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Understanding the Components of Eating Behaviour-Focused Weight Management Interventions Adjunct to Metabolic Bariatric Surgery: Systematic Review of Published Literature. 了解以饮食行为为中心的体重管理干预辅助代谢减肥手术的组成部分:已发表文献的系统回顾。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-01-03 DOI: 10.1007/s13679-024-00596-7
Reyhaneh Yousefi, Tair Ben-Porat, John O'Neill, Vincent Gosselin Boucher, Jovana Stojanovic, Annabelle Fortin, Kim L Lavoie, Simon L Bacon

Purpose of review: Eating behaviour-focused interventions are essential for improving health and weight-related outcomes in patients undergoing metabolic bariatric surgery (MBS). This work aims to examine the content of eating behaviour-focused weight management interventions adjunct to MBS in terms of the type and quantity of behaviour change techniques (BCTs). A literature search retrieved randomised controlled and parallel group trials up to March 2024.

Recent findings: A total of 25 trials were included in the final analysis. Trained coders used Michie's BCT taxonomy v1.0 to code intervention components from each trial and applied descriptive methods to report the types and frequency of BCTs. Calculated effect sizes were used to compare the impact of the experimental and comparator arms. Common BCTs applied in eating behaviour-focused interventions were '4.1 Instruction on how to perform a behaviour' (68%), '2.3 Self-monitoring of behaviour' (56%), '1.1 Goal setting (behaviour)' (52%), '1.2 Problem solving' (44%), '3.1 Social support (unspecified)' (40%), and '1.4 Action planning' (40%). However, the BCTs associated with the largest intervention effect sizes (2.1. Monitoring of behaviour by others without feedback and 4.2. Information about antecedents) were not among the most frequently employed techniques. Only one study described the intervention explicitly using BCT taxonomy groupings. In more than half of the studies (52%), authors did not use BCTs to describe interventions. This work highlights the importance of using standard frameworks for reporting the components of behavioural interventions to enhance scientific replication, evidence synthesis, and the ability to test interventions' effectiveness in the future.

综述目的:以饮食行为为重点的干预措施对于改善接受代谢减肥手术(MBS)的患者的健康和体重相关结果至关重要。本研究旨在从行为改变技术(bct)的类型和数量方面研究以饮食行为为中心的体重管理干预措施的内容,并将其与MBS相结合。文献检索检索了截至2024年3月的随机对照和平行组试验。最新发现:最终分析共纳入了25项试验。训练有素的编码员使用Michie的BCT分类法v1.0对每个试验的干预组件进行编码,并应用描述性方法报告BCT的类型和频率。计算的效应量用于比较实验组和比较组的影响。在以饮食行为为重点的干预措施中,常见的bct应用是“4.1如何执行行为的指导”(68%),“2.3行为的自我监控”(56%),“1.1目标设定(行为)”(52%),“1.2问题解决”(44%),“3.1社会支持(未指明)”(40%)和“1.4行动计划”(40%)。然而,bct与最大的干预效应量相关(2.1。在没有反馈的情况下监视他人的行为;关于前词的信息并不是最常用的技术。只有一项研究明确地使用BCT分类分组来描述干预。在超过一半(52%)的研究中,作者没有使用bct来描述干预措施。这项工作强调了使用标准框架报告行为干预措施组成部分的重要性,以加强科学复制、证据综合和未来测试干预措施有效性的能力。
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引用次数: 0
Long-Term Efficacy and Safety of Nutritional and Pharmacological Strategies for Obesity. 营养和药物治疗肥胖的长期疗效和安全性。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-01-03 DOI: 10.1007/s13679-024-00602-y
Luigi Barrea, Mara Boschetti, Elena Gangitano, Valeria Guglielmi, Ludovica Verde, Giovanna Muscogiuri

Purpose of review: This review examines the long-term efficacy and safety of various nutritional and pharmacological strategies for managing obesity. The focus is on the Mediterranean diet (MedDiet), very low-energy ketogenic therapy (VLEKT), and pharmacological interventions such as naltrexone/bupropion and liraglutide. Given the chronic nature of obesity, understanding the sustainability and impact of these treatments over time is critical.

