Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-36-39
S. I. Sukovatkin, R. Sulimanov, S. E. Suzdaltsev, I. V. Korotkov, O. Y. Kalyuzhnaya, T. M. Gasainiev
To date, treatment of cicatricial post-burn strictures of the esophagus remains one of the main challenges of thoracic surgery. Despite the signifi cant number of diff erent treatment methods, the number of patients requiring it, does not decrease. Conservative methods are mostly ineff ective. Bougienage of the esophagus remains the main method of treating scar strictures after burns.
{"title":"Results of treatment of patients with post-burn strictures of the esophagus by the booging method","authors":"S. I. Sukovatkin, R. Sulimanov, S. E. Suzdaltsev, I. V. Korotkov, O. Y. Kalyuzhnaya, T. M. Gasainiev","doi":"10.30629/0023-2149-2024-102-1-36-39","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-36-39","url":null,"abstract":"To date, treatment of cicatricial post-burn strictures of the esophagus remains one of the main challenges of thoracic surgery. Despite the signifi cant number of diff erent treatment methods, the number of patients requiring it, does not decrease. Conservative methods are mostly ineff ective. Bougienage of the esophagus remains the main method of treating scar strictures after burns.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"60 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-57-61
A. Sheptulin, A. A. Kirilovsky, K. Kirilovskaya
The presented article discusses the risk of side eff ects when using proton pump inhibitors (PPI): infectious complications (small intestinal bacterial overgrowth, Clostridium difficile-associated disease, community-acquired pneumonia, spontaneous bacterial peritonitis), stomach cancer, myocardial infarction, hypomagnesemia, iron and vitamin B12 deficiency, kidney damage, bone fractures, dementia, Alzheimer’s disease. An analysis of the literature indicates a weak causal relationship between the occurrence of these diseases and the use of PPI. Nevertheless, it is necessary to strive for the appointment of these drugs in the minimum effective dose and for as short a time as possible.
本文讨论了使用质子泵抑制剂（PPI）的副作用风险：感染性并发症（小肠细菌过度生长、艰难梭菌相关疾病、社区获得性肺炎、自发性细菌性腹膜炎）、胃癌、心肌梗塞、低镁血症、铁和维生素 B12 缺乏症、肾损伤、骨折、痴呆症、阿尔茨海默病。文献分析表明，这些疾病的发生与使用 PPI 之间的因果关系很弱。尽管如此，仍有必要争取在尽可能短的时间内以最小的有效剂量使用这些药物。
{"title":"Side effects of proton pump inhibitors: how real are they in clinical practice?","authors":"A. Sheptulin, A. A. Kirilovsky, K. Kirilovskaya","doi":"10.30629/0023-2149-2024-102-1-57-61","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-57-61","url":null,"abstract":"The presented article discusses the risk of side eff ects when using proton pump inhibitors (PPI): infectious complications (small intestinal bacterial overgrowth, Clostridium difficile-associated disease, community-acquired pneumonia, spontaneous bacterial peritonitis), stomach cancer, myocardial infarction, hypomagnesemia, iron and vitamin B12 deficiency, kidney damage, bone fractures, dementia, Alzheimer’s disease. An analysis of the literature indicates a weak causal relationship between the occurrence of these diseases and the use of PPI. Nevertheless, it is necessary to strive for the appointment of these drugs in the minimum effective dose and for as short a time as possible.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"331 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-90-96
P. A. Vorobyov
.
.
{"title":"Hypotheses. Тheories. Practice (95th anniversary of academician Andrey Ivanovich Vorobyov)","authors":"P. A. Vorobyov","doi":"10.30629/0023-2149-2024-102-1-90-96","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-90-96","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"10 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-62-68
A. A. Zaĭtsev, N. I. Briko, V. G. Akimkin, I. V. Shubin
Pneumococcal infection is a serious problem for practical healthcare. After the COVID-19 pandemic, there has been a significant increase in bacterial infections incidence, with pneumococcus remaining the main causative agent in all age groups. Among military personnel, pneumococcal pneumonia is the most common severe pathology requiring significant efforts in patient treatment. Vaccination remains an important factor in reducing the incidence of disease, and most importantly, in significant reduction of cases of invasive pneumococcal infection, which is characterized by high mortality. Currently, modern approaches to vaccination regimens in adults have been developed, which are reflected in this publication.
