magnifying endoscopy-narrow band imaging (ME-NBI)in clinical performance. \u0000 \u0000 \u0000Methods \u0000Twenty-eight patients who were diagnosed with EEC and accepted OCT and ME-NBI before endoscopic submucosal dissection(ESD)were enrolled in this prospective study. On the basis of OCT and ME-NBI images, real-time prediction of EEC invasion depth was conducted. Postoperative pathological results were taken as golden standard to compare the accuracy of OCT and ME-NBI in evaluation of EEC invasion depth. The procedure time and incidence of complications during evaluation process were also analyzed. \u0000 \u0000 \u0000Results \u0000The overall accuracy of OCT and ME-NBI in predicting invasion depth of 28 EEC patients were 67.9% (19/28) and 75.0% (21/28) respectively, with no significant difference(P>0.05). The accuracy of OCT and ME-NBI in distinguishing lesions located in epithelium/lamina propria mucosa (EP/LPM) lesions were 78.9%(15/19) and 68.4% (13/19), with no significant difference(P>0.05). The procedure time of OCT was significantly shorter than that of ME-NBI (6.0±2.9 min VS 16.3±5.4 min, P<0.001). \u0000 \u0000 \u0000Conclusion \u0000The ability of OCT to predict invasion depth of EEC and distinguish lesions located in the EP/LPM is comparable with that of ME-NBI. Besides, OCT requires shorter procedure time for evaluation. \u0000 \u0000 \u0000Key words: \u0000Tomography, optical coherence; Esophageal neoplasm; Invasion depth; Magnifying endoscopy with narrow band imaging; Accuracy","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"802-805"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43145723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.11.003
Gen Huang, Quanlin Li, P. Zhou
Objective To evaluate the feasibility, safety and efficacy of repeated peroral endoscopic myotomy (Re-POEM) as a make-up therapy after POEM failure. Methods Thirty-three patients with persistent/recurrent symptoms after first POEM (Eckardt symptom score≥4) were selected from a database of a total of 2 516 consecutive patients with achalasia. The main outcome measures was Eckardt score during follow-up; the secondary outcome measures were procedure-related adverse events, changes in manometric lower esophageal sphincter (LES) pressure, and reflux symptoms before and after Re-POEM. Results All patients successfully underwent Re-POEM in mean 18.6 months (ranging 3-55 months) after their first POEM procedures. The mean symptom score before Re-POEM was 5.5 (ranging 4-8). Mean operation time was 45.1 minutes (ranging 28-64 minutes). Submucosal tunnel infection occurred in 1 patient who recovered with conservative treatment. During a mean follow-up period of 36.6 months (ranging 12-58 months), symptom relief was achieved in all patients. Eckardt score reduced to 1.3 (ranging 0-3), significantly different from that before (P<0.001). Mean LES pressure also declined from 26.0 mmHg (1 mmHg=0.133 kPa) to 9.6 mmHg after Re-POEM (P<0.001). The incidence of gastroesophageal reflux of Re-POEM was 33.3% (11/33). Conclusions Re-POEM appears safe and effective as a make-up option after POEM failure. Key words: Esophageal achalasia; Peroral endoscopic myotomy; Repeated peroral endoscopic myotomy
{"title":"Clinical value of repeated peroral endoscopic myotomy for persistent/recurrent achalasia","authors":"Gen Huang, Quanlin Li, P. Zhou","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.11.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.11.003","url":null,"abstract":"Objective \u0000To evaluate the feasibility, safety and efficacy of repeated peroral endoscopic myotomy (Re-POEM) as a make-up therapy after POEM failure. \u0000 \u0000 \u0000Methods \u0000Thirty-three patients with persistent/recurrent symptoms after first POEM (Eckardt symptom score≥4) were selected from a database of a total of 2 516 consecutive patients with achalasia. The main outcome measures was Eckardt score during follow-up; the secondary outcome measures were procedure-related adverse events, changes in manometric lower esophageal sphincter (LES) pressure, and reflux symptoms before and after Re-POEM. \u0000 \u0000 \u0000Results \u0000All patients successfully underwent Re-POEM in mean 18.6 months (ranging 3-55 months) after their first POEM procedures. The mean symptom