Recent findings: The MedDiet has shown significant benefits for cardiovascular health and moderate long-term weight loss, though it does not always outperform other diets in terms of weight reduction. VLEKT is highly effective for rapid weight loss, but concerns remain about its long-term sustainability. Pharmacological treatments, including naltrexone/bupropion and liraglutide, have shown promise in promoting significant weight loss and improving metabolic markers. However, issues related to long-term adherence and potential side effects need further exploration. Both nutritional and pharmacological strategies offer valuable tools in obesity management. While treatments like VLEKT and pharmacological options provide significant short-term benefits, the MedDiet remains a sustainable long-term approach. The long-term efficacy and safety of naltrexone/bupropion and liraglutide require more investigation to address challenges in weight maintenance and side effects. Further studies are needed to establish the optimal duration and combination of these therapies for sustained obesity management.

综述目的:本综述探讨了各种营养和药物治疗肥胖的长期疗效和安全性。重点是地中海饮食(MedDiet)、极低能量生酮疗法(VLEKT)和药物干预,如纳曲酮/安非他酮和利拉鲁肽。鉴于肥胖的慢性本质,了解这些治疗方法的可持续性和长期影响至关重要。最近的研究发现:MedDiet对心血管健康和适度的长期减肥有显著的好处,尽管它在减肥方面并不总是优于其他饮食。VLEKT对快速减肥非常有效,但对其长期可持续性的担忧仍然存在。包括纳曲酮/安非他酮和利拉鲁肽在内的药物治疗,已显示出促进显著减肥和改善代谢指标的希望。然而,与长期依从性和潜在副作用相关的问题需要进一步探索。营养和药理学策略都为肥胖管理提供了有价值的工具。虽然像VLEKT和药物选择这样的治疗方法可以提供显着的短期效益,但MedDiet仍然是一种可持续的长期方法。纳曲酮/安非他酮和利拉鲁肽的长期疗效和安全性需要更多的研究来解决体重维持和副作用方面的挑战。需要进一步的研究来确定这些治疗持续肥胖的最佳持续时间和组合。
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引用次数: 0
Depression and Obesity. 抑郁和肥胖。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-01-03 DOI: 10.1007/s13679-024-00603-x
Gina Gerardo, Ninoska Peterson, Kasey Goodpaster, Leslie Heinberg

Purpose of review: To summarize the recent literature regarding the interaction between the public health concerns of obesity and depression and provide preliminary recommendations for assessment and management of patients with co-occurring obesity and depression. RECENT FINDINGS : Recent studies have reinforced that while there is a bi-directional link between obesity and depression, there is stronger evidence that obesity contributes to the development of depression. Recent research has also elucidated potential mediating factors in the association between depression and obesity (e.g., demographical, biological, and psychological) as well as a moderating effect of treatment of depression on outcomes for treatment of obesity. There is evidence to suggest that in co-occurring depression and obesity, it is beneficial to treat depression first. Cognitive behavioral therapies have demonstrated effectiveness in treating co-occurring depression and obesity and there is preliminary evidence suggesting that increasing emotion regulation and reducing weight bias internalization may be important treatment targets.

综述的目的:总结最近关于肥胖和抑郁之间相互作用的公共卫生问题的文献,并为同时发生的肥胖和抑郁患者的评估和管理提供初步建议。最近的发现:最近的研究强调,虽然肥胖和抑郁症之间存在双向联系,但有更有力的证据表明,肥胖会导致抑郁症的发展。最近的研究还阐明了抑郁症和肥胖之间的潜在中介因素(例如,人口统计学、生物学和心理学),以及抑郁症治疗对肥胖治疗结果的调节作用。有证据表明,在抑郁症和肥胖同时发生的情况下,首先治疗抑郁症是有益的。认知行为疗法在治疗同时发生的抑郁和肥胖方面已经证明了有效性,初步证据表明,增加情绪调节和减少体重偏见内化可能是重要的治疗目标。
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引用次数: 0
Antidepressants and Weight Gain: An Update on the Evidence and Clinical Implications. 抗抑郁药和体重增加:最新的证据和临床意义。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-01-03 DOI: 10.1007/s13679-024-00598-5
Lauren Moss, Marci Laudenslager, Kristine J Steffen, Sanjeev Sockalingam, Janelle W Coughlin

Purpose of review: To highlight recent research on antidepressant use and weight change and explore best clinical practices for reducing weight gain and obesity risk in individuals with depression.

