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Impact of anticoagulants on efficacy outcomes after initiation of Darolutamide in non- metastatic castrate resistant prostate cancer (nmCRPC) from the real world UK multi-centre RECORD study
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.10.026
A. Stavropoulos , A. Bahl , P. White , L. Ashurst , M. Randhawa , A. Challapalli
{"title":"Impact of anticoagulants on efficacy outcomes after initiation of Darolutamide in non- metastatic castrate resistant prostate cancer (nmCRPC) from the real world UK multi-centre RECORD study","authors":"A. Stavropoulos , A. Bahl , P. White , L. Ashurst , M. Randhawa , A. Challapalli","doi":"10.1016/j.clon.2024.10.026","DOIUrl":"10.1016/j.clon.2024.10.026","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Page 9"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of neoadjuvant Docetaxel, Carboplatin, Trastuzumab, Pertuzumab in patients with HER2-positive early breast cancer - A retrospective study
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.103717
L. Koudsi, C. Hockaday, N. Levitt, M. Tuthill, R. Roux, S. Lord, J. Chiramel
{"title":"Efficacy and safety of neoadjuvant Docetaxel, Carboplatin, Trastuzumab, Pertuzumab in patients with HER2-positive early breast cancer - A retrospective study","authors":"L. Koudsi, C. Hockaday, N. Levitt, M. Tuthill, R. Roux, S. Lord, J. Chiramel","doi":"10.1016/j.clon.2024.103717","DOIUrl":"10.1016/j.clon.2024.103717","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103717"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoadjuvant chemotherapy for early breast cancer in young patients: real-world outcomes
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.103714
S.R. Javed, S. Mathur, K. DeSouza, A. Konstantis, D. Ottaviani, F. Raja, R. Roylance, T. Walsh, E. Papadimitraki
{"title":"Neoadjuvant chemotherapy for early breast cancer in young patients: real-world outcomes","authors":"S.R. Javed, S. Mathur, K. DeSouza, A. Konstantis, D. Ottaviani, F. Raja, R. Roylance, T. Walsh, E. Papadimitraki","doi":"10.1016/j.clon.2024.103714","DOIUrl":"10.1016/j.clon.2024.103714","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103714"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single centre experience of neo-adjuvant chemotherapy for HER2 positive early breast cancer and impact of chemotherapy regimen on pathological complete response (pCR)
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.103707
M. Joseph, A. Guppy, S. Sutherland, C. Westbury, W. Ng, D. Miles
{"title":"Single centre experience of neo-adjuvant chemotherapy for HER2 positive early breast cancer and impact of chemotherapy regimen on pathological complete response (pCR)","authors":"M. Joseph, A. Guppy, S. Sutherland, C. Westbury, W. Ng, D. Miles","doi":"10.1016/j.clon.2024.103707","DOIUrl":"10.1016/j.clon.2024.103707","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103707"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpelisib in advanced breast cancer – a real world report of toxicity and efficacy, a multi-centre analysis
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.103708
L. Morrison , D. Banon , I. Gill , N. Cunningham , A. Dua , A. Ballesteros , P.L. Marti , P. Galera , M. Alvarez-Maldonado , A. Iglesias , E. Carrillo , N.C. Turner , M. Parton , S. Johnston , E. Kipps , A.F.C. Okines
{"title":"Alpelisib in advanced breast cancer – a real world report of toxicity and efficacy, a multi-centre analysis","authors":"L. Morrison , D. Banon , I. Gill , N. Cunningham , A. Dua , A. Ballesteros , P.L. Marti , P. Galera , M. Alvarez-Maldonado , A. Iglesias , E. Carrillo , N.C. Turner , M. Parton , S. Johnston , E. Kipps , A.F.C. Okines","doi":"10.1016/j.clon.2024.103708","DOIUrl":"10.1016/j.clon.2024.103708","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103708"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A retrospective audit of adherence to the IMPORT-HIGH recommendations on clip placement to facilitate breast boost radiotherapy
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.103710
L. Alizadeh, A. Mitchell, C. Kane, E. Halliday, S. Needleman
{"title":"A retrospective audit of adherence to the IMPORT-HIGH recommendations on clip placement to facilitate breast boost radiotherapy","authors":"L. Alizadeh, A. Mitchell, C. Kane, E. Halliday, S. Needleman","doi":"10.1016/j.clon.2024.103710","DOIUrl":"10.1016/j.clon.2024.103710","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103710"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Under-representation for Female Pelvis Cancers in Commercial Auto-segmentation Solutions and Open-source Imaging Datasets 商业自动分割解决方案和开源成像数据集中女性骨盆癌的代表性不足。
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.10.003
M. Thor , V. Williams , C. Hajj , L. Cervino , H. Veeraraghavan , S. Elguindi , N. Tyagi , A. Shukla-Dave , J.M. Moran

Aim

Artificial intelligence (AI) based auto-segmentation aids radiation therapy (RT) workflows and is being adopted in clinical environments facilitated by the increased availability of commercial solutions for organs at risk (OARs). In addition, open-source imaging datasets support training for new auto-segmentation algorithms. Here, we studied if the female and male anatomies are equally represented among these solutions.

