Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100404
Bo Zhang , Jiahua Wang , Azizah binti Abdullah
Objective
This study aimed to assess the effects of art therapy on anxiety among children and adolescents.
Methods
We searched several databases, including PubMed, Web of Science, Embase (via Ovid), PsychINFO (through EBSCO), and The Cochrane Library, comprising the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials. Additionally, Chinese databases such as CNKI (China National Knowledge Infrastructure) and Wan Fang Data were explored from their beginnings until October 22, 2023. Studies that investigated the impact of art therapy on anxiety compared to a control group were included. The methodological quality of these randomized controlled trials was evaluated using the Cochrane Handbook's risk of bias instrument.
Results
Six studies involving 422 participants were included. The findings indicated a notable decrease in anxiety symptoms due to art therapy, with a Standardized Mean Difference (SMD) of -1.42, 95% Confidence Interval (95%CI -2.33, -0.51), p < 0.002. Notably, there was pronounced heterogeneity, as evidenced by Tau2 = 1.41, Chi2 = 101.19, df = 6, and I² = 94%, with Z = 3.06.
Conclusion
Art therapy significantly improved the anxiety symptoms of children and adolescents, positioning it as an effective means of treating anxiety.
{"title":"The effects of art therapy interventions on anxiety in children and adolescents: A meta-analysis","authors":"Bo Zhang , Jiahua Wang , Azizah binti Abdullah","doi":"10.1016/j.clinsp.2024.100404","DOIUrl":"10.1016/j.clinsp.2024.100404","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to assess the effects of art therapy on anxiety among children and adolescents.</p></div><div><h3>Methods</h3><p>We searched several databases, including PubMed, Web of Science, Embase (via Ovid), PsychINFO (through EBSCO), and The Cochrane Library, comprising the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials. Additionally, Chinese databases such as CNKI (China National Knowledge Infrastructure) and Wan Fang Data were explored from their beginnings until October 22, 2023. Studies that investigated the impact of art therapy on anxiety compared to a control group were included. The methodological quality of these randomized controlled trials was evaluated using the Cochrane Handbook's risk of bias instrument.</p></div><div><h3>Results</h3><p>Six studies involving 422 participants were included. The findings indicated a notable decrease in anxiety symptoms due to art therapy, with a Standardized Mean Difference (SMD) of -1.42, 95% Confidence Interval (95%CI -2.33, -0.51), p < 0.002. Notably, there was pronounced heterogeneity, as evidenced by Tau<sup>2</sup> = 1.41, Chi<sup>2</sup> = 101.19, df = 6, and I² = 94%, with Z = 3.06.</p></div><div><h3>Conclusion</h3><p>Art therapy significantly improved the anxiety symptoms of children and adolescents, positioning it as an effective means of treating anxiety.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000814/pdfft?md5=ac0a2e3727944033bb04cf31d6e943d9&pid=1-s2.0-S1807593224000814-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100424
Fulvio A. Scorza , Feres Chaddad-Neto , Larissa Beltramim , Josef Finsterer , Tomás de la Rosa
{"title":"Water pollution and the brain","authors":"Fulvio A. Scorza , Feres Chaddad-Neto , Larissa Beltramim , Josef Finsterer , Tomás de la Rosa","doi":"10.1016/j.clinsp.2024.100424","DOIUrl":"10.1016/j.clinsp.2024.100424","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224001017/pdfft?md5=b57eb2b893e815c341bfa3e8ca3a0e69&pid=1-s2.0-S1807593224001017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.
Objective
The present study aimed at assessing the impact of PrEP on the QoL of its users.
Methods
Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.
Results
Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).
Conclusions
This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.