Recent findings: Research on antidepressant use and weight gain suggests that genetic and biological factors including metabolizer phenotypes and inflammation can help to predict an individual's threshold for weight change among specific agents. For individuals with increased susceptibility to metabolic complications, medications including bupropion, fluoxetine, and newer agents (e.g., gepirone) have shown to be efficacious in improving depressive symptoms while concurrently reducing metabolic risks. Additional areas of focus following antidepressant related weight gain include switching to a weight neutral drug alternative, integrated behavioral interventions, and/or pharmacotherapy including GLP-1 receptor agonists (e.g., metformin, liraglutide). Individuals experiencing depression are at heightened risk of metabolic disorders and weight gain, which may be further exacerbated by antidepressant treatment. The increased support of weight neutral antidepressant agents in addition to innovative lifestyle interventions, breakthroughs in drug mechanisms, anti-obesity medications and overall familiarity with the side effects of each antidepressant class will help clinicians make appropriate decisions when treating patients with depression.

综述目的:回顾抗抑郁药使用与体重变化的最新研究,探讨抑郁症患者减少体重增加和肥胖风险的最佳临床实践。最近的研究发现:抗抑郁药的使用和体重增加的研究表明,遗传和生物因素,包括代谢表型和炎症,可以帮助预测特定药物对个体体重变化的阈值。对于代谢并发症易感性增加的个体,包括安非他酮、氟西汀和较新的药物(如孕酮)在内的药物已被证明在改善抑郁症状的同时有效地降低代谢风险。抗抑郁药相关体重增加后的其他关注领域包括改用体重中性药物替代、综合行为干预和/或包括GLP-1受体激动剂(如二甲双胍、利拉鲁肽)在内的药物治疗。患有抑郁症的人患代谢紊乱和体重增加的风险更高,抗抑郁药物治疗可能会进一步加剧这种风险。增加对体重中性抗抑郁药物的支持,再加上创新的生活方式干预,药物机制的突破,抗肥胖药物以及对每种抗抑郁药物副作用的全面熟悉,将有助于临床医生在治疗抑郁症患者时做出适当的决定。
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引用次数: 0
Osteokines in Nonalcoholic Fatty Liver Disease. 非酒精性脂肪肝中的骨生成素
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-09-03 DOI: 10.1007/s13679-024-00586-9
Ilias D Vachliotis, Athanasios D Anastasilakis, Vasileios Rafailidis, Stergios A Polyzos

Purpose of review: To critically summarize evidence on the potential role of osteokines in the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD).

Recent findings: There are emerging data supporting that certain osteokines, which are specific bone-derived proteins, may beneficially or adversely affect hepatic metabolism, and their alterations in the setting of osteoporosis or other bone metabolic diseases may possibly contribute to the development and progression of NAFLD. There is evidence showing a potential bidirectional association between NAFLD and bone metabolism, which may imply the existence of a liver-bone axis. In this regard, osteocalcin, osteoprotegerin, bone morphogenic protein 4 (BMP4) and BMP6 appear to have a positive impact on the liver, thus possibly alleviating NAFLD, whereas osteopontin, receptor activator of nuclear factor kappa Β ligand (RANKL), sclerostin, periostin, BMP8B, and fibroblast growth factor 23 (FGF23) appear to have a negative impact on the liver, thus possibly exacerbating NAFLD. The potential implication of osteokines in NAFLD warrants further animal and clinical research in the field that may possibly result in novel therapeutic targets for NAFLD in the future.

