首页 > 最新文献

Revista Brasileira de Reumatologia (English Edition)最新文献

英文 中文
Disseminated histoplamosis in adolescent mimicking granulomatosis with polyangiitis 青少年弥散性组织浆状菌病与肉芽肿病合并多血管炎相似
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2015.01.003
Marlon van Weelden , Gabriela R. Viola , Katia T. Kozu , Nadia E. Aikawa , Claudia M. Ivo , Clovis A. Silva
{"title":"Disseminated histoplamosis in adolescent mimicking granulomatosis with polyangiitis","authors":"Marlon van Weelden , Gabriela R. Viola , Katia T. Kozu , Nadia E. Aikawa , Claudia M. Ivo , Clovis A. Silva","doi":"10.1016/j.rbre.2015.01.003","DOIUrl":"10.1016/j.rbre.2015.01.003","url":null,"abstract":"","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 479-482"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2015.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35515222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Whipple's disease manifested as difficult-to-diagnose polyarthralgia: a case report and literature review 惠普尔病表现为难以诊断的多关节痛:1例报告及文献复习
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2015.05.003
Guilherme Almeida Rosa da Silva, José Soares Pires Neto
{"title":"Whipple's disease manifested as difficult-to-diagnose polyarthralgia: a case report and literature review","authors":"Guilherme Almeida Rosa da Silva, José Soares Pires Neto","doi":"10.1016/j.rbre.2015.05.003","DOIUrl":"10.1016/j.rbre.2015.05.003","url":null,"abstract":"","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 483-486"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2015.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35515223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Association of vascular function and estimated cardiovascular risk in patients with rheumatoid arthritis 类风湿关节炎患者血管功能与心血管风险的关系
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2017.06.001
Herwig Pieringer , Erich Pohanka , Rudolf Puchner , Tobias Brummaier

Objectives

Rheumatoid arthritis (RA) patients should receive cardiovascular (CV) risk assessment. For this purpose CV risk calculators are available. In addition, parameters of vascular function can be measured and used for risk prediction. Aim of the present study was to assess the association of these two concepts.

Methods

287 RA patients (58.4 ± 12.6 years) and 232 controls (49.9 ± 13.4 years) were included in this cross-sectional study. We calculated 10 year CV risk with SCORE and QRISK2. For SCORE we used the recommended multiplier of 1.5 in eligible RA patients and estimated the risk also in patients younger than 40 years (mSCORE (0–65)). Augmentation index (AIx) and central pulse pressure (PP), markers of vascular integrity and CV risk, were assessed by pulse wave analysis (PWA). Primary endpoint was the correlation of AIx and the estimated CV risk using mSCORE (0–65).

Results

In RA patients AIx showed a statistically significant correlation with mSCORE (0–65) (rho = 0.3374; p < 0.0001) and QRISK2 (rho = 0.3307; p < 0.0001). The correlations of central PP with mSCORE (0–65) (rho = 0.4692; p < 0.0001) and QRISK2 (rho = 0.5828; p < 0.0001) were also statistically significant. Increasing quartiles of central PP were associated with an increased odds of being in the “high risk” category according to SCORE (OR 2.18; 95% CI 1.58–3.01) or QRISK2 (OR 2.18; 95% CI 1.75–2.72). In control patients we also found a correlation of AIx and central PP with SCORE (0–65) and QRISK2.

Conclusions

Parameters of central haemodynamics correlate with calculated CV risk. However, both do not give exactly the same information. The question arises whether a combination of both concepts would result in an improved CV risk prediction.

