【Objections】To study the cardioprotective effect of creatine phosphate sodium by measuring perioperative myocardial enzymes of allogeneic liver transplant patients.【Methods】The 26 cases of orthotopic liver transplant patients were randomly divided into control group and creatine phosphate sodium group,13 cases each.The creatine phosphate sodium group was given creatine phosphate sodium 30mg/kg at the time of induction.The control group was given equal amount of N.S.All patients at six-phase of before surgery,after anesthesia,before anhepatic phase,anhepatic phase,new liver and the 12 hours after surgery extraction radial artery.The CK,CK-MB and cTnI activity was measured.【Results】To compared with control group,creatine phosphate sodium group's plasma CK,CK-MB and cTnI concentrations before anhepatic phase,anhepatic phase,new liver and the 12 hours after surgery 4 phase were significantly lower(P 0.05).【Conclusion】The creatine phosphate sodium has a protective effect on liver transplantation in patients with myocardial damage.
【目的】通过对异体肝移植患者围手术期心肌酶的测定，探讨磷酸肌酸钠对心脏的保护作用。【方法】将26例原位肝移植患者随机分为对照组和磷酸肌酸钠组，各13例。磷酸肌酸钠组诱导时给予磷酸肌酸钠30mg/kg。对照组患者在术前、麻醉后、无肝期前、无肝期前、新肝期及术后12 h提取桡动脉6个阶段给予等量n.s.s。测定CK、CK- mb和cTnI活性。【结果】与对照组相比，磷酸肌酸钠组患者无肝期、无肝期、新肝期及术后12 h 4期血浆CK、CK- mb、cTnI浓度均显著降低(P < 0.05)。【结论】磷酸肌酸钠对心肌损伤肝移植患者有保护作用。
{"title":"The study of myocardial protective effect of creatine phosphate sodium in liver transplant patients","authors":"Kang Yu-qing","doi":"10.14725/dcc.v2n28-11","DOIUrl":"https://doi.org/10.14725/dcc.v2n28-11","url":null,"abstract":"【Objections】To study the cardioprotective effect of creatine phosphate sodium by measuring perioperative myocardial enzymes of allogeneic liver transplant patients.【Methods】The 26 cases of orthotopic liver transplant patients were randomly divided into control group and creatine phosphate sodium group,13 cases each.The creatine phosphate sodium group was given creatine phosphate sodium 30mg/kg at the time of induction.The control group was given equal amount of N.S.All patients at six-phase of before surgery,after anesthesia,before anhepatic phase,anhepatic phase,new liver and the 12 hours after surgery extraction radial artery.The CK,CK-MB and cTnI activity was measured.【Results】To compared with control group,creatine phosphate sodium group's plasma CK,CK-MB and cTnI concentrations before anhepatic phase,anhepatic phase,new liver and the 12 hours after surgery 4 phase were significantly lower(P 0.05).【Conclusion】The creatine phosphate sodium has a protective effect on liver transplantation in patients with myocardial damage.","PeriodicalId":10076,"journal":{"name":"中国现代医学杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67132682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2011.06.010
Ying Wang, Jian-fen Wei, Xiu-ping Jin, Su Liu
Objective To evaluate the relationship between serum levels of leptin, endothelin and diabetic retinopathy in type 2 diabetes patients. Methods Leptin, endothelia, FBG, PBG, HBA1C, CHOL, TG and other clinical characteristics were tested in 80 type2 diabetes patients and 30 control case. All diabetes patients were divided into three group: non-diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy(PDR) according to the examination results of fundus. Correlations between levels of serum leptin and other parameters were analyzed. Results Plasma level of leptin in the type 2 diabetes with PDR group[(17.41±5.81)μg/L] were higher than that in control, NPDR and NDR group (P＜0.01). Plasma level of ET in the type 2 diabetes with PDR group[(80.68±13.57)mg/L] were higher than that in control, NPDR and NDR group (P＜0.01). The serum leptin levels were positively correlated with BMI(r＝0.468,P＜0.01). Conclusions Serum leptin and endothelin levels were elevated in patient with diabetic retinopathy as diabetic retinopathy aggravated and serum level of leptin and endothelin raised. Key words: Diabetes mellitus/ME; Leptin/ME; Endothelins/ME; Diabetic retinopathy
{"title":"Study on the relationship between serum level of leptin, endothelin and different stages of diabetic retinopathy in type 2 diabetes patients","authors":"Ying Wang, Jian-fen Wei, Xiu-ping Jin, Su Liu","doi":"10.3760/CMA.J.ISSN.1008-1372.2011.06.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2011.06.010","url":null,"abstract":"Objective To evaluate the relationship between serum levels of leptin, endothelin and diabetic retinopathy in type 2 diabetes patients. Methods Leptin, endothelia, FBG, PBG, HBA1C, CHOL, TG and other clinical characteristics were tested in 80 type2 diabetes patients and 30 control case. All diabetes patients were divided into three group: non-diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy(PDR) according to the examination results of fundus. Correlations between levels of serum leptin and other parameters were analyzed. Results Plasma level of leptin in the type 2 diabetes with PDR group[(17.41±5.81)μg/L] were higher than that in control, NPDR and NDR group (P＜0.01). Plasma level of ET in the type 2 diabetes with PDR group[(80.68±13.57)mg/L] were higher than that in control, NPDR and NDR group (P＜0.01). The serum leptin levels were positively correlated with BMI(r＝0.468,P＜0.01). Conclusions Serum leptin and endothelin levels were elevated in patient with diabetic retinopathy as diabetic retinopathy aggravated and serum level of leptin and endothelin raised. \u0000 \u0000Key words: \u0000Diabetes mellitus/ME; Leptin/ME; Endothelins/ME; Diabetic retinopathy","PeriodicalId":10076,"journal":{"name":"中国现代医学杂志","volume":"13 1","pages":"757-759"},"PeriodicalIF":0.0,"publicationDate":"2011-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69916391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-01-01DOI: 10.1097/00007890-200607152-02451