背景：艾滋病毒暴露前预防疗法（PrEP）由巴西国家卫生系统免费提供。尽管 PrEP 能有效预防 HIV 感染，但人们对其对使用者健康相关生活质量（QoL）的影响知之甚少：本研究旨在评估 PrEP 对使用者生活质量的影响：前瞻性队列研究：114 名 18 岁或以上的 HIV 阴性参与者。在开始使用 PrEP 前和使用 7 个月后，使用自我响应式 WHOQOL-bref 问卷对参与者的 QoL 进行了评估。对社会人口学和行为学方面进行了描述，并进行了 Wilcoxon 符号秩检验，认为 p≤ 0.05 具有统计学意义：结果：环境领域的 QoL 分数有所提高（p = 0.02），该领域涉及身体安全感、信息和医疗服务的获取以及休闲活动的参与。此外，在被问及社会关系领域时，参与者对性生活的满意度也有所提高。总体 QoL 分数、总体健康分数、生理和心理领域以及社会关系领域的总分在统计上没有明显变化。在社会人口学特征方面，大多数参与者都是白人，受过高等教育的年轻男性同性恋者。76.3%的人在开始使用 PrEP 之前的 3 个月中发生过无保护措施的性行为。60.5%的人报告使用过药物：大麻（42.1%）、俱乐部毒品（35.1%）和兴奋剂（20.2%）：这项研究表明，PrEP 不仅能有效预防艾滋病病毒感染，还能改善环境方面的 QoL 以及对性生活的自我满意度。
{"title":"Impact of HIV pre-exposure prophylaxis (PREP) on health-related quality of life (QOL) of patients followed up at a reference center in São Paulo, Brazil","authors":"Michelle Kaoru Takada-de-Souza, Camila de Melo Picone, Vivian Iida Avelino-Silva, Angela Carvalho Freitas, Aluisio Cotrim Segurado","doi":"10.1016/j.clinsp.2024.100419","DOIUrl":"10.1016/j.clinsp.2024.100419","url":null,"abstract":"<div><h3>Background</h3><p>HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.</p></div><div><h3>Objective</h3><p>The present study aimed at assessing the impact of PrEP on the QoL of its users.</p></div><div><h3>Methods</h3><p>Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).</p></div><div><h3>Conclusions</h3><p>This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000966/pdfft?md5=665ef35b8f514ac0bdaa2a562965e3f9&pid=1-s2.0-S1807593224000966-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100451
Background
The emergence of the Nerve Growth Factor (NGF) has promoted the development of neuroprotective therapy; however, it has little effect on cerebral ischemia because of its poor Blood-Brain Barrier (BBB) permeability. Specific Mode Electroacupuncture Stimulation (SMES) can open BBB safely and effectively; however, it has shown inconclusive clinical effects and indirect clinical evidence in the recovery phase. Hence, the authors conducted a multicentre, randomized, placebo-controlled, assessor-blinded clinical trial to assess the effectiveness and safety of SMES combined with NGF treatment used during ischaemic stroke recovery.
Methods
A total of 288 stroke patients from three hospitals will be recruited and randomly allocated to four groups: acupuncture + placebo, acupuncture + NGF, SMES + placebo, and SMES + NGF, in a 1:1:1:1 ratio. Assessment data will be collected at baseline, 2-weeks, and 4-weeks during the treatment period, as well as at the 4-week and 8-week follow-up after treatment completion. The primary outcome measure will be the basic cure rate. The secondary outcome measures include the simplified Modified Barthel Index, Timed Up and Go Test, Fugl-Meyer Assessment of Motor Function Score, Tinetti Performance Oriented Mobility Assessment, Montreal Cognitive Assessment, and Loewenstein Occupational Therapy Cognitive Assessment. Moreover, resting-state functional magnetic resonance imaging and Functional near-infrared spectroscopy can detect changes in cerebral blood flow and brain function and investigate the relationship between the clinical efficacy and mechanism of the prescribed interventions.
Conclusion
This study will provide clinical evidence for the efficacy and safety of SMES combined with NGF in the treatment of stroke patients.