目的类风湿关节炎(RA)患者应接受心血管(CV)风险评估。为此,CV风险计算器是可用的。此外,可以测量血管功能参数,并用于风险预测。本研究的目的是评估这两个概念的关联。方法本横断面研究纳入287例RA患者(58.4±12.6年)和232例对照组(49.9±13.4年)。我们用SCORE和QRISK2计算10年CV风险。对于SCORE,我们在符合条件的RA患者中使用推荐的乘数1.5,并估计年龄小于40岁的患者的风险(mSCORE(0-65))。通过脉搏波分析(PWA)评估血管完整性和心血管风险指标增强指数(AIx)和中心脉压(PP)。主要终点是AIx与mSCORE(0-65)估计CV风险的相关性。结果RA患者的AIx与mSCORE(0 ~ 65)的相关性有统计学意义(rho = 0.3374;p & lt;0.0001)和QRISK2 (rho = 0.3307;p & lt;0.0001)。中心PP与mSCORE(0-65)的相关性(rho = 0.4692;p & lt;0.0001)和QRISK2 (rho = 0.5828;p & lt;0.0001)也具有统计学意义。根据SCORE,中心PP的四分位数增加与“高风险”类别的几率增加相关(OR 2.18;95% CI 1.58-3.01)或QRISK2 (or 2.18;95% ci 1.75-2.72)。在对照患者中,我们还发现AIx和中心PP与SCORE(0-65)和QRISK2相关。结论中心血流动力学参数与计算的CV风险相关。然而,两者给出的信息并不完全相同。问题是这两个概念的结合是否会导致心血管风险预测的改进。
{"title":"Association of vascular function and estimated cardiovascular risk in patients with rheumatoid arthritis","authors":"Herwig Pieringer ,&nbsp;Erich Pohanka ,&nbsp;Rudolf Puchner ,&nbsp;Tobias Brummaier","doi":"10.1016/j.rbre.2017.06.001","DOIUrl":"10.1016/j.rbre.2017.06.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Rheumatoid arthritis (RA) patients should receive cardiovascular (CV) risk assessment. For this purpose CV risk calculators are available. In addition, parameters of vascular function can be measured and used for risk prediction. Aim of the present study was to assess the association of these two concepts.</p></div><div><h3>Methods</h3><p>287 RA patients (58.4<!--> <!-->±<!--> <!-->12.6 years) and 232 controls (49.9<!--> <!-->±<!--> <!-->13.4 years) were included in this cross-sectional study. We calculated 10 year CV risk with SCORE and QRISK2. For SCORE we used the recommended multiplier of 1.5 in eligible RA patients and estimated the risk also in patients younger than 40 years (mSCORE (0–65)). Augmentation index (AIx) and central pulse pressure (PP), markers of vascular integrity and CV risk, were assessed by pulse wave analysis (PWA). Primary endpoint was the correlation of AIx and the estimated CV risk using mSCORE (0–65).</p></div><div><h3>Results</h3><p>In RA patients AIx showed a statistically significant correlation with mSCORE (0–65) (rho<!--> <!-->=<!--> <!-->0.3374; <em>p</em> <!-->&lt;<!--> <!-->0.0001) and QRISK2 (rho<!--> <!-->=<!--> <!-->0.3307; <em>p</em> <!-->&lt;<!--> <!-->0.0001). The correlations of central PP with mSCORE (0–65) (rho<!--> <!-->=<!--> <!-->0.4692; <em>p</em> <!-->&lt;<!--> <!-->0.0001) and QRISK2 (rho<!--> <!-->=<!--> <!-->0.5828; <em>p</em> <!-->&lt;<!--> <!-->0.0001) were also statistically significant. Increasing quartiles of central PP were associated with an increased odds of being in the “high risk” category according to SCORE (OR 2.18; 95% CI 1.58–3.01) or QRISK2 (OR 2.18; 95% CI 1.75–2.72). In control patients we also found a correlation of AIx and central PP with SCORE (0–65) and QRISK2.</p></div><div><h3>Conclusions</h3><p>Parameters of central haemodynamics correlate with calculated CV risk. However, both do not give exactly the same information. The question arises whether a combination of both concepts would result in an improved CV risk prediction.</p></div>","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 452-460"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2017.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35148377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring fatigue with multiple instruments in a Brazilian cohort of early rheumatoid arthritis patients 用多种仪器测量巴西早期类风湿关节炎患者的疲劳
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2017.05.004
Leonardo Rios Diniz , Sandor Balsamo , Talita Yokoy de Souza , Luciana Feitosa Muniz , Wagner Rodrigues Martins , Licia Maria Henrique da Mota

Objective

To assess the prevalence of fatigue in a Brazilian population with early rheumatoid arthritis using multiple instruments, and the predictors of these instruments by differents independent variables.

Methods

Cross-sectional study with direct interview and medical records review. Fatigue, dependent variable, was assessed using eight instruments: Profile of Mood States (POMS), Multidimensional Assessment of Fatigue scale (MAF), Fatigue Severity Scale (FSS), Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAF-MDQ), Numerical Rating Scales (BRAF-NRS), Short-form Survey 36 (SF-36), Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F) and Visual Analogic Scale for Fatigue (VASf). Independent variables: sociodemographic, clinical and serological, were measured using medical records and direct interview. Disability and disease activity were assessed using the Health Assessment Questionnaire (HAQ) and disease activity assessed using the Disease Activity Score 28 joints (DAS28). The scores of scales demonstrated the level of fatigue and multiple linear regression method used in statistical analysis to demonstrate prediction models.

