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Treatment of pectus excavatum with vacuum bell during puberty. 真空钟治疗青春期漏斗胸。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.11
M Prada Arias, J Gómez Veiras, P Rodríguez Iglesias, B Aneiros Castro, P Fernández Eire, M Montero Sánchez

Objective: To assess the efficacy of the vacuum bell during puberty, according to the daily hours of use and treatment duration.

Materials and methods: A retrospective analysis of patients treated with vacuum bell during puberty in the 2010-2021 period was carried out. Several variables were collected, including baseline and final sinking, repaired sinking expressed in cm and as a percentage from baseline sinking, daily hours of use, treatment duration, and complications. Patients were categorized into groups according to the daily hours of use (≤ 3 hours; 4-5 hours; ≥ 6 hours) and treatment duration (6-12 months; 13-24 months; 25-36 months; > 36 months), and they were statistically analyzed.

Results: A total of 50 patients -41 male and 9 female- were studied, with a mean age of 12.5 years (range: 10-14 years). No significant differences among groups were observed in terms of baseline sinking, thoracic index, and final sinking. Repaired sinking did increase with the daily hours of use, with significant differences. Complications were mild. 3 patients withdrew from follow-up, and 5 out of the 25 patients who completed treatment achieved a good repair.

Conclusions: To increase treatment efficacy, the vacuum bell should be used for 6 hours/day during puberty. This method is well-tolerated, causes mild complications, and may be an alternative to surgery in some cases.

目的:根据每日使用时间和治疗时间,评价真空钟在青春期的疗效。材料与方法:回顾性分析2010-2021年青春期使用真空钟治疗的患者。收集了几个变量,包括基线和最终下沉,以cm表示的修复下沉以及与基线下沉的百分比,每日使用时间,治疗时间和并发症。根据患者每日使用时间(≤3小时;4 - 5小时;≥6小时)和治疗时间(6-12个月;24里面个月;几个月的技能;> 36个月),并进行统计学分析。结果:共纳入50例患者,其中男41例,女9例,平均年龄12.5岁(范围:10-14岁)。在基线下沉、胸廓指数和最终下沉方面,各组间无显著差异。修复下沉确实随着每日使用时间的增加而增加,且差异显著。并发症轻微。3例患者退出随访,完成治疗的25例患者中有5例获得良好的修复。结论:为提高治疗效果,青春期应每天使用真空钟6小时。这种方法耐受性好,引起轻微的并发症,在某些情况下可以替代手术。
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引用次数: 0
Association between subglottic stenosis and endotracheal intubation in tracheostomized pediatric patients. 儿童气管造口术患者声门下狭窄与气管插管的关系。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.10
C Percul, L Lerendegui, P Lobos, D Liberto, J Moldes, M M Urquizo

Objective: Considering that intubation time is the primary cause of subglottic stenosis, tracheostomy is suggested in adult patients following 10-15 days. The objective of this study was to analyze the association between intubation time and stenosis in pediatric patients, as well as to establish whether there is an adequate timing for tracheostomy in order to reduce the incidence of stenosis.

Materials and methods: A retrospective study (2014-2019) of tracheostomized newborns and children after an intubation period was carried out. Endoscopic findings at tracheostomy were analyzed.

Results: Tracheostomy was conducted in 189 patients, 72 of whom met inclusion criteria. Mean age was 40 months (1 month - 16 years). The incidence of stenosis was 21%, with a mean age of 23 months and a mean intubation time of 30 days vs. 19 days in the non-stenosis group (p= 0.02). The incidence of stenosis increased by 7% five days following intubation, reaching 20% after one month. Patients under 6 months old had greater tolerance to intubation periods without stenosis (incidence < 6% after 40 days, and median time to stenosis of 56 days vs. 24 days in patients over 6 months old).

Conclusions: In patients with long intubation periods, preventive measures should be taken in order to avoid laryngotracheal injuries, and early tracheostomy should be considered.