{"title":"Effect of Specific mode electroacupuncture stimulation combined with NGF during the ischaemic stroke: Study protocol for a randomized controlled trial","authors":"","doi":"10.1016/j.clinsp.2024.100451","DOIUrl":"10.1016/j.clinsp.2024.100451","url":null,"abstract":"<div><h3>Background</h3><p>The emergence of the Nerve Growth Factor (NGF) has promoted the development of neuroprotective therapy; however, it has little effect on cerebral ischemia because of its poor Blood-Brain Barrier (BBB) permeability. Specific Mode Electroacupuncture Stimulation (SMES) can open BBB safely and effectively; however, it has shown inconclusive clinical effects and indirect clinical evidence in the recovery phase. Hence, the authors conducted a multicentre, randomized, placebo-controlled, assessor-blinded clinical trial to assess the effectiveness and safety of SMES combined with NGF treatment used during ischaemic stroke recovery.</p></div><div><h3>Methods</h3><p>A total of 288 stroke patients from three hospitals will be recruited and randomly allocated to four groups: acupuncture + placebo, acupuncture + NGF, SMES + placebo, and SMES + NGF, in a 1:1:1:1 ratio. Assessment data will be collected at baseline, 2-weeks, and 4-weeks during the treatment period, as well as at the 4-week and 8-week follow-up after treatment completion. The primary outcome measure will be the basic cure rate. The secondary outcome measures include the simplified Modified Barthel Index, Timed Up and Go Test, Fugl-Meyer Assessment of Motor Function Score, Tinetti Performance Oriented Mobility Assessment, Montreal Cognitive Assessment, and Loewenstein Occupational Therapy Cognitive Assessment. Moreover, resting-state functional magnetic resonance imaging and Functional near-infrared spectroscopy can detect changes in cerebral blood flow and brain function and investigate the relationship between the clinical efficacy and mechanism of the prescribed interventions.</p></div><div><h3>Conclusion</h3><p>This study will provide clinical evidence for the efficacy and safety of SMES combined with NGF in the treatment of stroke patients.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224001285/pdfft?md5=0df34f5d4f8473613725b3a4d66729f5&pid=1-s2.0-S1807593224001285-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The incidence of olfactory disorders has increased in recent years, mainly related to COVID-19 infection. In Brazil, over 37 million cases of COVID-19 have been reported, and approximately 10 % of those cases continue to experience olfactory disorders for more than one month. Despite the significant negative impact on well-being, there is currently no validated instrument to assess how olfactory disorders impact the quality of life in Brazil.
Objectives
This study aimed to validate the Questionnaire of Olfactory Disorders (QOD) for Brazilian Portuguese.
Methods
The authors first performed translation, back-translation, expert review, pre-testing, psychometric evaluation and cultural adaptation of the English version of the questionnaire. To assure linguistic and conceptual equivalence of the translated questionnaire, 126 participants from two Brazilian states and varying degrees of olfactory loss answered the QOD and the World Health Organization Quality of Life bref (WHOQOL-bref) questionnaires. The University of Pennsylvania Smell Identification Test (UPSIT®) was used to quantify the olfactory loss. Furthermore, to evaluate the reliability of the Portuguese version a test-retest was performed on a subgroup of patients. The authors observed a high Cronbach's alpha (α = 0.86) for internal consistency of the quality of Life (QOD-QOL) statements.
Findings
As expected, there was a negative correlation between QOD-QOL and UPSIT® (Spearman's ρ = -0.275, p = 0.002), since QOL score increases and UPSIT® score decreases with worsening of olfactory function. Correlations were moderate between QOD-QOL and WHOQOL-bref mean (Spearman's ρ = -0.374, p < 0.001) and weak to moderate between the QOD-QOL and Visual Analog Scale of the QOD regarding professional life, leisure, and private life (Spearman's ρ = -0.316, p = 0.000; Spearman's ρ = -0.293, p = 0.001; Spearman's ρ = -0.261, p = 0.004; respectively).
