Clinical and Experimental Hypertension最新文献_第9页

Proprotein convertase subtilisin/kexin type 9 is associated with atherosclerosis in patients with Behcet’s disease 蛋白转化酶枯草杆菌素/ keexin 9型与白塞氏病患者动脉粥样硬化相关

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-05-03 DOI: 10.1080/10641963.2022.2071921

R. Aydogan Baykara, Pinar Diydem Yilmaz, M. H. Göktepe, C. Kadıyoran, Mustafa Ogul, A. Kucuk, Medine Cumhur Cüre, Erkan Cüre

ABSTRACT Objectives The incidence of cardiovascular disease is increased in patients with Behcet’s disease (BD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) causes the acceleration of atherosclerosis. We aimed to investigate whether there is a relationship between PCSK9 with carotid artery intima-media thickness (cIMT), a marker of subclinical atherosclerosis, and BD disease activity. Methods Fifty-eight patients with BD and 58 age-, gender-, and body mass index (BMI)-matched healthy control subjects were included in the study. The disease activity of the patients was estimated. Individuals’ cIMT values were measured, and PCSK9 levels were studied. Results Patients with BD’ cIMT (0.51 ± 0.1 vs 0.41 ± 0.1 mm, p < .001) and PCSK9 (623.2 ± 101.7 ± 10.1 vs 528.3 ± 242.7 ng/ml, p = .007), values were significantly higher than the control group. In stepwise regression analysis, there was an independent relationship between cIMT with PCSK9 (β = 0.179, p < .050). There was no independent relationship between disease activities with PCSK9. Based on the ROC curve analysis, the PCSK9 optimal cutoff value for cIMT was 595.1 ng/ml, sensitivity 66.7%, specificity 64.7% (AUC = 0.672; 95% CI: 0.530–0.815, p = .040). Conclusion There is a strong independent association between subclinical atherosclerosis and PCSK9 in patients with BD. There may be no independent association between PCSK9 and disease activity.

【摘要】目的白塞氏病(BD)患者心血管疾病的发生率增高。蛋白转化酶枯草素/键合蛋白9型(PCSK9)导致动脉粥样硬化加速。我们的目的是研究PCSK9与颈动脉内膜-中膜厚度(cIMT)(亚临床动脉粥样硬化的标志)和BD疾病活动性之间是否存在关系。方法将58例BD患者和58例年龄、性别、体重指数(BMI)匹配的健康对照者纳入研究。估计患者的疾病活动性。测量个体的cIMT值，研究PCSK9水平。结果BD组患者cIMT(0.51±0.1 vs 0.41±0.1 mm, p < 0.001)、PCSK9(623.2±101.7±10.1 vs 528.3±242.7 ng/ml, p = 0.007)值均显著高于对照组。逐步回归分析显示，cIMT与PCSK9呈独立相关(β = 0.179, p < 0.050)。疾病活动与PCSK9之间没有独立的关系。ROC曲线分析显示，PCSK9检测cIMT的最佳临界值为595.1 ng/ml，灵敏度66.7%，特异性64.7% (AUC = 0.672;95% CI: 0.530-0.815, p = 0.040)。结论BD患者亚临床动脉粥样硬化与PCSK9有较强的独立相关性，PCSK9与疾病活动度可能无独立相关性。

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引用次数: 1

Effects of RAAS blocker use on AKI in elderly hypertensive STEMI patients with propensity score weighed method 倾向评分加权法观察RAAS阻滞剂对老年高血压STEMI患者AKI的影响

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-05-03 DOI: 10.1080/10641963.2022.2071922

G. Zeren, İ. Avcı, M. Sungur, B. Şimşek, Aylin Sungur, F. Can, M. F. Yılmaz, Ufuk Gürkan, S. Kalkan, A. Karagöz, I. Tanboğa, C. Karabay