{"title":"Вакцинопрофилактика пневмококковой инфекции в особых группах риска: современные клинические рекомендации","authors":"A. A. Zaĭtsev, N. I. Briko, V. G. Akimkin, I. V. Shubin","doi":"10.30629/0023-2149-2024-102-1-62-68","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-62-68","url":null,"abstract":"Pneumococcal infection is a serious problem for practical healthcare. After the COVID-19 pandemic, there has been a significant increase in bacterial infections incidence, with pneumococcus remaining the main causative agent in all age groups. Among military personnel, pneumococcal pneumonia is the most common severe pathology requiring significant efforts in patient treatment. Vaccination remains an important factor in reducing the incidence of disease, and most importantly, in significant reduction of cases of invasive pneumococcal infection, which is characterized by high mortality. Currently, modern approaches to vaccination regimens in adults have been developed, which are reflected in this publication.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"55 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-40-47
T. Brodskaya, T. S. Satalkina, B. Geltser, V. N. Kotelnikov
Research objective: to evaluate arterial stiff ness indicators and its correlation with parameters of 24-hour ambulatory blood pressure monitoring (ABPM) in women with newly diagnosed breast cancer (BC).Material and methods: a prospective cohort study in 158 women aged 27 to 64 years with a median age of 45.4 years and newly diagnosed BC at stage IIA–IIIB before chemotherapy was conducted. The first group included 109 patients with normal or high-normal office blood pressure (BP), and the second group included 49 women with previously diagnosed stage 1– 2 essential hypertension (EH) with low or moderate cardiovascular risk. All patients underwent indirect arteriography and ABPM. Results. According to ABPM data, “masked” arterial hypertension (MAH) was diagnosed in 54 (49.5%) women in the fi rst group. In patients with MAH, the mean daily level and diastolic BP time index exceeded the corresponding indicators in EH, and the magnitude of the morning rise in systolic BP was significantly lower. In 35.4% of the examined patients with EH, the pulse wave velocity (PWV) was increased, and in 17.4% it was pathological. With MAH, these changes were recorded in 28.5% and 14.1% of cases, respectively. The odds ratio showed that in women with normal BP, the probability of an increase in PWV >10 m/s increased by 1.6 times, and in the presence of comorbidity with MAH and EH, it increased by 2.2 and 2.4 times, respectively. The risk of an increase in central systolic BP >125 mm Hg and pulse BP >60 mm Hg was highest in patients with EH.Conclusion: Among young and middle-aged women with newly diagnosed BC, a significant number of cases of MAH and EH are detected, which determines the need to evaluate arterial stiff ness and daily BP profiles before starting antitumor therapy.