Conclusion
In conclusion, the authors have demonstrated a high internal consistency and validity of the Brazilian Portuguese version of the QOD for evaluating the quality of life in individuals with olfactory disorders.
{"title":"Validation of the questionnaire of olfactory disorders (QOD) for the Brazilian population","authors":"Amanda Beatriz Costa da Silva Bernardino , Márcio Andrade Barreto-Filho , Amanda Savieto Pompeu , Jaqueline dos Santos Andrade , Amanda Canário Andrade Azevedo , Michelle Queiroz Aguiar Brasil , Mariana Cedro , Cintia Araújo , Nilvano Andrade , Kevan Akrami , Henrique Ochoa Scussiatto , Viviane Sampaio Boaventura , Marco Aurélio Fornazieri","doi":"10.1016/j.clinsp.2024.100414","DOIUrl":"https://doi.org/10.1016/j.clinsp.2024.100414","url":null,"abstract":"<div><h3>Background</h3><p>The incidence of olfactory disorders has increased in recent years, mainly related to COVID-19 infection. In Brazil, over 37 million cases of COVID-19 have been reported, and approximately 10 % of those cases continue to experience olfactory disorders for more than one month. Despite the significant negative impact on well-being, there is currently no validated instrument to assess how olfactory disorders impact the quality of life in Brazil.</p></div><div><h3>Objectives</h3><p>This study aimed to validate the Questionnaire of Olfactory Disorders (QOD) for Brazilian Portuguese.</p></div><div><h3>Methods</h3><p>The authors first performed translation, back-translation, expert review, pre-testing, psychometric evaluation and cultural adaptation of the English version of the questionnaire. To assure linguistic and conceptual equivalence of the translated questionnaire, 126 participants from two Brazilian states and varying degrees of olfactory loss answered the QOD and the World Health Organization Quality of Life bref (WHOQOL-bref) questionnaires. The University of Pennsylvania Smell Identification Test (UPSIT®) was used to quantify the olfactory loss. Furthermore, to evaluate the reliability of the Portuguese version a test-retest was performed on a subgroup of patients. The authors observed a high Cronbach's alpha (α = 0.86) for internal consistency of the quality of Life (QOD-QOL) statements.</p></div><div><h3>Findings</h3><p>As expected, there was a negative correlation between QOD-QOL and UPSIT® (Spearman's ρ = -0.275, <em>p</em> = 0.002), since QOL score increases and UPSIT® score decreases with worsening of olfactory function. Correlations were moderate between QOD-QOL and WHOQOL-bref mean (Spearman's ρ = -0.374, <em>p</em> < 0.001) and weak to moderate between the QOD-QOL and Visual Analog Scale of the QOD regarding professional life, leisure, and private life (Spearman's ρ = -0.316, <em>p</em> = 0.000; Spearman's ρ = -0.293, <em>p</em> = 0.001; Spearman's ρ = -0.261, <em>p</em> = 0.004; respectively).</p></div><div><h3>Conclusion</h3><p>In conclusion, the authors have demonstrated a high internal consistency and validity of the Brazilian Portuguese version of the QOD for evaluating the quality of life in individuals with olfactory disorders.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000917/pdfft?md5=4f44d33de43893866146e5435443d235&pid=1-s2.0-S1807593224000917-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141323214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100367
Yi Zhang, Feng Wang, YongLi Huang
Objective
This study investigated the relationship between PDZK1 expression and Dynamic Contrast-Enhanced MRI (DCE-MRI) perfusion parameters in High-Grade Glioma (HGG).
Methods
Preoperative DCE-MRI scanning was performed on 80 patients with HGG to obtain DCE perfusion transfer coefficient (Ktrans), vascular plasma volume fraction (vp), extracellular volume fraction (ve), and reverse transfer constant (kep). PDZK1 in HGG patients was detected, and its correlation with DCE-MRI perfusion parameters was assessed by the Pearson method. An analysis of Cox regression was performed to determine the risk factors affecting survival, while Kaplan-Meier and log-rank tests to evaluate PDZK1′s prognostic significance, and ROC curve analysis to assess its diagnostic value.
