Pub Date : 1972-09-01DOI: 10.1097/00132586-197308000-00019
W. T. Ross, R. Cardell
The objective was to study the effects of halothane, a volatile anesthetic, on hepatic metabolism of a second volatile anesthetic, methoxyflurane, and to correlate these biochemical findings with hepatic morphological changes. Microsomal fractions isolated from rats treated with halothane and from control animals were assayed for their capacity to dechlorinate methoxyflurane. Microsomes from halothane-treated rats demonstrated about 2.6 times the capacity to dechlorinate methoxyflurane as microsomes from control animals. Electron microscopy showed that liver cells from halothane-treated animals, when compared with hepatocytes from control rats, had increased amounts of smooth endoplasmic reticulum, an increased number of lipid droplets, and more microbodies per cell. Rough endoplasmic reticulum and glycogen were decreased by halothane treatment. We interpret these results to mean that halothane induces the rough endoplasmic reticulum to synthesize enzymes required for the biotransformation of methoxyflurane. It is suggested that these enzymes are placed in membranes of the rough endoplasmic reticulum. This organelle is converted to smooth endoplasmic reticulum and here the biotransforming enzymes function to dechlorinate methoxyflurane.
{"title":"Effects of halothane on the ultrastructure of rat liver cells.","authors":"W. T. Ross, R. Cardell","doi":"10.1097/00132586-197308000-00019","DOIUrl":"https://doi.org/10.1097/00132586-197308000-00019","url":null,"abstract":"The objective was to study the effects of halothane, a volatile anesthetic, on hepatic metabolism of a second volatile anesthetic, methoxyflurane, and to correlate these biochemical findings with hepatic morphological changes. Microsomal fractions isolated from rats treated with halothane and from control animals were assayed for their capacity to dechlorinate methoxyflurane. Microsomes from halothane-treated rats demonstrated about 2.6 times the capacity to dechlorinate methoxyflurane as microsomes from control animals. Electron microscopy showed that liver cells from halothane-treated animals, when compared with hepatocytes from control rats, had increased amounts of smooth endoplasmic reticulum, an increased number of lipid droplets, and more microbodies per cell. Rough endoplasmic reticulum and glycogen were decreased by halothane treatment. We interpret these results to mean that halothane induces the rough endoplasmic reticulum to synthesize enzymes required for the biotransformation of methoxyflurane. It is suggested that these enzymes are placed in membranes of the rough endoplasmic reticulum. This organelle is converted to smooth endoplasmic reticulum and here the biotransforming enzymes function to dechlorinate methoxyflurane.","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1972-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128233291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1964-09-01DOI: 10.1097/00006254-196508000-00019
H. Salazar, R. R. Peterson
The processes involved in the release of secretory products from the parenchymal cells and the movement of these products into the circulating blood were studied by electron microscopic observations on the adenohypophyses of virgin estrous rabbits. The released secretory products were found in the form of discrete granules, with or without a perigranular membrane, in intercellular spaces, between the plasma membrane and the parenchymal basement membrane, in the perivascular space, in the endothelial cytoplasm, and in the lumen of capillaries. Vesicles containing material which resembled that in the perivascular space were observed in endothelial cells. Interpretation of these observations has led to the proposal of the theory that secretory products of the adenohypophysis may be liberated from parenchymal cells in the following way: by fusion of the perigranular membrane with the plasma membrane (merocrine) or by the detachment of small processes containing secretory granules (“microapocrine”). It is further believed that the discharged products may be transported into circulation in three different manners: by diffusion of dissolved material through the fenestrated endothelium, by active transport of dissolved secretory products by the endothelial cells, or by active transport of intact secretory granules through the endothelial cytoplasm.