score before Re-POEM was 5.5 (ranging 4-8). Mean operation time was 45.1 minutes (ranging 28-64 minutes). Submucosal tunnel infection occurred in 1 patient who recovered with conservative treatment. During a mean follow-up period of 36.6 months (ranging 12-58 months), symptom relief was achieved in all patients. Eckardt score reduced to 1.3 (ranging 0-3), significantly different from that before (P<0.001). Mean LES pressure also declined from 26.0 mmHg (1 mmHg=0.133 kPa) to 9.6 mmHg after Re-POEM (P<0.001). The incidence of gastroesophageal reflux of Re-POEM was 33.3% (11/33). \u0000 \u0000 \u0000Conclusions \u0000Re-POEM appears safe and effective as a make-up option after POEM failure. \u0000 \u0000 \u0000Key words: \u0000Esophageal achalasia; Peroral endoscopic myotomy; Repeated peroral endoscopic myotomy","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"806-810"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.11.006
M. Ren, Feng Ma, Xuejun Sun, Xiaopeng Yan, Wei Zhao, Jianbao Zheng, Wenhui Ma, Xinlan Lu, Shuixiang He, G. Lu
Objective To evaluate the feasibility and safety of magnetic tracer technique for preoperative endoscopic marking in laparoscopic surgery. Methods In the preliminary study, a total of 8 patients with gastric (n=3) or colorectal (n=5) tumors underwent endoscopic magnetic marking before laparoscopic surgery from April to June in 2019. First, a magnet was attached to the lesion by 2 titanium clips under the endoscope. Second, during the subsequent laparoscopic operations, the other magnet was sent to the vicinity of the lesion through the laparoscopic tunnel. The magnet in the abdominal cavity was quickly attracted to the one in the gastrointestinal tract to successfully locate the lesions. Data of preoperative marking and operations of 8 patients were reviewed. Results All 8 lesions were marked successfully, rapid and accurate intraoperative positioning was achieved. The mean time of endoscopic marking was 5.75±2.45 minutes, and the mean time of intraoperative localization was 1.94±0.56 minutes. All patients underwent laparoscopic tumor resections with accurate localization. The mean proximal and distal resection margins of colorectal tumors were 105 mm and 74 mm respectively. No complications occurred. Conclusion Magnetic tracer technique for laparoscopic localization, simple, safe and accurate for gastrointestinal lesions, can be performed without additional equipment or endoscopic procedures involved. Key words: Gastrointestinal tract; Laparoscopes; Orientation; Magnet
{"title":"Magnetic tracer technique in laparoscopic localization for gastrointestinal lesions","authors":"M. Ren, Feng Ma, Xuejun Sun, Xiaopeng Yan, Wei Zhao, Jianbao Zheng, Wenhui Ma, Xinlan Lu, Shuixiang He, G. Lu","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.11.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.11.006","url":null,"abstract":"Objective \u0000To evaluate the feasibility and safety of magnetic tracer technique for preoperative endoscopic marking in laparoscopic surgery. \u0000 \u0000 \u0000Methods \u0000In the preliminary study, a total of 8 patients with gastric (n=3) or colorectal (n=5) tumors underwent endoscopic magnetic marking before laparoscopic surgery from April to June in 2019. First, a magnet was attached to the lesion by 2 titanium clips under the endoscope. Second, during the subsequent laparoscopic operations, the other magnet was sent to the vicinity of the lesion through the laparoscopic tunnel. The magnet in the abdominal cavity was quickly attracted to the one in the gastrointestinal tract to successfully locate the lesions. Data of preoperative marking and operations of 8 patients were reviewed. \u0000 \u0000 \u0000Results \u0000All 8 lesions were marked successfully, rapid and accurate intraoperative positioning was achieved. The mean time of endoscopic marking was 5.75±2.45 minutes, and the mean time of intraoperative localization was 1.94±0.56 minutes. All patients underwent laparoscopic tumor resections with accurate localization. The mean proximal and distal resection margins of colorectal tumors were 105 mm and 74 mm respectively. No complications occurred. \u0000 \u0000 \u0000Conclusion \u0000Magnetic tracer technique for laparoscopic localization, simple, safe and accurate for gastrointestinal lesions, can be performed without additional equipment or endoscopic procedures involved. \u0000 \u0000 \u0000Key words: \u0000Gastrointestinal tract; Laparoscopes; Orientation; Magnet","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"821-825"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45808760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.10.003