Results
PDZK1 was upregulated in HGG patients and predicted poor overall survival and progression-free survival. Moreover, PDZK1 expression distinguished grade III from grade IV HGG. PDZK1 expression was positively correlated with Ktrans 90, and ve_90, and negatively correlated with kep_max, and kep_90.
Conclusion
PDZK1 is upregulated in HGG, predicts poor survival, and differentiates tumor grading in HGG patients. PDZK1 expression is correlated with DCE-MRI perfusion parameters.
{"title":"PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma","authors":"Yi Zhang, Feng Wang, YongLi Huang","doi":"10.1016/j.clinsp.2024.100367","DOIUrl":"https://doi.org/10.1016/j.clinsp.2024.100367","url":null,"abstract":"<div><h3>Objective</h3><p>This study investigated the relationship between PDZK1 expression and Dynamic Contrast-Enhanced MRI (DCE-MRI) perfusion parameters in High-Grade Glioma (HGG).</p></div><div><h3>Methods</h3><p>Preoperative DCE-MRI scanning was performed on 80 patients with HGG to obtain DCE perfusion transfer coefficient (K<sup>trans</sup>), vascular plasma volume fraction (v<sub>p</sub>), extracellular volume fraction (v<sub>e</sub>), and reverse transfer constant (k<sub>ep</sub>). PDZK1 in HGG patients was detected, and its correlation with DCE-MRI perfusion parameters was assessed by the Pearson method. An analysis of Cox regression was performed to determine the risk factors affecting survival, while Kaplan-Meier and log-rank tests to evaluate PDZK1′s prognostic significance, and ROC curve analysis to assess its diagnostic value.</p></div><div><h3>Results</h3><p>PDZK1 was upregulated in HGG patients and predicted poor overall survival and progression-free survival. Moreover, PDZK1 expression distinguished grade III from grade IV HGG. PDZK1 expression was positively correlated with K<sup>trans 90</sup>, and v<sub>e_90</sub>, and negatively correlated with k<sub>ep_max</sub>, and k<sub>ep_90</sub>.</p></div><div><h3>Conclusion</h3><p>PDZK1 is upregulated in HGG, predicts poor survival, and differentiates tumor grading in HGG patients. PDZK1 expression is correlated with DCE-MRI perfusion parameters.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000449/pdfft?md5=b44238d87a99eb309b1d27a3e9c508c7&pid=1-s2.0-S1807593224000449-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100401
Muneera Mohammed Almurdi
Introduction
This study aimed to compare different Body Mass Index (BMI) categories, body composition parameters, postural balance, and functional mobility among female students at a College of Applied Medical Sciences; and examine the relationship between BMI and body composition with postural balance and functional mobility among female students at the college of applied medical sciences.
Materials and methods
Female students, aged 18‒25 years old. They were subdivided into four groups according to their BMI category: underweight, normal, overweight, or obese, with n = 20 participants in each group. A Bioelectrical Impedance Human Body Analyzer (BIA) was used to assess the following body composition parameters: Fat Percentage (FATP), fat mass, muscle mass, and Total Body Water (TBW). A NeuroCom Balance Master was used to assess postural balance and functional mobility. A Timed Up and Go (TUG) test was employed to assess functional mobility. All data were analyzed using SPSS.
Results
Participants’ ages and heights were matched (p > 0.05). However, there were variables that were statistically significantly higher in terms of weight, BMI and body composition, including FATP, fat mass, muscle mass, and TBW (p = 0.000), among the obese group. Moreover, postural balance was lower among the obese group. There was a significant relationship between BMI and body composition variables in respect of postural balance but not in relation to functional mobility.