综述的目的:批判性地总结有关骨促性因子在非酒精性脂肪肝(NAFLD)发病机制和进展过程中的潜在作用的证据:新近的研究结果:有新的数据支持某些骨促性因子(特定的骨源性蛋白)可能会对肝脏代谢产生有利或不利的影响,在骨质疏松症或其他骨代谢疾病的情况下,骨促性因子的改变可能会导致非酒精性脂肪肝的发生和发展。有证据表明,非酒精性脂肪肝与骨代谢之间存在潜在的双向联系,这可能意味着存在肝-骨轴。在这方面,骨钙素、骨蛋白激酶、骨形态发生蛋白 4 (BMP4) 和 BMP6 似乎对肝脏有积极影响,因此可能减轻非酒精性脂肪肝,而骨素、核因子卡巴Β配体受体激活剂 (RANKL)、硬骨素、骨膜生长因子、BMP8B 和成纤维细胞生长因子 23 (FGF23) 似乎对肝脏有消极影响,因此可能加重非酒精性脂肪肝。骨促性因子在非酒精性脂肪肝中的潜在影响值得在该领域开展进一步的动物和临床研究,将来有可能为非酒精性脂肪肝找到新的治疗靶点。
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引用次数: 0
The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF). 体育锻炼作为改善脂肪性水肿的治疗工具的作用:意大利运动科学学会(SISMeS)和意大利静脉学会(SIF)的共识声明。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1007/s13679-024-00579-8
Giuseppe Annunziata, Antonio Paoli, Vincenzo Manzi, Elisabetta Camajani, Francesco Laterza, Ludovica Verde, Xavier Capó, Elvira Padua, Antonino Bianco, Attilio Carraro, Angela Di Baldassarre, Laura Guidetti, Samuele Maria Marcora, Stefania Orrù, Antonio Tessitore, Roberto Di Mitri, Lucia Auletta, Angela Piantadosi, Mario Bellisi, Edmondo Palmeri, Silvia Savastano, Annamaria Colao, Massimiliano Caprio, Giovanna Muscogiuri, Luigi Barrea

Purpose of review: This consensus statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) provides the official view on the role of exercise as a non-pharmacological approach in lipedema. In detail, this consensus statement SISMeS - SIF aims to provide a comprehensive overview of lipedema, focusing, in particular, on the role played by physical exercise (PE) in the management of its clinical features.

Recent findings: Lipedema is a chronic disease characterized by abnormal fat accumulation. It is often misdiagnosed as obesity, despite presenting distinct pathological mechanisms. Indeed, recent evidence has reported differences in adipose tissue histology, metabolomic profiles, and gene polymorphisms associated with this condition, adding new pieces to the complex puzzle of lipedema pathophysiology. Although by definition lipedema is a condition resistant to diet and PE, the latter emerges for its key role in the management of lipedema, contributing to multiple benefits, including improvements in mitochondrial function, lymphatic drainage, and reduction of inflammation. Various types of exercise, such as aquatic exercises and strength training, have been shown to alleviate symptoms and improve the quality of life of patients with lipedema. However, standardized guidelines for PE prescription and long-term management of patients with lipedema are lacking, highlighting the need for recommendations and further research in this area in order to optimise therapeutic strategies.

审查目的:这份由意大利运动与运动科学学会(SISMeS)和意大利静脉学会(SIF)共同发表的共识声明提供了官方观点,即运动作为一种非药物疗法在脂肪性水肿中的作用。详细而言,SISMeS - SIF 的这份共识声明旨在全面概述脂肪性水肿,尤其侧重于体育锻炼(PE)在控制其临床特征方面的作用:脂肪性水肿是一种以脂肪异常堆积为特征的慢性疾病。最新研究结果:脂肪性水肿是一种以脂肪异常堆积为特征的慢性疾病,尽管其病理机制与肥胖症不同,但却经常被误诊为肥胖症。事实上,最近有证据表明,脂肪组织组织学、代谢组学特征和基因多态性的差异与这种疾病有关,为脂肪性水肿病理生理学的复杂谜团增添了新的内容。虽然根据定义,脂肪性水肿是一种对饮食和体育锻炼有抵抗力的疾病,但体育锻炼在脂肪性水肿的治疗中发挥着关键作用,可带来多种益处,包括改善线粒体功能、淋巴引流和减少炎症。各种类型的运动,如水上运动和力量训练,已被证明可减轻脂肪性水肿患者的症状并改善其生活质量。然而,目前还缺乏针对脂肪性水肿患者的体育运动处方和长期管理的标准化指南,因此有必要在这一领域提出建议并开展进一步研究,以优化治疗策略。
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引用次数: 0
The Kidney in Obesity: Current Evidence, Perspectives and Controversies. 肥胖症的肾脏:当前证据、观点和争议。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1007/s13679-024-00583-y
Dimitris Kounatidis, Natalia G Vallianou, Theodora Stratigou, Maria Voukali, Irene Karampela, Maria Dalamaga

Purpose of review: As obesity and chronic kidney disease (CKD) remain a public health issue, we aim to elaborate on their complex relationship regarding pathogenetic mechanisms and therapeutic potential as well. The purpose of this review is to enhance our understanding of the interplay between obesity and CKD in order to timely diagnose and treat obesity-related CKD.