ABSTRACT Studies reported conflicting results on the effect of renin-angiotensin-aldosterone system (RAAS) blocker use on acute kidney injury (AKI) in patients undergoing elective coronary angiography but association in elderly patients with ST-elevation myocardial infarction (STEMI) is not known. Also, there are limited data on the effect of inflammatory markers on AKI. We aimed to investigate the effects of RAAS blocker pretreatment and inflammatory markers on AKI in this population. A total of 471 patients were compared according to presence of RAAS blocker pretreatment at admission. Conventional and inverse probability weighed conditional logistic regression were used to determine independent predictors of AKI. Mean age of the study group was 75.4 ± 7.1 years and 29.1% of the patients were female. AKI was observed in 17.2% of the study population. Weighted conditional multivariable logistic regression analysis revealed that AKI was associated with baseline creatinine levels and C-reactive protein/albumin ratio (CAR) (OR 2.08, 95% CI = 1.13–3.82, p = .02 and OR 1.19, 95% CI = 1.01–1.41, p = .04, respectively). No significant association was found between RAAS blocker pretreatment and AKI. CAR and elevated baseline creatinine levels were independent predictors of AKI in this patient group.

研究报告了肾素-血管紧张素-醛固酮系统(RAAS)阻滞剂对选择性冠状动脉造影患者急性肾损伤(AKI)的影响的相互矛盾的结果，但与老年st段抬高型心肌梗死(STEMI)患者的关联尚不清楚。此外，关于炎症标志物对AKI的影响的数据有限。我们的目的是研究RAAS阻断剂预处理和炎症标志物对该人群AKI的影响。471例患者根据入院时是否存在RAAS阻滞剂进行比较。采用常规和逆概率加权条件logistic回归确定AKI的独立预测因子。研究组平均年龄75.4±7.1岁，女性占29.1%。在17.2%的研究人群中观察到AKI。加权条件多变量logistic回归分析显示AKI与基线肌酐水平和c反应蛋白/白蛋白比(CAR)相关(OR分别为2.08,95% CI = 1.13-3.82, p = 0.02和OR为1.19,95% CI = 1.01-1.41, p = 0.04)。RAAS阻滞剂预处理与AKI之间无显著相关性。CAR和基线肌酐水平升高是该患者组AKI的独立预测因子。

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引用次数: 0

Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study 接受β受体阻滞剂或血管紧张素受体阻滞剂的高血压女性运动训练后心血管反应的不同:一项初步研究

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-23 DOI: 10.1080/10641963.2022.2065290

Igor M Mariano, A. Amaral, Victor Hugo V Carrijo, J. G. Costa, M. D. L. Rodrigues, T. Cunha, G. Puga

ABSTRACT Aim To verify the influence of β-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. Methods Postmenopausal women were allocated into: healthy control group (CON; n = 9); angiotensin receptor blockers users (ARB; n = 19); and β-adrenergic blockers users (BB; n = 19). Before and after 12 weeks of combined (aerobic and resistance) exercise training they were evaluated by: heart rate (HR) and its variability (HRV), blood pressure (BP) under stress (Cold pressor and Stroop color tests), and ambulatorial BP and its variability. Results In ambulatorial BP analysis only in ARB group awake systolic BP decreased (p = .011; ARB: From 122 ± 11 to 117 ± 9; BB: From 118 ± 7 to 114 ± 5; CON: From 121 ± 7 to 127 ± 11 mmHg). There were time effects in BP reactivity to stress, where BP reactivity after Stroop color and Cold pressor test decreased in all groups. In BP variability analysis, only BB group has significative decreased values in systolic SD24 (p = .007; ΔARB = −0.3 ± 2.0; ΔBB = −1.3 ± 2.0; ΔCON = 0.8 ± 1.7 mmHg) and SDdn (p = .006; ΔARB = −0.2 ± 1.6; ΔBB = −1.3 ± 2.0; ΔCON = 0.4 ± 2.1 mmHg). HRV analysis demonstrated that post-training, only in BB group LF/HF decreased (p = .001; ΔARB = 0.1 ± 0.8; ΔBB = −0.4 ± 1.5; ΔCON = 1.0 ± 1.7). Conclusion ARB present pronounced responses in awake ambulatorial systolic BP, while β-blockers users present greater responses in BP variability. Besides that, exercise can mitigate BP reactivity to stress with no differences between groups. Lastly, there were no major differences in HRV. Trial registry at “Clinicaltrials.gov” NCT03529838