Results

A total of 80 patients was assessed, and 57 reported clinically relevant fatigue (VASf > 2), representing 71.25% prevalence point (51 women [89.5%], mean age 48.35 ± 15 years, and mean disease duration of 4.92 ± 3.8 years). Eight predictive models showed statistical significance, one for each fatigue instrument. The highest coefficient of determination (R2) was 56% for SF-36 and the lowest (R2 = 21%) for FSS. The HAQ was the only independent variable to predict fatigue on all instruments.

Conclusion

Clinically relevant fatigue is a highly prevalent symptom and is mostly predicted by disability and age in the population assessed.

目的使用多种工具评估巴西早期类风湿关节炎人群的疲劳患病率,以及不同自变量对这些工具的预测。方法采用直接访谈法和病历法进行横断面研究。疲劳作为因变量,采用8种工具进行评估:情绪状态谱(POMS)、疲劳多维评估量表(MAF)、疲劳严重程度量表(FSS)、布里斯托尔类风湿性关节炎疲劳多维问卷(BRAF-MDQ)、数值评定量表(BRAF-NRS)、短表调查36 (SF-36)、慢性疾病治疗功能评估疲劳量表(FACIT-F)和疲劳视觉模拟量表(VASf)。独立变量:社会人口学、临床和血清学,采用医疗记录和直接访谈进行测量。使用健康评估问卷(HAQ)评估残疾和疾病活动性,使用疾病活动评分28关节(DAS28)评估疾病活动性。量表得分证明了疲劳水平,多元线性回归方法用于统计分析来证明预测模型。结果共评估了80例患者,其中57例报告临床相关疲劳(VASf >2),占71.25%的患病率点(女性51例[89.5%],平均年龄48.35±15岁,平均病程4.92±3.8年)。8个预测模型均具有统计学意义,每个疲劳仪器各1个。SF-36的决定系数最高(R2 = 56%), FSS的决定系数最低(R2 = 21%)。HAQ是预测所有仪器疲劳的唯一独立变量。结论临床相关性疲劳是一种非常普遍的症状,主要由残疾和年龄预测。
{"title":"Measuring fatigue with multiple instruments in a Brazilian cohort of early rheumatoid arthritis patients","authors":"Leonardo Rios Diniz ,&nbsp;Sandor Balsamo ,&nbsp;Talita Yokoy de Souza ,&nbsp;Luciana Feitosa Muniz ,&nbsp;Wagner Rodrigues Martins ,&nbsp;Licia Maria Henrique da Mota","doi":"10.1016/j.rbre.2017.05.004","DOIUrl":"10.1016/j.rbre.2017.05.004","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the prevalence of fatigue in a Brazilian population with early rheumatoid arthritis using multiple instruments, and the predictors of these instruments by differents independent variables.</p></div><div><h3>Methods</h3><p>Cross-sectional study with direct interview and medical records review. Fatigue, dependent variable, was assessed using eight instruments: Profile of Mood States (POMS), Multidimensional Assessment of Fatigue scale (MAF), Fatigue Severity Scale (FSS), Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAF-MDQ), Numerical Rating Scales (BRAF-NRS), Short-form Survey 36 (SF-36), Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F) and Visual Analogic Scale for Fatigue (VASf). Independent variables: sociodemographic, clinical and serological, were measured using medical records and direct interview. Disability and disease activity were assessed using the Health Assessment Questionnaire (HAQ) and disease activity assessed using the Disease Activity Score 28 joints (DAS28). The scores of scales demonstrated the level of fatigue and multiple linear regression method used in statistical analysis to demonstrate prediction models.</p></div><div><h3>Results</h3><p>A total of 80 patients was assessed, and 57 reported clinically relevant fatigue (VASf<!--> <!-->&gt;<!--> <!-->2), representing 71.25% prevalence point (51 women [89.5%], mean age 48.35<!--> <!-->±<!--> <!-->15 years, and mean disease duration of 4.92<!--> <!-->±<!--> <!-->3.8 years). Eight predictive models showed statistical significance, one for each fatigue instrument. The highest coefficient of determination (<em>R</em><sup>2</sup>) was 56% for SF-36 and the lowest (<em>R</em><sup>2</sup> <!-->=<!--> <!-->21%) for FSS. The HAQ was the only independent variable to predict fatigue on all instruments.</p></div><div><h3>Conclusion</h3><p>Clinically relevant fatigue is a highly prevalent symptom and is mostly predicted by disability and age in the population assessed.</p></div>","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 431-437"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2017.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35129971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Back pain and behavioral habits of high school students: a comparative study of two Brazil's regions 中学生背部疼痛与行为习惯:巴西两个地区的比较研究
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2016.07.014
Matias Noll , Priscilla Rayanne e Silva Noll , João Luiz Ribeiro Neto , Vanessa Nunes Leal , Bruna Nichele da Rosa , Cláudia Tarragô Candotti
{"title":"Back pain and behavioral habits of high school students: a comparative study of two Brazil's regions","authors":"Matias Noll ,&nbsp;Priscilla Rayanne e Silva Noll ,&nbsp;João Luiz Ribeiro Neto ,&nbsp;Vanessa Nunes Leal ,&nbsp;Bruna Nichele da Rosa ,&nbsp;Cláudia Tarragô Candotti","doi":"10.1016/j.rbre.2016.07.014","DOIUrl":"10.1016/j.rbre.2016.07.014","url":null,"abstract":"","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 495-499"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2016.07.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35455476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Latent tuberculosis infection screening in juvenile idiopathic arthritis patients preceding anti-TNF therapy in a tuberculosis high-risk country 在一个结核病高风险国家,在抗肿瘤坏死因子治疗前的青少年特发性关节炎患者的潜伏结核感染筛查
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2016.11.004
Juliana Barbosa Brunelli , Karina Rossi Bonfiglioli , Clovis A. Silva , Katia Tomie Kozu , Claudia Goldenstein-Schainberg , Eloisa Bonfa , Nadia Emi Aikawa