Recent findings: Obesity and CKD pose significant intertwined challenges to global health, affecting a substantial portion of the population worldwide. Obesity is recognized as an independent risk factor, intricately contributing to CKD pathogenesis through mechanisms such as lipotoxicity, chronic inflammation, and insulin resistance. Recent evidence highlights additional factors including hemodynamic changes and intestinal dysbiosis that exacerbate kidney dysfunction in obese individuals, leading to histologic alterations known as obesity-related glomerulopathy (ORG). This narrative review synthesizes current knowledge on the prevalence, pathophysiology, clinical manifestations, and diagnostic strategies of obesity-related kidney disease. Furthermore, it explores mechanistic insights to delineate current therapeutic approaches, future directions for managing this condition and controversies. By elucidating the multifaceted interactions between obesity and kidney health, this review aims to inform clinical practice and stimulate further research to address this global health epidemic effectively.

综述的目的:由于肥胖和慢性肾脏病(CKD)仍然是一个公共卫生问题,我们旨在阐述它们在发病机制和治疗潜力方面的复杂关系。本综述旨在加深我们对肥胖与慢性肾脏病之间相互作用的理解,以便及时诊断和治疗与肥胖相关的慢性肾脏病:肥胖和慢性肾脏病对全球健康构成了相互交织的重大挑战,影响着全球相当一部分人口。肥胖被认为是一个独立的风险因素,通过脂肪毒性、慢性炎症和胰岛素抵抗等机制,错综复杂地促成了慢性肾脏病的发病机制。最近的证据表明,包括血流动力学变化和肠道菌群失调在内的其他因素加剧了肥胖者的肾功能障碍,导致了被称为肥胖相关肾小球病(ORG)的组织学改变。这篇叙述性综述综述了目前关于肥胖相关肾病的发病率、病理生理学、临床表现和诊断策略的知识。此外,它还从机理角度探讨了目前的治疗方法、未来的治疗方向以及存在的争议。通过阐明肥胖与肾脏健康之间多方面的相互作用,本综述旨在为临床实践提供参考,并促进进一步的研究,以有效解决这一全球健康流行病。
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引用次数: 0
Mexican Clinical Practice Guidelines for Adult Overweight and Obesity Management. 墨西哥成人超重和肥胖症管理临床实践指南》。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1007/s13679-024-00585-w
Emma A Chávez-Manzanera, Juan M Vera-Zertuche, Martha Kaufer-Horwitz, Verónica Vázquez-Velázquez, José R Flores-Lázaro, Leonor Mireles-Zavala, Raúl Calzada-León, Juan C Garnica-Cuellar, Verónica Sánchez-Muñoz, Eduardo Ramírez-Butanda, Ricardo Hernández-González, María A Vargas-Martínez, Hugo Laviada-Molina, Rafael Violante-Ortíz, Héctor Esquivias-Zavala, Eduardo García-García, Fernando J Lavalle-González, Leonardo Mancillas-Adame, Juan C López-Alvarenga, Juan F Pérez-Hernández, Erika V Soto-Fuentes, Reina R Soriano-Cortés, Eduardo W Goicoechea-Turcott, Gerardo Magallanes-Díaz, Miguel F Herrera-Hernández, Simón Barquera-Cervera, Edith Vargas-Contreras, Cybele B Díaz-Wionczek, Morgan Salmon, Dinorah Ramírez-De Jesús, Juan P Villaseñor-Díaz, Javiera Peña, José Ramos-Rojas, Camila Ávila-Oliver, Gabriel Rada, Brad Hussey, Ximena Ramos Salas

Purpose: To develop Mexico's first methodologically rigorous clinical practice guideline for the management of adult overweight and obesity. The target audiences are interdisciplinary healthcare professionals across healthcare systems who are the first point of contact for patients with obesity in Mexico, patients, and health system decision makers.