Zihua Wang, Jie Yu, Shiying Yang
Objective To evaluate the diagnostic efficacy of Japan Narrow Band Imaging Expert Team(JNET) classification under narrow-band imaging (NBI) for colorectal laterally spreading tumors. Methods Data of 170 laterally spreading tumors (LST) detected by NBI and pigment dyeing were reviewed in the retrospective study. JNET classification under NBI was used for rediagnosis based on surface pattern and vessel pattern. Pit pattern(PP) was observed under pigment dyeing using PP classification. The results were compared with histologic results after endoscopic resection or surgery. Results The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of JNET classification and PP classification were 92.2% VS 70.3%, 82.3% VS 85.0%, 74.7% VS 72.6%, 94.9% VS 83.5%, 85.9% VS 79.7%, respectively (P=0.159). The consistency rates of JNET classification and PP classification in predicting shallow invasion depth of LST were 6.1% and 8.3% respectively and the consistency rates in predicting deep invasion were 30.8% and 4.8%, respectively. Conclusion JNET classification under NBI is effective in predicting malignant laterally spreading tumors, however, its efficacy in predicting tumor invasion depth is unsatisfied. PP classification can be used to improve the diagnostic accuracy for those with diagnostic difficulty. Key words: Colorectal neoplasms; Diagnosis; Laterally spreading tumor; Narrow-band imaging; JNET classification
{"title":"Diagnostic value of JNET classification under narrow-band imaging for colorectal laterally spreading tumors","authors":"Zihua Wang, Jie Yu, Shiying Yang","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.10.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.10.003","url":null,"abstract":"Objective \u0000To evaluate the diagnostic efficacy of Japan Narrow Band Imaging Expert Team(JNET) classification under narrow-band imaging (NBI) for colorectal laterally spreading tumors. \u0000 \u0000 \u0000Methods \u0000Data of 170 laterally spreading tumors (LST) detected by NBI and pigment dyeing were reviewed in the retrospective study. JNET classification under NBI was used for rediagnosis based on surface pattern and vessel pattern. Pit pattern(PP) was observed under pigment dyeing using PP classification. The results were compared with histologic results after endoscopic resection or surgery. \u0000 \u0000 \u0000Results \u0000The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of JNET classification and PP classification were 92.2% VS 70.3%, 82.3% VS 85.0%, 74.7% VS 72.6%, 94.9% VS 83.5%, 85.9% VS 79.7%, respectively (P=0.159). The consistency rates of JNET classification and PP classification in predicting shallow invasion depth of LST were 6.1% and 8.3% respectively and the consistency rates in predicting deep invasion were 30.8% and 4.8%, respectively. \u0000 \u0000 \u0000Conclusion \u0000JNET classification under NBI is effective in predicting malignant laterally spreading tumors, however, its efficacy in predicting tumor invasion depth is unsatisfied. PP classification can be used to improve the diagnostic accuracy for those with diagnostic difficulty. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Diagnosis; Laterally spreading tumor; Narrow-band imaging; JNET classification","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"725-730"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44265228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.10.008
Xiaoping Xia, E. Wang
