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Use of Prothrombin Complex Concentrate in Oral Anticoagulant-Associated Major Bleeding. 凝血酶原复合浓缩物在口服抗凝相关大出血中的应用。
IF 1.4 Q2 Nursing Pub Date : 2022-04-01 DOI: 10.1097/CNQ.0000000000000399
Jack G Lukas, Michael J Reichert, G Morgan Jones

Severe bleeding remains the most significant adverse effect associated with both warfarin and the direct oral anticoagulant agents. Due to the life-threatening nature of these bleeds, knowledge and understanding of agents that are able to rapidly overcome the anticoagulation effects of these medications is paramount to their use. Worldwide, the most commonly used agent for this indication is prothrombin complex concentrate (PCC). This review summarizes the evidence on the use of PCC in this population and provides practical information regarding patient-specific administration considerations.

严重出血仍然是华法林和直接口服抗凝剂最显著的不良反应。由于这些出血具有危及生命的性质,对能够迅速克服这些药物抗凝作用的药物的认识和理解对其使用至关重要。在世界范围内,这一适应症最常用的药物是凝血酶原复合物浓缩物(PCC)。这篇综述总结了在这一人群中使用PCC的证据,并提供了关于患者具体管理考虑的实用信息。
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引用次数: 0
SGLT-2 Inhibitor Use in Heart Failure: A Review for Nurses. SGLT-2抑制剂在心衰护理中的应用综述
IF 1.4 Q2 Nursing Pub Date : 2022-04-01 DOI: 10.1097/CNQ.0000000000000401
Katherine L March, Jack G Lukas, Theodore J Berei, Samarth P Shah, Brandon E Cave

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors (empagliflozin, canagliflozin, dapagliflozin, and ertugliflozin) are a new class of heart failure medications that have previously been exclusively utilized in the management of type 2 diabetes mellitus (T2DM). The rationale for using SGLT-2 inhibitors in patients with heart failure has stemmed from recent landmark clinical trials in T2DM in which reductions in mortality and hospitalization for heart failure were first observed. On the basis of these robust outcomes, empagliflozin has further been evaluated in heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction and dapagliflozin solely in the management of HFrEF. While cardiovascular outcomes among each agent vary depending on the patient population, updates among both the American and European guidelines have included SGLT-2 inhibitors as pillars of therapy. The exact mechanisms for how SGLT-2 inhibitors are beneficial in heart failure are unknown, but current hypotheses include multiple metabolic and hemodynamic mechanisms. The purpose of this review is to summarize available literature focusing on the use of the SGLT-2 inhibitors as adjunctive therapy in heart failure, as well as evaluate mechanisms for heart failure benefit, adverse effects, and practical considerations for using these agents in the clinical setting.

钠-葡萄糖共转运蛋白-2 (SGLT-2)抑制剂(恩格列净、卡格列净、达格列净和厄图格列净)是一类新的心力衰竭药物,以前专门用于2型糖尿病(T2DM)的治疗。在心力衰竭患者中使用SGLT-2抑制剂的理由源于最近具有里程碑意义的T2DM临床试验,其中首次观察到心力衰竭死亡率和住院率的降低。在这些强有力的结果的基础上,进一步评估了恩格列净在射血分数降低(HFrEF)和保留射血分数的心力衰竭中的作用,并单独评估了氨格列净在HFrEF治疗中的作用。虽然每种药物的心血管结果因患者群体而异,但美国和欧洲指南的更新已将SGLT-2抑制剂作为治疗的支柱。SGLT-2抑制剂对心力衰竭有益的确切机制尚不清楚,但目前的假设包括多种代谢和血液动力学机制。本综述的目的是总结现有的文献,重点是使用SGLT-2抑制剂作为心力衰竭的辅助治疗,并评估心力衰竭益处的机制,不良反应,以及在临床环境中使用这些药物的实际考虑。
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引用次数: 2
Foreword. 前言。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000380
Carmen G Warner
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引用次数: 0
COVID-19: Update on Health Care Workers' Mental Health and Coping During the Pandemic. COVID-19:大流行期间卫生保健工作者心理健康和应对的最新情况。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000384
Son Chae Kim, Larry Rankin

During the COVID-19 pandemic, health care workers experienced much higher symptoms of anxiety or depression than during the prepandemic period. As coping mechanisms, high resilience, spirituality, and satisfaction with family functioning were associated with 2- to 3-fold lower odds of anxiety or depression. Health care organizations may consider implementing evidence-based and practical supportive measures to help health care workers maintain good mental health during and after the pandemic.

