The technological advances of recent decades in immunodiagnostic techniques have enabled the development of methods capable of detecting the antigen-antibody complex with high efficiency and reliability. However, the cost of such procedures has remained high; they are not easy to handle for an unskilled professional, nor provide immediate results for multiple samples. Precision Photonics Corporation (PPC), with m/Bio Inc. and in partnership with the University of San Diego (UCSD), USA, created an integrated circuit reader (Biochip Reader), which is low cost, fast and easy to handle, based on an optical systems and multiplex arrangements for the detection of biological multi-markers at the same time. This study aimed to evaluate the operation of the integrated circuit reader system (Biochip Reader), the protocols and the results of the multiplex tests for antibodies against HIV and HCV in partnership with the Federal University of Bahia (UFBA). We tested a total of 65 samples in the Biochip reader, and they showed 100% of sensitivity and specificity when compared to the results obtained by ELISA for HIV and HCV. Nevertheless, the protocols and the results obtained in Bahia presented slide instability, such as the formation of crystals and trehalose residues, unnecessary steps and manipulation of the slides. This fact led to changing the protocol and improving the prototype. However, more tests with new biomarkers are needed to validate the method.
{"title":"Evaluation of PPC / mBio Inc.’s Biochip Reader Integrated Circuit Reader System for Diagnosis of HIV / HCV Infection: Preliminary Method","authors":"L. Knop, R. Badaró, Chris Myat","doi":"10.34178/jbth.v2i1.49","DOIUrl":"https://doi.org/10.34178/jbth.v2i1.49","url":null,"abstract":"The technological advances of recent decades in immunodiagnostic techniques have enabled the development of methods capable of detecting the antigen-antibody complex with high efficiency and reliability. However, the cost of such procedures has remained high; they are not easy to handle for an unskilled professional, nor provide immediate results for multiple samples. Precision Photonics Corporation (PPC), with m/Bio Inc. and in partnership with the University of San Diego (UCSD), USA, created an integrated circuit reader (Biochip Reader), which is low cost, fast and easy to handle, based on an optical systems and multiplex arrangements for the detection of biological multi-markers at the same time. This study aimed to evaluate the operation of the integrated circuit reader system (Biochip Reader), the protocols and the results of the multiplex tests for antibodies against HIV and HCV in partnership with the Federal University of Bahia (UFBA). We tested a total of 65 samples in the Biochip reader, and they showed 100% of sensitivity and specificity when compared to the results obtained by ELISA for HIV and HCV. Nevertheless, the protocols and the results obtained in Bahia presented slide instability, such as the formation of crystals and trehalose residues, unnecessary steps and manipulation of the slides. This fact led to changing the protocol and improving the prototype. However, more tests with new biomarkers are needed to validate the method.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132704297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mosquito Zero is an application that is designed to demonstrate the efficiency and effectiveness of information, education and communication between public authorities and citizens regarding Aedes aegypti, the diseases this mosquito transmits and the health impacts, providing citizens with a smooth and accessible channel of communication about the mosquito and arboviruses through the application and virtual robots.
{"title":"Mosquito ZeroTM","authors":"Alex Sandro Correia","doi":"10.34178/jbth.v2i1.53","DOIUrl":"https://doi.org/10.34178/jbth.v2i1.53","url":null,"abstract":"Mosquito Zero is an application that is designed to demonstrate the efficiency and effectiveness of information, education and communication between public authorities and citizens regarding Aedes aegypti, the diseases this mosquito transmits and the health impacts, providing citizens with a smooth and accessible channel of communication about the mosquito and arboviruses through the application and virtual robots.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122374020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabricio Avelino Bispo, Marinilda Lima Souza, Sergio Pitombo
With the accelerated growth of the health area in Brazil, institutions increasingly seek to optimize the operations by leveraging the results and becoming competitive in the market. Ensuring the high availability of infrastructure and assets provides that the organization is a strategic tool to achieve positive productivity results. However, it is necessary to structure the engineering department of the maintenance and correct administration of the flows that integrate the sector to meet the expected results. The use of computerized maintenance control tools helps in the management of environments and equipment, assuring the operational reliability of the health care establishment. This article presents the stages of implementation of management and maintenance in a health care establishment. The results demonstrate the evolution in the control of the maintenance department with greater efficiency, planning, increased availability of infrastructure and equipment as well as reduced costs for the operation of health sector processes in Brazil.