目的:考虑到插管时间是导致声门下狭窄的主要原因,建议成人患者在10-15天后行气管切开术。本研究的目的是分析儿科患者插管时间与狭窄的关系,并确定是否有适当的气管切开术时机,以减少狭窄的发生率。材料与方法:回顾性研究2014-2019年气管造口新生儿及气管插管后患儿的情况。分析气管切开术的内镜表现。结果:189例患者行气管切开术,其中72例符合纳入标准。平均年龄40个月(1个月- 16岁)。狭窄发生率为21%,平均年龄为23个月,平均插管时间为30天,而非狭窄组为19天(p= 0.02)。插管后5天狭窄发生率增加7%,1个月后达到20%。6月龄以下患者对插管时间耐受性较好,无狭窄发生率(p < 0.05)。结论:对于插管时间较长的患者,应采取预防措施,避免喉气管损伤,应考虑早期气管切开。
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引用次数: 0
Analysis of a clinical guideline for treatment and early discharge in complicated acute appendicitis. 复杂急性阑尾炎治疗及早期出院临床指南分析。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.12
C Pérez Costoya, A Gómez Farpón, E M Enríquez Zarabozo, C Granell Suárez, N Vega Mata, S Amat Valero, V Álvarez Muñoz

Objective: The objective of this study was to assess the results of a clinical guideline for the treatment and early discharge of patients with complicated acute appendicitis in terms of infectious complications and hospital stay.

Materials and methods: A guideline for appendicitis treatment according to severity was created. Complicated appendicitis cases were treated with ceftriaxone-metronidazole for 48h, with discharge being approved if certain clinical and blood test criteria were met. A retrospective analytical study comparing the incidence of postoperative intra-abdominal abscess (IAA) and surgical site infection (SSI) in patients under 14 years of age to whom the new guideline was applied (Group A) vs. the historical cohort (Group B, treated with gentamicin-metronidazole for 5 days) was carried out. A prospective cohort study to assess which antibiotic therapy (amoxicillin-clavulanic acid or cefuroxime-metronidazole) proved more effective in patients meeting early discharge criteria was also conducted.

Results: 205 patients under 14 years of age were included in Group A, whereas 109 patients were included in Group B. IAA was present in 14.3% of patients from Group A vs. 13.8% from Group B (p= 0.83), while SSI was present in 1.9% of patients from Group A vs. 8.25% from Group B (p= 0.008). Early discharge criteria were met by 62.7% of patients from Group A. Median hospital stay decreased from 6 to 3 days. At discharge, 57% of patients received amoxicillin-clavulanic acid, whereas 43% received cefuroxime-metronidazole, with no differences being found in terms of SSI (p= 0.24) or IAA (p= 0.12).

Conclusions: Early discharge reduces hospital stay without increasing the risk of postoperative infectious complications. Amoxicillin-clavulanic acid is a safe option for at-home oral antibiotic therapy.

目的:本研究的目的是评估临床指南的治疗和早期出院的合并急性阑尾炎患者的感染并发症和住院时间的结果。材料与方法:建立了阑尾炎分级治疗指南。复杂阑尾炎患者应用头孢曲松-甲硝唑治疗48h,符合临床及血液检查标准后批准出院。一项回顾性分析研究比较了应用新指南的14岁以下患者(A组)与历史队列(B组,使用庆大霉素-甲硝唑治疗5天)术后腹内脓肿(IAA)和手术部位感染(SSI)的发生率。还进行了一项前瞻性队列研究,以评估哪种抗生素治疗(阿莫西林-克拉维酸或头孢呋辛-甲硝唑)对符合早期出院标准的患者更有效。结果:A组有205例14岁以下患者,B组有109例。A组有14.3%的患者存在IAA, B组有13.8% (p= 0.83); A组有1.9%的患者存在SSI, B组有8.25% (p= 0.008)。a组62.7%的患者符合早期出院标准,中位住院时间从6天减少到3天。出院时,57%的患者接受阿莫西林-克拉维酸治疗,43%的患者接受头孢呋辛-甲硝唑治疗,SSI (p= 0.24)和IAA (p= 0.12)无差异。结论:早期出院可减少住院时间,且未增加术后感染并发症的发生风险。阿莫西林-克拉维酸是一种安全的家庭口服抗生素治疗选择。
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引用次数: 0
Transoral endoscopic thyroidectomy vestibular approach (TOETVA): a novel option in the treatment of pediatric patients. 经口内窥镜甲状腺切除术前庭入路(TOETVA):一种治疗儿科患者的新选择。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.14
S Marchionatti, S Rapp, M C Negueruela, A Begueri, G Russier, A I Voogd

Introduction: Thyroid surgery has increased in the pediatric population. One of the main issues following this surgery is the presence of a neck scar, which has been reported to have an impact on quality of life. Transoral endoscopic thyroidectomy is used in adult patients with good results, but there are few reports on the use of this technique in pediatrics.

