N. Lachine, Eman Y. Morsy, A. Elnekiedy, Mohamed A. Sadaka, G. I. Khalil, Hesham G. Imam, H. Kassab, Noha G. Amin
Objective: The current study aims to assess the relationship between serum osteocalcin (OCN) and osteoprotegerin (OPG) levels and subclinical atherosclerosis. Material and methods: This case-control study included 80 male subjects divided into 2 groups: 40 subjects with type 2 diabetes (T2D) without coronary artery disease and 40 control subjects without diabetes. To assess the association of OCN and OPG with subclinical atherosclerosis (defined as carotid intima-media thick - ness (cIMT) ≥ 0.9mm), multivariable linear regression models were applied. Results: The mean age in the diabetes group was 54.1 ± ± 5.1 years while in the control group, it was 53.7 ± ± 6.6 years. The mean serum OCN level was signifi - cantly negatively correlated with hs-CRP, cIMT, HbA1c and FPG in the total sample (p = 0.001, < 0.001, < 0.001 and 0.006 respectively) while OPG level was significantly positively correlated with age and HbA1c (p = 0.047 and 0.009 respectively) in the total sample. Age and HbA1c were the only independent risk factors identifying subclinical atherosclerosis in multivariate analysis. A cut-off value of serum OCN level of ≤ 22 ng/mL was able to discriminate patients with subclinical atherosclerosis in the total sample (p = 0.003 * ) using receiver operator characteristic (ROC) curve analysis. Serum OCN level was significantly lower in the subclini - cal atherosclerosis group than in the control while OPG showed no significant difference between both groups. Conclusions: OCN may be a better marker for subclinical atherosclerosis than OPG. This effect is attenuated in the presence of DM. (Clin Diabetol 2024; 13, 1: 43–51)
{"title":"Association of Bone Turnover Biomarkers and Subclinical Atherosclerosis in Subjects with Type 2 Diabetes: A Case-Control Study","authors":"N. Lachine, Eman Y. Morsy, A. Elnekiedy, Mohamed A. Sadaka, G. I. Khalil, Hesham G. Imam, H. Kassab, Noha G. Amin","doi":"10.5603/cd.98236","DOIUrl":"https://doi.org/10.5603/cd.98236","url":null,"abstract":"Objective: The current study aims to assess the relationship between serum osteocalcin (OCN) and osteoprotegerin (OPG) levels and subclinical atherosclerosis. Material and methods: This case-control study included 80 male subjects divided into 2 groups: 40 subjects with type 2 diabetes (T2D) without coronary artery disease and 40 control subjects without diabetes. To assess the association of OCN and OPG with subclinical atherosclerosis (defined as carotid intima-media thick - ness (cIMT) ≥ 0.9mm), multivariable linear regression models were applied. Results: The mean age in the diabetes group was 54.1 ± ± 5.1 years while in the control group, it was 53.7 ± ± 6.6 years. The mean serum OCN level was signifi - cantly negatively correlated with hs-CRP, cIMT, HbA1c and FPG in the total sample (p = 0.001, < 0.001, < 0.001 and 0.006 respectively) while OPG level was significantly positively correlated with age and HbA1c (p = 0.047 and 0.009 respectively) in the total sample. Age and HbA1c were the only independent risk factors identifying subclinical atherosclerosis in multivariate analysis. A cut-off value of serum OCN level of ≤ 22 ng/mL was able to discriminate patients with subclinical atherosclerosis in the total sample (p = 0.003 * ) using receiver operator characteristic (ROC) curve analysis. Serum OCN level was significantly lower in the subclini - cal atherosclerosis group than in the control while OPG showed no significant difference between both groups. Conclusions: OCN may be a better marker for subclinical atherosclerosis than OPG. This effect is attenuated in the presence of DM. (Clin Diabetol 2024; 13, 1: 43–51)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"'Clinical Diabetology': Highlights of 2023 and Future Direction","authors":"Viral N. Shah, Łukasz Stolarczyk","doi":"10.5603/cd.99403","DOIUrl":"https://doi.org/10.5603/cd.99403","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Erukulapati, Manikandan R. M., Leenatha Reddy Jakkidi, S. Sathyanarayana, U. Ayyagari, Srinath Ashwathiah, S. Nalla, Satish Kumar Sampath, S. Manohar, Sanjay Shah, Chandan Kamath, Bhanu Praveen, M. Kushe, Radhika V. Kumar, Ravikumar Bachuwar, Murali Ganguri
guiding general physicians and general practitioners. Hence, this consensus statement uses the modified Delphi method. The Association of Clinical Endocrinologists is a non-profit, non-commercial body registered in India, that serves as a platform for like-minded Endocrinologists who aspire to work for the cause of the science of Diabetes and Endocrinology, its utility and application for the betterment of the health of the people and the country. The authors request the readers to please do not confuse this Association of Clinical Endocri - nologists with the American College of Endocrinology/ /American Association of Clinical Endocrinologists (ACE/AACE) of the United States of America (USA).