{"title":"Maintenance Management in a Health Care Establishment","authors":"Fabricio Avelino Bispo, Marinilda Lima Souza, Sergio Pitombo","doi":"10.34178/jbth.v2i1.52","DOIUrl":"https://doi.org/10.34178/jbth.v2i1.52","url":null,"abstract":"With the accelerated growth of the health area in Brazil, institutions increasingly seek to optimize the operations by leveraging the results and becoming competitive in the market. Ensuring the high availability of infrastructure and assets provides that the organization is a strategic tool to achieve positive productivity results. However, it is necessary to structure the engineering department of the maintenance and correct administration of the flows that integrate the sector to meet the expected results. The use of computerized maintenance control tools helps in the management of environments and equipment, assuring the operational reliability of the health care establishment. This article presents the stages of implementation of management and maintenance in a health care establishment. The results demonstrate the evolution in the control of the maintenance department with greater efficiency, planning, increased availability of infrastructure and equipment as well as reduced costs for the operation of health sector processes in Brazil.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130811026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ITS/SENAI CIMATEC created The Journal of Bioengineering and Technology Applied to Health (JBTH) in order to develop a platform for innovative researchers and scientists to explore the advanced and latest research developments in the field of Biomedical Engineering and related disciplines that are applied to the development of new tools for diagnostics and treatment in the area of health.
{"title":"Journal of Bioengineering and Technology Applied to Health: A New Journal of Health Institute of Technology - ITS/SENAI CIMATEC","authors":"Leone Peter Andrade","doi":"10.34178/jbth.v1i1.20","DOIUrl":"https://doi.org/10.34178/jbth.v1i1.20","url":null,"abstract":"ITS/SENAI CIMATEC created The Journal of Bioengineering and Technology Applied to Health (JBTH) in order to develop a platform for innovative researchers and scientists to explore the advanced and latest research developments in the field of Biomedical Engineering and related disciplines that are applied to the development of new tools for diagnostics and treatment in the area of health.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129395581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. P. D. Anjos, S. Sherratt, J. Viana, Valdir Gomes Barbosa Júnior, R. P. Manson, R. Badaró
Impurities found in generic medicinesmay contribute to loss of efficacy and adverse side effects when administered to patients suffering from various diseases. Methods of analysis of the quality of drug products are well advanced. Herein, we used Liquid Chromatography with Diode Array Detector coupled to Mass Spectrometry to detect the presence of organic impurities and determine the quantity of the Active Pharmaceutical Ingredient (API) present in representative Antibiotics (2) and Antifungals (2). Possible impurities were detected in some of the generic drugs in both classes of anti-infective drugs. No impurities were detected in the amoxicillin. The compounds 3’-N,N-Di(demethyl) azithromycin (azithromycin impurity E) and 3’-De(dimethylamino)-3’-keto azithromycin (azithromycin impurity N) were detected in generic azithromycin. For itraconazole, the compounds cis-[2-(2,4 dichlorophenyl)-2-(1H-1,2,4-triazol-4-yl-methyl)-1,3-dioxolan-4 yl] methylmethanesulfonate and trans-[2-(2,4-dichlorophenyl)-2-(1H 1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methylmethanesulfonate, besides a third substance identified as 2- (2-Butyl) -4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one were detected as possible impurities. Interestingly, an additional peak was noted in the chromatogram for the generic fluconazole, in addition to the peak of the API; however, none of known impurities of fluconazole were identified. We conclude that tests in addition to bioequivalence measurements may be required to assess post-market generic quality. Such surveillance of generic quality should be performed routinely.
{"title":"Detection of Impurities in Anti-infective Generic Drugs in Brazil by Liquid Chromatography-Mass Spectrometry","authors":"J. P. D. Anjos, S. Sherratt, J. Viana, Valdir Gomes Barbosa Júnior, R. P. Manson, R. Badaró","doi":"10.34178/jbth.v2i2.55","DOIUrl":"https://doi.org/10.34178/jbth.v2i2.55","url":null,"abstract":"Impurities found in generic medicinesmay contribute to loss of efficacy and adverse side effects when administered to patients suffering from various diseases. Methods of analysis of the quality of drug products are well advanced. Herein, we used Liquid Chromatography with Diode Array Detector coupled to Mass Spectrometry to detect the presence of organic impurities and determine the quantity of the Active Pharmaceutical Ingredient (API) present in representative Antibiotics (2) and Antifungals (2). Possible impurities were detected in some of the generic drugs in both classes of anti-infective drugs. No impurities were detected in the amoxicillin. The compounds 3’-N,N-Di(demethyl) azithromycin (azithromycin impurity E) and 3’-De(dimethylamino)-3’-keto azithromycin (azithromycin impurity N) were detected in generic azithromycin. For itraconazole, the compounds cis-[2-(2,4 dichlorophenyl)-2-(1H-1,2,4-triazol-4-yl-methyl)-1,3-dioxolan-4 yl] methylmethanesulfonate and trans-[2-(2,4-dichlorophenyl)-2-(1H 1,2,4-triazol-1-yl-methyl)-1,3-dioxolan-4-yl]methylmethanesulfonate, besides a third substance identified as 2- (2-Butyl) -4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one were detected as possible impurities. Interestingly, an additional peak was noted in the chromatogram for the generic fluconazole, in addition to the peak of the API; however, none of known impurities of fluconazole were identified. We conclude that tests in addition to bioequivalence measurements may be required to assess post-market generic quality. Such surveillance of generic quality should be performed routinely.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123081236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical Assistance Equipment (MAE), Orthotics, Prosthetics and Special Materials (OPSM) are strategic subsectors of the Industrial Health Complex (IHC).The dynamism and peculiar characteristics of these technologies characterize the innovation field and the short life cycle of technological developments. The study aims to consolidate the products in a single list by analyzing computerized databases and consulting the technical and other areas in the Ministry of Health. The study strengthens the data obtained and investigates the repeated items in the adopted criteria, crossing this information with previous publications. We established standards about MAE and OPSM in this study that have already been repeated in previous publications. Thus, there is a concentration of skills needs for these technologies in industrial and technological development, as well as in technological services requirement of these products.