Objective To evaluate the feasibility and safety of maintaining general anesthesia without neuromuscular blockade in oral double-balloon enteroscopy. Methods Totally 120 patients undergoing oral double-balloon enteroscopy under general anesthesia were randomly assigned into two groups: the observation group and the control group. The observation group was not given muscle relaxants for anesthesia maintenance, while the control group was given muscle relaxants punctually. Observation indexes were monitored, including the mean arterial pressure (MAP), heart rate (HR), peak airway pressure (Ppeak) and end-tidal CO2 partial pressure (PETCO2) before anesthesia (T0), immediately after intubation (T1), at the time of endoscopy placement (T2), at the end of endoscopy withdrawal (T3), and at the time of waking-up (T4). The cases of spontaneous breathing recovery before the end of endoscopy, postoperative recovery time, extubation time, length of PACU stay, postoperative adverse reactions and satisfactory rates were recorded. Results Twelve cases were removed by the exclusion criteria, and the remaining 108 cases completed the study, including 56 cases in the observation group and 52 cases in the control group. The one-time success rate of induction was both 100% in the two groups. There were no significant differences in MAP, HR, Ppeak, and PETCO2 between the two groups at each observation point (all P>0.05), and the same is true for within group comparison with T0 (all P>0.05). The recovery rate of spontaneous respiration in the observation group was significantly higher than that in the control group [100% (56/56) VS 42% (22/52), χ2=44.73, P=0.000]. The awaken time, extubation time and length of PACU stay were 6±2 min, 10±3 min, and 11±4 min, respectively, in the observation group, compared with 15±5 min (t=-12.64, P=0.000), 17±5 min (t=-8.90, P=0.000), and 17±7 min (t=-5.73, P=0.000) in the control group. None of the patients required assisted ventilation. Hypoxemia occurred in 2 cases and nausea in 3 cases in the control group, while only nausea occurred in 1 patient in the observation group. The overall incidence of adverse reactions was not statisticaly different between the two groups (P>0.05). Anesthesia satisfaction rate of two groups was 100%. Conclusion It is feasible and safe to perform oral double-balloon enteroscopy without muscle relaxants during maintaining under general anesthesia, with quick recovery of spontaneous breathing and awakening, early extubation and less cost. Key words: Anesthesia, intravenous; Without muscle relaxants; Double-balloon enteroscopy
{"title":"Effects of general anesthesia maintenance without muscle relaxants for double-balloon enteroscopy: a randomized controlled trial","authors":"Xiaoping Xia, E. Wang","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.10.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.10.008","url":null,"abstract":"Objective \u0000To evaluate the feasibility and safety of maintaining general anesthesia without neuromuscular blockade in oral double-balloon enteroscopy. \u0000 \u0000 \u0000Methods \u0000Totally 120 patients undergoing oral double-balloon enteroscopy under general anesthesia were randomly assigned into two groups: the observation group and the control group. The observation group was not given muscle relaxants for anesthesia maintenance, while the control group was given muscle relaxants punctually. Observation indexes were monitored, including the mean arterial pressure (MAP), heart rate (HR), peak airway pressure (Ppeak) and end-tidal CO2 partial pressure (PETCO2) before anesthesia (T0), immediately after intubation (T1), at the time of endoscopy placement (T2), at the end of endoscopy withdrawal (T3), and at the time of waking-up (T4). The cases of spontaneous breathing recovery before the end of endoscopy, postoperative recovery time, extubation time, length of PACU stay, postoperative adverse reactions and satisfactory rates were recorded. \u0000 \u0000 \u0000Results \u0000Twelve cases were removed by the exclusion criteria, and the remaining 108 cases completed the study, including 56 cases in the observation group and 52 cases in the control group. The one-time success rate of induction was both 100% in the two groups. There were no significant differences in MAP, HR, Ppeak, and PETCO2 between the two groups at each observation point (all P>0.05), and the same is true for within group comparison with T0 (all P>0.05). The recovery rate of spontaneous respiration in the observation group was significantly higher than that in the control group [100% (56/56) VS 42% (22/52), χ2=44.73, P=0.000]. The awaken time, extubation time and length of PACU stay were 6±2 min, 10±3 min, and 