{"title":"A Practical Approach to the Initiation, Titration and Intensification of Insulin Therapy in Adults with Diabetes in the Indian Context: Recommendations by Association of Clinical Endocrinologists Consensus Group","authors":"R. Erukulapati, Manikandan R. M., Leenatha Reddy Jakkidi, S. Sathyanarayana, U. Ayyagari, Srinath Ashwathiah, S. Nalla, Satish Kumar Sampath, S. Manohar, Sanjay Shah, Chandan Kamath, Bhanu Praveen, M. Kushe, Radhika V. Kumar, Ravikumar Bachuwar, Murali Ganguri","doi":"10.5603/cd.98136","DOIUrl":"https://doi.org/10.5603/cd.98136","url":null,"abstract":"guiding general physicians and general practitioners. Hence, this consensus statement uses the modified Delphi method. The Association of Clinical Endocrinologists is a non-profit, non-commercial body registered in India, that serves as a platform for like-minded Endocrinologists who aspire to work for the cause of the science of Diabetes and Endocrinology, its utility and application for the betterment of the health of the people and the country. The authors request the readers to please do not confuse this Association of Clinical Endocri - nologists with the American College of Endocrinology/ /American Association of Clinical Endocrinologists (ACE/AACE) of the United States of America (USA).","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Hasnani, Santosh Jha, B. Saboo, Pusala Lakshmi Prasanna, Ami Sanghvi, Alpana Sowani, V. Chavda
{"title":"Efficacy of Insulin Degludec/Insulin Aspart (IDegAsp) vs. Insulin Glargine (IGlarU300) in Insulin-Naïve Patients with Type 2 Diabetes: A Retrospective Study","authors":"D. Hasnani, Santosh Jha, B. Saboo, Pusala Lakshmi Prasanna, Ami Sanghvi, Alpana Sowani, V. Chavda","doi":"10.5603/cd.98892","DOIUrl":"https://doi.org/10.5603/cd.98892","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140275163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sahebkar, Peyman Habibi, Faeze Sadat Talebian, S. M. Haftcheshmeh, Fatemeh Abdollahi, Nazanin Fekri, T. Jamialahmadi, Željko Reiner, S. Mirhafez
Objective: To evaluate the association between high-sensitivity C-reactive protein (hsCRP) and metabolic syndrome (MetS), components of the MetS as well as diabetes, and cardiovascular complications. Materials and methods: In this cross-sectional analysis, the data were collected from the registration phase of Neyshabur Longitudinal Study on Ageing (NeLSA) comprising a total of 6034 people aged 50 and older. Association between hsCRP and MetS and its components was conducted by univariate and multivariate analyses in the presence of covariates and confounding factors. Results: Baseline data including age, body fat mass, body mass index, waist-to-hip ratio, fasting plasma glucose, triglyceride, creatinine, albumin, and hsCRP also systolic blood pressure, and diastolic blood pressure were higher in the MetS group compared to the control group (p < 0.001 for all variables other than hsCRP, which was not significant (p = 0.06)). Also the univariate and multi variate analysis illustrated one-unit increase in the serum level of hsCRP was associated with 18% higher risk for diabetes [OR: 1.18; 95% confidence interval (CI), 1.06–1.30] and increased high-density lipoprotein cholesterol (HDL-C) by 15% (OR:1.15; (95% CI, 1.01–1.29). In subjects with MetS, one-unit (log of 1 mg/L) increase in the serum level of hsCRP was associated with 34% higher risk for atherosclerotic cardiovascular disease (ASCVD) (OR: 1.34; 95% CI, 1.11–1.63). Conclusions: There is an association between serum level of hsCRP and the presence of the components of MetS including HDL-C and diabetes, especially in women. (Clin Diabetol 2024; 13, 1: 52–59)
