R. Najjar-Debbiny, O. Barnett-Griness, J. Khoury, N. Gronich, G. Weber, Yochay Adir, Michal Steinberg, Sonia Shneir, Lokesh Sharma, W. Saliba
BACKGROUND Pulmonary fibrosis is associated with significant morbidity. Data are scarce on the link between COVID-19 and pulmonary fibrosis. We aimed to assess the association between COVID-19 with pulmonary fibrosis. METHODS We conducted a nested case-control study in a cohort of 2,894,801 adults without a diagnosis of pulmonary fibrosis. The underlying cohort consisted of members of the largest healthcare provider in Israel aged 18 years or older as of May 1, 2020. Subjects were followed up from cohort entry until June 30, 2022 for the occurrence of pulmonary fibrosis. Ten randomly selected controls were matched to each case of pulmonary fibrosis on age, sex and calendar time. To account for surveillance bias a lag-time of 60 days was used for ascertainment of prior COVID-19 and COVID-severity. RESULTS During follow-up 1,284 patients were newly diagnosed with pulmonary fibrosis and matched with 12,840 controls. Multivariable conditional logistic-regression models showed that the OR for pulmonary fibrosis was 1.80 (95% CI, 1.47-2.19) in patients with COVID-19 compared to no COVID-19. The multivariable OR for pulmonary fibrosis was 1.33 (1.06-1.68), 2.98 (1.16-7.65), and 9.30 (5.77-14.98) for mild, moderate, and severe COVID-19, respectively, compared to no COVID-19. The magnitude of the association was attenuated but remained statistically significant for severe disease when the lag-time was extended to 180 days; 1.08 (0.78-1.49), 2.37 (0.75-7.46), and 5.34 (2.75-10.36) for mild, moderate, and severe COVID-19, respectively. CONCLUSIONS COVID-19 appears to be associated with an increased risk of pulmonary fibrosis and the magnitude of the association increases with COVID-19 severity.
{"title":"Association between COVID-19 infection and pulmonary fibrosis: a nested case-control study.","authors":"R. Najjar-Debbiny, O. Barnett-Griness, J. Khoury, N. Gronich, G. Weber, Yochay Adir, Michal Steinberg, Sonia Shneir, Lokesh Sharma, W. Saliba","doi":"10.2139/ssrn.4385523","DOIUrl":"https://doi.org/10.2139/ssrn.4385523","url":null,"abstract":"BACKGROUND\u0000Pulmonary fibrosis is associated with significant morbidity. Data are scarce on the link between COVID-19 and pulmonary fibrosis. We aimed to assess the association between COVID-19 with pulmonary fibrosis.\u0000\u0000\u0000METHODS\u0000We conducted a nested case-control study in a cohort of 2,894,801 adults without a diagnosis of pulmonary fibrosis. The underlying cohort consisted of members of the largest healthcare provider in Israel aged 18 years or older as of May 1, 2020. Subjects were followed up from cohort entry until June 30, 2022 for the occurrence of pulmonary fibrosis. Ten randomly selected controls were matched to each case of pulmonary fibrosis on age, sex and calendar time. To account for surveillance bias a lag-time of 60 days was used for ascertainment of prior COVID-19 and COVID-severity.\u0000\u0000\u0000RESULTS\u0000During follow-up 1,284 patients were newly diagnosed with pulmonary fibrosis and matched with 12,840 controls. Multivariable conditional logistic-regression models showed that the OR for pulmonary fibrosis was 1.80 (95% CI, 1.47-2.19) in patients with COVID-19 compared to no COVID-19. The multivariable OR for pulmonary fibrosis was 1.33 (1.06-1.68), 2.98 (1.16-7.65), and 9.30 (5.77-14.98) for mild, moderate, and severe COVID-19, respectively, compared to no COVID-19. The magnitude of the association was attenuated but remained statistically significant for severe disease when the lag-time was extended to 180 days; 1.08 (0.78-1.49), 2.37 (0.75-7.46), and 5.34 (2.75-10.36) for mild, moderate, and severe COVID-19, respectively.