Clinical case: 17-year-old female patient diagnosed with toxic nodular goiter. As a result of the patient's refusal to undergo conventional surgery due to the scar, transoral endoscopic lobectomy was carried out. The surgical technique used will be described.

Discussion: In order to prevent the psychological and social impact of neck scars in children, and given the results published on the use of this technique in pediatrics, transoral endoscopic thyroidectomy stands as an alternative to conventional thyroidectomy in adequately selected patients eager to avoid neck scars.

简介:甲状腺手术在儿科人群中有所增加。手术后的主要问题之一是颈部疤痕的存在,据报道,这对生活质量有影响。经口内窥镜甲状腺切除术在成人患者中使用效果良好,但在儿科中使用该技术的报道很少。临床病例:17岁女性,诊断为中毒性结节性甲状腺肿。由于患者因疤痕而拒绝接受常规手术,我们进行了经口内窥镜肺叶切除术。所使用的手术技术将被描述。讨论:为了防止儿童颈部疤痕的心理和社会影响,并考虑到该技术在儿科应用的结果,经口内窥镜甲状腺切除术可以作为传统甲状腺切除术的替代方案,用于充分选择渴望避免颈部疤痕的患者。
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引用次数: 0
Thoracoscopic pneumonectomy in a 4 year-old-child with destroyed lung following viral pneumonia. 病毒性肺炎后肺破坏的4岁儿童的胸腔镜全肺切除术。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.15
L Pérez Egido, M A García Casillas, J A Cerdá Berrocal, A Del Cañizo López, J Ordóñez Pereira, I Bada Bosch, J C de Agustín Asensio

Pediatric pneumonectomies are exceptional nowadays, being reserved for cases with destroyed lungs with frequent exacerbations and reinfections and only two cases of thoracoscopic pneumonectomy have been previously published. We present the case of a 4-year-old patient with no relevant history who developed complete atelectasis of the left lung (LL) after influenza A pneumonia, followed by secondary recurrent infections. A year later a diagnostic bronchoscopy without alterations was performed. A complete loss of volume and hypoperfusion of the LL (right lung perfusion 95%, LL perfusion: 5%) with bronchiectasis and hyperinsufflation and herniation of the right lung into the left hemithorax was observed in a pulmonary perfusion SPECT-CT. After unsuccessful conservative management and recurrent infections a pneumonectomy was indicated. The pneumonectomy was performed through a five-port thoracoscopy. The dissection of the hilum was made using hook electrocautery and sealing device. The left main bronchus was sectioned with an endostapler. There were no intraoperative complications. An endothoracic drain was removed the first postoperative day. The patient was discharged on the fourth postoperative day. The patient has not presented any complications 10 months after surgery. Although pneumonectomy is an exceptional surgery in children, it can be performed by minimally invasive surgery with success and safety in centers with extensive experience in pediatric thoracoscopic surgery.

目前,小儿肺切除术是罕见的,仅用于肺部受损且经常恶化和再感染的病例,以前仅发表过两例胸腔镜肺切除术。我们提出一个病例4岁的病人没有相关的历史,谁发展完全的左肺不张(LL)甲型流感肺炎后,继发复发感染。一年后进行无改变支气管镜诊断。肺灌注SPECT-CT观察到肺活量完全丧失和左半胸灌注不足(右肺灌注95%,左半胸灌注5%),支气管扩张、过度充血和右肺疝入左半胸。在保守治疗失败和复发感染后,需要行全肺切除术。全肺切除术通过五孔胸腔镜进行。采用钩式电灼和封闭装置切开脐部。用吻合器切开左主支气管。无术中并发症。术后第一天取出胸内引流管。患者于术后第四天出院。术后10个月未出现任何并发症。虽然全肺切除术在儿童中是一种特殊的手术,但在具有丰富儿科胸腔镜手术经验的中心,可以通过微创手术成功且安全地进行。
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引用次数: 0
Severe penile fibrotic reaction secondary to a non-absorbable suture: a case report. 继发于不可吸收缝线的严重阴茎纤维化反应1例。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.16
J Arredondo Montero, S Hernández-Martín, L Ayuso González, C Bardají Pascual

Introduction: Circumcision is one of the most frequent urological surgical procedures in the pediatric population globally. Complications, although rare, can be severe.

