Revista da Associa??o Médica Brasileira (English Edition)最新文献

Objective

To review the effects of methylphenidate on cognitive enhancement, memory, and performance in medical students.

Methods

Areview of four databases (LILACS, PubMed, ScienceDirect, and SciELO), analyzing the title and abstract of all articles published between 1990 and 2012 in English, Portuguese, and Spanish. Selected articles were read in entirety, including in the review those that met the established criteria.

Results

The prevalence of use among medical students reached 16%, with no gender dif- ference. Most students began using the drug after entering the university, and the reasons cited to justify it are related to enhancing academic performance.

Conclusion

There is no evidence in the literature that the use of methylphenidate is benefi- cial in terms of memory or learning. The drug simply increases wakefulness and alertness, reducing the time of sleep.

Education plays an important role in diabetes mellitus (DM) treatment, as it enables patients to manage their disease. There is a wide range of tested educational interventions, and, to date, no universal model that can be standardized and recognized as effective for all individuals with the disease has been defined. This article aims to review the effect of different types of educational interventions for self-management of glycemic control in patients with DM type 2, in addition to define general recommendations for this treatment strategy.

Objective

Until the present moment, the lack of efficient therapeutic options available for hyperhidrosis treatment in obese patients has left this population without prospect of clinical or quality of life (QOL) improvements. Outcomes of oxybutynin treatment for overweight and obese patients with hyperhidrosis are unknown. This study aims to investigate the results related to clinical and QOL improvements in this specific population, submitted to a 12-week protocol treatment with oxybutynin.

Methods

559 patients with palmar and axillary hyperhidrosis, routinely followed in this service, were divided into the groups, according to their body mass index (BMI) (< 25 kg/m²; 25 < BMI < 30 kg/m², > 30 kg/m²). Improvements in QOL and in the level of hyperhidrosis were analyzed after 12 weeks of protocol treatment with oxybutynin. These parameters were investigated using a scoring system based on a scientifically validated clinical questionnaire, applied before and after treatment.

Results

67.8% of the overweight sample group and 63% of the obese patients presented “partial” or “great” improvement in the level of hyperhidrosis. Over 65% of patients demonstrated improvement in QOL (“much better” or “slightly better”) for all three groups, with no statistical difference between them. The only adverse event associated with oxybutynin was dry mouth, observed in 63.0% of the patients.

Conclusion

Overweight and obese patients with palmar or axillary hyperhidrosis present significant improvement in QOL after treatment with oxybutynin, and the results are comparable to those of normal weight individuals.

This study reviewed the lipid profile of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients in relation to use of antiretroviral therapy (ART), and its different classes of drugs. A total of 190 articles published in peer-reviewed journals were retrieved from PubMed and LILACS databases; 88 of them met the selection criteria and were included in the review. Patients with HIV/AIDS without ART presented an increase of triglycerides and decreases of total cholesterol, low density lipoprotein (LDL-c), and high density lipoprotein (HDL-c) levels. Distinct ART regimens appear to promote different alterations in lipid metabolism. Protease inhibitors, particularly indinavir and lopinavir, were commonly associated with hypercholesterolemia, high LDL-c, low HDL-c, and hypertriglyceridemia. The protease inhibitor atazanavir is apparently associated with a more advantageous lipid profile. Some nucleoside reverse-transcriptase inhibitors (didanosine, stavudine, and zidovudine) induced lipoatrophy and hypertriglyceridemia, whereas abacavir increased the risk of cardiovascular diseases even in the absence of apparent lipid disorders, and tenofovir resulted in lower levels of cholesterol and triglycerides. Although non-nucleoside reverse-transcriptase inhibitors predisposed to hypertriglyceridemia and hypercholesterolemia, nevirapine was particularly associated with high HDL-c levels, a protective factor against cardiovascular diseases. Therefore, the infection itself, different classes of drugs, and some drugs from the same class of ART appear to exert distinct alterations in lipid metabolism.

Objective

To screen the risk of developing diabetes mellitus type 2 (DM2) in adult individuals.

Methods

Several risk factors for DM2 (sedentary lifestyle, previous coronary artery disease, hyperglycemia-inducing medications, body mass index [BMI], blood pressure, serum triglyceride, and HDL-cholesterol levels) were assessed in 314 adults as a function of gender and age group.

Results

73.2% of the population had two or more concurrent risk factors and 26.8% had less than two factors. The occurrence of risk factors for DM2 development was observed even in young adults, and the risk factors are likely associated with aging. Differences in risk factors and incidence were observed between men and women in the same age group.

Conclusion

Regardless the age studied, the most prevalent risk factors associated with DM2 were: BMI, sedentary lifestyle, and reduced serum HDL-cholesterol, which are modifiable, thus increasing the importance of preventive measures. Discrepancies found in prevalent risk factors in men and women also suggest that sociocultural differences influence the risk of developing DM.

Objective

To verify the correlation between handgrip strength (HGS) and flexibility with age and anthropometric variables in the elderly.

Methods

This was a cross-sectional home-based study of elderly individuals enrolled in the Family Health Strategy of Campina Grande/PB. Gender, age, HGS, flexibility, arm muscle circumference (AMC), corrected arm muscle area (CAMA), and body mass index (BMI) were recorded.

Results

A total of 420 elderly individuals were evaluated. Correlations of HGS with age, AMC and CAMA, in both genders, were observed. BMI correlated with HGS only in females. Flexibility correlated with BMI in males. In the multivariate analysis, age and AMC were predictive variables of the HGS variation in females. In males, age was the only variable predictive of HGS, and BMI was the predictor of flexibility variation.

Conclusion

The results indicate a probable influence of age and anthropometric variables in muscular strength, as well as that of excess weight in flexibility limitation.