在COVID-19大流行期间,卫生保健工作者的焦虑或抑郁症状比大流行前时期高得多。作为应对机制,高适应力、灵性和对家庭功能的满意度与焦虑或抑郁的几率降低2- 3倍有关。卫生保健组织可考虑实施以证据为基础的实际支持措施,帮助卫生保健工作者在大流行期间和之后保持良好的心理健康。
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引用次数: 3
The Attitude of Iranian Critical Care Nurses Toward Euthanasia: A Multicenter Cross-sectional Study. 伊朗重症护士对安乐死的态度:一项多中心横断面研究。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000389
Amir Emami Zeydi, Mohammad Javad Ghazanfari, Olive Fast, Saman Maroufizadeh, Keyvan Heydari, Mohammad Hashem Gholampour, Samad Karkhah

Today, one of the major ethical challenges facing the world's health care system, and in particular nurses in the intensive care unit, is euthanasia or death out of pity. The aim of this study was to investigate the attitude of Iranian nurses in the intensive care unit toward euthanasia. This was an analytical cross-sectional study using census sampling. The data collection tool was the Euthanasia Attitude Scale. A total of 206 nurses working in the intensive care unit in 4 hospitals in the Mazandaran province of Iran were included in this study. The mean of total Euthanasia Attitude Scale score in intensive care unit nurses was 2.96. The mean euthanasia dimensions were ethical consideration, practical considerations, treasuring life, and naturalistic beliefs, 3.03, 2.92, 2.98, and 2.99, respectively. There was significant but low negative correlation between age and total Euthanasia Attitude Scale score, ethical considerations, and practical considerations. Male nurses exhibited significantly higher Euthanasia Attitude Scale scores, specifically in regard to ethical and practical considerations compared with female nurses. The most Iranian nurses in the intensive care unit had a negative attitude toward euthanasia for patients in the later stages of the disease. However, this opposition was less than similar studies in Iran in the past.

今天,世界卫生保健系统,特别是重症监护病房的护士面临的主要道德挑战之一是安乐死或因怜悯而死亡。本研究的目的是调查伊朗重症监护病房护士对安乐死的态度。这是一项采用人口普查抽样的分析性横断面研究。数据收集工具为安乐死态度量表。在伊朗马赞达兰省4家医院的重症监护室工作的206名护士被纳入本研究。重症监护病房护士安乐死态度量表总得分均值为2.96分。安乐死的平均维度分别为伦理考虑、实际考虑、珍惜生命和自然主义信仰,分别为3.03、2.92、2.98和2.99。年龄与安乐死态度量表总得分、伦理考虑和实际考虑之间存在显著但低的负相关。男护士在安乐死态度量表上的得分明显高于女护士,特别是在道德和实际考虑方面。重症监护病房的大多数伊朗护士对晚期患者的安乐死持否定态度。然而,这种反对意见比过去在伊朗进行的类似研究要少。
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引用次数: 1
A New Patient Acuity Tool to Support Equitable Patient Assignments in a Progressive Care Unit. 一个新的病人敏锐度工具,以支持公平的病人分配在一个渐进的护理单位。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000388
Debra Eastman, Kristine Kernan

Making fair and equitable staffing decisions and patient assignments created complexities and undue nursing dissatisfaction on a 20-bed progressive care unit. Common themes shared by the nursing staff included inadequate staffing ratios, increased workload, and unease for patient safety. On the basis of these concerns, a unit-based needs assessment provided insight into what perceived and actual barriers exist preventing nurses from providing excellent care. Information gathered helped determine what could be done to overcome some barriers, and performing a comprehensive unit profile assessment allowed for better insight into how the unit was currently functioning. A comprehensive review of literature was undertaken to examine articles related to patient acuity utilizing the electronic databases CINAHL, PubMed, and MEDLINE. Key words and phrases included the following: acuity, patient acuity, acuity tools, progressive care acuity, nurse-patient assignment, workload, nursing assignments, and equitable staffing. Utilizing the results of the nurse survey, and information gained from articles gathered during the literature review, a patient acuity tool was created. The tool was believed to be an accurate representation of the patients' acuity, and the majority of charge nurses reported that they utilized the patient acuity tool score when making nurse-patient assignments. Overall staff satisfaction and perceptions of nurse-patient assignment equity were improved.