Materials and Methods

Inquiries were sent to eight vendors regarding their clinically available OAR auto-segmentation solutions for each gender. The Cancer Imaging Archive (TCIA) was also screened for publicly available imaging datasets specific to the female and the male anatomy.

Results

All vendors provided AI based auto-segmentation solutions for the male pelvis and female breasts, while 5/8 vendors provided solutions for the female pelvis. The female breast and the female pelvis solutions were released at a median of 0.6 years and 2.3 years, respectively, after the release of the male pelvis solutions. Among 27 TCIA datasets identified, 15 involved the female anatomy (breast: 10; pelvis: 5) and 12 involved the male pelvis but no female-specific dataset included OAR segmentations, while three male pelvis datasets included OARs (ejaculatory duct, neurovascular bundle, penile bulb and verumontanum).

Conclusion

Commercial AI auto-segmentation solutions and open-source imaging datasets include considerably more solutions and OAR segmentations for male cancer over female cancer sites. This gender disparity is likely to propagate throughout the RT pipeline.
目的:基于人工智能(AI)的自动分割辅助放射治疗(RT)工作流程,并且由于风险器官(OARs)商业解决方案的可用性增加,正在临床环境中采用。此外,开源图像数据集支持新的自动分割算法的训练。在这里,我们研究了女性和男性的解剖结构是否在这些解决方案中是平等的。材料和方法:向8家供应商发送关于其临床可用的针对每个性别的OAR自动分割解决方案的询问。癌症影像档案(TCIA)也筛选了针对女性和男性解剖结构的公开可用的影像数据集。结果:所有供应商都提供了基于人工智能的男性骨盆和女性乳房自动分割解决方案,5/8供应商提供了女性骨盆的解决方案。女性乳房和女性骨盆分别在男性骨盆释放后的中位数0.6年和2.3年释放。在鉴定的27个TCIA数据集中,15个涉及女性解剖(乳房:10;骨盆:5)和12涉及男性骨盆,但没有女性特异性数据集包括桨叶分割,而3个男性骨盆数据集包括桨叶(射精管、神经血管束、阴茎球和睾丸)。结论:商业人工智能自动分割解决方案和开源成像数据集包含的男性癌症的解决方案和OAR分割比女性癌症部位多得多。这种性别差异可能会在整个RT管道中蔓延。
{"title":"Under-representation for Female Pelvis Cancers in Commercial Auto-segmentation Solutions and Open-source Imaging Datasets","authors":"M. Thor ,&nbsp;V. Williams ,&nbsp;C. Hajj ,&nbsp;L. Cervino ,&nbsp;H. Veeraraghavan ,&nbsp;S. Elguindi ,&nbsp;N. Tyagi ,&nbsp;A. Shukla-Dave ,&nbsp;J.M. Moran","doi":"10.1016/j.clon.2024.10.003","DOIUrl":"10.1016/j.clon.2024.10.003","url":null,"abstract":"<div><h3>Aim</h3><div>Artificial intelligence (AI) based auto-segmentation aids radiation therapy (RT) workflows and is being adopted in clinical environments facilitated by the increased availability of commercial solutions for organs at risk (OARs). In addition, open-source imaging datasets support training for new auto-segmentation algorithms. Here, we studied if the female and male anatomies are equally represented among these solutions.</div></div><div><h3>Materials and Methods</h3><div>Inquiries were sent to eight vendors regarding their clinically available OAR auto-segmentation solutions for each gender. The Cancer Imaging Archive (TCIA) was also screened for publicly available imaging datasets specific to the female and the male anatomy.</div></div><div><h3>Results</h3><div>All vendors provided AI based auto-segmentation solutions for the male pelvis and female breasts, while 5/8 vendors provided solutions for the female pelvis. The female breast and the female pelvis solutions were released at a median of 0.6 years and 2.3 years, respectively, after the release of the male pelvis solutions. Among 27 TCIA datasets identified, 15 involved the female anatomy (breast: 10; pelvis: 5) and 12 involved the male pelvis but no female-specific dataset included OAR segmentations, while three male pelvis datasets included OARs (ejaculatory duct, neurovascular bundle, penile bulb and verumontanum).</div></div><div><h3>Conclusion</h3><div>Commercial AI auto-segmentation solutions and open-source imaging datasets include considerably more solutions and OAR segmentations for male cancer over female cancer sites. This gender disparity is likely to propagate throughout the RT pipeline.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103651"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is exercise an important consideration in metastatic breast cancer? 运动是转移性乳腺癌患者的重要考虑因素吗?
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2024.103718
A. Kuciejewska, C. Lai, M. Kitson, C. McDaid, M. Chody, N. Chopra
{"title":"Is exercise an important consideration in metastatic breast cancer?","authors":"A. Kuciejewska,&nbsp;C. Lai,&nbsp;M. Kitson,&nbsp;C. McDaid,&nbsp;M. Chody,&nbsp;N. Chopra","doi":"10.1016/j.clon.2024.103718","DOIUrl":"10.1016/j.clon.2024.103718","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"38 ","pages":"Article 103718"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review of Deep Inspiration Breath Hold and Free Breathing in Proton Beam Therapy Plans for Breast Cancer Radiotherapy
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2025.103782
F. Wilson , P. Gupta , H. Halvorsen , C. Anandadas , D. Lines , M. Aznar

