Dermatology online journal最新文献

A 53-year-old woman with a history of arterial hypertension, diabetes mellitus, and morbid obesity presented with abdominal lesions persisting for 3 months, resistant to previous treatment. Physical examination revealed characteristic erythematous-violaceous plaques with serpiginous distribution and central ulceration. Histological examination confirmed diffuse dermal angiomatosis with underlying fat tissue necrosis, a rare association. Diffuse dermal angiomatosis typically affects middle-aged women with cardiovascular risk factors, and treatment involves addressing underlying vascular alterations.

Gingival recession is characterized by exposure of the tooth root owing to displacement of the gingival margin. Although commonly managed by dentists and periodontists, recognition of gingival recession could be expanded to other specialists, including dermatologists. Dermatologists are important because gingival health can be negatively impacted in several dermatologic diseases, such as pemphigus vulgaris and oral lichen planus. This review aims to expand the understanding of treatment options for gingival recession, highlighting their relevance not only to dentists and periodontists, but also to dermatologists, who are uniquely positioned to contribute to multidisciplinary care. This review focuses on non-surgical treatment options, as these are most relevant to dermatologists. Non-surgical management largely involves addressing the underlying etiology, treating symptoms, and improving aesthetics. Dermatologists may contribute to multidisciplinary care by educating patients on aspects of non-surgical management, including improving oral hygiene and treating hypersensitivity.

Cutaneous immune-related adverse events are increasingly reported with the expanding use of immune checkpoint inhibitors to treat various cancers. A subacute cutaneous lupus erythematosus-like drug eruption was observed in a patient with durvalumab infusion, with increasing severity after each dose. The eruption improved with cessation of durvalumab, hydroxychloroquine therapy, and sun protection.

Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal neoplasm originating from the excretory portion of the eccrine sweat glands. Its clinical presentation varies and includes multiple papules, erythematous plaques, or a solitary nodule, the latter being the most common. ESFA is classified into 5 clinical subtypes, all of which share the same histopathological features. To illustrate a typical presentation, we present a case of solitary ESFA successfully treated with surgical excision.

Penile ulcers are diagnostically challenging dermatologic manifestations with diverse etiologies that make medical management complex. We report a unique presentation of penile ulcers in a man with newly diagnosed antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Penile ulcers are rarely reported in ANCA-associated vasculitides. We aim to provide information about this patient's clinical presentation, diagnostic workup, treatment, and outcome.

Stevens-Johnson syndrome (SJS) is a severe cutaneous adverse reaction frequently associated with a drug and, rarely, with an infection. It is characterized by atypical targetoid lesions resulting in epidermal detachment of the skin and mucosa. We report a SJS case as the initial manifestation in human immunodeficiency virus (HIV) and syphilis coinfection and explore the potential pathomechanism leading to its development. A 25-year-old man presented to the emergency room with a 1-week history of erythematous to violaceous macules and patches. This was accompanied by fever, cough, and colds. The lesions evolved into blisters with areas of erosion. He was admitted and diagnosed with SJS based on clinical and histopathologic findings. However, no potential drug triggers were identified. Further laboratory studies found and confirmed HIV and syphilis coinfection. The study explored the potential role of HIV and syphilis coinfection in the development of SJS. Immune dysregulation and concomitant infection in the skin of an HIV patient were considered as factors in the development of SJS in this case. A comprehensive review for potential infection must be warranted among patients with SJS, especially in those cases without a clear culprit drug trigger. Further reports must be documented to establish the occurrence of SJS in newly diagnosed HIV.

Subepidermal calcified nodule, a rare variant of calcinosis cutis, is a benign lesion typically affecting the eyelid in children. We report a 14-year-old boy presenting with bilateral nodules on the upper eyelids. Clinical examination revealed a papule on the right eyelid and a plaque measuring 0.5 × 1 cm on the left, both pearly white, firm, and non-tender. Dermoscopy showed whitish, flocculent areas with linear vessels. Excisional biopsy confirmed dermal calcium deposits with surrounding collagenous fibrosis, establishing the diagnosis. Serum calcium, phosphorus, and parathyroid hormone levels were normal. No recurrence was observed at 6 months. This case highlights the unusual bilateral and symmetrical presentation of eyelid SCNs and the role of dermoscopy in supporting the diagnosis.