11±4 min, respectively, in the observation group, compared with 15±5 min (t=-12.64, P=0.000), 17±5 min (t=-8.90, P=0.000), and 17±7 min (t=-5.73, P=0.000) in the control group. None of the patients required assisted ventilation. Hypoxemia occurred in 2 cases and nausea in 3 cases in the control group, while only nausea occurred in 1 patient in the observation group. The overall incidence of adverse reactions was not statisticaly different between the two groups (P>0.05). Anesthesia satisfaction rate of two groups was 100%. \u0000 \u0000 \u0000Conclusion \u0000It is feasible and safe to perform oral double-balloon enteroscopy without muscle relaxants during maintaining under general anesthesia, with quick recovery of spontaneous breathing and awakening, early extubation and less cost. \u0000 \u0000 \u0000Key words: \u0000Anesthesia, intravenous; Without muscle relaxants; Double-balloon enteroscopy","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"750-754"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47774773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.10.009
Fumei Yin, Fengjun Shen
Objective To systematically evaluate the efficacy and safety of endoscopic resection and laparoscopic surgery for gastrointestinal stromal tumors(GIST) (diameter<3.5 cm). Methods According to the Cocharane system search strategy, Chinese and English literature comparing endoscopic with laparoscopic treatment of GIST published from January 2000 to March 2018 were collected. Ten articles meeting the inclusion criteria were included and analyzed with Revman 5.3. Results Of the 10 articles, 1 was a prospective randomized controlled trial and 9 were retrospective non-randomized controlled trials. The total number of patients was 1 062. There were 732 cases in the endoscopic treatment group, and 330 cases in the laparoscopic surgery group. The meta-analysis results showed that the endoscopic treatment group had shorter operation time (MD=-30.58 min, 95%CI: -39.31--21.84, P<0.05), less blood loss (MD=-12.99 mL, 95%CI: -16.40--9.57, P<0.05), shorter hospital stay (MD=-3.17 d, 95%CI: -4.76--1.59, P<0.05), and less total cost (MD=-1.63 ten thousand RMB, 95%CI: -2.42--0.84, P<0.05) than those of the laparoscopic group. But there were no significant differences in the positive rate of margin(RR=2.35, 95%CI: 0.52-10.69, P=0.27) or perioperative complications(RR=1.08, 95%CI: 0.48-2.42, P=0.85). Conclusion Existing studies have shown that endoscopic treatment for GIST is effective, minimally invasive, economical with better prognosis, ensuring complete resection. Key words: Meta-analysis; Endoscopes; Laparoscopes; Gastric stromal tumor
{"title":"Efficacy and safety of endoscopic and laparoscopic treatment for gastric stromal tumor: a meta-analysis","authors":"Fumei Yin, Fengjun Shen","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.10.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.10.009","url":null,"abstract":"Objective \u0000To systematically evaluate the efficacy and safety of endoscopic resection and laparoscopic surgery for gastrointestinal stromal tumors(GIST) (diameter<3.5 cm). \u0000 \u0000 \u0000Methods \u0000According to the Cocharane system search strategy, Chinese and English literature comparing endoscopic with laparoscopic treatment of GIST published from January 2000 to March 2018 were collected. Ten articles meeting the inclusion criteria were included and analyzed with Revman 5.3. \u0000 \u0000 \u0000Results \u0000Of the 10 articles, 1 was a prospective randomized controlled trial and 9 were retrospective non-randomized controlled trials. The total number of patients was 1 062. There were 732 cases in the endoscopic treatment group, and 330 cases in the laparoscopic surgery group. The meta-analysis results showed that the endoscopic treatment group had shorter operation time (MD=-30.58 min, 95%CI: -39.31--21.84, P<0.05), less blood loss (MD=-12.99 mL, 95%CI: -16.40--9.57, P<0.05), shorter hospital stay (MD=-3.17 d, 95%CI: -4.76--1.59, P<0.05), and less total cost (MD=-1.63 ten thousand RMB, 95%CI: -2.42--0.84, P<0.05) than those of the laparoscopic group. But there were no significant differences in the positive rate of margin(RR=2.35, 95%CI: 0.52-10.69, P=0.27) or perioperative complications(RR=1.08, 95%CI: 0.48-2.42, P=0.85). \u0000 \u0000 \u0000Conclusion \u0000Existing studies have shown that endoscopic treatment for GIST is effective, minimally invasive, economical with better prognosis, ensuring complete resection. \u0000 \u0000 \u0000Key words: \u0000Meta-analysis; Endoscopes; Laparoscopes; Gastric stromal tumor","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"755-760"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49128266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.10.002