Objectives

To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers.

Methods

This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patients were screened for LTBI prior to anti-TNF using tuberculin skin test (TST), chest X-ray and history of exposure to TB. Subjects were regularly followed at 2-month intervals.

Results

Sixty-nine JIA patients with current age of 17.4 ± 5.8 years, mean disease duration of 5.0 ± 4.9 years were included. Forty-seven patients received a single anti-TNF, while 22 patients switched to another anti-TNF once or twice: 57 were treated with etanercepte, 33 patients with adalimumab and 3 infliximab. LTBI screening was positive in three patients: one had TST-positive and history of TB exposure and two had solely TST-positive. No active TB was diagnosed during the study period (median of follow-up was 3.8 years).

Conclusion

Long-term evaluation revealed that LTBI screening and primary prophylaxis before anti-TNF treatment was effective in a high-risk country and TST was the most sensitive parameter to identify these patients.

目的评价在一个结核病流行国家,接受肿瘤坏死因子阻滞剂治疗的JIA患者进行潜伏性结核感染(LTBI)筛查和初级预防的长期疗效。方法这是一个回顾性队列,包括适合抗tnf治疗的JIA患者。在抗肿瘤坏死因子之前,使用结核菌素皮肤试验(TST)、胸部x光片和结核病暴露史筛查患者是否有LTBI。每隔2个月对受试者进行定期随访。结果入选JIA患者69例,年龄17.4±5.8岁,平均病程5.0±4.9年。47名患者接受单一抗tnf治疗,而22名患者一次或两次切换到另一种抗tnf治疗:57名患者接受依那赛普治疗,33名患者接受阿达木单抗治疗,3名患者接受英夫利昔单抗治疗。3例患者LTBI筛查呈阳性:1例tst阳性并有结核暴露史,2例单纯tst阳性。在研究期间未诊断出活动性结核病(中位随访时间为3.8年)。结论长期评估显示,在高风险国家,LTBI筛查和抗tnf治疗前的初级预防是有效的,而TST是识别这些患者最敏感的参数。
{"title":"Latent tuberculosis infection screening in juvenile idiopathic arthritis patients preceding anti-TNF therapy in a tuberculosis high-risk country","authors":"Juliana Barbosa Brunelli ,&nbsp;Karina Rossi Bonfiglioli ,&nbsp;Clovis A. Silva ,&nbsp;Katia Tomie Kozu ,&nbsp;Claudia Goldenstein-Schainberg ,&nbsp;Eloisa Bonfa ,&nbsp;Nadia Emi Aikawa","doi":"10.1016/j.rbre.2016.11.004","DOIUrl":"10.1016/j.rbre.2016.11.004","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers.</p></div><div><h3>Methods</h3><p>This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patients were screened for LTBI prior to anti-TNF using tuberculin skin test (TST), chest X-ray and history of exposure to TB. Subjects were regularly followed at 2-month intervals.</p></div><div><h3>Results</h3><p>Sixty-nine JIA patients with current age of 17.4<!--> <!-->±<!--> <!-->5.8 years, mean disease duration of 5.0<!--> <!-->±<!--> <!-->4.9 years were included. Forty-seven patients received a single anti-TNF, while 22 patients switched to another anti-TNF once or twice: 57 were treated with etanercepte, 33 patients with adalimumab and 3 infliximab. LTBI screening was positive in three patients: one had TST-positive and history of TB exposure and two had solely TST-positive. No active TB was diagnosed during the study period (median of follow-up was 3.8 years).</p></div><div><h3>Conclusion</h3><p>Long-term evaluation revealed that LTBI screening and primary prophylaxis before anti-TNF treatment was effective in a high-risk country and TST was the most sensitive parameter to identify these patients.</p></div>","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 392-396"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2016.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35514779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Coexistence of hypertrophic osteoarthropathy and myelofibrosis 肥厚性骨关节病与骨髓纤维化共存