Clinical case: We present the case of a Senegalese 10-year-old male patient who had undergone ritual circumcision in his early childhood and developed a progressive circumferential tumor in the penile body with no further associated symptoms. Surgical exploration was carried out. A fibrotic-looking penile ring, which was interpreted as an injury secondary to the non-absorbable suturing material used in the previous surgery, was identified. The tissue involved was removed, and on-demand preputioplasty was conducted. Due to technical limitations, the resected tissue could not be analyzed, which means diagnosis could not be histopathologically confirmed. The patient had a favorable progression.

Conclusions: This case demonstrates that the medical personnel in charge of performing circumcisions should be adequately trained in order to prevent severe complications.

简介:包皮环切术是全球儿科人群中最常见的泌尿外科手术之一。并发症虽然罕见,但可能很严重。临床病例:我们提出一例塞内加尔10岁男性患者,他在童年早期接受了割礼仪式,并在阴茎体中发展为进行性周周肿瘤,没有进一步的相关症状。手术探查。一个纤维状的阴茎环,被认为是先前手术中使用的不可吸收的缝合材料造成的继发损伤。切除受累组织,按需进行包皮成形术。由于技术限制,切除的组织无法进行分析,这意味着无法进行组织病理学诊断。病人病情进展良好。结论:本病例表明,负责执行包皮环切术的医务人员应接受充分的培训,以防止严重的并发症。
{"title":"Severe penile fibrotic reaction secondary to a non-absorbable suture: a case report.","authors":"J Arredondo Montero,&nbsp;S Hernández-Martín,&nbsp;L Ayuso González,&nbsp;C Bardají Pascual","doi":"10.54847/cp.2023.03.16","DOIUrl":"https://doi.org/10.54847/cp.2023.03.16","url":null,"abstract":"<p><strong>Introduction: </strong>Circumcision is one of the most frequent urological surgical procedures in the pediatric population globally. Complications, although rare, can be severe.</p><p><strong>Clinical case: </strong>We present the case of a Senegalese 10-year-old male patient who had undergone ritual circumcision in his early childhood and developed a progressive circumferential tumor in the penile body with no further associated symptoms. Surgical exploration was carried out. A fibrotic-looking penile ring, which was interpreted as an injury secondary to the non-absorbable suturing material used in the previous surgery, was identified. The tissue involved was removed, and on-demand preputioplasty was conducted. Due to technical limitations, the resected tissue could not be analyzed, which means diagnosis could not be histopathologically confirmed. The patient had a favorable progression.</p><p><strong>Conclusions: </strong>This case demonstrates that the medical personnel in charge of performing circumcisions should be adequately trained in order to prevent severe complications.</p>","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"36 3","pages":"144-146"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric intestinal failure: an update. 儿科肠衰竭:最新进展。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.09
A M Andrés Moreno, E Ramos Boluda, F Hernández Oliveros
{"title":"Pediatric intestinal failure: an update.","authors":"A M Andrés Moreno, E Ramos Boluda, F Hernández Oliveros","doi":"10.54847/cp.2023.03.09","DOIUrl":"10.54847/cp.2023.03.09","url":null,"abstract":"","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"36 3","pages":"97-109"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10165084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation: experience in a pediatric oncological institution. 异基因造血干细胞移植后出血性膀胱炎:在儿科肿瘤机构的经验。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.54847/cp.2023.03.13
S de la Puente, M L Espinoza, I Carrillo, C Rico, H Souto, J A Acedo, C Riñón, C Garcés, P Ramos, D Muñoz, B Zamora, R Espinosa, A L Huertas, I Rozas, M González, A Martín, J L Alonso

Objective: To analyze the risk factors associated with hemorrhagic cystitis (HC) severity and the treatment strategies available in HC patients following allogeneic hematopoietic stem cell transplantation (AHSCT).

