Revista Portuguesa de Cardiologia (English Edition)最新文献

英文中文

Applicability of Martin-Hopkins formula and comparison with Friedewald formula for estimated low-density lipoprotein cholesterol in e_COR study population e_COR研究人群低密度脂蛋白胆固醇估算的Martin-Hopkins公式的适用性及与Friedewald公式的比较

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-10-01 DOI: 10.1016/j.repce.2021.07.001

Cátia Ferrinho , Ana Catarina Alves , Mafalda Bourbon , Sequeira Duarte

Introduction

Low-density lipoprotein cholesterol (LDL) is essential in managing cardiovascular disease risk. Since 1972, the Friedewald formula has been used to estimate LDL concentration, although with some limitations. In 2013, Martin et al. proposed a similar but more accurate formula for calculating LDL.

Aim

To assess the applicability of the new formula, which we have named the Martin-Hopkins formula, in the Portuguese population and compare it with the Friedewald formula using direct LDL.

Methods

Cross-sectional study, including 1689 participants from the e_COR study. We applied the Martin-Hopkins and Friedewald formulas for estimated LDL (LDL-M and LDL-F). The Friedewald formula was not applied in 12 cases due to triglycerides ≥400 mg/dL. Direct LDL was measured and the accepted significance level was p<0.05.

Results

Of the total subjects, 50.2% were male and had a median age of 51 (34) years. LDL-D was 117.0 (44.0) mg/dL, LDL-M was 114.6 (43.7) mg/dL and LDL-F was 113.8 (43.2) mg/dL. The Spearman coefficient (ρ) between LDL-M/LDL-D was 0.987 and between LDL-F/LDL-D was 0.983, p=0.001. This strong correlation was maintained in the group with diabetes (LDL-M/LDL-D ρ=0.987; LDL-F/LDL-D ρ=0.978, p=0.001) and hypertriglyceridemia (LDL-M/LDL-D ρ=0.983; LDL-F/LDL-D ρ=0.982, p=0.001). In terms of agreement, the highest value of κ=0.90 was obtained for LDL-M when LDL-D <100 mg/dL.

Conclusion

The Martin-Hopkins formula performed well and had good applicability, showing superiority in relation to the Friedewald formula, especially for LDL-D values <100 mg/dL, diabetes, and hypertriglyceridemia.

低密度脂蛋白胆固醇(LDL)在控制心血管疾病风险中至关重要。自1972年以来，弗里德瓦尔德公式被用于估计LDL浓度，尽管有一些局限性。2013年，Martin等人提出了一个类似但更准确的计算LDL的公式。目的评估新公式(我们将其命名为Martin-Hopkins公式)在葡萄牙人群中的适用性，并将其与使用直接LDL的Friedewald公式进行比较。方法横断面研究，包括来自e_COR研究的1689名参与者。我们应用Martin-Hopkins和Friedewald公式估算LDL (LDL- m和LDL- f)。由于甘油三酯≥400mg /dL, 12例患者未应用Friedewald公式。直接LDL测定，可接受的显著性水平为p<0.05。结果男性占50.2%，中位年龄51(34)岁。LDL-D为117.0 (44.0)mg/dL, LDL-M为114.6 (43.7)mg/dL, LDL-F为113.8 (43.2)mg/dL。LDL-M/LDL-D之间的Spearman系数(ρ)为0.987,LDL-F/LDL-D之间的ρ为0.983,p=0.001。这种强相关性在糖尿病组中保持(LDL-M/LDL-D ρ=0.987;LDL-F/LDL-D ρ=0.978, p=0.001)和高甘油三酯血症(LDL-M/LDL-D ρ=0.983;LDL-F/LDL-D ρ=0.982, p=0.001)。在一致性方面，当LDL-D <100 mg/dL时，LDL-M的κ=0.90达到最大值。结论Martin-Hopkins配方性能较好，适用性较好，在LDL-D值为100mg /dL、糖尿病、高甘油三酯血症等方面优于Friedewald配方。

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引用次数: 1

Beta-blockers in acute coronary syndrome patients: The concept of ‘gradient of benefit’ -受体阻滞剂在急性冠脉综合征患者中的应用:“获益梯度”的概念

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-10-01 DOI: 10.1016/j.repce.2021.10.017

Fernando Montenegro Sá , João Morais

引用次数: 0

Arterial switch operation for transposition of great arteries: Is coronary artery circulation evaluation necessary? 大动脉转位的动脉转换手术:是否有必要进行冠状动脉循环评估?

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-10-01 DOI: 10.1016/j.repce.2021.10.003

António Marinho-da-Silva

引用次数: 0

Diastolic dysfunction and type 1 diabetes: A sweet link? 舒张功能障碍与1型糖尿病:甜蜜的联系?

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-10-01 DOI: 10.1016/j.repce.2021.10.007

José Ribeiro

引用次数: 0

Consensus document on chronic coronary syndrome assessment and risk stratification in Portugal: A position paper statement from the [Portuguese Society of Cardiology’s] Working Groups on Nuclear Cardiology, Magnetic Resonance and Cardiac Computed Tomography, Echocardiography, and Exercise Physiology 关于葡萄牙慢性冠状动脉综合征评估和风险分层的共识文件:来自[葡萄牙心脏病学会]核心脏病学、磁共振和心脏计算机断层扫描、超声心动图和运动生理学工作组的立场文件声明

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-10-01 DOI: 10.1016/j.repce.2021.08.004

N. Bettencourt, Lígia Mendes, J. Fontes, P. Matos, C. Ferreira, A. Botelho, S. Carvalho, A. Durazzo, A. Faustino, R. Ladeiras-Lopes, M. Vasconcelos, C. Vieira, M. Correia, A. Ferreira, N. Ferreira, G. Pires-Morais, A. Almeida, M. Ferreira, M. Teixeira

引用次数: 0

Risk prediction for adverse events in pediatric acute myocarditis: Are we there yet? 儿童急性心肌炎不良事件的风险预测:我们做到了吗?