{"title":"Study of Medical-Assistance Equipment, Orthotics, Prosthetics, and Special Materials in the Unified Health System (SUS) in Brazil","authors":"F. Toscas, Thiago Rodrigues Santos, E. Oliveira","doi":"10.34178/jbth.v2i1.51","DOIUrl":"https://doi.org/10.34178/jbth.v2i1.51","url":null,"abstract":"Medical Assistance Equipment (MAE), Orthotics, Prosthetics and Special Materials (OPSM) are strategic subsectors of the Industrial Health Complex (IHC).The dynamism and peculiar characteristics of these technologies characterize the innovation field and the short life cycle of technological developments. The study aims to consolidate the products in a single list by analyzing computerized databases and consulting the technical and other areas in the Ministry of Health. The study strengthens the data obtained and investigates the repeated items in the adopted criteria, crossing this information with previous publications. We established standards about MAE and OPSM in this study that have already been repeated in previous publications. Thus, there is a concentration of skills needs for these technologies in industrial and technological development, as well as in technological services requirement of these products.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123776174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SENAI CIMATEC Publishing Group aims to develop into an enlightening interactive network for researchers all over the world through its scientific publications and meetings in the Journal of Bioengineering and Technology Applied to Health (JBTH).
{"title":"Scope of The Journal of Bioengineering and Technology Applied to Health","authors":"L. Knop","doi":"10.34178/JBTH.V1I1.15","DOIUrl":"https://doi.org/10.34178/JBTH.V1I1.15","url":null,"abstract":"SENAI CIMATEC Publishing Group aims to develop into an enlightening interactive network for researchers all over the world through its scientific publications and meetings in the Journal of Bioengineering and Technology Applied to Health (JBTH).","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129138516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Each year, when we look at Google and other information research sites on the internet about what is happening in the world of medical science, the list of necessary technologies increases dramatically. Within today, the medical curriculum has lagged, bringing a fundamental issue to universities that graduate doctors and health professionals. Are we training health professionals able to care for patients in the light of the most appropriate scientific knowledge to be used in medical practice? The JBTH will be a great opportunity to share these new knowledgements of fast technological innovations applied to health.
{"title":"History of Medicine and Advanced Manufacturing for Modernization of Health Services: The New Paradigm for the Learning and Practicing of Medicine Shortly","authors":"R. Badaró, J. Barbosa, L. P. Andrade","doi":"10.34178/JBTH.V1I1.14","DOIUrl":"https://doi.org/10.34178/JBTH.V1I1.14","url":null,"abstract":"Each year, when we look at Google and other information research sites on the internet about what is happening in the world of medical science, the list of necessary technologies increases dramatically. Within today, the medical curriculum has lagged, bringing a fundamental issue to universities that graduate doctors and health professionals. Are we training health professionals able to care for patients in the light of the most appropriate scientific knowledge to be used in medical practice? The JBTH will be a great opportunity to share these new knowledgements of fast technological innovations applied to health.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123802170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article will guide the author to prepare the paper to submit to JBTH.
本文将指导作者准备提交给JBTH的论文。
{"title":"Template for Preparing an Article","authors":"L. Knop","doi":"10.34178/JBTH.V1I1.17","DOIUrl":"https://doi.org/10.34178/JBTH.V1I1.17","url":null,"abstract":"This article will guide the author to prepare the paper to submit to JBTH.","PeriodicalId":103143,"journal":{"name":"JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH","volume":"445 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116020957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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