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Preliminary Results of New Modification of Vertical Muscle Transposition to Enhance Abducting Force in Sixth Nerve Palsy. 垂直肌移位术增强第六神经麻痹外展力的初步结果。
Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.1159/000533628
Santa Heede, William Astle, Emi Sanders, Irina Kovalevskaya, Sandra Valeina, Uwe Griebenow

Introduction: Since 1907, multiple transposition procedures have been established for the treatment of abducens paralysis. The purpose of the study was to determine where the transposed muscle should be reattached in order to increase the tangential force necessary to improve abduction.

Methods: Retrospective case review of 12 consecutive patients with abducens paralysis who underwent transposition procedures between 2016 and 2019 was conducted. Vertical rectus muscles are transposed to the insertion of lateral rectus muscle; the temporal parts are joined and sutured to the sclera on top of the lateral rectus muscle in the middle of the insertion. The nasal parts are sutured to the sclera following the spiral of Tillaux. The muscle junction suture is placed 8 mm from the insertion, with the temporal parts of the vertical muscles bellies joined and sutured to the lateral rectus muscle. A full-tendon transposition was performed on 11 patients, a half-tendon transposition procedure on 1 patient. The minimum follow-up was 3 months.

Results: The mean preoperative deviation was ET of 37° (range: ET 24° to ET 51°). The mean preoperative abduction limitation was 5 mm from midline (range: 7 to 1 mm). The postoperative mean deviation was ET of 2° (range: 0° to ET 5°). The postoperative mean abduction improvement was 5 mm past midline (range: 2-6 mm). There were no complications or signs of anterior segment ischemia.

Conclusion: To achieve the maximal abductive force from the transposed muscles, we suggest that the vertical muscles be reattached as close as possible to the middle of the lateral rectus insertion.

引言:自1907年以来,已经建立了多种转位手术来治疗外展神经麻痹。这项研究的目的是确定移位的肌肉应该在哪里重新连接,以增加改善外展所需的切向力。方法:对2016年至2019年间连续12例接受转位手术的外展神经麻痹患者进行回顾性病例回顾。垂直直肌是转置到插入侧直肌;将颞部连接并缝合到插入物中间的外直肌顶部的巩膜上。鼻腔部分在蒂洛螺旋术后缝合在巩膜上。肌肉连接缝合线放置在距离插入物8mm的位置,垂直肌肉腹部的颞部连接并缝合到外侧直肌。对11名患者进行了全腱移位术,对1名患者进行半腱移位术。最低随访时间为3个月。结果:术前平均偏差为ET 37°(范围:ET 24°~ET 51°)。术前平均外展限度为距中线5毫米(范围:7至1毫米)。术后平均偏差为ET 2°(范围:0°~5°)。术后平均外展改善为中线后5 mm(范围:2-6 mm)。没有并发症或眼前段缺血的迹象。结论:为了使移位肌获得最大的外展力,我们建议将垂直肌复位到尽可能靠近外直肌插入的中间位置。
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引用次数: 0
Life Satisfaction among Older Adults in Rural and Urban Mongolia: A Cross-Sectional Survey Study. 蒙古农村和城市老年人的生活满意度:一项横断面调查研究。
Pub Date : 2023-10-25 eCollection Date: 2023-01-01 DOI: 10.1159/000533917
Saranchuluun Otgon, Denise Burnette, Yerkyebulan Mukhtar, Fabio Casati, Sugarmaa Myagmarjav

Introduction: Life satisfaction is a strong indicator of well-being for older adults. In this study, we aimed to assess the level and correlates of life satisfaction among older adults in urban and rural Mongolia.

Methods: We recruited 304 community-dwelling older adults in urban and rural regions of Mongolia. We compared levels of life satisfaction for the two groups, and then used hierarchical regression to examine the association of sociodemographic, health, psychosocial factors, and urban/rural status with life satisfaction.

Results: Older adults in urban areas reported higher levels of life satisfaction than their rural counterparts. In the final step of the hierarchical regression model, more grandchildren in the household, better self-rated health, and reporting more positive than negative affect were associated with better life satisfaction at p < 0.05 as were engaging in paid work and lower levels of loneliness at p < 0.10. Net the effects of all other variables in the analysis, older adults in rural areas reported lower levels of life satisfaction.

Conclusion: Our findings indicate that living in rural areas of Mongolia leads to lower levels of life satisfaction. We identify potential points to intervene through policies, programs, and practices that target the strengths and needs of older adults in rural areas by addressing inequities in socioeconomics, health, mental health, and opportunities for social integration.

引言:生活满意度是老年人幸福感的有力指标。在这项研究中,我们旨在评估蒙古城乡老年人的生活满意度水平及其相关性。方法:我们在蒙古城乡地区招募了304名居住在社区的老年人。我们比较了两组人的生活满意度,然后使用层次回归来检验社会人口、健康、心理社会因素和城市/农村状况与生活满意度的关系。结果:城市地区的老年人的生活满意度高于农村地区。在分层回归模型的最后一步中,家庭中更多的孙辈、更好的自我评估健康状况以及报告的积极影响多于消极影响与更好的生活满意度相关(p<0.05),与从事有偿工作和更低的孤独感相关(p<0.01)。除去分析中所有其他变量的影响,农村地区的老年人报告的生活满意度较低。结论:我们的研究结果表明,生活在蒙古国农村地区会导致生活满意度较低。我们通过针对农村地区老年人的优势和需求的政策、计划和实践,确定潜在的干预点,解决社会经济、健康、心理健康和社会融合机会方面的不平等问题。
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引用次数: 0
Postoperative Swallowing Function in Patients with Deep Neck Infection. 深颈部感染患者术后吞咽功能。
Pub Date : 2023-10-18 eCollection Date: 2023-01-01 DOI: 10.1159/000533526
Shohei Ashizawa, Takuma Hisaoka, Ryoukichi Ikeda, Rina Kamihata, Jun Suzuki, Ai Hirano-Kawamoto, Jun Ohta, Yukio Katori

Introduction: Early detection of dysphagia risk, initiating rehabilitation, and resumption of appropriate diet based on swallowing function is important during deep neck infection (DNI) control. This study aimed to evaluate the extent of cervical abscess development, particularly in the deep neck space, and its relationship to postoperative swallowing function.

