Journal of Liver Transplantation最新文献

{"title":"Molecular evidence of solitary lung metastasis as the initial recurrence of hepatocellular carcinoma a decade more after liver transplantation","authors":"Cheng-Maw Ho , Hsao-Hsun Hsu , Hui-Ling Chen , Po-Huang Lee , Rey-Heng Hu","doi":"10.1016/j.liver.2025.100266","DOIUrl":"10.1016/j.liver.2025.100266","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental hepatocellular carcinoma in explanted livers: Prevalence, prognosis and features","authors":"Emilie Kerstens ,&nbsp;Samuele Iesari ,&nbsp;Eliano Bonaccorsi ,&nbsp;Laurent Coubeau ,&nbsp;Géraldine Dahlqvist ,&nbsp;Coralie Hamoir ,&nbsp;Olga Ciccarelli ,&nbsp;Bénédicte Delire","doi":"10.1016/j.liver.2025.100264","DOIUrl":"10.1016/j.liver.2025.100264","url":null,"abstract":"<div><h3>Background and aims</h3><div>Incidental hepatocellular carcinoma (iHCC) on cirrhotic liver specimens is not rare. The aim of this study was to evaluate prevalence and outcomes of liver transplant recipients (LTRs) with iHCC. We compared this group to cirrhotic patients who underwent liver transplantation (LT) for previously known hepatocellular carcinoma (pkHCC) or tumor-free end-stage liver disease (ESLD).</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 268 cirrhotic patients who underwent LT at our center between 2010 and 2020<em>.</em> Patient selection was made according to the indication for LT and histopathological analyses of surgical specimens (tumor-free ESLD, hepatocellular carcinoma (HCC)). Results were compared using Fisher's exact or Mann-Whitney U tests as appropriate. We used the Kaplan-Meier method to analyze the rate of death and log-rank tests to compare survival curves.</div></div><div><h3>Results</h3><div>The prevalence of iHCC was 12 %. Alcohol-related liver disease was more frequent in iHCC LTRs than in the other groups (<em>p</em> = 0.046). iHCC patients spent more time on the waiting list than patients with tumor-free ESLD cirrhosis (Ci) (12.2 months vs. 3.5 months; <em>p</em> = 0.04). Five-year overall survival of iHCC LTRs was significantly reduced compared to the survival of Ci LTRs (44 % vs. 87 %, <em>p</em> = 0.028).</div></div><div><h3>Conclusions</h3><div>The prevalence of iHCC within LT candidates is significant. iHCC LTRs show a lower survival rate than Ci LTRs, but a reduced rate of tumor recurrence compared to pkHCC LTRs. HCC screening protocol of ESLD LT candidates might include a larger use of high-resolution imaging techniques and iHCC LTRs should be approached as pkHCC LTRs with regards to postoperative imaging follow-up.</div></div><div><h3>Summary</h3><div>Prevalence of incidental hepatocellular carcinoma is considerable among LT candidates. These patients have a lower survival rate than recipients with tumor-free ESLD cirrhosis. Optimizing screening methods for hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation could improve their prognosis.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From severe acute cholangitis to aggressive intrahepatic cholangiocarcinoma: Causal or coincidental association?","authors":"Victoria Ramdour ,&nbsp;Thomas Lévi-Strauss ,&nbsp;Patrick Chevallier ,&nbsp;Delphine Ouvrier ,&nbsp;Antonio Iannelli ,&nbsp;Albert Tran ,&nbsp;Rodolphe Anty","doi":"10.1016/j.liver.2024.100250","DOIUrl":"10.1016/j.liver.2024.100250","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worse clinical outcomes of TACE when liver function is decompensated in a cohort of patients with cirrhosis and HCC waiting for liver transplantation","authors":"Elizaveta Makarova ,&nbsp;Xuanjia Fan ,&nbsp;Iman Farooqi ,&nbsp;Katrina Bakhl ,&nbsp;Terrence E. Murphy ,&nbsp;Elizabeth S. Stonesifer ,&nbsp;Alison Faust","doi":"10.1016/j.liver.2024.100257","DOIUrl":"10.1016/j.liver.2024.100257","url":null,"abstract":"<div><div>Trans arterial chemoembolization (TACE) is the most frequently utilized locoregional therapy for patients with hepatocellular carcinoma (HCC). The reported evidence has been mixed regarding outcomes in patients with decompensated cirrhosis who undergo TACE. The aim of our study was to evaluate the clinical outcomes of patients with cirrhosis and HCC that underwent TACE procedures while awaiting liver transplantation. This was a retrospective cohort study of patients listed for transplant between February 2018 and April 2022. We analyzed 74 patients that had a total of 171 TACE procedures, and defined outcomes within 90 days of TACE in four categorical levels as follows: clinical stability/improvement (1), worsening of liver functioning (2), hospitalization (3), and death or delisting (4). The primary statistical analysis was based on multinomial modeling of this categorical outcome. Patients with decompensated liver function at the time of TACE had odds of being hospitalized within 90 days of the TACE procedure that were 8 times higher than those with compensated liver function (p=0.007). Patients with albumin &lt;3 g/dL or bilirubin &gt;3mg/dL were more likely to experience poor outcomes within 90 days following TACE. There was no statistically significant difference in death and delisting after TACE between patients with compensated and decompensated liver function, though the sample size in this outcome was small.