{"title":"Laboratory toxicological diagnosis of fluoxetine poisonings","authors":"S. A. Karpushyna, S. V. Baiurka","doi":"10.24959/cphj.20.1538","DOIUrl":"https://doi.org/10.24959/cphj.20.1538","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":" 8","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91513395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The screening study of the hypoglycemic activity of herbal mixtures (presentation 3)","authors":"A. Savych, S. Marchyshyn, I. Milian","doi":"10.24959/cphj.20.1537","DOIUrl":"https://doi.org/10.24959/cphj.20.1537","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"42 1","pages":"38-46"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75268438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The analysis of the evidence base of the clinical efficiency and safety of acyclovir for topical application","authors":"O. Tkachova, I. Y. Bylov","doi":"10.24959/cphj.20.1542","DOIUrl":"https://doi.org/10.24959/cphj.20.1542","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"70 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85479432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. M. Tryschuk, I. Kireyev, K. Sytnik, S. Kolisnyk
{"title":"The study of the diuretic activity of new benzyl acid derivatives","authors":"N. M. Tryschuk, I. Kireyev, K. Sytnik, S. Kolisnyk","doi":"10.24959/cphj.20.1534","DOIUrl":"https://doi.org/10.24959/cphj.20.1534","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78174594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Sakharova, K. Zupanets, K. Ratushna, I. Otrishko, N. Bezugla
{"title":"The pathophysiological and experimental substantiation for the use of a phytoneering drug for the treatment of acute respiratory viral infections and prevention of their complications","authors":"T. Sakharova, K. Zupanets, K. Ratushna, I. Otrishko, N. Bezugla","doi":"10.24959/cphj.20.1531","DOIUrl":"https://doi.org/10.24959/cphj.20.1531","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"6 1","pages":"04-16"},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79503360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dubenko, S. Sazonov, D. Kutikov, O. Kutikov, T. Kolesnik
{"title":"Some pharmacoeconomic aspects of epilepsy in adult patients","authors":"A. Dubenko, S. Sazonov, D. Kutikov, O. Kutikov, T. Kolesnik","doi":"10.24959/cphj.20.1535","DOIUrl":"https://doi.org/10.24959/cphj.20.1535","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"174 1","pages":"30-38"},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73817761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Type 2 diabetes mellitus (DM2) has been increasing steadily all over the world. A large number of medicinal plants that have the hypoglycemic effect are known, but, unfortunately, currently there is very limited choice of antidiabetic herbal medicines. Aim. To design the experiment in order to study the hypoglycemic effect of polyphenolic extracts from bearberry (Arctostaphylos uva-ursi) leaves under the experimental insulin resistance (IR) in rats. Materials and methods. The experimental IR was induced by dexamethasone injections (Dex) and feeding with a high-fructose diet (HFD). Male outbred albino rats were randomized depending on the purpose of the experiment. As the study objects 50 % ethanolic polyphenol extracts obtained from bearberry leaves with addition of arginine (PE50_arg) and cysteine (PE50_cys) were selected. The oral glucose tolerance test (OGTT) was performed in all experimental groups of animals. Results. Dex had a more pronounced effect on tolerance to glucose compared to the HFD. It was shown that PE50_arg and PE50_cys after two weeks of administration revealed the ability to decrease the blood glucose level in rats, as well as reduce IR development and improve tolerance to glucose under the experimental IR. The hypoglycemic activity found did not much differ from the action of Metformin, but exceeded the activity of Arphazetin. These results can be the evidence of activation of glucose utilization processes, and it, in turn, indicates the insulin sensitivity improvement due to the action of the extracts studied. The data obtained indicate that the corrective effect of arginine and cysteine on signal transduction processes in insulin target cells plays an important role in the IR treatment. Conclusions. Bearberry leaves are the promising raw material for creating an anti-diabetic drug. Thus, it is necessary to further study the mechanisms of regulation of metabolic disorders when introducing new polyphenolic extracts.