【摘要】目的探讨β受体阻滞剂或血管紧张素受体阻滞剂对绝经后高血压妇女运动训练后心血管反应的影响。方法将绝经后妇女分为健康对照组(CON;N = 9);血管紧张素受体阻滞剂使用者;N = 19);β-肾上腺素受体阻滞剂使用者(BB;N = 19)。在12周(有氧和阻力)联合运动训练前后，通过心率(HR)及其变异性(HRV)，应激下血压(BP)(冷压和Stroop颜色试验)和动态血压及其变异性来评估他们。结果在动态血压分析中，只有ARB组清醒时收缩压降低(p = 0.011;ARB: 122±11 ~ 117±9;BB:从118±7到114±5;CON:从121±7到127±11 mmHg)。血压对应激的反应性存在时间效应，实验组和冷压试验后血压反应性均下降。在血压变异性分析中，只有BB组的收缩期SD24值显著降低(p = 0.007;Δarb =−0.3±2.0;Δbb =−1.3±2.0;ΔCON = 0.8±1.7 mmHg)和SDdn (p = 0.006;Δarb =−0.2±1.6;Δbb =−1.3±2.0;ΔCON = 0.4±2.1 mmHg)。HRV分析显示，训练后，只有BB组LF/HF降低(p = .001;Δarb = 0.1±0.8;Δbb =−0.4±1.5;Δcon = 1.0±1.7)。结论ARB对清醒时动态收缩压有明显的反应，而β受体阻滞剂对血压变异性有更大的反应。除此之外，运动可以减轻血压对压力的反应，两组之间没有差异。最后，两组HRV无显著差异。临床试验注册网站:Clinicaltrials.gov, NCT03529838

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引用次数: 1

Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats 莪术提取物对肾血管性高血压大鼠的抗高血压作用

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-20 DOI: 10.1080/10641963.2022.2065286

Xoan Thi Le, Loan Thanh Thi Nguyen, Phuong Thi Tuyet Nguyen, Tai Van Nguyen, Hiep Van Nguyen, Hang Thi Nguyet Pham, Hong Nguyen Tran, Thang Dac Hoang, Dong Van Le, Kinzo Matsumoto

ABSTRACT Objectives This study aims to investigate the anti-hypertensive effects of aqueous extract of Callisia fragrans and their underlying mechanism using a two-kidney one-clip (2K1C) model of reno-vascular hypertension in rats. Methods The reno-vascular hypertensive rats were treated with C. fragrans leaf extract (100 and 500 mg/kg; p.o.) and a reference drug, captopril (20 mg/kg; p.o.), for 4 weeks. The blood pressure and heart rate were recorded using a tail-cuff. The heart weight, left ventricular wall thickness, and serum creatinine and urea levels were measured. A spectrophotometric assay was used to analyze the angiotensin-converting enzyme (ACE) inhibition activity of the extract and the reference drug. The total volume and the concentration of sodium, potassium, and chloride in urine samples were evaluated. Results C. fragrans extract significantly reduced both systolic and diastolic blood pressures in the reno-vascular hypertensive rats. No significant difference in the heart rate was observed between each animal group. C. fragrans extract reduced the 2K1C-induced increase in the heart and body weight ratio and the left ventricular wall thickness. Moreover, the extract also attenuated the increase in serum urea induced by the 2K1C treatment. C. fragrans extract inhibited ACE activity in vitro with an IC50 of 20.97 ± 3.94 µg/ml. The urine output and urinary electrolyte excretion significantly increased in C. fragrans extract-treated rats. Conclusions These findings demonstrated that C. fragrans extract can mitigate hypertension and alleviate ventricular hypertrophy and renal dysfunction in reno-vascular hypertensive rats, at least in part via ACE activity inhibition and diuretic property.

【摘要】目的通过大鼠肾血管高血压双肾一夹(2K1C)模型，探讨莪术水提物的降压作用及其机制。方法用桂花叶提取物(100、500 mg/kg;p.o.)和对照药物卡托普利(20mg /kg;p.o.)，为期四周。用尾袖记录血压和心率。测量心脏重量、左心室壁厚度、血清肌酐和尿素水平。采用分光光度法测定其对血管紧张素转换酶(ACE)的抑制活性。评估尿液样本中钠、钾、氯的总体积和浓度。结果桂花提取物能显著降低肾血管性高血压大鼠的收缩压和舒张压。各组动物心率无显著差异。桂花提取物降低了2k1c诱导的心体重比和左室壁厚度的增加。此外，提取物还能减弱由2K1C处理引起的血清尿素升高。香薷提取物体外抑制ACE活性的IC50为20.97±3.94µg/ml。藿香提取物处理大鼠的尿量和尿电解质排泄明显增加。结论桂花提取物对肾血管性高血压大鼠的高血压、心室肥厚和肾功能不全具有一定的缓解作用，其作用机制可能与抑制ACE活性和利尿作用有关。