研究目的：评估新诊断为乳腺癌（BC）的女性患者的动脉僵化指标及其与 24 小时动态血压监测（ABPM）参数的相关性。材料与方法：对 158 名年龄在 27-64 岁之间、中位年龄为 45.4 岁、化疗前新诊断为 IIA-IIIB 期 BC 的女性患者进行了前瞻性队列研究。第一组包括109名办公室血压（BP）正常或高正常的患者，第二组包括49名既往诊断为1-2期本质性高血压（EH）且心血管风险较低或中等的女性患者。所有患者均接受了间接动脉造影术和 ABPM。结果。根据 ABPM 数据，第一组中有 54 名（49.5%）女性被诊断为 "掩蔽性 "动脉高血压（MAH）。在 MAH 患者中，日平均血压水平和舒张压时间指数均超过 EH 的相应指标，而晨起收缩压的升高幅度明显较低。在接受检查的 EH 患者中，35.4% 的患者脉搏波速度（PWV）增加，17.4% 的患者脉搏波速度呈病态。在 MAH 患者中，分别有 28.5% 和 14.1% 的病例出现了这些变化。几率比表明，在血压正常的妇女中，脉搏波速度增加 >10 m/s 的几率增加了 1.6 倍，而在合并 MAH 和 EH 的情况下，几率分别增加了 2.2 倍和 2.4 倍。EH患者中心收缩压升高>125毫米汞柱和脉搏血压升高>60毫米汞柱的风险最高：结论：在新确诊的中青年女性 BC 患者中，发现了大量的 MAH 和 EH 病例，这就决定了在开始抗肿瘤治疗前评估动脉僵硬度和日常血压状况的必要性。
{"title":"Assessment of arterial rigidity and daily profile of arterial pressure in women with newly detected breast cancer","authors":"T. Brodskaya, T. S. Satalkina, B. Geltser, V. N. Kotelnikov","doi":"10.30629/0023-2149-2024-102-1-40-47","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-40-47","url":null,"abstract":"Research objective: to evaluate arterial stiff ness indicators and its correlation with parameters of 24-hour ambulatory blood pressure monitoring (ABPM) in women with newly diagnosed breast cancer (BC).Material and methods: a prospective cohort study in 158 women aged 27 to 64 years with a median age of 45.4 years and newly diagnosed BC at stage IIA–IIIB before chemotherapy was conducted. The first group included 109 patients with normal or high-normal office blood pressure (BP), and the second group included 49 women with previously diagnosed stage 1– 2 essential hypertension (EH) with low or moderate cardiovascular risk. All patients underwent indirect arteriography and ABPM. Results. According to ABPM data, “masked” arterial hypertension (MAH) was diagnosed in 54 (49.5%) women in the fi rst group. In patients with MAH, the mean daily level and diastolic BP time index exceeded the corresponding indicators in EH, and the magnitude of the morning rise in systolic BP was significantly lower. In 35.4% of the examined patients with EH, the pulse wave velocity (PWV) was increased, and in 17.4% it was pathological. With MAH, these changes were recorded in 28.5% and 14.1% of cases, respectively. The odds ratio showed that in women with normal BP, the probability of an increase in PWV >10 m/s increased by 1.6 times, and in the presence of comorbidity with MAH and EH, it increased by 2.2 and 2.4 times, respectively. The risk of an increase in central systolic BP >125 mm Hg and pulse BP >60 mm Hg was highest in patients with EH.Conclusion: Among young and middle-aged women with newly diagnosed BC, a significant number of cases of MAH and EH are detected, which determines the need to evaluate arterial stiff ness and daily BP profiles before starting antitumor therapy.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"48 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-80-84
P. E. Krynyukov, A. G. Abashin, I. I. Velichko
Data on the first military aeronautical schools in Gatchina and in Kacha are presented. Information is given about the first military doctors of aeronautical schools and the first studies of the effect of flights on the human body.
{"title":"Aviation and medicine. Gatchina Officer Aviation School","authors":"P. E. Krynyukov, A. G. Abashin, I. I. Velichko","doi":"10.30629/0023-2149-2024-102-1-80-84","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-80-84","url":null,"abstract":"Data on the first military aeronautical schools in Gatchina and in Kacha are presented. Information is given about the first military doctors of aeronautical schools and the first studies of the effect of flights on the human body.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"331 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-27-35
A. Demyanenko, N. A. Varavin, A. A. Santakov
Cardiac amyloidosis is considered a rare disease, but as diagnostic capabilities increase, so does the assessment of its prevalence. Cardiac amyloidosis manifests itself with symptoms of restrictive cardiomyopathy, leading to progressive heart failure. However, the underlying pathogenetic mechanisms of the disease differ. This literature review provides an overview of cardiac amyloidosis, from classification to molecular mechanisms and modern treatment options.