Recent findings: A review of recent international obesity clinical practice guidelines and an expert consensus process identified: i) common recommendations appropriate for implementation in Mexico and ii) knowledge gaps requiring the formulation of new recommendations. In all, 20 new recommendations and 20 good practice statements were developed using the GRADE Evidence-to-Decision Framework and expert consensus. Overweight and obesity negatively impact the health and well-being of individuals and populations in Mexico. This guideline aims to establish a new evidence-based, patient-centered, non-stigmatizing, and practical treatment and management framework, based on the fundamental principles of chronic disease prevention and management.

目的:制定墨西哥第一份方法严谨的成人超重和肥胖症管理临床实践指南。目标受众是各医疗系统的跨学科医护专业人员,他们是墨西哥肥胖症患者的第一接触点、患者和医疗系统决策者:最新研究结果:通过对近期国际肥胖症临床实践指南的回顾和专家共识程序,确定了:i)适合在墨西哥实施的共同建议;ii)需要制定新建议的知识差距。利用 GRADE "从证据到决策 "框架和专家共识,共制定了 20 项新建议和 20 项良好实践声明。超重和肥胖对墨西哥个人和人口的健康和福祉造成了负面影响。本指南旨在根据慢性病预防和管理的基本原则,建立一个以证据为基础、以患者为中心、无污名化、实用的治疗和管理框架。
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引用次数: 0
A Systematic Review of Early General Parenting Interventions: Long-term Effects in Underrepresented Populations and Implications for Obesity Prevention. 早期普通育儿干预的系统回顾:对代表性不足人群的长期影响以及对预防肥胖的意义。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1007/s13679-024-00590-z
Hope I White, Katherine Holmbeck, Jennifer Ratmansky, Kai Ling Kong, Stephanie Anzman-Frasca

Purpose of review: While some parenting interventions designed for early-life obesity prevention have demonstrated short-term success, there is limited evidence of longer-term impacts and feasibility with underrepresented populations. The goal of this review was to examine existing general parenting programs for parents of children 0-5 years that were not designed to target obesity but investigated long-term effects on parenting and/or were conducted with underrepresented populations to offer recommendations for the modification or development of parenting-focused obesity prevention programs.

Recent findings: Most studies with sustained impacts on parenting in underrepresented populations were brief, group-based programs for parents of children 2-5 years. Many effective interventions included guided practice of skills and cultural adaptations. Unique intervention approaches included remote or school-based delivery models and motivational interviewing. Brief, group-based programs for parents of young children may be a promising approach to achieving longer-term impacts of parenting interventions on obesity risk among underrepresented populations.

审查目的:虽然一些为预防早期肥胖而设计的育儿干预措施取得了短期成功,但有关长期影响和对代表性不足人群的可行性的证据却很有限。本综述旨在研究现有的针对 0-5 岁儿童父母的一般育儿计划,这些计划并非针对肥胖症设计,但调查了对育儿的长期影响和/或对代表性不足人群的影响,从而为修改或开发以育儿为重点的肥胖症预防计划提供建议:大多数对代表性不足人群的养育方式产生持续影响的研究都是针对 2-5 岁儿童家长的简短、以小组为基础的计划。许多有效的干预措施包括指导技能练习和文化适应。独特的干预方法包括远程或校本实施模式和动机访谈。针对幼儿家长的简短小组计划可能是一种很有前景的方法,可以使育儿干预措施对代表性不足人群的肥胖风险产生长期影响。
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引用次数: 0
Resmetirom and Metabolic Dysfunction-Associated Steatohepatitis: Perspectives on Multidisciplinary Management from Global Healthcare Professionals. 雷美替罗与代谢功能障碍相关性脂肪性肝炎:来自全球医疗保健专业人士的多学科管理视角。
IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-08-07 DOI: 10.1007/s13679-024-00582-z
Kahei Au, Ming-Hua Zheng, Wei-Jei Lee, Omar M Ghanem, Kamal Mahawar, Asim Shabbir, Carel W le Roux, Giovanni Targher, Christopher D Byrne, Yusuf Yilmaz, Luca Valenti, Giada Sebastiani, Sombat Treeprasertsuk, Hannah Xiaoyan Hui, Nasser Sakran, Manoel Galvao Neto, Mohammad Kermansaravi, Lilian Kow, Yosuke Seki, Kwang Wei Tham, Jerry Dang, Ricardo V Cohen, Christine Stier, Salman AlSabah, Rodolfo J Oviedo, Sonja Chiappetta, Chetan Parmar, Wah Yang