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引用次数: 0

Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension 老年高血压患者急性高强度间歇运动与中等强度连续热水运动的血流动力学、心脏自主神经和血管反应对比

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-19 DOI: 10.1080/10641963.2022.2065288

I. Roque Marçal, Vanessa Teixeira Do Amaral, Bianca Fernandes, Raphael Martins de Abreu, Cristian Alvarez, Guilherme Veiga Guimarães, V. Cornelissen, Emmanuel Gomes Ciolac

ABSTRACT Objectives This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension. Methods Twenty (67 ± 7 y) older individuals with hypertension were randomly assigned to perform HIIE, MICE, or control (CON) sessions in the heated swimming pool (30–32°C). Blood pressure (BP), arterial stiffness, endothelial reactivity, and heart rate variability (HRV) were measured pre, post, and 45 min (recovery) after each intervention followed by 24-h ambulatory BP and HRV. Results One single aerobic exercise session was not effective to provoke post-exercise hypotension and vascular improvements. HIIE was superior to MICE and CON to increasing parasympathetic modulation at post and recovery. Exercise sessions showed to disturb the autonomic system at nighttime compared to CON. Conclusions These results may have important implications in water-based therapy and the elderly with hypertension

目的:本交叉研究旨在评估老年高血压患者在高强度间歇运动(HIIE)与中强度连续运动(MICE)时的血流动力学、心脏自主神经和血管反应。方法将20例(67±7岁)老年高血压患者随机分为HIIE组、小鼠组和对照组(CON)，分别在30-32°C的温水游泳池中进行实验。测量血压(BP)、动脉硬度、内皮反应性和心率变异性(HRV)，并在每次干预前、后和45分钟(恢复)后测量24小时动态血压和HRV。结果单次有氧运动不能引起运动后低血压和血管改善。HIIE在增强恢复后和恢复后副交感神经调节方面优于小鼠和CON。与对照组相比，夜间运动可干扰自主神经系统。结论这些结果可能对水基疗法和老年高血压患者有重要意义

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引用次数: 1

Efficacy of using walnuts as statin adjuvants in hypertension management 核桃作为他汀类药物辅助治疗高血压的疗效观察

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-17 DOI: 10.1080/10641963.2022.2065287

P. Amadi, E. Agomuo, J. Amadi, A.I. Bob-Chile Agada, U. Njoku, Chinedu S Ogunwa, Prince C. Odika, J. O. Osuoha, A. Ogbolosingha, Chiamaka Adumekwe, I. N. Chigbu

ABSTRACT Background Due to the widespread unorthodox use of nuts to improve cardiovascular health, this clinical trial was carried out to evaluate the efficacy of walnut as an adjuvant statin in hypertensive subjects. Method A single-blind placebo-controlled randomized clinical trial that lasted for 3 months. Forty-five screened hypertensive subjects on treatment, aged 45–65 years, were randomized into intervention and placebo groups according to their blood pressure defined by the American Heart Association criteria. Fifteen (15) normotensive subjects were also recruited for this study. The participants in the intervention group included daily 7 g of boiled walnut taken as snacks. The study was not controlled for type of diet and frequency of meals in a day. Low-density lipoprotein cholesterol (LDLc) was the primary endpoint for this study. Results The mean LDLc levels of the intervention groups (84.6 mg/dl and 79.7 mg/dl, respectively) were significantly (p < .005) lower than the placebo (137.6 mg/dl). The high-density lipoprotein cholesterol (HDLc) levels of the intervention groups were significantly higher than the placebo. The mean total cholesterol levels of the intervention groups were significantly lower than the placebo group. The intervention groups recorded a significantly lower systolic and diastolic blood pressure compared to the placebo. The supplementation of walnut significantly decreased the apolipoprotein E (APOE), proprotein convertase subtilisin kexin 9 (PCSK9), and cholesteryl ester transfer protein (CETP) activities relative to the placebo. Conclusion The use of walnut as a statin adjuvant during hypertension treatment reduced LDLc levels within 42.1% and improved HDL levels by 33.6%, and the LDLc decrease related to reduced PCSK9 and APOE activities while the HDLc increase related to reduced CETP activities.