Conclusion
Postural instability but not functional mobility was related to higher BMI and body composition values among the study groups.
{"title":"Postural balance and functional mobility in relation to BMI and body composition among female students at a College of Applied Medical Sciences: A cross-sectional study","authors":"Muneera Mohammed Almurdi","doi":"10.1016/j.clinsp.2024.100401","DOIUrl":"https://doi.org/10.1016/j.clinsp.2024.100401","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to compare different Body Mass Index (BMI) categories, body composition parameters, postural balance, and functional mobility among female students at a College of Applied Medical Sciences; and examine the relationship between BMI and body composition with postural balance and functional mobility among female students at the college of applied medical sciences.</p></div><div><h3>Materials and methods</h3><p>Female students, aged 18‒25 years old. They were subdivided into four groups according to their BMI category: underweight, normal, overweight, or obese, with <em>n</em> = 20 participants in each group. A Bioelectrical Impedance Human Body Analyzer (BIA) was used to assess the following body composition parameters: Fat Percentage (FATP), fat mass, muscle mass, and Total Body Water (TBW). A NeuroCom Balance Master was used to assess postural balance and functional mobility. A Timed Up and Go (TUG) test was employed to assess functional mobility. All data were analyzed using SPSS.</p></div><div><h3>Results</h3><p>Participants’ ages and heights were matched (<em>p</em> > 0.05). However, there were variables that were statistically significantly higher in terms of weight, BMI and body composition, including FATP, fat mass, muscle mass, and TBW (<em>p</em> = 0.000), among the obese group. Moreover, postural balance was lower among the obese group. There was a significant relationship between BMI and body composition variables in respect of postural balance but not in relation to functional mobility.</p></div><div><h3>Conclusion</h3><p>Postural instability but not functional mobility was related to higher BMI and body composition values among the study groups.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000784/pdfft?md5=02731da58283cdd24a10eb9126f6e914&pid=1-s2.0-S1807593224000784-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100398
Vinícius Dokkedal-Silva, Priscila Kalil Morelhão, Sergio Tufik, Monica Levy Andersen
{"title":"The increasing popularity of Peruvian maca (Lepidium meyenii) and its potential impacts on sleep and quality of life","authors":"Vinícius Dokkedal-Silva, Priscila Kalil Morelhão, Sergio Tufik, Monica Levy Andersen","doi":"10.1016/j.clinsp.2024.100398","DOIUrl":"https://doi.org/10.1016/j.clinsp.2024.100398","url":null,"abstract":"","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000759/pdfft?md5=12eed40a456bfb350c7c7f1d9658d51f&pid=1-s2.0-S1807593224000759-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2024.100360
DongLiang Zhou, HongWei Qin, Lei Miao, Ying Xu, Lan Yu, JianMin Wang
Objective
To explore the value of serum Dickkopf-3 (sDKK3) in predicting Early Neurological Deterioration (END) and in-hospital adverse outcomes in acute ischemic stroke (AIS) patients.
Methods
AIS patients (n = 200) were included and assessed by the National Institutes of Health Stroke Rating Scale. Serum Dkk3 levels were assessed by ELISA. END was defined as an increase of ≥ 4 points in NIHSS score within 72h. The biological threshold of sDKK3 level and END occurrence were predicted based on X-tile software. Primary outcomes were END and all-cause death, and the secondary outcome was ICU admission during hospitalization. The logistic regression model and Cox risk regression model were applied to evaluate the relationship between DKK3 level and END incidence, all-cause in-hospital mortality, and in-hospital adverse outcomes (ICU admission).
Results
During hospitalization, the incidence of END in patients with AIS was 13.0 %, and the mortality rate within 7 days after END was 11.54 % (3/26). In patients below the serum DKK3 cutoff (93.0 pg/mL), the incidence of END was 43.5 % (20/48). Patients with lower sDKK3 levels were associated with a 1.188-fold increased risk of developing END (OR = 1.188, 95 % CI 1.055‒1.369, p < 0.0001). However, there was no significant association with admission to the ICU. sDKK3 below the threshold (93.0 pg/mL) was a risk factor for death.
