Frontiers in science最新文献

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Accelerating the end of the fossil fuel era: a human and planetary health imperative and opportunity 加速结束化石燃料时代：人类和地球健康的当务之急和机遇

Frontiers in science

Pub Date : 2024-04-04 DOI: 10.3389/fsci.2024.1383921

Edward Maibach

引用次数: 0

Climate change-associated health impacts: a way forward 与气候变化相关的健康影响：前进之路

Frontiers in science

Pub Date : 2024-04-04 DOI: 10.3389/fsci.2024.1395850

Marsha Wills-Karp

引用次数: 0

A multiscale inflammatory map: linking individual stress to societal dysfunction 多尺度炎症地图：将个人压力与社会功能障碍联系起来

Frontiers in science

Pub Date : 2024-03-12 DOI: 10.3389/fsci.2023.1239462

Y. Vodovotz, Julia C. Arciero, P. Verschure, David L. Katz

As populations worldwide show increasing levels of stress, understanding emerging links among stress, inflammation, cognition, and behavior is vital to human and planetary health. We hypothesize that inflammation is a multiscale driver connecting stressors that affect individuals to large-scale societal dysfunction and, ultimately, to planetary-scale environmental impacts. We propose a “central inflammation map” hypothesis to explain how the brain regulates inflammation and how inflammation impairs cognition, emotion, and action. According to our hypothesis, these interdependent inflammatory and neural processes, and the inter-individual transmission of environmental, infectious, and behavioral stressors—amplified via high-throughput digital global communications—can culminate in a multiscale, runaway, feed-forward process that could detrimentally affect human decision-making and behavior at scale, ultimately impairing the ability to address these same stressors. This perspective could provide non-intuitive explanations for behaviors and relationships among cells, organisms, and communities of organisms, potentially including population-level responses to stressors as diverse as global climate change, conflicts, and the COVID-19 pandemic. To illustrate our hypothesis and elucidate its mechanistic underpinnings, we present a mathematical model applicable to the individual and societal levels to test the links among stress, inflammation, control, and healing, including the implications of transmission, intervention (e.g., via lifestyle modification or medication), and resilience. Future research is needed to validate the model’s assumptions and conclusions against empirical benchmarks and to expand the factors/variables employed. Our model illustrates the need for multilayered, multiscale stress mitigation interventions, including lifestyle measures, precision therapeutics, and human ecosystem design. Our analysis shows the need for a coordinated, interdisciplinary, international research effort to understand the multiscale nature of stress. Doing so would inform the creation of interventions that improve individuals’ lives; enhance communities’ resilience to stress; and mitigate the adverse effects of stress on the world.

随着全球人口的压力水平不断增加，了解压力、炎症、认知和行为之间新出现的联系对于人类和地球健康至关重要。我们假设，炎症是一个多尺度的驱动因素，它将影响个人的压力因素与大规模的社会功能障碍联系起来，并最终与地球尺度的环境影响联系起来。我们提出了 "中心炎症地图 "假说，以解释大脑如何调节炎症，以及炎症如何损害认知、情感和行动。根据我们的假说，这些相互依存的炎症和神经过程，以及环境、传染病和行为压力源在个体间的传播--通过高通量的数字全球通信进行放大--可能最终形成一个多尺度、失控的前馈过程，对人类的大规模决策和行为产生不利影响，最终损害应对这些压力源的能力。这种观点可以为细胞、生物体和生物群落之间的行为和关系提供非直观的解释，可能包括对全球气候变化、冲突和 COVID-19 大流行等各种压力因素的种群级反应。为了说明我们的假设并阐明其机理基础，我们提出了一个适用于个体和社会层面的数学模型，以检验压力、炎症、控制和愈合之间的联系，包括传播、干预（如通过改变生活方式或药物治疗）和恢复力的影响。未来的研究需要根据经验基准来验证模型的假设和结论，并扩大所采用的因素/变量。我们的模型说明，需要采取多层次、多尺度的压力缓解干预措施，包括生活方式措施、精准治疗和人类生态系统设计。我们的分析表明，有必要开展协调一致的跨学科国际研究，以了解压力的多尺度性质。这样做可以为制定干预措施提供依据，从而改善个人生活，提高社区对压力的适应能力，并减轻压力对世界的不利影响。

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引用次数: 4

From cells to society: untangling the web of stress, inflammation, and social determinants of health 从细胞到社会：解开压力、炎症和健康的社会决定因素之网

Frontiers in science

Pub Date : 2024-03-12 DOI: 10.3389/fsci.2024.1358784

Ioannis P. Androulakis

引用次数: 0

Societal factors in network medicine and causation 网络医学和因果关系中的社会因素

Frontiers in science

Pub Date : 2024-03-12 DOI: 10.3389/fsci.2024.1349430

Pietro Ghezzi

引用次数: 0

The time is now for integrative multilayered stress research and mitigation 现在是进行多层次综合压力研究和缓解的时候了