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation for hepatocellular carcinoma with stem cell features in an adult patient","authors":"Kymentie Ferdinande ,&nbsp;Anne Hoorens ,&nbsp;Christine Sempoux ,&nbsp;Simon Meganck ,&nbsp;Hasan Eker ,&nbsp;Michael Saerens ,&nbsp;Siebe Loontiens ,&nbsp;Joni Van Der Meulen ,&nbsp;Sarah Raevens ,&nbsp;Xavier Verhelst ,&nbsp;Anja Geerts ,&nbsp;Helena Degroote ,&nbsp;Hans Van Vlierberghe","doi":"10.1016/j.liver.2024.100255","DOIUrl":"10.1016/j.liver.2024.100255","url":null,"abstract":"<div><div>A 32-year-old female patient presented with a liver mass of unknown origin. The alpha-fetoprotein was markedly elevated up to 142 300 µg/L. MRI of the liver documented a bulky lobulated lesion in the right liver lobe with diameters of 11.7 × 12 × 12.6 cm with multiple satellite lesions. Staging revealed no extrahepatic metastases. Histological examination was consistent with a hepatocellular carcinoma (HCC) with stem cell features, a rare but distinct subtype of HCC with gene expression pattern similar to fetal hepatoblasts. Because of overlapping features with hepatoblastoma she was treated according to the Pediatric Hepatic Malignancy International Therapeutic Trial protocol and received induction chemotherapy with cisplatin and doxorubicin. Due to persistent involvement of the portal vein, surgical R0 resection was impossible after 6 cycles of chemotherapy, despite radiological downstaging. After multidisciplinary consultation our patient underwent a liver transplantation. Nine months after liver transplantation, a solitary pulmonary metastasis was observed necessitating wedge resection. However, &gt;2 years after liver transplantation, the patient remains recurrence-free according to the latest available data.</div><div>This is the first report of an adult patient treated for HCC with stem cell features with a liver transplant beyond the Milan criteria. This case demonstrates that early liver transplantation should be considered in adult patients with highly aggressive subtypes of HCC.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized immunosuppressive protocol to prevent rejection under immunotherapy for post liver transplantation HCC recurrence: A French center's experience","authors":"Héloïse Giudicelli ,&nbsp;Filomena Conti ,&nbsp;Olivier Scatton ,&nbsp;Dominique Thabut ,&nbsp;Manon Allaire","doi":"10.1016/j.liver.2024.100252","DOIUrl":"10.1016/j.liver.2024.100252","url":null,"abstract":"<div><div>In current guidelines, liver transplantation (LT) should be considered in patients with early-stage hepatocellular carcinoma (HCC) because of their lower risk of recurrence and excellent long-term overall survival (OS). To broaden curative opportunities in intermediate and advanced HCC, downstaging strategies are emerging and associated with similar OS compared to patients initially meeting LT criteria. These strategies may however expose these patients to higher HCC recurrence risk. HCC recurrence post LT is essentially metastatic and extrahepatic, and these patients’ prognosis is very poor. The treatments used in this case are tyrosine kinase inhibitors (TKIs) with a low response rate and bad tolerance. If immunotherapy is the new standard of care for advanced and metastatic HCC, scarce data about their administration in liver transplanted recipients in case of HCC recurrence are available. As immunosuppressive (IS) treatment and immunotherapy agents share common targets, utilization of immunotherapy in liver recipients remains complex and exposes patients to acute cellular rejection (ACR). We would like to share in this letter our center experience with eight patients that received immunotherapy post LT as long as a standardized specific IS regimen that aims to lower ACR risk and allow immunotherapy to be effective.