{"title":"The study of the hypoglycemic action of extracts from bearberry leaves under experimental insulin resistance in rats","authors":"G. Kravchenko, O. Krasilnikova, M. Mazen","doi":"10.24959/cphj.20.1527","DOIUrl":"https://doi.org/10.24959/cphj.20.1527","url":null,"abstract":"Type 2 diabetes mellitus (DM2) has been increasing steadily all over the world. A large number of medicinal plants that have the hypoglycemic effect are known, but, unfortunately, currently there is very limited choice of antidiabetic herbal medicines. Aim. To design the experiment in order to study the hypoglycemic effect of polyphenolic extracts from bearberry (Arctostaphylos uva-ursi) leaves under the experimental insulin resistance (IR) in rats. Materials and methods. The experimental IR was induced by dexamethasone injections (Dex) and feeding with a high-fructose diet (HFD). Male outbred albino rats were randomized depending on the purpose of the experiment. As the study objects 50 % ethanolic polyphenol extracts obtained from bearberry leaves with addition of arginine (PE50_arg) and cysteine (PE50_cys) were selected. The oral glucose tolerance test (OGTT) was performed in all experimental groups of animals. Results. Dex had a more pronounced effect on tolerance to glucose compared to the HFD. It was shown that PE50_arg and PE50_cys after two weeks of administration revealed the ability to decrease the blood glucose level in rats, as well as reduce IR development and improve tolerance to glucose under the experimental IR. The hypoglycemic activity found did not much differ from the action of Metformin, but exceeded the activity of Arphazetin. These results can be the evidence of activation of glucose utilization processes, and it, in turn, indicates the insulin sensitivity improvement due to the action of the extracts studied. The data obtained indicate that the corrective effect of arginine and cysteine on signal transduction processes in insulin target cells plays an important role in the IR treatment. Conclusions. Bearberry leaves are the promising raw material for creating an anti-diabetic drug. Thus, it is necessary to further study the mechanisms of regulation of metabolic disorders when introducing new polyphenolic extracts.","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81322567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The use of decongestants for the treatment of runny nose symptom in children: the clinical and pharmaceutical analysis of the pharmaceutical market of Ukraine","authors":"V. V. Propisnova, S. V. Mіsiurova","doi":"10.24959/cphj.20.1516","DOIUrl":"https://doi.org/10.24959/cphj.20.1516","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"97 1","pages":"17-29"},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81377049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Bezruk, V. Grudko, V. Georgiyants, L. Ivanauskas
Hedera helix is widely used as a remedy to treat the respiratory infections and cold accompanied with cough due to its anti-inflammatory effect. In addition, the antioxidant activity of its extracts has been confirmed. It is explained by the high content of flavonoids and phenolic acids among all phytochemicals of H. helix leaves. However, it remains uncertain which exactly components are responsible for the antioxidant activity and what is the best way to perform extraction. Aim. To determine the antioxidant profile of different extracts from H. helix leaves using the in vitro HPLC method combined with the ABTS reagent. Materials and methods. Extraction of H. helix leaves was conducted with different solvents (from 20 % methanol to 100 % methanol using an ultrasound bath); the method described in the Pharmacopeia was also used. A Waters chromatograph was used to determine the antioxidant profile. Results. About 90 % of the components responsible for the antioxidant activity were determined using the HPLC method proposed. Among them, chlorogenic acid and 3,5-caffeoylquinic acid showed the highest activities. Other components, such as neochlorogenic acid, hyperoside and 3,4-caffeoylquinic acid were revealed as components with the antioxidant scavenging activities in H. helix lextracts. Conclusions. The results obtained indicate that extracts from H. helix leaves possess the high antioxidant scavenging capacity. In addition, the in vitro HPLC method proposed can be used for the primary screening of components in the plant raw material.
{"title":"Screening of the antioxidant activity of extracts from Hedera helix leaves using the HPLC/ABTS method","authors":"I. Bezruk, V. Grudko, V. Georgiyants, L. Ivanauskas","doi":"10.24959/cphj.20.1533","DOIUrl":"https://doi.org/10.24959/cphj.20.1533","url":null,"abstract":"Hedera helix is widely used as a remedy to treat the respiratory infections and cold accompanied with cough due to its anti-inflammatory effect. In addition, the antioxidant activity of its extracts has been confirmed. It is explained by the high content of flavonoids and phenolic acids among all phytochemicals of H. helix leaves. However, it remains uncertain which exactly components are responsible for the antioxidant activity and what is the best way to perform extraction. Aim. To determine the antioxidant profile of different extracts from H. helix leaves using the in vitro HPLC method combined with the ABTS reagent. Materials and methods. Extraction of H. helix leaves was conducted with different solvents (from 20 % methanol to 100 % methanol using an ultrasound bath); the method described in the Pharmacopeia was also used. A Waters chromatograph was used to determine the antioxidant profile. Results. About 90 % of the components responsible for the antioxidant activity were determined using the HPLC method proposed. Among them, chlorogenic acid and 3,5-caffeoylquinic acid showed the highest activities. Other components, such as neochlorogenic acid, hyperoside and 3,4-caffeoylquinic acid were revealed as components with the antioxidant scavenging activities in H. helix lextracts. Conclusions. The results obtained indicate that extracts from H. helix leaves possess the high antioxidant scavenging capacity. In addition, the in vitro HPLC method proposed can be used for the primary screening of components in the plant raw material.","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"113 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82456761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Iermolenko, N. Chorna, O. V. Krivoshapka, O. Vlasenko
{"title":"The experimental study of pharmacological properties of the Phallus impudicus tincture","authors":"T. Iermolenko, N. Chorna, O. V. Krivoshapka, O. Vlasenko","doi":"10.24959/cphj.20.1532","DOIUrl":"https://doi.org/10.24959/cphj.20.1532","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"11 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74067983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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