Materials and methods: A retrospective study of medical records was carried out. Patients with HC following AHSCT treated from 2017 to 2021 were divided into two groups according to severity -mild and severe. Demographic data, disease-specific characteristics, urological sequelae, and overall mortality were compared between both groups. The hospital's protocol was used for patient management.

Results: 33 episodes of HC were collected in 27 patients, 72.7% of whom were male. HC incidence following AHSCT was 23.4% (33/141). 51.5% of HCs were severe (grades III-IV). Severe graft host disease (GHD) (grades III-IV) and thrombopenia at HC onset were associated with severe HC (p= 0.043 and p= 0.039, respectively). This group had longer hematuria times (p< 0.001) and required more platelet transfusions (p= 0.003). In addition, 70.6% required bladder catheterization, but only 1 case needed percutaneous cystostomy. None of the patients with mild HC required catheterization. No differences were found in terms of urological sequelae or overall mortality.

Conclusions: Severe HC could be predicted thanks to the presence of severe GHD or thrombopenia at HC onset. Severe HC can be managed with bladder catheterization in most of these patients. A standardized protocol may help reduce the need for invasive procedures in patients with mild HC.

目的:分析异体造血干细胞移植(AHSCT)后出血性膀胱炎(HC)严重程度的相关危险因素及治疗策略。材料和方法:回顾性研究了病历资料。2017 - 2021年AHSCT术后HC患者按严重程度分为轻度和重度两组。比较两组患者的人口学数据、疾病特异性特征、泌尿系统后遗症和总死亡率。医院的规章制度被用于病人管理。结果:27例患者共检出HC 33次,男性占72.7%。AHSCT后HC发病率为23.4%(33/141)。51.5%的hcc为重度(III-IV级)。HC发病时严重移植物宿主病(GHD) (III-IV级)和血小板减少与严重HC相关(p= 0.043和p= 0.039)。结论:由于HC发病时存在严重的GHD或血小板减少症,可以预测严重的HC。严重的丙型肝炎可以通过膀胱导尿治疗。标准化的方案可能有助于减少轻度HC患者对侵入性手术的需要。
{"title":"Hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation: experience in a pediatric oncological institution.","authors":"S de la Puente,&nbsp;M L Espinoza,&nbsp;I Carrillo,&nbsp;C Rico,&nbsp;H Souto,&nbsp;J A Acedo,&nbsp;C Riñón,&nbsp;C Garcés,&nbsp;P Ramos,&nbsp;D Muñoz,&nbsp;B Zamora,&nbsp;R Espinosa,&nbsp;A L Huertas,&nbsp;I Rozas,&nbsp;M González,&nbsp;A Martín,&nbsp;J L Alonso","doi":"10.54847/cp.2023.03.13","DOIUrl":"https://doi.org/10.54847/cp.2023.03.13","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the risk factors associated with hemorrhagic cystitis (HC) severity and the treatment strategies available in HC patients following allogeneic hematopoietic stem cell transplantation (AHSCT).</p><p><strong>Materials and methods: </strong>A retrospective study of medical records was carried out. Patients with HC following AHSCT treated from 2017 to 2021 were divided into two groups according to severity -mild and severe. Demographic data, disease-specific characteristics, urological sequelae, and overall mortality were compared between both groups. The hospital's protocol was used for patient management.</p><p><strong>Results: </strong>33 episodes of HC were collected in 27 patients, 72.7% of whom were male. HC incidence following AHSCT was 23.4% (33/141). 51.5% of HCs were severe (grades III-IV). Severe graft host disease (GHD) (grades III-IV) and thrombopenia at HC onset were associated with severe HC (p= 0.043 and p= 0.039, respectively). This group had longer hematuria times (p< 0.001) and required more platelet transfusions (p= 0.003). In addition, 70.6% required bladder catheterization, but only 1 case needed percutaneous cystostomy. None of the patients with mild HC required catheterization. No differences were found in terms of urological sequelae or overall mortality.</p><p><strong>Conclusions: </strong>Severe HC could be predicted thanks to the presence of severe GHD or thrombopenia at HC onset. Severe HC can be managed with bladder catheterization in most of these patients. A standardized protocol may help reduce the need for invasive procedures in patients with mild HC.</p>","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"36 3","pages":"128-134"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment with oral or topical sirolimus in complex vascular anomalies in pediatrics. Experience in a third-level hospital. 口服或外用西罗莫司治疗儿科复杂血管异常。有三级医院工作经验。
Q3 Medicine Pub Date : 2023-04-01 DOI: 10.54847/cp.2023.02.12
C Fernández Oliveira, C Martínez Roca, M Gómez Tellado, M P Salvador Garrido, M Outeda Macías, I Martín Herranz