Xiao Li, Min Zhu
Objective To investigate risk factors of procedure time of endoscopic submucosal dissection (ESD) for treatment of esophageal lesions. Methods A total of 160 patients with single esophageal lesion who underwent ESD at department of gastroenterology, Beijing Friendship Hospital from January 2015 to October 2017 were enrolled. Medical information including general information (age and gender), and lesion’s characteristics (location, size, gross morphology, pathological type, differentiation degree, and depth of invasion), operators’experience, circumferential resection size, operation and anesthesia time were retrospectively collected. According to the operation time, the cases were divided into the long-term operation group (exceeded 120 min) and the short-time operation group (less than 120 min). The factors affecting the esophageal ESD operation time were analyzed by univariate and multivariate analysis. Results Among the 160 patients, 120 (75.0%) were men and 40 (25.0%) were women. The age was 62.65±8.48 years. The median (interquartile range) size of lesion was 1.70 (1.00, 2.65) cm. The median time of ESD was 113.54 (81.25, 168.75) min. Univariate analysis showed that age >65 years, the lesions of type Ⅱa+ Ⅱc/Ⅱc, lesion size >2 cm and >1/2 esophageal circumference resection were associated with a longer ESD operation time (P 0.05). Multivariate analysis showed that the type Ⅱa+ Ⅱc/Ⅱc (OR=2.47, 95%CI: 1.01-6.06, P=0.047), lesion size>2 cm (OR=3.41, 95%CI: 1.34-8.64, P=0.010) and > 1/2 esophageal circumference resection (OR=4.24, 95%CI: 1.62-11.11, P=0.030) were independent risk factors for the operation time of longer than 120 min. Conclusion Type Ⅱa+ Ⅱc/Ⅱc lesions, the lesion size >2 cm and the resection area >1/2 esophageal circumference were independent risk factors for a prolonged operation time of esophageal ESD procedure. Key words: Risk factors; Early esophageal cancers; Endoscopic submucosal dissection; Procedure time
{"title":"Risk factors of procedure time of endoscopic submucosal dissection for esophageal lesions","authors":"Xiao Li, Min Zhu","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.10.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.10.002","url":null,"abstract":"Objective \u0000To investigate risk factors of procedure time of endoscopic submucosal dissection (ESD) for treatment of esophageal lesions. \u0000 \u0000 \u0000Methods \u0000A total of 160 patients with single esophageal lesion who underwent ESD at department of gastroenterology, Beijing Friendship Hospital from January 2015 to October 2017 were enrolled. Medical information including general information (age and gender), and lesion’s characteristics (location, size, gross morphology, pathological type, differentiation degree, and depth of invasion), operators’experience, circumferential resection size, operation and anesthesia time were retrospectively collected. According to the operation time, the cases were divided into the long-term operation group (exceeded 120 min) and the short-time operation group (less than 120 min). The factors affecting the esophageal ESD operation time were analyzed by univariate and multivariate analysis. \u0000 \u0000 \u0000Results \u0000Among the 160 patients, 120 (75.0%) were men and 40 (25.0%) were women. The age was 62.65±8.48 years. The median (interquartile range) size of lesion was 1.70 (1.00, 2.65) cm. The median time of ESD was 113.54 (81.25, 168.75) min. Univariate analysis showed that age >65 years, the lesions of type Ⅱa+ Ⅱc/Ⅱc, lesion size >2 cm and >1/2 esophageal circumference resection were associated with a longer ESD operation time (P 0.05). Multivariate analysis showed that the type Ⅱa+ Ⅱc/Ⅱc (OR=2.47, 95%CI: 1.01-6.06, P=0.047), lesion size>2 cm (OR=3.41, 95%CI: 1.34-8.64, P=0.010) and > 1/2 