{"title":"Cardiac amyloidosis, features of diagnosis and treatment","authors":"A. Demyanenko, N. A. Varavin, A. A. Santakov","doi":"10.30629/0023-2149-2024-102-1-27-35","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-27-35","url":null,"abstract":"Cardiac amyloidosis is considered a rare disease, but as diagnostic capabilities increase, so does the assessment of its prevalence. Cardiac amyloidosis manifests itself with symptoms of restrictive cardiomyopathy, leading to progressive heart failure. However, the underlying pathogenetic mechanisms of the disease differ. This literature review provides an overview of cardiac amyloidosis, from classification to molecular mechanisms and modern treatment options.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"341 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.30629/0023-2149-2024-102-1-85-89
V. G. Abashin, S. V. Beskrovniy
The article presents some data on maternity care in Ancient Russia. The connection of myths and legends of Ancient Russia, Ancient Greece and Rome with modern elements of medical care for women in labor and newborns is traced.
{"title":"Midwifery: legends and myths of Ancient Russia through the eyes of contemporaries","authors":"V. G. Abashin, S. V. Beskrovniy","doi":"10.30629/0023-2149-2024-102-1-85-89","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-85-89","url":null,"abstract":"The article presents some data on maternity care in Ancient Russia. The connection of myths and legends of Ancient Russia, Ancient Greece and Rome with modern elements of medical care for women in labor and newborns is traced.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"42 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.30629/0023-2149-2024-102-1-19-26
Y. Skirdenko, M. A. Zorkina, D. G. Novikov, A. N. Zolotov, K. Andreev, K. G. Zinchenko, N. A. Nikolaev
One of the links in the pathogenesis of cardiovascular diseases is chronic low-intensity systemic inflammation. In 2004, a previously unknown process was discovered — the formation of extracellular neutrophil traps (NETs) — NETosis (n eutrophil extracellular traps). NETs play a role in antimicrobial immunity though in certain cases they become a factor in the development of pathology. This review presents data on the effect of extracellular neutrophil traps on individual pathologies of the cardiovascular system (atherosclerosis, atrial fibrillation, thrombosis). The authors describe the mechanisms of NET formation (vital NETosis, suicidal NETosis) and their role in thrombus formation (as a framework for thrombus formation, initiation of coagulation), in the development of endothelial dysfunction, and electrical heterogeneity of the atrial myocardium. Data are presented indicating the connection between atherosclerosis, thrombosis, and atrial fibrillation with the activity of NETosis. Most studies demonstrate existing correlations on laboratory models, while the determination of NETs in patients with cardiovascular pathology in real clinical practice is almost absent. At the same time, understanding the processes associated with NETosis can help to identify specific markers and further strategies for the therapy of cardiovascular diseases.
心血管疾病的发病机制之一是慢性低强度全身性炎症。2004 年，人们发现了一个以前未知的过程--细胞外中性粒细胞陷阱（NET）的形成--NETosis（中性粒细胞胞外陷阱）。NETs在抗菌免疫中发挥作用，但在某些情况下，NETs会成为病理发展的一个因素。本综述介绍了细胞外嗜中性粒细胞陷阱对心血管系统个别病症（动脉粥样硬化、心房颤动、血栓形成）的影响。作者描述了细胞外中性粒细胞陷阱的形成机制（生命性细胞外中性粒细胞陷阱、自杀性细胞外中性粒细胞陷阱）及其在血栓形成（作为血栓形成的框架、凝血的启动）、内皮功能障碍的发展和心房心肌电异质性中的作用。研究数据表明，动脉粥样硬化、血栓形成和心房颤动与 NETosis 的活动有关。大多数研究证明了实验室模型中存在的相关性，而在实际临床实践中，几乎没有对心血管病患者体内的 NET 进行测定。同时，了解与 NETosis 相关的过程有助于确定心血管疾病治疗的特定标志物和进一步策略。