Chen Bi-cheng
[Objective] To study the protective effects of genistein(GEN) in preventing and treating transplant arteriosclerosis and potential mechanisms. [Methods] Arotic transplantation was performed with male Brown-Norway rats as donors and male Lewis rats as recipients. The recipients in the experiment was randomly divided into four groups: (1) high-dose group (n=8), the recipients were administered with GEN at a dose of 20 mg/kg body weight for 60 days continuously; (2) high-low dose group (n=8), at a dose of 20 mg/kg for 14 days and at dose of 2 mg/kg for 46 days continuously; (3) solvent control (n=5), 0.5 mL DMSO for 60 days; (4) control (n=5), no treatment. Histological changes were monitored 60 days after transplantation, and the average depth of intima was calculated with computer imaging analysis systes. Immunohistochemistry was used to detect infiltration of CD4+, CD8+ T lymphocyte in the transplanted vessels, and ELISA to detect the change of VEGF in different group. [Results] Compared with two control groups, there were less lymphocytes and macrophages infiltration, the average depth of intima in two experimental groups markedly lowed (seperatedly P 0.001) and infiltration of CD4+, CD8+ T lymphocyte in the transplanted vessels was less (seperatedly P 0.01). Expression of VEGF in high dose group was lower than that in two control (8.6731±1.0466 Vs 21.8340±0.7558 and 23.2068±1.2028 P 0.01), but there was no statistic difference compared with high-low dose group. [Conclusion] Genistein can prevent the development of graft arteriosclerosis and the lowed infiltration of lymphocytes and the influenced expression of growth factors may be involved in the mechanisms.
[目的]研究染料木素(genstein, GEN)防治移植动脉硬化的保护作用及其可能机制。[方法]以雄性布朗-挪威大鼠为供体，雄性刘易斯大鼠为受体进行骨移植。实验对象随机分为4组:(1)高剂量组(n=8)，以20 mg/kg体重的剂量给药，连续60 d;(2)高低剂量组(n=8)， 20 mg/kg剂量组，连续14天，2 mg/kg剂量组，连续46天;(3)溶剂对照(n=5)， 0.5 mL DMSO, 60天;(4)对照组(n=5)，不处理。观察移植后60天的组织学变化，利用计算机成像分析系统计算内膜的平均深度。采用免疫组化法检测移植血管内CD4+、CD8+ T淋巴细胞浸润情况，ELISA法检测各组血管内皮生长因子的变化。[结果]与对照组相比，两实验组移植血管中淋巴细胞和巨噬细胞浸润减少，内膜平均深度明显降低(P分别为0.001)，CD4+、CD8+ T淋巴细胞浸润减少(P分别为0.01)。高剂量组VEGF表达低于对照组(8.6731±1.0466 Vs 21.8340±0.7558和23.2068±1.2028 P 0.01)，但与高、低剂量组比较差异无统计学意义。[结论]染料木素可预防移植物动脉硬化的发生，降低淋巴细胞的浸润，影响生长因子的表达可能与其机制有关。
{"title":"Experimental study of genistein in preventing and treating transplant arteriosclerosis in arotic transplantation of rat","authors":"Chen Bi-cheng","doi":"10.1097/00007890-200607152-02451","DOIUrl":"https://doi.org/10.1097/00007890-200607152-02451","url":null,"abstract":"[Objective] To study the protective effects of genistein(GEN) in preventing and treating transplant arteriosclerosis and potential mechanisms. [Methods] Arotic transplantation was performed with male Brown-Norway rats as donors and male Lewis rats as recipients. The recipients in the experiment was randomly divided into four groups: (1) high-dose group (n=8), the recipients were administered with GEN at a dose of 20 mg/kg body weight for 60 days continuously; (2) high-low dose group (n=8), at a dose of 20 mg/kg for 14 days and at dose of 2 mg/kg for 46 days continuously; (3) solvent control (n=5), 0.5 mL DMSO for 60 days; (4) control (n=5), no treatment. Histological changes were monitored 60 days after transplantation, and the average depth of intima was calculated with computer imaging analysis systes. Immunohistochemistry was used to detect infiltration of CD4+, CD8+ T lymphocyte in the transplanted vessels, and ELISA to detect the change of VEGF in different group. [Results] Compared with two control groups, there were less lymphocytes and macrophages infiltration, the average depth of intima in two experimental groups markedly lowed (seperatedly P 0.001) and infiltration of CD4+, CD8+ T lymphocyte in the transplanted vessels was less (seperatedly P 0.01). Expression of VEGF in high dose group was lower than that in two control (8.6731±1.0466 Vs 21.8340±0.7558 and 23.2068±1.2028 P 0.01), but there was no statistic difference compared with high-low dose group. [Conclusion] Genistein can prevent the development of graft arteriosclerosis and the lowed infiltration of lymphocytes and the influenced expression of growth factors may be involved in the mechanisms.","PeriodicalId":10076,"journal":{"name":"中国现代医学杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00007890-200607152-02451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61487511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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