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-09-01 DOI: 10.1016/j.repce.2021.08.007

Soham Dasgupta

引用次数: 0

Balloon pulmonary angioplasty – welcome to chronic thromboembolic pulmonary hypertension treatment 球囊肺动脉成形术-欢迎慢性血栓栓塞性肺动脉高压治疗

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-09-01 DOI: 10.1016/j.repce.2021.08.009

Nick H. Kim

引用次数: 0

Prognostic impact of high flow nasal cannula compared to noninvasive positive-pressure ventilation in the treatment of acute pulmonary edema 高流量鼻插管与无创正压通气治疗急性肺水肿的预后影响比较

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-09-01 DOI: 10.1016/j.repce.2021.04.006

Williams Hinojosa , Carolina Iglesias , Silvio Vera , Marta Marcos , Aitor Uribarri , Itziar Gómez , Gemma Pastor

引用次数: 0

Could the unfortunate outcome of pediatric acute myocarditis be predicted? Factors contributing to a poor outcome in myocarditis 小儿急性心肌炎的不幸结局可以预测吗?导致心肌炎预后不良的因素

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-09-01 DOI: 10.1016/j.repce.2020.10.020

Stasa Krasic , Sergej Prijic , Sanja Ninic , Dejan Nesic , Bojko Bjelakovic , Gordana Petrovic , Ivana Cerovic , Vladislav Vukomanovic

Objective

Myocarditis has spontaneous resolution in 50% of patients. Our study aimed to define risk factors for developing dilated cardiomyopathy (DCM) and death in pediatric patients with acute myocarditis (AM).

Methods

The retrospective cohort study included all patients with treated AM. The Mother and Child Health Institute from January 2011 to March 2019.

Results

In the study, 62 patients were included, 40 boys and 22 girls (11.15±5.86 years) with AM. Twelve out of sixty-two children had acute fulminant myocarditis. Four patients died in the acute phase of AM, and 11 developed DCM. Follow up was 27.14±36.52 months. Patients with poor outcome (DCM development) were under the age of seven (odds ratio [OR] 10.1; p=0.003), more likely to be girls (OR 4.6; p=0.03), and had fulminant myocarditis (OR 27.0; <0.001). An ejection fraction (EF) <55% and fractional shortening (FS) <30% increased risk of DCM 13- and 5-fold, respectively, but patients with EF between 40 and 55% remain at highest risk of developing DCM. There was a 12-fold increased risk for DCM in patients with left ventricular end-diastolic diameter Z score >2+. The receiver operator curve showed that the lactate dehydrogenase (LDH) cut-off value for developing DCM was 1780 mmol/l (sensitivity 80%, specificity 100%).

Conclusion

Acute fulminant myocarditis was an independent risk factor for DCM. Children with EF between 40 and 50% at admission were at highest risk of developing DCM. Lactate dehydrogenase value could be a significant prognostic value for the outcome of pediatric myocarditis.

目的50%的心肌炎患者可自行痊愈。本研究旨在确定急性心肌炎(AM)患儿发生扩张型心肌病(DCM)和死亡的危险因素。方法回顾性队列研究纳入所有治疗过的AM患者。母亲和儿童健康研究所，2011年1月至2019年3月。结果本组共纳入AM患者62例，男40例，女22例(11.15±5.86岁)。62例患儿中有12例发生急性暴发性心肌炎。AM急性期死亡4例，DCM 11例。随访27.14±36.52个月。预后不良(DCM发展)的患者年龄在7岁以下(优势比[OR] 10.1;p=0.003)，女孩的可能性更大(OR 4.6;p=0.03)，并发暴发性心肌炎(OR 27.0;& lt; 0.001)。射血分数(EF) 55%和分数缩短(FS) 30%分别使DCM的风险增加13倍和5倍，但EF在40 - 55%之间的患者发生DCM的风险仍然最高。左室舒张末期直径Z评分为2+的患者发生DCM的风险增加了12倍。受试者操作曲线显示乳酸脱氢酶(LDH)临界值为1780 mmol/l(敏感性80%，特异性100%)。结论急性暴发性心肌炎是DCM的独立危险因素。入院时EF在40 - 50%之间的儿童发生DCM的风险最高。乳酸脱氢酶值对小儿心肌炎预后有重要的预测价值。

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引用次数: 1

2020 European Society of Cardiology Core Curriculum for the Cardiologist. Is it time for change in the Portuguese cardiology training program? 2020年欧洲心脏病学会心脏病专家核心课程。是时候改变葡萄牙心脏病学培训计划了吗?

Revista Portuguesa de Cardiologia (English Edition)

Pub Date : 2021-09-01 DOI: 10.1016/j.repce.2021.03.010

Kevin Domingues , Lino Gonçalves , Maria João Vidigal , Felix C. Tanner , Miguel Mendes

引用次数: 0

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