{"title":"MORPHOLOGIC OBSERVATIONS CONCERNING THE RELEASE AND TRANSPORT OF SECRETORY PRODUCTS IN THE ADENOHYPOPHYSIS.","authors":"H. Salazar, R. R. Peterson","doi":"10.1097/00006254-196508000-00019","DOIUrl":"https://doi.org/10.1097/00006254-196508000-00019","url":null,"abstract":"The processes involved in the release of secretory products from the parenchymal cells and the movement of these products into the circulating blood were studied by electron microscopic observations on the adenohypophyses of virgin estrous rabbits. The released secretory products were found in the form of discrete granules, with or without a perigranular membrane, in intercellular spaces, between the plasma membrane and the parenchymal basement membrane, in the perivascular space, in the endothelial cytoplasm, and in the lumen of capillaries. Vesicles containing material which resembled that in the perivascular space were observed in endothelial cells. \u0000 \u0000 \u0000 \u0000Interpretation of these observations has led to the proposal of the theory that secretory products of the adenohypophysis may be liberated from parenchymal cells in the following way: by fusion of the perigranular membrane with the plasma membrane (merocrine) or by the detachment of small processes containing secretory granules (“microapocrine”). It is further believed that the discharged products may be transported into circulation in three different manners: by diffusion of dissolved material through the fenestrated endothelium, by active transport of dissolved secretory products by the endothelial cells, or by active transport of intact secretory granules through the endothelial cytoplasm.","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1964-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129562354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1962-09-01DOI: 10.1097/00006254-196306000-00036
C. A. Perrotta
{"title":"Initiation of cell proliferation in the vaginal and uterine epithelia of the mouse.","authors":"C. A. Perrotta","doi":"10.1097/00006254-196306000-00036","DOIUrl":"https://doi.org/10.1097/00006254-196306000-00036","url":null,"abstract":"","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1962-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115277827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1948-11-01DOI: 10.1097/00006254-194812000-00013
J. Wilson, J. Warkany
{"title":"Malformations in the genito-urinary tract induced by maternal vitamin A deficiency in the rat.","authors":"J. Wilson, J. Warkany","doi":"10.1097/00006254-194812000-00013","DOIUrl":"https://doi.org/10.1097/00006254-194812000-00013","url":null,"abstract":"","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"244 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1948-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124695466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1948-09-01DOI: 10.1097/00006254-194906000-00043
M. Williams
{"title":"The vascular architecture of the rat uterus as influenced by estrogen and progesterone.","authors":"M. Williams","doi":"10.1097/00006254-194906000-00043","DOIUrl":"https://doi.org/10.1097/00006254-194906000-00043","url":null,"abstract":"","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1948-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126913697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1947-02-01DOI: 10.1097/00006254-194702000-00048
D. Phelps
{"title":"Endometrial vascular reactions and the mechanism of nidation.","authors":"D. Phelps","doi":"10.1097/00006254-194702000-00048","DOIUrl":"https://doi.org/10.1097/00006254-194702000-00048","url":null,"abstract":"","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1947-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129979737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1946-09-01DOI: 10.1097/00006254-194706000-00006
A. B. Dawson
{"title":"The effects of lactation on the postpartum involution of the uterus of the cat.","authors":"A. B. Dawson","doi":"10.1097/00006254-194706000-00006","DOIUrl":"https://doi.org/10.1097/00006254-194706000-00006","url":null,"abstract":"","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1946-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130108026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1946-05-01DOI: 10.1097/00006254-194612000-00047
C. F. Morgan
{"title":"Sexual rhythms in the reproductive tract of the adult female opossum and effects of hormonal treatments.","authors":"C. F. Morgan","doi":"10.1097/00006254-194612000-00047","DOIUrl":"https://doi.org/10.1097/00006254-194612000-00047","url":null,"abstract":"","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"383 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1946-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117086793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1097/00006254-197508000-00016
D. Keefer, W. Stumpf, P. Petrusz, M. Sar
A combined autoradiographic and immunohistochemical technique is introduced which is suitable to simultaneously localize hypophyseal sites of nuclear (3-H)-estradiol uptake and anti-hCG-characterized "gonadotropes". Most, but not all, "gonadotropes" show significant nuclear concentration of radioactivity. A large percentage of non-"gonadotropes" also show nuclear uptake of label.
{"title":"Simultaneous autoradiographic and immunohistochemical localization of estrogen and gonadotropin in the rat pituitary.","authors":"D. Keefer, W. Stumpf, P. Petrusz, M. Sar","doi":"10.1097/00006254-197508000-00016","DOIUrl":"https://doi.org/10.1097/00006254-197508000-00016","url":null,"abstract":"A combined autoradiographic and immunohistochemical technique is introduced which is suitable to simultaneously localize hypophyseal sites of nuclear (3-H)-estradiol uptake and anti-hCG-characterized \"gonadotropes\". Most, but not all, \"gonadotropes\" show significant nuclear concentration of radioactivity. A large percentage of non-\"gonadotropes\" also show nuclear uptake of label.","PeriodicalId":101557,"journal":{"name":"The American journal of anatomy","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132657445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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