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Respiratory Medicine: COPD Update最新文献

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An introduction to conducting COPD exacerbation research 进行COPD恶化研究的介绍
Respiratory Medicine: COPD Update
Pub Date : 2009-05-01 DOI: 10.1016/j.rmedu.2009.06.001
John R. Hurst, Jadwiga A. Wedzicha
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引用次数: 1
The Expert - E-Interview: Professor Wisia Wedzicha 专家访谈:Wisia Wedzicha教授
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.01.003
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引用次数: 0
Do patients with Gastro oesophageal reflux disease (GORD) symptoms have an increased incidence of Chronic obstructive pulmonary disease (COPD) exacerbations? 有胃食管反流病(GORD)症状的患者慢性阻塞性肺疾病(COPD)恶化的发生率增加吗?
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.02.004
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引用次数: 0
Should we use the lower limit of normal (LLN) of FEV1/FVC ratio for the classification of airway obstruction? 是否应以FEV1/FVC比值的正常下限(LLN)作为气道阻塞的分类标准?
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.02.003
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引用次数: 0
Are beta-blockers good for COPD patients? -受体阻滞剂对慢性阻塞性肺病患者有益吗?
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.02.002
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引用次数: 0
Reviews: Self-Assessment Questions 回顾:自我评估问题
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.02.010
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引用次数: 0
ERS 2008 Conference Report ERS 2008会议报告
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.01.004
G. Rohde
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引用次数: 0
Skeletal muscle dysfunction in chronic obstructive pulmonary disease 慢性阻塞性肺疾病的骨骼肌功能障碍
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.01.002
Dinesh Shrikrishna, Nicholas S. Hopkinson

Skeletal muscle dysfunction is considered to be one of the key systemic co-morbidities in chronic obstructive pulmonary disease (COPD) influencing exercise capacity and quality of life. The loss of skeletal muscle bulk and skeletal muscle strength are now recognised as important predictors of mortality in this patient group. The mechanisms involved in the development of muscle weakness are likely to be multifactorial, and systemic factors including inflammation and oxidative stress are thought to interact with local factors such as muscle inactivity. A greater understanding of the molecular pathways involved in muscle weakness may provide target areas for future treatments as an adjunct to pulmonary rehabilitation, which remains the mainstay of current therapy. Further research is required to increase and sustain the benefits of pulmonary rehabilitation and to develop novel interventions for this chronic, debilitating condition.

骨骼肌功能障碍被认为是慢性阻塞性肺疾病(COPD)影响运动能力和生活质量的关键全身性合并症之一。骨骼肌体积和骨骼肌力量的损失现在被认为是该患者组死亡率的重要预测因素。肌肉无力发生的机制可能是多因素的，包括炎症和氧化应激在内的全身性因素被认为与肌肉缺乏活动等局部因素相互作用。对肌肉无力分子通路的更深入了解可能为未来的治疗提供靶点区域，作为肺部康复的辅助治疗，这仍然是当前治疗的主要内容。需要进一步的研究来增加和维持肺部康复的益处，并为这种慢性衰弱疾病开发新的干预措施。
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引用次数: 298
Are depression and anxiety independent predictors of COPD exacerbations and hospitalisations? 抑郁和焦虑是COPD恶化和住院的独立预测因素吗?
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.02.007
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引用次数: 0
Are patients with airflow obstruction and emphysema at a higher risk of developing lung cancer? 气流阻塞和肺气肿患者患肺癌的风险更高吗?
Respiratory Medicine: COPD Update
Pub Date : 2009-02-01 DOI: 10.1016/j.rmedu.2009.02.006
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引用次数: 0
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