Conclusion
Predictive threshold levels of serum DKK3 based on X-tile software may be a potential predictive biomarker of in-hospital END in patients with AIS, and low levels of DKK3 are independently associated with increased in-hospital mortality.
{"title":"Predictive value of glycoprotein DKK3 for early neurological deterioration after ischemic stroke","authors":"DongLiang Zhou, HongWei Qin, Lei Miao, Ying Xu, Lan Yu, JianMin Wang","doi":"10.1016/j.clinsp.2024.100360","DOIUrl":"https://doi.org/10.1016/j.clinsp.2024.100360","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the value of serum Dickkopf-3 (sDKK3) in predicting Early Neurological Deterioration (END) and in-hospital adverse outcomes in acute ischemic stroke (AIS) patients.</p></div><div><h3>Methods</h3><p>AIS patients (<em>n</em> = 200) were included and assessed by the National Institutes of Health Stroke Rating Scale. Serum Dkk3 levels were assessed by ELISA. END was defined as an increase of ≥ 4 points in NIHSS score within 72h. The biological threshold of sDKK3 level and END occurrence were predicted based on X-tile software. Primary outcomes were END and all-cause death, and the secondary outcome was ICU admission during hospitalization. The logistic regression model and Cox risk regression model were applied to evaluate the relationship between DKK3 level and END incidence, all-cause in-hospital mortality, and in-hospital adverse outcomes (ICU admission).</p></div><div><h3>Results</h3><p>During hospitalization, the incidence of END in patients with AIS was 13.0 %, and the mortality rate within 7 days after END was 11.54 % (3/26). In patients below the serum DKK3 cutoff (93.0 pg/mL), the incidence of END was 43.5 % (20/48). Patients with lower sDKK3 levels were associated with a 1.188-fold increased risk of developing END (OR = 1.188, 95 % CI 1.055‒1.369, <em>p</em> < 0.0001). However, there was no significant association with admission to the ICU. sDKK3 below the threshold (93.0 pg/mL) was a risk factor for death.</p></div><div><h3>Conclusion</h3><p>Predictive threshold levels of serum DKK3 based on X-tile software may be a potential predictive biomarker of in-hospital END in patients with AIS, and low levels of DKK3 are independently associated with increased in-hospital mortality.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000371/pdfft?md5=b3661ea26dcfcc923f009c9170a60f8e&pid=1-s2.0-S1807593224000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.clinsp.2023.100314
Wenqing Xu , Zhihong Zhong , Long Gu , Yiming Xiao , BinShen Chen , Weilie Hu
Objective
circCPA4 has been defined to be an oncogenic gene. This study examined whether circCPA4 regulates Prostate Cancer (PC) development and revealed its molecular mechanism.
Methods
PC tissues and PC cell lines were collected, in which circCPA4/miR-491-5p/SHOC2 levels were evaluated by RT-qPCR and immunoblot. Colony formation assay and EdU assay assessed cell proliferation, flow cytometry measured apoptosis, and Transwell assessed invasion and migration. Ki-67, cleaved caspase-3, E-cadherin, and N-cadherin were evaluated by immunoblot. Based on the luciferase reporter assay and RIP assay the authors investigated the targeting relationship between circCPA4/miR-491-5p/SHOC2. The effect of circCPA4 on tumor growth was evaluated by xenotransplantation in nude mice.
Results
circCPA4 and SHOC2 levels were abundant while miR-491-5p expression was low in PC. Loss of circCPA4 decreased the proliferation and EdU-positive rate of PC cells, enhanced apoptosis, and inhibited invasion, migration, and EMT. Upregulation of circCPA4 forced the malignant behaviors of PC cells, and this promotion could be abolished when miR-491-5p was overexpressed or SHOC2 was silenced. CircCAP4 competitively decoyed miR-491-5p mediating SHOC2 expression. circCAP4 suppression inhibited PC tumor growth.