背景:由于坚果被广泛用于改善心血管健康，本临床试验旨在评估核桃作为他汀类药物辅助治疗高血压患者的疗效。方法采用单盲安慰剂对照随机临床试验，为期3个月。45名年龄在45-65岁之间的高血压患者根据美国心脏协会的血压标准被随机分为干预组和安慰剂组。本研究还招募了15名血压正常的受试者。干预组的参与者每天吃7克煮核桃作为零食。这项研究没有控制饮食类型和一天中吃饭的频率。低密度脂蛋白胆固醇(LDLc)是这项研究的主要终点。结果干预组的平均ldl水平分别为84.6 mg/dl和79.7 mg/dl，显著低于安慰剂组(137.6 mg/dl) (p < 0.005)。干预组的高密度脂蛋白胆固醇(HDLc)水平明显高于安慰剂组。干预组的平均总胆固醇水平明显低于安慰剂组。与安慰剂组相比，干预组的收缩压和舒张压明显降低。与安慰剂相比，核桃的添加显著降低了载脂蛋白E (APOE)、蛋白转化酶枯草杆菌蛋白9 (PCSK9)和胆固醇酯转移蛋白(CETP)的活性。结论在高血压治疗过程中，核桃作为他汀类药物的辅助剂，ldl水平降低42.1%以内，HDL水平提高33.6%，ldl降低与PCSK9和APOE活性降低有关，HDL升高与CETP活性降低有关。

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引用次数: 0

Blood Pressure and Blood Glucose Responses to Combined Exercise Sessions of Different Intensities in Individuals with Cardiovascular Risk Factors 有心血管危险因素个体不同强度联合运动对血压和血糖的反应

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-14 DOI: 10.1080/10641963.2022.2065289

Mabel Diesel, Isabel Heberle, G. Juchem, Guilherme Tadeu de Barcelos, Juliana Cavestré Coneglian, A. Gerage, R. S. Delevatti

ABSTRACT Objective The purpose of the present study was to verify the acute effects of blood pressure and blood glucose after two sessions of combined exercise sessions performed at two levels of intensity in trained individuals with cardiovascular risk factors. Methods Eighteen individuals (66.22 ± 8.61 years) of both sexes (6 women/12 men) with cardiovascular risk factors performed two sessions of combined exercises at different levels of intensity: moderate (MOD) and high (HI). To control the intensity of the aerobic training, the Borg Rating of Perceived Exertion (RPE) Scale was used. For the strength training, the maximum number of repetitions was carried out within a predetermined duration of sets. Blood pressure and blood glucose measurements were collected before and 20 minutes after the sessions. The data were analyzed using Generalized Estimating Equations, α 5%. Results Reductions were observed in systolic blood pressure (MOD – Δ = −4.95 mmHg; HI – Δ = −3.31 mmHg) and blood glucose (MOD – Δ = −16.06 mg/dL; HI – Δ = −29.45 mg/dL) after the two sessions, with no difference between sessions. Diastolic blood pressure did not change (p < .05). Conclusion Combined exercises sessions of moderate or high intensity can promote an acute reduction in systolic blood pressure and glycemia in individuals with cardiovascular risk factors.

【摘要】目的本研究的目的是验证具有心血管危险因素的训练个体在两种强度下进行两次联合运动后对血压和血糖的急性影响。方法有心血管危险因素的18例男女(66.22±8.61岁)(6女12男)分别进行中等(MOD)和高(HI)两组不同强度的组合运动。为了控制有氧训练的强度，采用Borg感知运动强度评分(RPE)量表。对于力量训练，最大次数的重复是在预定的时间内进行的。在训练前和训练后20分钟采集血压和血糖测量值。用α 5%的广义估计方程对数据进行分析。结果收缩压降低(MOD - Δ = - 4.95 mmHg;HI - Δ =−3.31 mmHg)和血糖(MOD - Δ =−16.06 mg/dL;HI - Δ =−29.45 mg/dL)，两组间无差异。舒张压无明显变化(p < 0.05)。结论中等或高强度的联合运动可促进心血管危险因素患者收缩压和血糖的急性降低。