Aims

To conduct a systematic review of breast cancer radiotherapy studies reporting a comparison of proton beam therapy (PBT) in deep inspiration breath hold (DIBH) and in free breathing (FB).

Methods and materials

Studies comparing DIBH and FB proton beam therapy plans, in the same patient, published between 2015 and 2023 were included. Doses to organs at risk were compared between DIBH and FB plans.

Results

Nine papers were identified for inclusion, reporting on 97 patients in total. All plans were for left-sided treatment. Average weighted mean heart dose was 0.31 Gy for DIBH and 0.48 Gy for FB. Average weighted mean left lung dose was 5.27 Gy for DIBH and 4.80 Gy for FB. Average weighted mean near maximum/maximum left anterior descending artery dose was 6.49 Gy for DIBH and 8.74 Gy for FB.

Conclusion

Based on the current literature, it does not appear that DIBH offers a marked dosimetric benefit to most breast cancer patients treated with PBT. However, the benefits of combining PBT and DIBH for individual breast RT patients cannot be excluded.
{"title":"A Systematic Review of Deep Inspiration Breath Hold and Free Breathing in Proton Beam Therapy Plans for Breast Cancer Radiotherapy","authors":"F. Wilson ,&nbsp;P. Gupta ,&nbsp;H. Halvorsen ,&nbsp;C. Anandadas ,&nbsp;D. Lines ,&nbsp;M. Aznar","doi":"10.1016/j.clon.2025.103782","DOIUrl":"10.1016/j.clon.2025.103782","url":null,"abstract":"<div><h3>Aims</h3><div>To conduct a systematic review of breast cancer radiotherapy studies reporting a comparison of proton beam therapy (PBT) in deep inspiration breath hold (DIBH) and in free breathing (FB).</div></div><div><h3>Methods and materials</h3><div>Studies comparing DIBH and FB proton beam therapy plans, in the same patient, published between 2015 and 2023 were included. Doses to organs at risk were compared between DIBH and FB plans.</div></div><div><h3>Results</h3><div>Nine papers were identified for inclusion, reporting on 97 patients in total. All plans were for left-sided treatment. Average weighted mean heart dose was 0.31 Gy for DIBH and 0.48 Gy for FB. Average weighted mean left lung dose was 5.27 Gy for DIBH and 4.80 Gy for FB. Average weighted mean near maximum/maximum left anterior descending artery dose was 6.49 Gy for DIBH and 8.74 Gy for FB.</div></div><div><h3>Conclusion</h3><div>Based on the current literature, it does not appear that DIBH offers a marked dosimetric benefit to most breast cancer patients treated with PBT. However, the benefits of combining PBT and DIBH for individual breast RT patients cannot be excluded.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103782"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National Oncology Trainee Collaborative for Healthcare Research (NOTCH)-Five Years On. 全国肿瘤受训人员医疗保健研究合作组织(NOTCH)--五周年。
IF 3.2 3区 医学 Q2 ONCOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.clon.2025.103777
K Purshouse, M Denholm
{"title":"National Oncology Trainee Collaborative for Healthcare Research (NOTCH)-Five Years On.","authors":"K Purshouse, M Denholm","doi":"10.1016/j.clon.2025.103777","DOIUrl":"https://doi.org/10.1016/j.clon.2025.103777","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":" ","pages":"103777"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical oncology
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