\u0000\u0000\u0000CONCLUSIONS\u0000COVID-19 appears to be associated with an increased risk of pulmonary fibrosis and the magnitude of the association increases with COVID-19 severity.","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81084764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION Although tooth loss is widely recognized as a typical sign of aging, whether it is associated with accelerated aging, and to what extent diet quality mediates this association are unknown. METHODS Data were collected from the National Health and Nutrition Examination Survey. The missing tooth counts were recorded as the number of edentulous sites. Phenotypic accelerated aging was calculated using nine routine clinical chemistry biomarkers and chronological age. Healthy Eating Index 2015 (HEI-2015) score was used to evaluate diet quality. Multivariate logistic regression and linear regression were used to analyze the association between tooth loss and accelerated aging. Mediation analyses were used to examine the mediation role of diet quality in the association. RESULTS The association between tooth loss and accelerated aging was confirmed. The highest quartile of tooth loss showed a positive association with accelerated aging (β=1.090; 95%CI 0.555, 1.625; P<0.001). Diet quality decreased with increase number of missing teeth and showed a negative association with accelerated aging. Mediation analysis suggested that the HEI-2015 score partially mediated the association between tooth loss and accelerated aging (proportion of mediation: 5.302%; 95%CI 3.422%, 7.182%; P<0.001). Plant foods such as fruits and vegetables were considered the key mediating food. CONCLUSIONS The association between tooth loss and accelerated aging, as well as the partially mediating role of dietary quality in this association, was confirmed. These findings suggested that more attention should be paid to the population with severe tooth loss and the changes of their dietary quality.
{"title":"Association of tooth loss and diet quality with acceleration of aging: Evidence from NHANES.","authors":"Kehui Xu, Ling Li, Shuailin Jia, Qihong Li, Jiaxin Hao, Sai Ma, Zikang He, Qianqian Wan, Yunfan Cai, Zhiting Li, Franklin Tay, Lina Niu","doi":"10.2139/ssrn.4310422","DOIUrl":"https://doi.org/10.2139/ssrn.4310422","url":null,"abstract":"INTRODUCTION\u0000Although tooth loss is widely recognized as a typical sign of aging, whether it is associated with accelerated aging, and to what extent diet quality mediates this association are unknown.\u0000\u0000\u0000METHODS\u0000Data were collected from the National Health and Nutrition Examination Survey. The missing tooth counts were recorded as the number of edentulous sites. Phenotypic accelerated aging was calculated using nine routine clinical chemistry biomarkers and chronological age. Healthy Eating Index 2015 (HEI-2015) score was used to evaluate diet quality. Multivariate logistic regression and linear regression were used to analyze the association between tooth loss and accelerated aging. Mediation analyses were used to examine the mediation role of diet quality in the association.\u0000\u0000\u0000RESULTS\u0000The association between tooth loss and accelerated aging was confirmed. The highest quartile of tooth loss showed a positive association with accelerated aging (β=1.090; 95%CI 0.555, 1.625; P<0.001). Diet quality decreased with increase number of missing teeth and showed a negative association with accelerated aging. Mediation analysis suggested that the HEI-2015 score partially mediated the association between tooth loss and accelerated aging (proportion of mediation: 5.302%; 95%CI 3.422%, 7.182%; P<0.001). Plant foods such as fruits and vegetables were considered the key mediating food.\u0000\u0000\u0000CONCLUSIONS\u0000The association between tooth loss and accelerated aging, as well as the partially mediating role of dietary quality in this association, was confirmed. These findings suggested that more attention should be paid to the population with severe tooth loss and the changes of their dietary quality.","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88347827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1016/s0735-1097(23)03098-x