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引用次数: 0

Inter-arm blood pressure difference is associated with contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. st段抬高型心肌梗死患者行原发性经皮冠状动脉介入治疗后，臂间血压差与造影剂肾病相关。

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-03 Epub Date: 2022-01-21 DOI: 10.1080/10641963.2022.2029471

Zeki Simsek, Regayip Zehir, Sedat Kalkan, Doğancan Ceneli, Elnur Alizade, Emrah Bayam, Özkan Candan

Objective: Contrast-induced nephropathy (CIN) is a serious complication in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (p-PCI). An interarm systolic blood pressure difference (IASBD) ≥10 mmHg has been identified as an independent risk factor for cardiovascular disease and mortality. The aim of this study was to evaluate the predictive value of the IASBD for the risk of CIN in patients with STEMI who underwent p-PCI.

Method: We prospectively investigated 2120 consecutive patients who were hospitalized with a diagnosis of STEMI and underwent p-PCI. A relative increase in serum creatinine levels of ≥ 25% or an absolute increase of ≥ 0.5 mg/dL from baseline within 72 h of contrast exposure was defined as CIN. The IASBD was calculated on admission to the emergency department. The risk of CIN was evaluated.

Results: The incidence of CIN was 6.6% (n = 139). The patients were divided into 2 groups based on the development of CIN. Age (p = .001), baseline creatinine levels (p < .001), DM (p < .001), HT (p < .001) and anemia (p = .001) were higher in patients with CIN. An IASBD ≥10 mmHg was noted in 13 (9.3%) patients in the CIN group and 83 (4.1%) (p = .001) in the non-CIN group (Table 1). According to the multivariate analysis, the IASBD was found to be a predictor of CIN development (OR: 2.36, 95% CI: 1.42-3.90, p: 0.001).

Conclusion: The IASBD on admission can be a potential predictor of CIN development in patients with STEMI who underwent p-PCI.

目的:造影剂肾病(CIN)是ST段抬高型心肌梗死(STEMI)患者接受初级经皮冠状动脉介入治疗(p-PCI)的严重并发症。收缩压差(IASBD)≥10 mmHg已被确定为心血管疾病和死亡的独立危险因素。本研究的目的是评估IASBD对STEMI患者行p-PCI后发生CIN风险的预测价值。方法:我们前瞻性调查了2120例诊断为STEMI并接受p-PCI治疗的连续住院患者。对比剂暴露后72小时内血清肌酐水平相对增加≥25%或绝对增加≥0.5 mg/dL被定义为CIN。IASBD在进入急诊科时计算。评估CIN的风险。结果:CIN发生率为6.6% (n = 139)。根据CIN的发展情况将患者分为两组。结论:入院时的IASBD可作为STEMI患者行p- pci后CIN发展的潜在预测指标。

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引用次数: 0

Cardiovascular protective effect of nano selenium in hypothyroid rats: protection against oxidative stress and cardiac fibrosis. 纳米硒对甲状腺功能减退大鼠的心血管保护作用:对氧化应激和心脏纤维化的保护作用。

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-03 Epub Date: 2022-02-10 DOI: 10.1080/10641963.2022.2036994

Seyed Hamidreza Rastegar Moghaddam, Mahmoud Hosseini, Fereshteh Sabzi, Fatemeh Hojjati Fard, Narges Marefati, Farimah Beheshti, Majid Darroudi, Alireza Ebrahimzadeh Bideskan, Akbar Anaeigoudari

Background: Nano selenium (Nano Sel) has many therapeutic properties including antioxidant, anticancer, and anti-inflammatory actions.

Objective: Impacts of Nano Sel administration against cardiac fibrosis and heart and aorta tissue oxidative damage observed in hypothyroid rats were explored.

Methods: The animals were randomly grouped and treated as: 1) Control; 2) Propylthiouracil (PTU) in which PTU was added to the drinking water (0.05%) to induce hypothyroidism; 3-5) PTU-Nano Sel 50, PTU-Nano Sel 100, and PTU-Nano Sel 150 groups, which received daily PTU plus 50,100 or 150 µg/kg of Nano Sel for 6 weeks intraperitoneally. The heart and aorta tissues were removed under deep anesthesia and then biochemical parameters including malondialdehyde (MDA), total thiol groups, catalase (CAT), and superoxide dismutase (SOD), as well as cardiac fibrosis were assessed.