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive models for post-liver transplant survival using machine learning techniques in three critical time intervals","authors":"Aref Abdollahzade ,&nbsp;Hoda Rahimi ,&nbsp;Amir Mahmoud Ahmadzade ,&nbsp;Farnaz Khoshrounejad ,&nbsp;Atefeh Rahimi ,&nbsp;Hossein Jamalirad ,&nbsp;Saeid Eslami ,&nbsp;Mohsen Aliakbarian ,&nbsp;Rozita Khodashahi","doi":"10.1016/j.liver.2024.100253","DOIUrl":"10.1016/j.liver.2024.100253","url":null,"abstract":"<div><h3>Background</h3><div>Liver transplantation is critical for end-stage liver disease, but limited donor availability necessitates prioritizing patients on waiting lists. Predictive models like the Model for End-stage Liver Disease (MELD) are used for organ allocation and survival probabilities, but MELD's effectiveness is debated. This study aimed to develop machine learning models to predict postoperative survival at 1-month, 3-month, and 1-year intervals using preoperative data.</div></div><div><h3>Methods</h3><div>The dataset, after excluding missing or invalid data, comprised 454 patients with 52 features each. Leave-One-Out cross-validation was used to address data imbalance. K-Nearest Neighbor imputation handled missing values, ensuring robustness. Feature selection was performed using Decision Trees (DT) and Random Forests (RF), incorporating both clinically used and new features.</div><div>Various algorithms were evaluated, including DT, RF, Logistic Regression, Gaussian Naive Bayes (GuassianNB), and Linear Discriminant (LD) Analysis, to predict survival outcomes.</div></div><div><h3>Results</h3><div>indicated that DT outperformed other feature selection methods, while GuassianNB excelled in predicting 1-year survival with an area under the curve of 0.61, a sensitivity of 0.98, and an F1-score of 0.89, demonstrating superior discrimination power. The LD model combined with RF feature selection was superior for 1-month and 3-month predictions. Additionally, a performance comparison of models for 1-year survival using MELD features and various selection methods was analyzed.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that advanced machine learning models, particularly GuassianNB and LD Analysis with robust feature selection methods, can improve the prediction of postoperative survival in liver transplant patients. These findings could lead to better patient prioritization and outcomes in liver transplantation.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100253"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of Hepatitis B Core Antibody and nucleic acid testing positive organs in safe and effective in Hepatitis B naïve liver transplant recipients","authors":"Julie Giannini ,&nbsp;Stephanie Hamel ,&nbsp;Jenna Lawson ,&nbsp;Kimberly Bone ,&nbsp;Jinyuan Liu ,&nbsp;Manhal Izzy ,&nbsp;Seth Karp ,&nbsp;Martin Montenovo ,&nbsp;Alexandra Shingina","doi":"10.1016/j.liver.2024.100254","DOIUrl":"10.1016/j.liver.2024.100254","url":null,"abstract":"<div><div>Our objective was to examine the outcomes of transplanting Hepatitis B Virus nucleic acid test positive organs (HBV NAT+) and HBcAb+ NAT negative (HBV NAT-) organs into HBV seronegative(HBV-) recipients. We chose to evaluate NAT+ organs since NAT is highly sensitive and specific for viral nucleic acid, amplifying a targeted region of viral ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) and detecting HBV earlier than other screening methods. This study is a retrospective review of patients who were HBV- recipients of HBV NAT+ or HBcAb+ NAT- organs. Primary outcomes include patient and graft survival. Secondary outcomes were manifestations of HBV, including HBV viremia and viral clearance. There were 15 HBV NAT+ recipients and 68 HBcAb+ NAT- recipients who were evaluated for a mean period of 2.6 years and 4.2 years, respectively. Patient survival rates of the HBV NAT+ and HBcAb+ NAT- groups were 92.9 %/92.6 % at 6 months and 1 year (<em>p</em> = 0.97) and 85.7 %/90.7 % at 3 years (<em>p</em> = 0.64). Graft survival rates were 85.7 %/92.6 % at 6 months and 1 year (<em>p</em> = 0.52), and 78.6 %/90.7 % at 3 years (<em>p</em> = 0.33). None of the patient deaths or graft failures were related to HBV. HBV viremia developed in 43 %/19 % recipients (<em>p</em> = 0.12) but viral clearance was observed in 67 %/60 % patients (<em>p</em> = 0.81). There was no statistically significant difference in patient and graft survival when comparing outcomes of HBV NAT+ and HBcAb+ NAT- LT. It may be safe to use these grafts for transplantation into HBV- recipients.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100254"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of donor-recipient weight ratios on outcomes after pediatric deceased donor whole-liver transplantation","authors":"Patrick B. McGeoghegan ,&nbsp;John J. Miggins ,&nbsp;Megan Crawford ,&nbsp;Evert Sugarbaker ,&nbsp;Abbas Rana","doi":"10.1016/j.liver.2024.100249","DOIUrl":"10.1016/j.liver.2024.100249","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;It has been shown that recipients receiving grafts from both undersized and oversized donors have worse clinical outcomes. However, donor-recipient size (DR) mismatch is an understudied metric in pediatric whole-liver deceased donor liver transplantation (DDLT). Here, we analyzed the utility of both DR weight ratio (WR) and body surface area ratio (BSAR) in predicting outcomes among all pediatric whole-liver DDLT recipients. We also performed subgroup analyses for patients with biliary atresia (BA) as well as for other diagnoses with ascites to evaluate these ratios’ utility among patients with increased abdominal domain.