Objective: The use of sirolimus in vascular anomalies is a special indication not authorized in its data sheet. The objective of this study was to increase the evidence of oral or topical use of sirolimus for this indication in the pediatric population.

Materials and methods: An observational, retrospective study of patients under 18 years of age treated with oral or topical sirolimus for vascular anomalies was carried out. Diagnosis and location of lesions, administration route and dosage of sirolimus, blood levels of sirolimus in patients who received oral treatment, treatment duration, response, and toxicity were collected.

Results: 18 patients - 7 with oral treatment and 11 with topical treatment - were included. With oral sirolimus, the overall response rate was 85.7%. Sirolimus was discontinued in 2 cases - as a result of full resolution and progression. 57.1% of patients had adverse effects, most of which were mild. Dyslipidemia was the most frequent adverse effect. Blood levels were monitored in all patients for dose adjustment purposes. With topical treatment, the overall response rate was 72.7%. Sirolimus was discontinued in 3 cases -due to progression in 2 cases and to stability in 1. 27.3% of patients had adverse effects, with itching standing out as the most frequent one.

Conclusions: The favorable results of sirolimus treatment in our patients seem to confirm its effectiveness and safety in vascular anomalies, which make it stand as a therapeutic option in pediatric patients. However, further research is required to establish the optimal treatment regimen, treatment duration, and potential long-term adverse effects.

目的:西罗莫司用于血管异常是一种特殊适应症,在其数据表中未被授权。本研究的目的是增加口服或局部使用西罗莫司在儿童人群中用于该指征的证据。材料和方法:对18岁以下口服或局部西罗莫司治疗血管异常的患者进行了一项观察性回顾性研究。收集病变的诊断和部位、西罗莫司给药途径和剂量、口服治疗患者西罗莫司血药水平、治疗时间、疗效和毒性。结果:共纳入18例患者,其中口服治疗7例,局部治疗11例。口服西罗莫司,总有效率为85.7%。西罗莫司停药2例-由于完全解决和进展。57.1%的患者出现不良反应,以轻度为主。血脂异常是最常见的不良反应。监测所有患者的血药浓度以调整剂量。局部治疗的总有效率为72.7%。西罗莫司停药3例,其中2例因病情进展,1例因病情稳定。27.3%的患者出现不良反应,其中瘙痒是最常见的不良反应。结论:西罗莫司治疗患儿的良好结果似乎证实了其治疗血管异常的有效性和安全性,使其成为儿科患者的治疗选择。然而,需要进一步的研究来确定最佳的治疗方案、治疗时间和潜在的长期不良反应。
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引用次数: 0
Single-port transumbilical pediatric cholecystectomy: any benefits for the patient? 单孔经脐小儿胆囊切除术:对患者有什么好处?
Q3 Medicine Pub Date : 2023-04-01 DOI: 10.54847/cp.2023.02.13
J C Moreno Alfonso, A Molina Caballero, R Ros Briones, A Pérez Martínez, C Bardají Pascual

Objective: To compare the perioperative results of single-port laparoscopic cholecystectomy (SPLC) with those of laparoscopic cholecystectomy (LC), and to analyze whether there were any differences between both techniques in our patients.

Materials and methods: A retrospective, observational analysis was carried out in non-homogeneous groups of patients under 15 years of age undergoing LC and SPLC over a 6-year period. LC was conducted using four ports, while SPLC was performed through an umbilical incision using a wound retractor to which a surgical glove was coupled for the insertion of 3 ports and instruments curved as required. 15 clinical, surgical, and economic variables were compared by means of a univariate and bivariate analysis.

