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Clinical and Molecular Hepatology最新文献

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Reply to "Development of risk scores for prognosis prediction among patients with early-stage hepatocellular carcinoma". 对 "早期肝细胞癌患者预后预测风险评分的开发 "的答复
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0946
Chun-Ting Ho, Elise Chia-Hui Tan, Chien-Wei Su
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引用次数: 0
Reply to correspondence on "Understanding the impact on digestive disease in the post-COVID-19 condition". 对关于 "了解后 COVID-19 条件对消化系统疾病的影响 "的信函的答复。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0966
Yang-Hyun Baek
{"title":"Reply to correspondence on \"Understanding the impact on digestive disease in the post-COVID-19 condition\".","authors":"Yang-Hyun Baek","doi":"10.3350/cmh.2024.0966","DOIUrl":"https://doi.org/10.3350/cmh.2024.0966","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel clinical trial for primary sclerosing cholangitis from Asia: all regional endeavors should improve global management of PSC. 来自亚洲的原发性硬化性胆管炎新型临床试验:所有地区的努力都应改善全球对原发性硬化性胆管炎的管理。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0945
Atsumasa Komori
{"title":"A novel clinical trial for primary sclerosing cholangitis from Asia: all regional endeavors should improve global management of PSC.","authors":"Atsumasa Komori","doi":"10.3350/cmh.2024.0945","DOIUrl":"https://doi.org/10.3350/cmh.2024.0945","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence on Letter regarding "Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis". 关于 "肝细胞癌伴有门静脉血栓形成时经动脉放射栓塞术与酪氨酸激酶抑制剂的对比 "信件的通信。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0943
Moon Haeng Hur, Yoon Jun Kim
{"title":"Correspondence on Letter regarding \"Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis\".","authors":"Moon Haeng Hur, Yoon Jun Kim","doi":"10.3350/cmh.2024.0943","DOIUrl":"https://doi.org/10.3350/cmh.2024.0943","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence on Letter Regarding "Contemporary Awareness of Viral Hepatitis between 2012 and 2022 among Korean Adults". 关于 "2012 年至 2022 年韩国成年人对病毒性肝炎的当代认识 "信函的通信。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0944
Chang Hun Lee, In Hee Kim, Sook-Hyang Jeong
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引用次数: 0
Stabilizing Hepatic Fatty Acid Oxidation: USP29 Secures Acyl-CoA Synthesis through ACSL5. 稳定肝脏脂肪酸氧化:USP29 通过 ACSL5 确保酰基-CoA 的合成
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0971
Myeung Gi Choi, Na Young Lee, Ja Hyun Koo
{"title":"Stabilizing Hepatic Fatty Acid Oxidation: USP29 Secures Acyl-CoA Synthesis through ACSL5.","authors":"Myeung Gi Choi, Na Young Lee, Ja Hyun Koo","doi":"10.3350/cmh.2024.0971","DOIUrl":"https://doi.org/10.3350/cmh.2024.0971","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights on Risk Score Development: Considerations for Early-Stage Hepatocellular Carcinoma Models. 风险评分开发的启示:早期肝细胞癌模型的注意事项
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.3350/cmh.2024.0958
Zhanna Zhang, Gongqiang Wu
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引用次数: 0
Response to the letter. 回信。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-04 DOI: 10.3350/cmh.2024.0937
Hee Yeon Kim, Miyoung Choi, Dae Won Jun
{"title":"Response to the letter.","authors":"Hee Yeon Kim, Miyoung Choi, Dae Won Jun","doi":"10.3350/cmh.2024.0937","DOIUrl":"https://doi.org/10.3350/cmh.2024.0937","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Innovations in PSC Clinical Trials: Evaluating HK-660S and the Path Forward. PSC 临床试验的挑战与创新:评估 HK-660S 和前进之路。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-04 DOI: 10.3350/cmh.2024.0942
Nilanga Nishad
{"title":"Challenges and Innovations in PSC Clinical Trials: Evaluating HK-660S and the Path Forward.","authors":"Nilanga Nishad","doi":"10.3350/cmh.2024.0942","DOIUrl":"https://doi.org/10.3350/cmh.2024.0942","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALCOHOL-ASSOCIATED LIVER DISEASE: NATURAL HISTORY, MANAGEMENT AND NOVEL TARGETED THERAPIES. 酒精相关肝病:自然史、管理和新型靶向疗法。
IF 14 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-31 DOI: 10.3350/cmh.2024.0709
Edilmar Alvarado-Tapias, Elisa Pose, Jordi Gratacós, Ana Clemente-Sánchez, Hugo Hugo López-Pelayo, Ramón Bataller

Alcohol consumption is a leading cause of preventable morbidity and mortality worldwide and the primary cause of advanced liver disease. Alcohol use disorder (AUD) is a chronic, frequently relapsing condition characterized by persistent alcohol consumption despite its negative consequences. Alcohol-associated liver disease (ALD) encompasses a series of stages, from fatty liver (steatosis) to inflammation (steatohepatitis), fibrosis, and, ultimately, liver cirrhosis and its complications. The development of ALD is complex, involving both genetic and environmental factors, yet the exact mechanisms at play remain unclear. Alcohol-associated hepatitis (AH), a severe form of ALD, presents with sudden jaundice and liver failure. Currently, there are no approved targeted therapies able to interfere in the pathogenesis of ALD to stop the progression of the disease, making alcohol abstinence the most effective way to improve prognosis across all stages of ALD. For patients with advanced ALD who do not respond to medical therapy, liver transplantation is the only option that can improve prognosis. Recently, AH has become an early indication for liver transplantation in non-responders to medical treatment, showing promising results in carefully selected patients. This review provides an update on the epidemiology, natural history, pathogenesis, and current treatments for ALD. A deeper insight into novel targeted therapies investigated for AH focusing on new pathophysiologically-based agents is also discussed, including anti-inflammatory and antioxidative stress drugs, gut-liver axis modulators, and hepatocyte regenerative molecules.

饮酒是全球可预防的发病率和死亡率的主要原因,也是晚期肝病的主要病因。酒精使用障碍(AUD)是一种慢性、经常复发的疾病,其特点是尽管会产生不良后果,但仍持续饮酒。酒精相关性肝病(ALD)包括一系列阶段,从脂肪肝(脂肪变性)到炎症(脂肪性肝炎)、纤维化,最终发展为肝硬化及其并发症。ALD 的发展过程十分复杂,涉及遗传和环境因素,但其确切的作用机制仍不清楚。酒精相关性肝炎(AH)是 ALD 的一种严重形式,表现为突发性黄疸和肝功能衰竭。目前,还没有获批的靶向疗法能够干预 ALD 的发病机制以阻止疾病进展,因此戒酒成为改善 ALD 各个阶段预后的最有效方法。对于药物治疗无效的晚期ALD患者来说,肝移植是改善预后的唯一选择。最近,AH已成为药物治疗无反应患者进行肝移植的早期适应症,在精心挑选的患者中显示出良好的效果。本综述介绍了ALD的流行病学、自然史、发病机制和当前治疗方法的最新进展。此外,文章还深入探讨了针对急性肝病研究的新型靶向疗法,重点关注基于病理生理学的新药物,包括抗炎和抗氧化应激药物、肠肝轴调节剂和肝细胞再生分子。
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引用次数: 0
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Clinical and Molecular Hepatology
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