Pub Date : 2017-09-01 DOI: 10.1016/j.rbre.2014.11.004
Bayram Kelle , Fatih Yıldız , Semra Paydas , Emine Kılıc Bagır , Melek Ergin , Erkan Kozanoglu
{"title":"Coexistence of hypertrophic osteoarthropathy and myelofibrosis","authors":"Bayram Kelle ,&nbsp;Fatih Yıldız ,&nbsp;Semra Paydas ,&nbsp;Emine Kılıc Bagır ,&nbsp;Melek Ergin ,&nbsp;Erkan Kozanoglu","doi":"10.1016/j.rbre.2014.11.004","DOIUrl":"10.1016/j.rbre.2014.11.004","url":null,"abstract":"","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 5","pages":"Pages 472-474"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2014.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35515220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of four serum biomarkers in rheumatoid arthritis: association with extra articular manifestations in patients and arthralgia in relatives 类风湿关节炎的四种血清生物标志物分析:与患者关节外表现和亲属关节痛的关系
Pub Date : 2017-07-01 DOI: 10.1016/j.rbre.2016.03.001
Flávia R. Nass , Thelma L. Skare , Isabela Goeldner , Renato Nisihara , Iara T. Messias-Reason , Shirley R.R. Utiyama

Objectives

To evaluate the frequency of four serum biomarkers in RA patients and their relatives and identify possible associations with clinical findings of the disease.

Methods

This was a transversal analytical study. Anti-cyclic citrullinated peptide (anti-CCP), anti-mutated citrullinated vimentin (anti-MCV) and IgA-rheumatoid factor (RF) were determined by ELISA and IgM-RF by latex agglutination in 210 RA patients, 198 relatives and 92 healthy controls from Southern Brazil. Clinical and demographic data were obtained through charts review and questionnaires.

Results

A higher positivity for all antibodies was observed in RA patients when compared to relatives and controls (p < 0.0001). IgA-RF was more frequent in relatives compared to controls (14.6% vs. 5.4%, p = 0.03, OR = 2.98; 95% CI = 1.11–7.98) whereas anti-CCP was the most common biomarker among RA patients (75.6%). Concomitant positivity for the four biomarkers was more common in patients (46.2%, p < 0.0001). Relatives and controls were mostly positive for just one biomarker (20.2%, p < 0.0001 and 15.2%, p = 0.016, respectively). No association was observed between the number of positive biomarkers and age of disease onset, functional class or tobacco exposure. In seronegative patients predominate absence of extra articular manifestations (EAMs) (p = 0.01; OR = 3.25; 95% CI = 1.16–10.66). Arthralgia was present in positive relatives, regardless the type of biomarker.

Conclusions

A higher number of biomarkers was present in RA patients with EAMs. Positivity of biomarkers was related to arthralgia in relatives. These findings reinforce the link between distinct biomarkers and the pathophysiologic mechanisms of AR.