{"title":"Association between High-Sensitivity C-Reactive Protein and Metabolic Syndrome and Its Components in Older Adults: Findings from Neyshabur Longitudinal Study on Ageing (NeLSA)","authors":"A. Sahebkar, Peyman Habibi, Faeze Sadat Talebian, S. M. Haftcheshmeh, Fatemeh Abdollahi, Nazanin Fekri, T. Jamialahmadi, Željko Reiner, S. Mirhafez","doi":"10.5603/cd.98280","DOIUrl":"https://doi.org/10.5603/cd.98280","url":null,"abstract":"Objective: To evaluate the association between high-sensitivity C-reactive protein (hsCRP) and metabolic syndrome (MetS), components of the MetS as well as diabetes, and cardiovascular complications. Materials and methods: In this cross-sectional analysis, the data were collected from the registration phase of Neyshabur Longitudinal Study on Ageing (NeLSA) comprising a total of 6034 people aged 50 and older. Association between hsCRP and MetS and its components was conducted by univariate and multivariate analyses in the presence of covariates and confounding factors. Results: Baseline data including age, body fat mass, body mass index, waist-to-hip ratio, fasting plasma glucose, triglyceride, creatinine, albumin, and hsCRP also systolic blood pressure, and diastolic blood pressure were higher in the MetS group compared to the control group (p < 0.001 for all variables other than hsCRP, which was not significant (p = 0.06)). Also the univariate and multi variate analysis illustrated one-unit increase in the serum level of hsCRP was associated with 18% higher risk for diabetes [OR: 1.18; 95% confidence interval (CI), 1.06–1.30] and increased high-density lipoprotein cholesterol (HDL-C) by 15% (OR:1.15; (95% CI, 1.01–1.29). In subjects with MetS, one-unit (log of 1 mg/L) increase in the serum level of hsCRP was associated with 34% higher risk for atherosclerotic cardiovascular disease (ASCVD) (OR: 1.34; 95% CI, 1.11–1.63). Conclusions: There is an association between serum level of hsCRP and the presence of the components of MetS including HDL-C and diabetes, especially in women. (Clin Diabetol 2024; 13, 1: 52–59)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
André Henrique Freitas de Braga e Bessa, Julieta Ueta, V. D. Mayrink, R. Oliveira
Objective: To analyze the clinical and pharmacothera-peutic profile of people with type 2 diabetes (T2D) at a military health center in Brazil. Materials and methods: This is a cross-sectional study. The sample of 170 medical records was selected by means of probabilistic sampling. The data collected were sociodemographic, clinical and laboratory data related to diabetes, as well as prescribed medications. Results: Most of the subjects were male (57.6%), elderly (64.7%) and inactive military (55.2%). Adequate gly - cemic control was observed in 75.9% of the subjects, which was positively associated with multimorbidity and mono-therapeutic treatment (p < 0.05). Negative associations were observed in those subjects attend - ing medical appointments less frequently and using prescribed insulin (p < 0.05). Medications prescribed for treatment of T2D were the following: metformin (90.6%), sulfonylureas (22.9%), dipeptidyl peptidase in - hibitors-4 (16.5%) and sodium-glucose 2 co-transporter inhibitors (10.0%), in which 50.6% were monotherapy. Multimorbidity was 97.6%, in which systemic arte - rial hypertension (71.8%), lipid disorders (65.9%) and cardiovascular diseases (26.5%) were the main clinical conditions.
