Pain Forum最新文献

{"title":"Understanding of cerebral processing of human pain (II) by source modeling of laser-evoked potentials in conjunction with neuroimaging","authors":"Andrew C.N. Chen ,&nbsp;Lars Arendt-Nielsen ,&nbsp;Leon Plaghki","doi":"10.1016/S1082-3174(98)80009-3","DOIUrl":"10.1016/S1082-3174(98)80009-3","url":null,"abstract":"<div><p>Our current positions (Focus articles I and II) regarding the cerebral processing of human pain in the research of LEPs are the following:</p><ul><li><span>1.</span><span><p>Discrete, repeated sensory stimulation in evoked potential research, including laser stimulation in LEPs, is not a usual, natural experience, but an artificial convenience for probing into the window of human brain function.</p></span></li><li><span>2.</span><span><p>LEP methodology requires fundamental standardization.</p></span></li><li><span>3.</span><span><p>LEPs largely reflected neural pathways associated with some aspects of nociceptive processing (the LEPs focused on are those arising from activation of A-δ fibers).</p></span></li><li><span>4.</span><span><p>LEPs, in some circumstances, may dissociate from pain perception.</p></span></li><li><span>5.</span><span><p>Absence of evidence is not evidence of absence. Some neural events (eg, silent generators) and other biophysical constraints (eg, scalp smearing of cortical potentials) can occur. Consequently, no detectable trace of neural activity as ensured in the cortex or at the scalp. Thus, LEPs can never be used to validate the absence of nociception/pain in a person.</p></span></li><li><span>6.</span><span><p>Conversely, non-nociceptive events can influence some aspects of LEPs. Thus, interpretation of LEPs demands full control and understanding of the experimental conditions.</p></span></li><li><span>7.</span><span><p>LEPs attributes are likely to reflect the sensory—discriminatory dimension, but are not sufficient for equating the full multidimensional aspects of human pain.</p></span></li><li><span>8.</span><span><p>The pain experience can be correlated with changes of the amplitudes/latencies in LEPs; but it is not true to state that pain can be inversely inferred from the parameters of the LEPs since other nonpain-related factors can also, simultaneously, affect the LEPs.</p></span></li><li><span>9.</span><span><p>Exploration of the nociceptive processing using LEPs requires quantification of the temporospatial dynamics of the topographic brain activities.</p></span></li><li><span>10.</span><span><p>The precision of measuring the brain topography associated with human pain requires high-resolution EEG (&gt;64 channel), based on the spatial sampling principle (the shallow generators and refined small focal activation demand higher density of electrode arrays than the deep generators; detection of tangent generators demand different assumptions than the radial generators).</p></span></li><li><span>11.</span><span><p>Equivalent current dipole modeling is useful, it can be approximated by the spherical model, but requires the realistic epilloid head model coregistered with MRI for concise analysis.</p></span></li><li><span>12.</span><span><p>Without proper MRI coregistration, the isolated dipole parameters should be reported in the coordinate terms only, and not anatomic attribution.</p></span></li><li><spa","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"7 4","pages":"Pages 221-230"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(98)80009-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90518616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}