目的评估四种血清生物标志物在RA患者及其亲属中的频率,并确定其与RA临床表现的可能关联。方法采用横向分析研究。采用ELISA和胶乳凝集法检测巴西南部210例RA患者、198例亲属和92例健康对照者的抗环瓜氨酸肽(anti-CCP)、抗突变瓜氨酸静脉蛋白(anti-MCV)和iga -类风湿因子(RF)水平。临床和人口统计数据通过图表审查和问卷调查获得。结果RA患者所有抗体的阳性率均高于亲属和对照组(p <0.0001)。IgA-RF在亲属中的发生率高于对照组(14.6% vs. 5.4%, p = 0.03, OR = 2.98;95% CI = 1.11-7.98),而抗ccp是RA患者中最常见的生物标志物(75.6%)。这四种生物标志物的同时阳性在患者中更为常见(46.2%,p <0.0001)。亲属和对照组大多只有一种生物标志物呈阳性(20.2%,p <0.0001和15.2%,p = 0.016)。未观察到阳性生物标志物的数量与发病年龄、功能类别或烟草暴露之间的关联。血清阴性患者以无关节外表现(EAMs)为主(p = 0.01;或= 3.25;95% ci = 1.16-10.66)。无论生物标志物类型如何,阳性亲属均存在关节痛。结论eam组RA患者存在较多的生物标志物。生物标志物阳性与亲属关节痛有关。这些发现加强了不同生物标志物与AR病理生理机制之间的联系。
{"title":"Analysis of four serum biomarkers in rheumatoid arthritis: association with extra articular manifestations in patients and arthralgia in relatives","authors":"Flávia R. Nass ,&nbsp;Thelma L. Skare ,&nbsp;Isabela Goeldner ,&nbsp;Renato Nisihara ,&nbsp;Iara T. Messias-Reason ,&nbsp;Shirley R.R. Utiyama","doi":"10.1016/j.rbre.2016.03.001","DOIUrl":"10.1016/j.rbre.2016.03.001","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the frequency of four serum biomarkers in RA patients and their relatives and identify possible associations with clinical findings of the disease.</p></div><div><h3>Methods</h3><p>This was a transversal analytical study. Anti-cyclic citrullinated peptide (anti-CCP), anti-mutated citrullinated vimentin (anti-MCV) and IgA-rheumatoid factor (RF) were determined by ELISA and IgM-RF by latex agglutination in 210 RA patients, 198 relatives and 92 healthy controls from Southern Brazil. Clinical and demographic data were obtained through charts review and questionnaires.</p></div><div><h3>Results</h3><p>A higher positivity for all antibodies was observed in RA patients when compared to relatives and controls (<em>p</em> <!-->&lt;<!--> <!-->0.0001). IgA-RF was more frequent in relatives compared to controls (14.6% vs. 5.4%, <em>p</em> <!-->=<!--> <!-->0.03, OR<!--> <!-->=<!--> <!-->2.98; 95% CI<!--> <!-->=<!--> <!-->1.11–7.98) whereas anti-CCP was the most common biomarker among RA patients (75.6%). Concomitant positivity for the four biomarkers was more common in patients (46.2%, <em>p</em> <!-->&lt;<!--> <!-->0.0001). Relatives and controls were mostly positive for just one biomarker (20.2%, <em>p</em> <!-->&lt;<!--> <!-->0.0001 and 15.2%, <em>p</em> <!-->=<!--> <!-->0.016, respectively). No association was observed between the number of positive biomarkers and age of disease onset, functional class or tobacco exposure. In seronegative patients predominate absence of extra articular manifestations (EAMs) (<em>p</em> <!-->=<!--> <!-->0.01; OR<!--> <!-->=<!--> <!-->3.25; 95% CI<!--> <!-->=<!--> <!-->1.16–10.66). Arthralgia was present in positive relatives, regardless the type of biomarker.</p></div><div><h3>Conclusions</h3><p>A higher number of biomarkers was present in RA patients with EAMs. Positivity of biomarkers was related to arthralgia in relatives. These findings reinforce the link between distinct biomarkers and the pathophysiologic mechanisms of AR.</p></div>","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 4","pages":"Pages 286-293"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2016.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35197619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Prevalence of fibromyalgia: literature review update 纤维肌痛的患病率:最新文献综述
Pub Date : 2017-07-01 DOI: 10.1016/j.rbre.2017.01.005
Amelia Pasqual Marques, Adriana de Sousa do Espírito Santo, Ana Assumpção Berssaneti, Luciana Akemi Matsutani, Susan Lee King Yuan

The present study aimed to update the literature review on the prevalence of fibromyalgia published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of fibromyalgia. Fibromyalgia studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: (A) prevalence of fibromyalgia in the general population; (B) prevalence of fibromyalgia in women; (C) prevalence of fibromyalgia in rural and urban areas; (D) prevalence of fibromyalgia in special populations. The literature shows values of fibromyalgia prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in fibromyalgia prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general.