在一个20张床位的渐进护理单元中,做出公平和公平的人员配置决定和患者分配造成了复杂性和过度的护理不满。护理人员的共同主题包括人员配备比例不足、工作量增加以及对患者安全的不安。在这些问题的基础上,以单位为基础的需求评估深入了解了阻碍护士提供优质护理的感知和实际障碍。收集的信息有助于确定如何克服一些障碍,并且执行全面的单元概况评估可以更好地了解单元当前的运行情况。利用电子数据库CINAHL、PubMed和MEDLINE对文献进行全面的回顾,检查与患者视力相关的文章。关键词和短语包括:视力,患者视力,视力工具,渐进式护理视力,护士-患者分配,工作量,护理分配和公平的人员配置。利用护士调查的结果和从文献综述中收集的文章中获得的信息,创建了一个患者敏锐度工具。该工具被认为是患者敏锐度的准确代表,大多数主管护士报告说,他们在进行护士-患者分配时使用了患者敏锐度工具评分。整体员工满意度和对护士-病人分配公平的看法得到改善。
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引用次数: 2
A Tale of Two Pulmonary Artery Catheters. 两个肺动脉导管的故事。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000382
Jeremy C Durack, Leon L Chen, Saira Imran, Neil A Halpern

Innovative catheter-based therapies are increasingly being used for the treatment of patients with submassive pulmonary embolism. These patients may be monitored in the intensive care unit following insertion of specialized pulmonary artery catheters. However, the infusion catheters utilized in catheter-based therapies differ greatly from traditional pulmonary artery catheters designed for hemodynamic monitoring. As such, the critical care team will have to be familiar with the monitoring and management of these novel catheters. Important distinctions between the catheters are illustrated using a clinical case report.

创新的基于导管的治疗方法越来越多地被用于治疗亚块状肺栓塞患者。这些患者可以在插入专门的肺动脉导管后在重症监护病房进行监测。然而,导管治疗中使用的输注导管与用于血流动力学监测的传统肺动脉导管有很大不同。因此,重症监护团队必须熟悉这些新型导管的监测和管理。导管之间的重要区别是用临床病例报告说明。
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引用次数: 0
Heparin-Induced Thrombocytopenia: A Management Review for Nurses. 肝素性血小板减少症:护士管理综述。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000381
Raymond Smith, Zackery Bullard

Heparin-induced thrombocytopenia (HIT) is a life-threatening adverse drug reaction that relies on quick assessment and treatment by the health care team to prevent poor outcomes. Nurses can play a critical role in recognizing disease, advocating for patients, and facilitating treatment by being familiar with current guideline recommendations and risk stratification approaches. The purpose of this article is to review management of HIT including pathogenesis, clinical presentation, current guideline recommendations for risk assessment, laboratory testing, and treatment, as well as discuss nonheparin anticoagulation options that may be ordered when HIT is suspected.

肝素诱导的血小板减少症(HIT)是一种危及生命的药物不良反应,依赖于卫生保健团队的快速评估和治疗,以防止不良后果。护士可以通过熟悉当前的指南建议和风险分层方法,在识别疾病、倡导患者和促进治疗方面发挥关键作用。本文的目的是回顾HIT的管理,包括发病机制、临床表现、目前的风险评估指南建议、实验室检测和治疗,并讨论当怀疑HIT时可选择的非肝素抗凝治疗方案。
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引用次数: 1
Nursing Strategies to Safeguard COVID-19 Patients From Harm in the Intensive Care Unit. 保护重症监护室COVID-19患者免受伤害的护理策略。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000383
Darcy Shiner, Bethany Bock, Crystal Simpson, Timothy Skorupski

The aim of this article is to identify quality improvement nursing strategies that have been implemented to safeguard COVID-19 patients from harm while being cared for in the intensive care unit (ICU). This article incorporates a literature review on the experiences of nurses working at a large urban teaching hospital in the areas of critical care, quality, safety, and regulatory. As leaders in the delivery of health care, nurses have always pioneered innovative ways to deliver care despite difficult circumstances. COVID-19 is a novel viral disease with many unknowns, and it required nurses to integrate innovative approaches with evidence-based practice in order to meet the needs of the patient and to ensure patient safety. While in the critical care setting, COVID-19 patients are at an increased risk for various hospital-acquired injuries, threats to personal safety, and decline in mental health. Through ingenuity and adaptability, successful nursing strategies have been identified in the delivery of quality, evidence-based nursing care to safeguard the vulnerable COVID-19 patient population from harm while in the ICU.