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We evaluated all pediatric patients undergoing primary whole-liver DDLT within the UNOS database from 3/1/2002–1/23/2023. We identified 5286 patients &lt;18 years old and divided them into five groups based on increasing DR weight ratios (WRs) and body surface area ratios (BSARs) (&lt;10th percentile, 10th–20th percentile, 20th–80th percentile [reference], 80th–90th percentile, and &gt;90th percentile). Subgroup analyses were performed for patients with BA and other diagnoses with ascites. Chi-square tests were also used to compare patients with and without BA. A Cox proportional hazards model adjusted for both donor and recipient factors was used to identify associations between WR and BSAR percentiles and graft survival, patient survival, and length of stay (LOS). Kaplan–Meier curves and log-rank test were used to compare each of the time-to-event outcomes among the percentiles.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In multivariable analysis, both WR and BSAR impacted clinical outcomes. However, WR remains to be explored in pediatric transplant and is easier to calculate. We therefore focused our analysis on WR.&lt;/div&gt;&lt;div&gt;The &lt;10th WR percentile (WR ≤ 0.70) and &gt;90th WR percentile (WR &gt; 2.0) were associated with increased hazard of graft failure and death. The &lt;10th percentile WR hazard ratio (HR) for graft survival was 1.45 (95 % confidence interval [CI] 1.12, 1.87, &lt;em&gt;p =&lt;/em&gt; 0.004). The &gt;90th percentile WR for graft survival was 1.61 (95 % CI 1.22, 2.13, &lt;em&gt;p =&lt;/em&gt; 0.001). Bottom 10th WR percentile for patient survival was 1.46 (95 % CI 1.14, 1.88, &lt;em&gt;p =&lt;/em&gt; 0.01), while the &gt;90th WR for patient survival was 1.54 (95 % CI 1.28, 2.23, &lt;em&gt;p&lt;/em&gt; &lt; 0.001). Only the &gt;90th percentile WR (HR 0.86, 95 % CI 0.77, 0.96, &lt;em&gt;p =&lt;/em&gt; 0.007) was associated with increased LOS.&lt;/div&gt;&lt;div&gt;The relationship between WR and outcomes did not hold in patients with BA or in other diagnoses with ascites (&lt;em&gt;p&lt;/em&gt; &gt; 0.05).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;DR WR is a significant predictor of adverse outcomes in pediatric whole-liver DDLT recipients, and WR is a superior metric to BSAR. The utility of size-matching metrics is decreased in patients with BA or significant ascites. Transplant surgeons should exercise caution if they encounter ","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning technique for automatic liver and liver tumor segmentation in CT images","authors":"Gowda N Yashaswini ,&nbsp;R.V. Manjunath ,&nbsp;B Shubha ,&nbsp;Punya Prabha ,&nbsp;N Aishwarya ,&nbsp;H M Manu","doi":"10.1016/j.liver.2024.100251","DOIUrl":"10.1016/j.liver.2024.100251","url":null,"abstract":"<div><div>Segmenting the liver and tumors from computed tomography (CT) scans is crucial for medical studies utilizing machine and deep learning techniques. Semantic segmentation, a critical step in this process, is accomplished effectively using fully convolutional neural networks (CNNs). Most Popular networks like UNet and ResUNet leverage diverse resolution features through meticulous planning of convolutional layers and skip connections. This study introduces an automated system employing different convolutional layers that automatically extract features and preserve the spatial information of each feature. In this study, we employed both UNet and a modified Residual UNet on the 3Dircadb (3D Image Reconstruction for computer Assisted Diagnosis database) dataset to segment the liver and tumor. The ResUNet model achieved remarkable results with a Dice Similarity Coefficient of <strong>91.44%</strong> for liver segmentation and <strong>75.84%</strong> for tumor segmentation on 128 × 128 pixel images. These findings validate the effectiveness of the developed models. Notably both models exhibited excellent performance in tumor segmentation. The primary goal of this paper is to utilize deep learning algorithms for liver and tumor segmentation, assessing the model using metrics such as the Dice Similarity Coefficient, accuracy, and precision.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}