esophageal circumference resection (OR=4.24, 95%CI: 1.62-11.11, P=0.030) were independent risk factors for the operation time of longer than 120 min. \u0000 \u0000 \u0000Conclusion \u0000Type Ⅱa+ Ⅱc/Ⅱc lesions, the lesion size >2 cm and the resection area >1/2 esophageal circumference were independent risk factors for a prolonged operation time of esophageal ESD procedure. \u0000 \u0000 \u0000Key words: \u0000Risk factors; Early esophageal cancers; Endoscopic submucosal dissection; Procedure time","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"720-724"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41475376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.10.007
Jinlong Hu, N. Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang
Objective To analyze the diagnosis treatment and methods for pancreatic pseudoaneurysms complicated with pancreatitis. Methods The diagnostic methods, treatments and clinical effects of 11 patients with pancreatic pseudoaneurysms complicated with pancreatitis from January 2006 to December 2014 were retrospectively analyzed in Shengjing hospital. Results Two cases of pancreatic pseudoaneurysms were diagnosed by endoscopic ultrasonography(EUS). Eight cases were diagnosed with contrast-enhanced computed tomography. One case was diagnosed by angiography. Ten patients received endovascular embolization, and nine of them were successfully treated. Rebleeding occurred in one patient 28 days after embolization, and was successfully treated by repeated embolization. One patient was successfully treated by surgery. Conclusion Contrast-enhanced computed tomography and angiography are the current main methods to diagnose pancreatic pseudoaneurysms. With the wide use of EUS in the diagnosis of pancreatic disease, EUS becomes an option for diagnosis of pancreatic pseudoaneurysm. Traditionally, pancreatic pseudoaneurysm is treated by surgery. With the advancement of endovascular techniques, endovascular treatment has become the first-line treatment. Further studies with a large sample size are needed to establish the better diagnostic methods and treatments for pancreatic pseudoaneurysm. Key words: Pancreatitis; Aneurysm, false; Gastrointestinal hemorrhage; Endosonography; Embolization, therapeutic
{"title":"Diagnosis and treatment of pseudoaneurysm complicated with pancreatitis","authors":"Jinlong Hu, N. Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.10.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.10.007","url":null,"abstract":"Objective \u0000To analyze the diagnosis treatment and methods for pancreatic pseudoaneurysms complicated with pancreatitis. \u0000 \u0000 \u0000Methods \u0000The diagnostic methods, treatments and clinical effects of 11 patients with pancreatic pseudoaneurysms complicated with pancreatitis from January 2006 to December 2014 were retrospectively analyzed in Shengjing hospital. \u0000 \u0000 \u0000Results \u0000Two cases of pancreatic pseudoaneurysms were diagnosed by endoscopic ultrasonography(EUS). Eight cases were diagnosed with contrast-enhanced computed tomography. One case was diagnosed by angiography. Ten patients received endovascular embolization, and nine of them were successfully treated. Rebleeding occurred in one patient 28 days after embolization, and was successfully treated by repeated embolization. One patient was successfully treated by surgery. \u0000 \u0000 \u0000Conclusion \u0000Contrast-enhanced computed tomography and angiography are the current main methods to diagnose pancreatic pseudoaneurysms. With the wide use of EUS in the diagnosis of pancreatic disease, EUS becomes an option for diagnosis of pancreatic pseudoaneurysm. Traditionally, pancreatic pseudoaneurysm is treated by surgery. With the advancement of endovascular techniques, endovascular treatment has become the first-line treatment. Further studies with a large sample size are needed to establish the better diagnostic methods and treatments for pancreatic pseudoaneurysm. \u0000 \u0000 \u0000Key words: \u0000Pancreatitis; Aneurysm, false; Gastrointestinal hemorrhage; Endosonography; Embolization, therapeutic","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"746-749"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42208081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1007-5232.2019.10.006