本研究旨在更新2006年发表的关于纤维肌痛患病率的文献综述。2005 - 2014年对MEDLINE、Web of Science、Embase、LILACS和SciELO数据库进行了文献调查,确定了3274条记录。五名研究人员根据纳入标准选择了研究:获得纤维肌痛患病率的研究。排除纤维肌痛相关疾病的研究。通过题目和摘要筛选,排除了2073篇无关文章。210篇文章的全文被评估为合格,本综述包括39项研究,在41篇文章中描述。选定的研究分为四类:(A)一般人群中纤维肌痛的患病率;(B)女性纤维肌痛的患病率;(C)城乡纤维肌痛患病率;(D)纤维肌痛在特殊人群中的患病率。文献显示,纤维肌痛的患病率在一般人群中为0.2 - 6.6%,在女性中为2.4 - 6.8%,在城市地区为0.7 - 11.4%,在农村地区为0.1 - 5.2%,在特殊人群中为0.6 - 15%。最新的文献综述显示,世界范围内纤维肌痛患病率研究显著增加。新的2010年美国风湿病学会标准尚未被广泛使用,而COPCORD(风湿病控制社区项目)方法已经提高了风湿病流行研究的质量。
{"title":"Prevalence of fibromyalgia: literature review update","authors":"Amelia Pasqual Marques,&nbsp;Adriana de Sousa do Espírito Santo,&nbsp;Ana Assumpção Berssaneti,&nbsp;Luciana Akemi Matsutani,&nbsp;Susan Lee King Yuan","doi":"10.1016/j.rbre.2017.01.005","DOIUrl":"10.1016/j.rbre.2017.01.005","url":null,"abstract":"<div><p>The present study aimed to update the literature review on the prevalence of fibromyalgia published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of fibromyalgia. Fibromyalgia studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: (A) prevalence of fibromyalgia in the general population; (B) prevalence of fibromyalgia in women; (C) prevalence of fibromyalgia in rural and urban areas; (D) prevalence of fibromyalgia in special populations. The literature shows values of fibromyalgia prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in fibromyalgia prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general.</p></div>","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 4","pages":"Pages 356-363"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2017.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35200658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 194
Obesity is the main determinant of insulin resistance more than the circulating pro-inflammatory cytokines levels in rheumatoid arthritis patients 在类风湿关节炎患者中,肥胖是胰岛素抵抗的主要决定因素,而不是循环促炎细胞因子水平
Pub Date : 2017-07-01 DOI: 10.1016/j.rbre.2017.01.008
Jesus Castillo-Hernandez , Martha Imelda Maldonado-Cervantes , Juan Pablo Reyes , Nuria Patiño-Marin , Enrique Maldonado-Cervantes , Claudia Solorzano-Rodriguez , Esperanza de la Cruz Mendoza , Brenda Alvarado-Sanchez

Background

Systemic blockade of TNF-α in Rheumatoid arthritis with insulin resistance seems to produce more improvement in insulin sensitivity in normal weight patients with Rheumatoid arthritis than in obese patients with Rheumatoid arthritis, suggesting that systemic-inflammation and obesity are independent risk factors for insulin resistance in Rheumatoid arthritis patients.

Objectives

To evaluate the insulin resistance in: normal weight patients with Rheumatoid arthritis, overweight patients with Rheumatoid arthritis, obese Rheumatoid arthritis patients, and matched control subjects with normal weight and obesity; and its association with major cytokines involved in the pathogenesis of the disease.

Methods

Assessments included: body mass index, insulin resistance by Homeostasis Model Assessment, ELISA method, and enzymatic colorimetric assay.

Results

Outstanding results from these studies include: (1) In Rheumatoid arthritis patients, insulin resistance was well correlated with body mass index, but not with levels of serum cytokines. In fact, levels of cytokines were similar in all Rheumatoid arthritis patients, regardless of being obese, overweight or normal weight (2) Insulin resistance was significantly higher in Rheumatoid arthritis with normal weight than in normal weight (3) No significant difference was observed between insulin resistances of Rheumatoid arthritis with obesity and obesity (4) As expected, levels of circulating cytokines were significantly higher in Rheumatoid arthritis patients than in obesity.