{"title":"Extracellular neutrophil traps in cardiovascular diseases: problems and prospects of research","authors":"Y. Skirdenko, M. A. Zorkina, D. G. Novikov, A. N. Zolotov, K. Andreev, K. G. Zinchenko, N. A. Nikolaev","doi":"10.30629/0023-2149-2024-102-1-19-26","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-19-26","url":null,"abstract":"One of the links in the pathogenesis of cardiovascular diseases is chronic low-intensity systemic inflammation. In 2004, a previously unknown process was discovered — the formation of extracellular neutrophil traps (NETs) — NETosis (n eutrophil extracellular traps). NETs play a role in antimicrobial immunity though in certain cases they become a factor in the development of pathology. This review presents data on the effect of extracellular neutrophil traps on individual pathologies of the cardiovascular system (atherosclerosis, atrial fibrillation, thrombosis). The authors describe the mechanisms of NET formation (vital NETosis, suicidal NETosis) and their role in thrombus formation (as a framework for thrombus formation, initiation of coagulation), in the development of endothelial dysfunction, and electrical heterogeneity of the atrial myocardium. Data are presented indicating the connection between atherosclerosis, thrombosis, and atrial fibrillation with the activity of NETosis. Most studies demonstrate existing correlations on laboratory models, while the determination of NETs in patients with cardiovascular pathology in real clinical practice is almost absent. At the same time, understanding the processes associated with NETosis can help to identify specific markers and further strategies for the therapy of cardiovascular diseases.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.30629/0023-2149-2024-102-1-12-18
Yu. V. Shkurenko, A. D. Ibatov, U. E. Alieva
Preeclampsia (PE) is a relevant healthcare problem and represents a high risk for the development of various diseases in both the mother and fetus. In domestic and foreign literature, the number of works on the influence of PE on the cardiovascular and nervous systems of the fetus is constantly increasing. Thus, PE is associated with an increased risk of congenital heart defects, high blood pressure (BP), increased body mass index (BMI), and systemic vascular dysfunction in off spring. In addition, PE leads to disorders of the development of the nervous system, such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). PE is one of the main causes of adverse perinatal outcomes and neonatal mortality. This review also presents the correlation between PE and the risk of developing cardiovascular diseases (CVDs), stroke, and chronic kidney disease (CKD). In recent decades, there has been increasing evidence that manifestations of PE are not limited to pregnancy but also increase the risk of long-term complications. Thus, PE is a common disease that can lead to severe consequences for the mother and fetus in later life.
子痫前期（PE）是一个相关的医疗问题，是母亲和胎儿发生各种疾病的高危因素。在国内外文献中，有关子痫前期对胎儿心血管系统和神经系统影响的论著不断增加。因此，PE 与胎儿先天性心脏缺陷、高血压（BP）、体重指数（BMI）增加和全身血管功能障碍的风险增加有关。此外，PE 还会导致神经系统发育紊乱，如注意力缺陷/多动症（ADHD）和自闭症谱系障碍（ASD）。PE 是围产期不良结局和新生儿死亡的主要原因之一。本综述还介绍了 PE 与心血管疾病（CVD）、中风和慢性肾病（CKD）发病风险之间的相关性。近几十年来，越来越多的证据表明 PE 的表现不仅限于妊娠期，还会增加长期并发症的风险。因此，PE 是一种常见疾病，可对母亲和胎儿日后的生活造成严重后果。
{"title":"Medical and social aspects of preeclampsia","authors":"Yu. V. Shkurenko, A. D. Ibatov, U. E. Alieva","doi":"10.30629/0023-2149-2024-102-1-12-18","DOIUrl":"https://doi.org/10.30629/0023-2149-2024-102-1-12-18","url":null,"abstract":"Preeclampsia (PE) is a relevant healthcare problem and represents a high risk for the development of various diseases in both the mother and fetus. In domestic and foreign literature, the number of works on the influence of PE on the cardiovascular and nervous systems of the fetus is constantly increasing. Thus, PE is associated with an increased risk of congenital heart defects, high blood pressure (BP), increased body mass index (BMI), and systemic vascular dysfunction in off spring. In addition, PE leads to disorders of the development of the nervous system, such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). PE is one of the main causes of adverse perinatal outcomes and neonatal mortality. This review also presents the correlation between PE and the risk of developing cardiovascular diseases (CVDs), stroke, and chronic kidney disease (CKD). In recent decades, there has been increasing evidence that manifestations of PE are not limited to pregnancy but also increase the risk of long-term complications. Thus, PE is a common disease that can lead to severe consequences for the mother and fetus in later life.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：