Results: Hypothyroidism induced by PTU was remarkably associated with myocardial hypertrophy and perivascular fibrosis in Masson's trichrome staining. Moreover, hypothyroidism increased MDA level, while it subtracted total thiol group content and activity of SOD and CAT. Treatment with Nano Sel recovered hypothyroidism-induced cardiac fibrosis in the histological assessment. Nano Sel also promoted CAT and SOD activity and thiol content, whereas alleviated MDA levels in the heart and aorta tissues.

Conclusion: Results propose that administration of Nano Sel exerts a protective role in the cardio vascular system via preventing cardiac fibrosis and inhibiting oxidative stress.

背景:纳米硒(Nano Sel)具有许多治疗特性，包括抗氧化、抗癌和抗炎作用。目的:探讨纳米硒对甲状腺功能减退大鼠心肌纤维化和心脏及主动脉组织氧化损伤的影响。方法:随机分组，实验组:1)对照组;2)丙基硫脲嘧啶(PTU)，将PTU添加到饮用水中(0.05%)诱导甲状腺功能减退;3-5) PTU-Nano Sel 50、PTU-Nano Sel 100和PTU-Nano Sel 150组，每天腹腔注射PTU加50,100或150µg/kg纳米Sel，持续6周。在深度麻醉下切除心脏和主动脉组织，评估丙二醛(MDA)、总巯基、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)等生化指标及心肌纤维化情况。结果:马氏三色染色显示PTU诱导的甲状腺功能减退与心肌肥大和血管周围纤维化有显著相关性。甲状腺功能减退使MDA水平升高，使总硫醇组含量降低，SOD、CAT活性降低。用纳米Sel治疗甲状腺功能减退引起的心脏纤维化的组织学评估。纳米Sel还能提高CAT、SOD活性和硫醇含量，降低心脏和主动脉组织MDA水平。结论:纳米Sel通过预防心肌纤维化和抑制氧化应激对心血管系统具有保护作用。

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引用次数: 5

Serum irisin and adropin levels may be predictors for coronary artery ectasia. 血清鸢尾素和促肾上腺素水平可能是冠状动脉扩张的预测因子。

IF 12.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension

Pub Date : 2022-04-03 Epub Date: 2022-01-07 DOI: 10.1080/10641963.2021.2018601

Bayram Ali Uysal, Mevlut Serdar Kuyumcu

Background: There is strong evidence that oxidative stress and inflammation may contribute to the coronary artery ectasia (CAE) pathophysiology. Recent studies have shown that serum irisin and adropin levels are associated with oxidative stress and inflammation. In the light of this information, we aimed to investigate the possible relationship between serum irisin, adropin levels and CAE.

Patients & methods: A total of 50 consecutive patients with CAE and 50 consecutive patients with normal coronary anatomy (NCA) were enrolled into the study. Serum irisin, adropin and other clinical parameters were compared between groups.

Results: Adropin (p < .001) and irisin (p < .001) levels were lower in the CAE group. Low adropin (p = .014) and irisin (p < .001) levels were detected as an independent risk factor for CAE in multiple regression analysis. Receiver operating characteristic curve analysis showed that serum adropin (p < .001) and irisin (p < .001) leves was significant predictor of CAE.

Conclusions: The results of this study showed that serum irisin and adropin level was lower in the CAE group than in the NCA group. Irisin and adropin could play a role in the pathogenesis of CAE.

背景:有强有力的证据表明，氧化应激和炎症可能与冠状动脉扩张(CAE)的病理生理有关。最近的研究表明，血清鸢尾素和促肾上腺素水平与氧化应激和炎症有关。根据这些信息，我们旨在探讨血清鸢尾素、adropin水平与CAE之间的可能关系。患者和方法:共50例连续CAE患者和50例连续冠状动脉解剖正常(NCA)患者入组研究。各组血清鸢尾素、adropin等临床指标比较。结果:Adropin (p p p = 0.014)和irisin (p p p p)的差异有统计学意义。结论:CAE组血清irisin和Adropin水平明显低于NCA组。鸢尾素和adropin可能参与CAE的发病机制。

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引用次数: 1