Conclusions

Obesity appears to be a dominant condition above inflammation to produce IR in RA patients. The dissociation of the inflammation and obesity components to produce IR suggests the need of an independent therapeutic strategy in obese patients with RA.

背景:与肥胖类风湿关节炎患者相比,全身阻断类风湿关节炎伴胰岛素抵抗患者的TNF-α似乎对正常体重的类风湿关节炎患者的胰岛素敏感性有更大的改善,提示全身性炎症和肥胖是类风湿关节炎患者胰岛素抵抗的独立危险因素。目的评价正常体重类风湿关节炎患者、超重类风湿关节炎患者、肥胖类风湿关节炎患者以及正常体重和肥胖对照者的胰岛素抵抗情况;以及它与主要细胞因子在疾病发病机制中的关联。方法评价方法包括:体重指数、胰岛素抵抗、酶联免疫吸附法和酶比色法。结果:①类风湿关节炎患者胰岛素抵抗与体重指数相关,与血清细胞因子水平无关;事实上,无论是肥胖、超重还是正常体重,所有类风湿关节炎患者的细胞因子水平都是相似的(2)正常体重的类风湿关节炎患者的胰岛素抵抗明显高于正常体重的类风湿关节炎患者(3)肥胖和肥胖的类风湿关节炎患者的胰岛素抵抗无显著差异(4)正如预期的那样,类风湿关节炎患者的循环细胞因子水平明显高于肥胖患者。结论肥胖可能是RA患者炎症外产生IR的主要条件。炎症和肥胖成分分离产生IR提示肥胖类风湿性关节炎患者需要一个独立的治疗策略。
{"title":"Obesity is the main determinant of insulin resistance more than the circulating pro-inflammatory cytokines levels in rheumatoid arthritis patients","authors":"Jesus Castillo-Hernandez ,&nbsp;Martha Imelda Maldonado-Cervantes ,&nbsp;Juan Pablo Reyes ,&nbsp;Nuria Patiño-Marin ,&nbsp;Enrique Maldonado-Cervantes ,&nbsp;Claudia Solorzano-Rodriguez ,&nbsp;Esperanza de la Cruz Mendoza ,&nbsp;Brenda Alvarado-Sanchez","doi":"10.1016/j.rbre.2017.01.008","DOIUrl":"10.1016/j.rbre.2017.01.008","url":null,"abstract":"<div><h3>Background</h3><p>Systemic blockade of TNF-α in Rheumatoid arthritis with insulin resistance seems to produce more improvement in insulin sensitivity in normal weight patients with Rheumatoid arthritis than in obese patients with Rheumatoid arthritis, suggesting that systemic-inflammation and obesity are independent risk factors for insulin resistance in Rheumatoid arthritis patients.</p></div><div><h3>Objectives</h3><p>To evaluate the insulin resistance in: normal weight patients with Rheumatoid arthritis, overweight patients with Rheumatoid arthritis, obese Rheumatoid arthritis patients, and matched control subjects with normal weight and obesity; and its association with major cytokines involved in the pathogenesis of the disease.</p></div><div><h3>Methods</h3><p>Assessments included: body mass index, insulin resistance by Homeostasis Model Assessment, ELISA method, and enzymatic colorimetric assay.</p></div><div><h3>Results</h3><p>Outstanding results from these studies include: (1) In Rheumatoid arthritis patients, insulin resistance was well correlated with body mass index, but not with levels of serum cytokines. In fact, levels of cytokines were similar in all Rheumatoid arthritis patients, regardless of being obese, overweight or normal weight (2) Insulin resistance was significantly higher in Rheumatoid arthritis with normal weight than in normal weight (3) No significant difference was observed between insulin resistances of Rheumatoid arthritis with obesity and obesity (4) As expected, levels of circulating cytokines were significantly higher in Rheumatoid arthritis patients than in obesity.</p></div><div><h3>Conclusions</h3><p>Obesity appears to be a dominant condition above inflammation to produce IR in RA patients. The dissociation of the inflammation and obesity components to produce IR suggests the need of an independent therapeutic strategy in obese patients with RA.</p></div>","PeriodicalId":101096,"journal":{"name":"Revista Brasileira de Reumatologia (English Edition)","volume":"57 4","pages":"Pages 320-329"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rbre.2017.01.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35197624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
期刊
Revista Brasileira de Reumatologia (English Edition)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1