Gu Jiaoyang, L. Lan, Xin Yu, Ren Jingmin, Wang Li, Zhang Nan, Wu Honglei, Lin Xingfeng, Guo Jian-qiang
Objective To evaluate the disinfection efficacy of peracetic acid disinfectant (type Ⅲ ) on gastrointestinal endoscopy. Methods Endoscopes were disinfected respectively by 2% glutaraldehyde (GA group) and peracetic acid disinfectant (type Ⅲ ) (PAA group) according to the process by the 2016 version of "Regulation for cleaning and disinfection technique of flexible endoscope" , and then samples were collected through biopsy channel at the specified steps. The bacterial count and pathogenic bacteria of these samples were detected. Hepatitis B virus surface antigen (HBsAg), hepatitis C virus (HCV) antibody and Treponemia pallidum antibody (TP-Ab) were detected by chemiluminesent microparticle immunoassay (CMIA) in the PAA group. The PAA group were continuously sampled for 5 days. Results A total of 56 gastroscopes and 16 colonoscopes were disinfected in the GA group, and 46 gastroscopes and 15 colonoscopes were disinfected in the PAA group. Compared with pre-disinfection, the bacterial count was both significantly reduced in the two groups after disinfection (P 0.05; total qualified rate: 98.36% (60/61) VS 94.44% (68/72), P>0.05]. The qualified rate of colonoscopes in the two groups were both 100.00% (15/15, 16/16). After disinfecting by peracetic acid disinfectant (Type Ⅲ), HBsAg, anti-HCV and TP-Ab were negative. There were no significant differences on colonies number at different steps in a 5-day continuous sampling (P>0.05). Conclusion Peracetic acid disinfectant (type Ⅲ) can provide a satisfied disinfectant effect, and be applied in clinic to meet the requests of high-level disinfection for gastrointestinal endoscopy. Key words: Endoscopes, gastrointestinal; Disinfectants; Peracetic acid disinfectant (type Ⅲ)
{"title":"Disinfection efficacy of peracetic acid disinfectant (type III) on gastrointestinal endoscopy","authors":"Gu Jiaoyang, L. Lan, Xin Yu, Ren Jingmin, Wang Li, Zhang Nan, Wu Honglei, Lin Xingfeng, Guo Jian-qiang","doi":"10.3760/CMA.J.ISSN.1007-5232.2019.10.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-5232.2019.10.006","url":null,"abstract":"Objective \u0000To evaluate the disinfection efficacy of peracetic acid disinfectant (type Ⅲ ) on gastrointestinal endoscopy. \u0000 \u0000 \u0000Methods \u0000Endoscopes were disinfected respectively by 2% glutaraldehyde (GA group) and peracetic acid disinfectant (type Ⅲ ) (PAA group) according to the process by the 2016 version of \"Regulation for cleaning and disinfection technique of flexible endoscope\" , and then samples were collected through biopsy channel at the specified steps. The bacterial count and pathogenic bacteria of these samples were detected. Hepatitis B virus surface antigen (HBsAg), hepatitis C virus (HCV) antibody and Treponemia pallidum antibody (TP-Ab) were detected by chemiluminesent microparticle immunoassay (CMIA) in the PAA group. The PAA group were continuously sampled for 5 days. \u0000 \u0000 \u0000Results \u0000A total of 56 gastroscopes and 16 colonoscopes were disinfected in the GA group, and 46 gastroscopes and 15 colonoscopes were disinfected in the PAA group. Compared with pre-disinfection, the bacterial count was both significantly reduced in the two groups after disinfection (P 0.05; total qualified rate: 98.36% (60/61) VS 94.44% (68/72), P>0.05]. The qualified rate of colonoscopes in the two groups were both 100.00% (15/15, 16/16). After disinfecting by peracetic acid disinfectant (Type Ⅲ), HBsAg, anti-HCV and TP-Ab were negative. There were no significant differences on colonies number at different steps in a 5-day continuous sampling (P>0.05). \u0000 \u0000 \u0000Conclusion \u0000Peracetic acid disinfectant (type Ⅲ) can provide a satisfied disinfectant effect, and be applied in clinic to meet the requests of high-level disinfection for gastrointestinal endoscopy. \u0000 \u0000 \u0000Key words: \u0000Endoscopes, gastrointestinal; Disinfectants; Peracetic acid disinfectant (type Ⅲ)","PeriodicalId":10072,"journal":{"name":"Chinese Journal of Digestive Endoscopy","volume":"36 1","pages":"741-745"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46964908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}