{"title":"Type 2 Diabetes at a Military Health Centre in Brazil: Clinical and Pharmacotherapeutic Profile","authors":"André Henrique Freitas de Braga e Bessa, Julieta Ueta, V. D. Mayrink, R. Oliveira","doi":"10.5603/cd.98362","DOIUrl":"https://doi.org/10.5603/cd.98362","url":null,"abstract":"Objective: To analyze the clinical and pharmacothera-peutic profile of people with type 2 diabetes (T2D) at a military health center in Brazil. Materials and methods: This is a cross-sectional study. The sample of 170 medical records was selected by means of probabilistic sampling. The data collected were sociodemographic, clinical and laboratory data related to diabetes, as well as prescribed medications. Results: Most of the subjects were male (57.6%), elderly (64.7%) and inactive military (55.2%). Adequate gly - cemic control was observed in 75.9% of the subjects, which was positively associated with multimorbidity and mono-therapeutic treatment (p < 0.05). Negative associations were observed in those subjects attend - ing medical appointments less frequently and using prescribed insulin (p < 0.05). Medications prescribed for treatment of T2D were the following: metformin (90.6%), sulfonylureas (22.9%), dipeptidyl peptidase in - hibitors-4 (16.5%) and sodium-glucose 2 co-transporter inhibitors (10.0%), in which 50.6% were monotherapy. Multimorbidity was 97.6%, in which systemic arte - rial hypertension (71.8%), lipid disorders (65.9%) and cardiovascular diseases (26.5%) were the main clinical conditions.","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140281046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Okada, Kazuya Okada, Junichi Okada, Eijiro Yamada, Kumeo Ono
{"title":"SGLT2 Inhibitor Significantly Improved Plasma Glucose Levels in a Patient with Latent Autoimmune Diabetes of Adults: A Case Report","authors":"S. Okada, Kazuya Okada, Junichi Okada, Eijiro Yamada, Kumeo Ono","doi":"10.5603/cd.99034","DOIUrl":"https://doi.org/10.5603/cd.99034","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dotting the I’s and Crossing the T’s of Insulin Therapy in India","authors":"Om J Lakhani","doi":"10.5603/cd.99116","DOIUrl":"https://doi.org/10.5603/cd.99116","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140275346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matin Mojaveri Samak, F. Joukar, S. Maroufizadeh, Soheil Hassanipour, Zahra Abbasi Ranjbar, S. Yeganeh, Elahe Abbaspour, M. Aleali, F. Mansour-Ghanaei
{"title":"Prevalence of Gastrointestinal Symptoms among Individuals with and without Diabetes: A Cross-Sectional Study from the PERSIAN Guilan Cohort Study","authors":"Matin Mojaveri Samak, F. Joukar, S. Maroufizadeh, Soheil Hassanipour, Zahra Abbasi Ranjbar, S. Yeganeh, Elahe Abbaspour, M. Aleali, F. Mansour-Ghanaei","doi":"10.5603/cd.96670","DOIUrl":"https://doi.org/10.5603/cd.96670","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perceived Loneliness in Children with and without Type 1 Diabetes: A Cross-Sectional Study","authors":"E. Kobos, Alicja Szewczyk, Beata Dziedzic","doi":"10.5603/cd.96600","DOIUrl":"https://doi.org/10.5603/cd.96600","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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