Arthrosis of the thumb carpometacarpal joint is a very common, and often debilitating, affliction of postmenopausal women. Coexistent pathologic conditions are frequent. A thorough history and physical examination should lead the physician to an accurate diagnosis. Radiographs support the clinical suspicion and guide the treatment plan. Most patients, regardless of the severity of degeneration, will benefit from a conservative approach. However, when conservative management fails to relieve the patient’s symptoms adequately, surgical intervention is indicated. A plethora of surgical options are available, and controversy exists regarding the most effective surgical approach. Regardless of the technique used, one can usually expect pain relief, improved strength, and an overall increase in function. Therefore, satisfaction rates are high when surgery is performed on properly selected patients and associated conditions are addressed.