Purpose of review: The approval of resmetirom brings great hope to patients with metabolic dysfunction-associated steatohepatitis (MASH). The purpose of this review is to explore its impact on the global health environment. The implementation of multidisciplinary management MASH is proposed.

Recent findings: Resmetirom has benefits in the treatment of MASH, and its safety and effectiveness have been studied. The adverse events (AEs) need to be noticed. To improve patient outcomes, a multimodal approach with medication such as resmetirom, combined with metabolic and bariatric surgery (MBS) and lifestyle interventions can be conducted. MASH, a liver disease linked with obesity, is a challenging global healthcare burden compounded by the absence of any approved pharmacotherapy. The recent conditional approval by the Food and Drug Administration (FDA) in the United States of resmetirom, an oral, liver-directed, thyroid hormone receptor beta-selective agonist, marks a significant milestone, offering a treatment option for adults with non-cirrhotic MASH and who have moderate to advanced liver fibrosis. This narrative review discusses the efficacy and safety of resmetirom and its role in the therapeutic landscape of MASH treatment. Despite the promising hepatoprotective effect of resmetirom on histological liver endpoints, its use need further research, particularly regarding ethnic differences, effectiveness and cost-effectiveness, production scalability, social acceptance and accessibility. In addition, integrating resmetirom with other multidisciplinary therapeutic approaches, including lifestyle changes and MBS, might further improve clinical liver-related and cardiometabolic outcomes of individuals with MASH. This review highlights the importance of a comprehensive treatment strategy, supporting continued innovation and collaborative research to refine treatment guidelines and consensus for managing MASH, thereby improving clinical patient outcomes in the growing global epidemic of MASH. Studies done to date have been relatively short and ongoing, the course of the disease is highly variable, the conditions of various patients vary, and given this complex clinical phenotype, it may take many years of clinical trials to show long-term benefits.

审查目的:瑞美替罗的批准为代谢功能障碍相关性脂肪性肝炎(MASH)患者带来了巨大希望。本综述旨在探讨其对全球健康环境的影响。建议实施多学科管理 MASH:Resmetirom 可用于治疗 MASH,其安全性和有效性已得到研究。不良事件(AEs)需要引起注意。为改善患者预后,可采用瑞美替罗等药物治疗结合代谢与减肥手术(MBS)和生活方式干预的多模式方法。MASH是一种与肥胖有关的肝脏疾病,由于没有任何获批的药物疗法,它成为全球医疗保健领域的一大难题。美国食品和药物管理局(FDA)最近有条件批准了一种口服、肝脏导向性甲状腺激素受体β选择性激动剂resmetirom,这是一个重要的里程碑,为患有非肝硬化MASH且肝纤维化程度为中晚期的成人患者提供了一种治疗选择。这篇叙述性综述讨论了雷美替罗的疗效和安全性及其在MASH治疗中的作用。尽管瑞美替罗对肝脏组织学终点具有良好的保肝作用,但其使用仍需进一步研究,尤其是在种族差异、有效性和成本效益、生产可扩展性、社会接受度和可及性方面。此外,将瑞美替罗与其他多学科治疗方法(包括改变生活方式和MBS)相结合,可能会进一步改善MASH患者的临床肝脏相关结果和心脏代谢结果。本综述强调了综合治疗策略的重要性,支持持续创新和合作研究,以完善治疗指南和达成管理MASH的共识,从而在MASH全球流行病日益增多的情况下改善患者的临床治疗效果。迄今为止所做的研究时间相对较短且仍在进行中,该疾病的病程变化很大,不同患者的病情各不相同,鉴于这种复杂的临床表型,可能需要多年的临床试验才能显示出长期疗效。
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Current Obesity Reports
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