Methods: A retrospective chart review was performed for all DNI cases treated between April 2015 and April 2021. Deep neck spaces were divided into categories based on computed tomography findings. Functional Oral Intake Scale (FOIS) scores of 4 or higher was defined as normal or slight swallowing disorder and 3 or lower as dysphagia.

Results: Seventeen cases were included in the analysis. Based on FOIS, 14 cases were classified into the dysphagia group at 2 weeks after surgery, 11 cases at 4 weeks, and 8 cases at 8 weeks. There was no significant difference between the location of the abscess and dysphagia at 2 weeks after surgery. Patients with anterior cervical space abscess significantly increased dysphagia 4 weeks (p = 0.018) and 8 weeks (p = 0.036) after surgery.

Conclusion: Abscess formation in the anterior cervical space may be associated with prolonged dysphagia after treatment due to inflammation and scarring of the muscles associated with swallowing.

引言:早期发现吞咽困难风险,开始康复,并根据吞咽功能恢复适当的饮食,在控制深颈部感染(DNI)过程中非常重要。本研究旨在评估宫颈脓肿的发展程度,特别是在颈深间隙,及其与术后吞咽功能的关系。方法:对2015年4月至2021年4月期间接受治疗的所有DNI病例进行回顾性图表审查。根据计算机断层扫描结果将深颈部空间分为几类。功能性口腔摄入量表(FOIS)评分4分或更高被定义为正常或轻度吞咽障碍,3分或更低被定义为吞咽困难。结果:17例纳入分析。根据FOIS,14例患者在术后2周被分为吞咽困难组,11例在4周,8例在8周。术后2周脓肿的位置和吞咽困难之间没有显著差异。术后4周(p=0.018)和8周(p=0.036),颈前间隙脓肿患者吞咽困难显著增加。结论:颈前间隙脓肿的形成可能与治疗后吞咽困难的延长有关,因为吞咽相关肌肉的炎症和瘢痕形成。
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引用次数: 0
Population Genome Programs across the Middle East and North Africa: Successes, Challenges, and Future Directions. 中东和北非的人口基因组计划:成功、挑战和未来方向。
Pub Date : 2023-09-14 eCollection Date: 2023-01-01 DOI: 10.1159/000530619
Hagar Ateia, Pauline Ogrodzki, Hannah V Wilson, Subhashini Ganesan, Rabih Halwani, Ashish Koshy, Walid A Zaher

In this review, we discuss the current state of population genome programs (PGPs) conducted in the Middle East and North African (MENA) region. This region has high prevalence of genetic diseases and significant health challenges as well as being a significantly underrepresented population in public genetic databases. The majority of ongoing PGPs represent regions in Europe, North and South America, South Asia, Australia, and Africa, with little to no descriptive information highlighted only on the MENA Region when it comes to genome programs databases, outcomes, or the challenges that MENA region countries may face establishing their own national programs. This review has identified 6 PGPs currently underway in the MENA region, namely in the Kingdom of Saudi Arabia, Qatar, Egypt, the United Arab Emirates, Bahrain, and Iran. Due to the rapidly growing involvement of the MENA region in national-scale genomic data collection, an increase in representation in public genetic databases is to be expected to occur in the near future. Whilst significant progress is being made in some MENA countries, future initiatives as well as ongoing programs will be facing several challenges related to collaboration, finance, infrastructure and institutional data access, data analysis, sustainability, health records, and biobanks. The review also reiterates the need for ensuring ethical and regulated genomic initiatives which can drive developments in personalized medicine treatments to improve patient prognosis and quality of life.

在这篇综述中,我们讨论了在中东和北非(MENA)地区进行的人口基因组计划(PGP)的现状。该地区遗传病发病率高,健康面临重大挑战,而且在公共遗传数据库中的人口代表性严重不足。大多数正在进行的PGP代表欧洲、北美和南美、南亚、澳大利亚和非洲的地区,在基因组计划数据库、结果或中东和北非地区国家在建立自己的国家计划时可能面临的挑战方面,几乎没有或根本没有只强调中东和北非区域的描述性信息。本次审查确定了中东和北非地区目前正在进行的6个PGP,即沙特阿拉伯王国、卡塔尔、埃及、阿拉伯联合酋长国、巴林和伊朗。由于中东和北非地区在全国范围内的基因组数据收集中的参与迅速增加,预计在不久的将来,公共基因数据库中的代表性将增加。虽然中东和北非地区的一些国家正在取得重大进展,但未来的举措以及正在进行的项目将面临与合作、资金、基础设施和机构数据访问、数据分析、可持续性、健康记录和生物库有关的几项挑战。该综述还重申,需要确保伦理和规范的基因组计划,以推动个性化药物治疗的发展,从而改善患者的预后和生活质量。
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引用次数: 0
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