本文的目的是确定已经实施的质量改进护理策略,以保护COVID-19患者在重症监护室(ICU)接受护理时免受伤害。本文结合了一篇文献综述,介绍了在一家大型城市教学医院工作的护士在重症监护、质量、安全和监管方面的经验。作为提供卫生保健服务的领导者,护士总是在困难的情况下开创创新的方式来提供护理。COVID-19是一种具有许多未知因素的新型病毒性疾病,需要护士将创新方法与循证实践相结合,以满足患者需求并确保患者安全。在重症监护环境中,COVID-19患者面临各种医院获得性伤害、人身安全威胁和精神健康下降的风险增加。通过独创性和适应性,在提供高质量的循证护理方面确定了成功的护理策略,以保护重症监护室的弱势COVID-19患者群体免受伤害。
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引用次数: 0
Development, Implementation, and Evaluation of an Early Mobility Protocol in a Regional Level II Trauma Center. 区域二级创伤中心早期活动能力方案的制定、实施和评估。
IF 1.4 Q2 Nursing Pub Date : 2022-01-01 DOI: 10.1097/CNQ.0000000000000391
Catherine A McCarty, Colleen M Renier, Pat G Conway, Linda Vogel, Theo A Woehrle, Leslie A Anderson, Eric J Hanson, Lisa M Benrud, Mary Gerchman-Smith

The purpose of this project was to develop and evaluate a collaborative nursing/therapist protocol for early mobility in a medical-surgical intensive care unit (MICU) in a regional level II trauma center. Data for patients in the MICU were compared for the periods August 3, 2015-August 2, 2016, and August 3, 2014-August 2, 2015. Semistructured interviews were conducted with 10 nurses and 1 therapist. Average MICU length of stay decreased from 3.81 to 3.50 days (P = .057). Mean time in mobility chairs did not change (0.12 days vs 0.11 days, P = .389). Mean number of days to first documented level 2-5 activity decreased significantly, from 1.81 to 1.51 days (P = .036). The percentage of hospitalizations with any documented level 3 or 4 activity increased significantly (from 3.8% to 7.4% and from 61.5% to 66.7%, P = .003 and P = .031, respectively). Barriers/challenges to implementation included having enough people to assist, space, documentation, having to coax the physician to place order for upright mobility, availability of therapists for later stages of protocol, patient variability, fear of patient falls, availability of therapy chairs, staff changes, time, and patient refusal. A multidisciplinary approach to protocol development for early mobility in an intensive care unit was successfully implemented at a regional level II trauma center.

该项目的目的是制定和评估区域二级创伤中心内科-外科重症监护病房(MICU)早期行动的协作护理/治疗师方案。比较2015年8月3日- 2016年8月2日和2014年8月3日- 2015年8月2日期间MICU患者的数据。对10名护士和1名治疗师进行半结构化访谈。平均住院天数由3.81天降至3.50天(P = 0.057)。在活动椅上的平均时间没有变化(0.12天vs 0.11天,P = 0.389)。首次记录2-5级活动的平均天数显著减少,从1.81天减少到1.51天(P = 0.036)。任何记录的3级或4级活动的住院比例显著增加(分别从3.8%增加到7.4%和从61.5%增加到66.7%,P = 0.003和P = 0.031)。实施的障碍/挑战包括有足够的人员协助、空间、文件、必须哄哄医生下直立活动的订单、方案后期是否有治疗师、患者的可变性、对患者跌倒的恐惧、是否有治疗椅、工作人员更换、时间和患者拒绝。在一个地区二级创伤中心成功实施了一种多学科方法来制定重症监护病房早期活动的方案。
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引用次数: 0
期刊
Critical Care Nursing Quarterly
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