Conclusion
circCAP4 acts as a novel oncogenic factor in PC, accelerating the malignant behavior of PC cells via miR-491-5p/SHOC2 interaction. This novel ceRNA axis may be a potential target for PC drug development and targeted therapy in the future.
目的circCPA4已被定义为一种致癌基因。方法 收集前列腺癌组织和 PC 细胞系，通过 RT-qPCR 和免疫印迹评估 circCPA4/miR-491-5p/SHOC2 的水平。集落形成试验和 EdU 试验评估细胞增殖，流式细胞术检测细胞凋亡，Transwell 试验评估侵袭和迁移。免疫印迹法评估了 Ki-67、裂解的 Caspase-3、E-cadherin 和 N-cadherin。根据荧光素酶报告实验和RIP实验，作者研究了circCPA4/miR-491-5p/SHOC2之间的靶向关系。结果circCPA4和SHOC2水平很高，而miR-491-5p在PC中的表达很低。缺失 circCPA4 会降低 PC 细胞的增殖和 EdU 阳性率，增强细胞凋亡，抑制侵袭、迁移和 EMT。circCPA4的上调会促进PC细胞的恶性行为，而当miR-491-5p被过表达或SHOC2被沉默时，这种促进作用就会消失。CircCAP4可竞争性地诱导介导SHOC2表达的miR-491-5p，抑制CircCAP4可抑制PC肿瘤的生长。这一新型 ceRNA 轴可能是未来 PC 药物开发和靶向治疗的潜在靶点。
{"title":"circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop","authors":"Wenqing Xu , Zhihong Zhong , Long Gu , Yiming Xiao , BinShen Chen , Weilie Hu","doi":"10.1016/j.clinsp.2023.100314","DOIUrl":"https://doi.org/10.1016/j.clinsp.2023.100314","url":null,"abstract":"<div><h3>Objective</h3><p>circCPA4 has been defined to be an oncogenic gene. This study examined whether circCPA4 regulates Prostate Cancer (PC) development and revealed its molecular mechanism.</p></div><div><h3>Methods</h3><p>PC tissues and PC cell lines were collected, in which circCPA4/miR-491-5p/SHOC2 levels were evaluated by RT-qPCR and immunoblot. Colony formation assay and EdU assay assessed cell proliferation, flow cytometry measured apoptosis, and Transwell assessed invasion and migration. Ki-67, cleaved caspase-3, E-cadherin, and N-cadherin were evaluated by immunoblot. Based on the luciferase reporter assay and RIP assay the authors investigated the targeting relationship between circCPA4/miR-491-5p/SHOC2. The effect of circCPA4 on tumor growth was evaluated by xenotransplantation in nude mice.</p></div><div><h3>Results</h3><p>circCPA4 and SHOC2 levels were abundant while miR-491-5p expression was low in PC. Loss of circCPA4 decreased the proliferation and EdU-positive rate of PC cells, enhanced apoptosis, and inhibited invasion, migration, and EMT. Upregulation of circCPA4 forced the malignant behaviors of PC cells, and this promotion could be abolished when miR-491-5p was overexpressed or SHOC2 was silenced. CircCAP4 competitively decoyed miR-491-5p mediating SHOC2 expression. circCAP4 suppression inhibited PC tumor growth.</p></div><div><h3>Conclusion</h3><p>circCAP4 acts as a novel oncogenic factor in PC, accelerating the malignant behavior of PC cells via miR-491-5p/SHOC2 interaction. This novel ceRNA axis may be a potential target for PC drug development and targeted therapy in the future.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593223001503/pdfft?md5=c5311340e218d03a86de4bb020ab3e42&pid=1-s2.0-S1807593223001503-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139435876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号