Arturo Hernandez, Brendan A. Andres, P. Jagadish, Suzanne K. Oskouie, Tushar Acharya, E. Juneman, D. Acharya
{"title":"STEROID-RESPONSIVE FULMINANT LYMPHOCYTIC MYOCARDITIS MIMICKING GIANT-CELL MYOCARDITIS.","authors":"Arturo Hernandez, Brendan A. Andres, P. Jagadish, Suzanne K. Oskouie, Tushar Acharya, E. Juneman, D. Acharya","doi":"10.1016/s0735-1097(23)03098-x","DOIUrl":"https://doi.org/10.1016/s0735-1097(23)03098-x","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76445329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1016/j.amjmed.2022.05.032
A. Garber, A. Ferris, T. Vu
{"title":"The Importance of Adding Discernment to the Acting Internship - A Necessary Shift in Culture Towards Competency-Based Metrics.","authors":"A. Garber, A. Ferris, T. Vu","doi":"10.1016/j.amjmed.2022.05.032","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.05.032","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78989948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.amjmed.2022.04.025
A. Annamalai, V. Prajna, Gunja Chowdhury, R. Santhi, Mariappan Kannan, S. Vedantham, M. Gurnell
{"title":"WILSON'S DISEASE - NEVER TOO LATE.","authors":"A. Annamalai, V. Prajna, Gunja Chowdhury, R. Santhi, Mariappan Kannan, S. Vedantham, M. Gurnell","doi":"10.1016/j.amjmed.2022.04.025","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.04.025","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89514392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.amjmed.2022.04.032
Tamer Ghanayim, L. Lupu, Sivan Naveh, N. Bachner-Hinenzon, D. Adler, S. Adawi, S. Banai, A. Shiran
{"title":"Artificial intelligence-based stethoscope for the diagnosis of aortic stenosis.","authors":"Tamer Ghanayim, L. Lupu, Sivan Naveh, N. Bachner-Hinenzon, D. Adler, S. Adawi, S. Banai, A. Shiran","doi":"10.1016/j.amjmed.2022.04.032","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.04.032","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88391812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.amjmed.2022.04.026
Marc Levine, L. Levine, Helen Xun, Prakash J Mathew, Devinder Singh, Adam Gerber, Michael Antonietti
{"title":"Face Off: 3D Printed Masks as a Cost-Effective and Reusable Alternative to N95 Respirators: A Feasibility Study.","authors":"Marc Levine, L. Levine, Helen Xun, Prakash J Mathew, Devinder Singh, Adam Gerber, Michael Antonietti","doi":"10.1016/j.amjmed.2022.04.026","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.04.026","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72983719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.amjmed.2022.04.020
Jenice X. Cheah, N. Assarzadegan, Jyotsna Ghosh, C. Connolly, A. Gelber
{"title":"Intolerable unilateral hip pain: Clues from the history.","authors":"Jenice X. Cheah, N. Assarzadegan, Jyotsna Ghosh, C. Connolly, A. Gelber","doi":"10.1016/j.amjmed.2022.04.020","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.04.020","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86130316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.amjmed.2022.04.030
D. Sagris, S. Harrison, B. Buckley, G. Ntaios, G. Lip
{"title":"Long-term cardiac monitoring after embolic stroke of undetermined source. Search longer - look harder.","authors":"D. Sagris, S. Harrison, B. Buckley, G. Ntaios, G. Lip","doi":"10.1016/j.amjmed.2022.04.030","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.04.030","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"443 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82883058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1016/j.amjmed.2022.04.022
B. Cheng, Mufrad Zaman, W. Cox
{"title":"Correlation of Pyuria and Bacteriuria in Acute Care.","authors":"B. Cheng, Mufrad Zaman, W. Cox","doi":"10.1016/j.amjmed.2022.04.022","DOIUrl":"https://doi.org/10.1016/j.amjmed.2022.04.022","url":null,"abstract":"","PeriodicalId":101216,"journal":{"name":"The American Journal of Medicine Supplements","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87555996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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