Results: 11 patients underwent surgery - 5 through SPLC and 6 through LC. No significant differences were found in terms of mean operating time (SPLC: 144 minutes vs. LC: 139, P= 0.855) or hospital stay, but a slight increase in hospital cost was noted (SPLC: 1,160 € vs. LC: 1,177 €). The cost of LC was 1,322 € vs. 1,367 € for SPLC, with a premium of 44.30 € owing to the use of the wound retractor. None of the patients had perioperative complications, and all of them felt the cosmetic result was excellent.

Conclusions: In our limited experience, the differences between SPLC and LC do not clearly support one or the other. SPLC could provide patients with a better cosmetic result and allow surgeons to improve their skills. However, we believe cholecystectomy is not the most adequate procedure to start a career in single-port laparoscopy because potential complications may be severe.

目的:比较单孔腹腔镜胆囊切除术(SPLC)与腹腔镜胆囊切除术(LC)的围手术期效果,分析两种技术在我院患者中是否存在差异。材料和方法:对15岁以下接受LC和SPLC的非均匀组患者进行了为期6年的回顾性观察分析。LC通过四个端口进行,SPLC通过脐带切口进行,使用伤口牵开器,连接手术手套以插入3个端口,并根据需要弯曲器械。通过单因素和双因素分析比较15个临床、手术和经济变量。结果:11例患者行手术,5例经SPLC, 6例经LC。在平均手术时间(SPLC: 144分钟vs LC: 139分钟,P= 0.855)或住院时间方面没有发现显著差异,但注意到住院费用略有增加(SPLC: 1,160欧元vs LC: 1,177欧元)。LC的费用为1322欧元,而SPLC的费用为1367欧元,由于使用了伤口牵开器,费用为44.30欧元。所有患者均无围手术期并发症发生,术后美观效果良好。结论:在我们有限的经验中,SPLC和LC之间的差异并不能明确地支持哪一个。SPLC可以为患者提供更好的美容效果,并允许外科医生提高他们的技能。然而,我们认为胆囊切除术并不是开始单孔腹腔镜职业生涯的最合适的手术,因为潜在的并发症可能很严重。
{"title":"Single-port transumbilical pediatric cholecystectomy: any benefits for the patient?","authors":"J C Moreno Alfonso,&nbsp;A Molina Caballero,&nbsp;R Ros Briones,&nbsp;A Pérez Martínez,&nbsp;C Bardají Pascual","doi":"10.54847/cp.2023.02.13","DOIUrl":"https://doi.org/10.54847/cp.2023.02.13","url":null,"abstract":"<p><strong>Objective: </strong>To compare the perioperative results of single-port laparoscopic cholecystectomy (SPLC) with those of laparoscopic cholecystectomy (LC), and to analyze whether there were any differences between both techniques in our patients.</p><p><strong>Materials and methods: </strong>A retrospective, observational analysis was carried out in non-homogeneous groups of patients under 15 years of age undergoing LC and SPLC over a 6-year period. LC was conducted using four ports, while SPLC was performed through an umbilical incision using a wound retractor to which a surgical glove was coupled for the insertion of 3 ports and instruments curved as required. 15 clinical, surgical, and economic variables were compared by means of a univariate and bivariate analysis.</p><p><strong>Results: </strong>11 patients underwent surgery - 5 through SPLC and 6 through LC. No significant differences were found in terms of mean operating time (SPLC: 144 minutes vs. LC: 139, P= 0.855) or hospital stay, but a slight increase in hospital cost was noted (SPLC: 1,160 € vs. LC: 1,177 €). The cost of LC was 1,322 € vs. 1,367 € for SPLC, with a premium of 44.30 € owing to the use of the wound retractor. None of the patients had perioperative complications, and all of them felt the cosmetic result was excellent.</p><p><strong>Conclusions: </strong>In our limited experience, the differences between SPLC and LC do not clearly support one or the other. SPLC could provide patients with a better cosmetic result and allow surgeons to improve their skills. However, we believe cholecystectomy is not the most adequate procedure to start a career in single-port laparoscopy because potential complications may be severe.</p>","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"36 2","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9446362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
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