Teresa Grieco, Elisa Moliterni, Giovanni Paolino, Camilla Chello, Alvise Sernicola, Colin Gerard Egan, Fabrizio Nannipieri, Santina Battaglia, Marina Accoto, Erika Tirotta, Silvia Trasciatti, Silvano Bonaretti, Simona Nencioni, Elena Biasci, Giovanni Pellacani, Stefano Calvieri
Introduction: Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD).
Methods: From 43 adult AD patients, VDR polymorphisms were genotyped from peripheral blood samples using polymerase chain reaction-restriction fragment length polymorphism. VDR, occludin, claudin-1 and ZO-1 protein expression from skin lesion biopsies were assessed by immunohistochemistry.
Results: The A1012G heterozygous VDR polymorphism exhibited a lower odds ratio (OR) for juvenile AD onset (OR: 0.046, 95% CI 0.004-0.51, p=0.012). In contrast, the presence of ≥2 homozygous VDR polymorphisms were significantly associated with positive skin prick test (SPT) (10/20, 50%) vs. negative SPT (1/23, 4.3%; p=0.0003). The most highly expressed TJ proteins in lesions of AD patients were claudin-1 and zonulin-1 (ZO-1), while VDR and occludin were less prevalent. A significant correlation was observed between ZO-1 expression and a body mass index ≥30 kg/m2 (OR: 12.1, 95% CI 1.06-137.9, p=0.045). Claudin-1 expression was associated with a positive SPT (OR: 8.23, 95% CI 1.04-65.5, p=0.046) and serum 25(OH)D levels were negatively correlated with ZO-1 expression (rho= -0.43, p=0.0058).
Conclusion: This study provides novel insights into the relationship between VDR gene polymorphisms, VDR, TJ protein expression, and clinical features in adult AD patients, highlighting a significant role of vitamin D in the pathophysiology of this disease.
导言:很少有研究探讨维生素D受体(VDR)基因多态性、VDR、紧密连接蛋白(TJ)表达与特应性皮炎(AD)临床特征之间的复杂联系:方法:利用聚合酶链式反应-限制性片段长度多态性,对 43 名成年 AD 患者的外周血样本进行 VDR 多态性基因分型。免疫组化法评估了皮肤活检组织中 VDR、闭塞素、Claudin-1 和 ZO-1 蛋白的表达情况:结果:A1012G杂合VDR多态性表现出较低的幼年AD发病几率(OR:0.046,95% CI 0.004-0.51,P=0.012)。相反,存在≥2个同源VDR多态性与皮肤点刺试验(SPT)阳性(10/20,50%)与SPT阴性(1/23,4.3%;P=0.0003)显著相关。在 AD 患者的病变中,TJ 蛋白表达量最高的是 claudin-1 和 zonulin-1 (ZO-1),而 VDR 和闭塞素的表达量较低。ZO-1的表达与体重指数≥30 kg/m2之间存在明显的相关性(OR:12.1,95% CI 1.06-137.9,P=0.045)。Claudin-1的表达与SPT阳性相关(OR:8.23,95% CI 1.04-65.5,p=0.046),血清25(OH)D水平与ZO-1的表达呈负相关(rho= -0.43,p=0.0058):这项研究为了解成人AD患者VDR基因多态性、VDR、TJ蛋白表达和临床特征之间的关系提供了新的视角,凸显了维生素D在该疾病病理生理学中的重要作用。
{"title":"Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.","authors":"Teresa Grieco, Elisa Moliterni, Giovanni Paolino, Camilla Chello, Alvise Sernicola, Colin Gerard Egan, Fabrizio Nannipieri, Santina Battaglia, Marina Accoto, Erika Tirotta, Silvia Trasciatti, Silvano Bonaretti, Simona Nencioni, Elena Biasci, Giovanni Pellacani, Stefano Calvieri","doi":"10.5826/dpc.1403a214","DOIUrl":"10.5826/dpc.1403a214","url":null,"abstract":"<p><strong>Introduction: </strong>Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD).</p><p><strong>Methods: </strong>From 43 adult AD patients, VDR polymorphisms were genotyped from peripheral blood samples using polymerase chain reaction-restriction fragment length polymorphism. VDR, occludin, claudin-1 and ZO-1 protein expression from skin lesion biopsies were assessed by immunohistochemistry.</p><p><strong>Results: </strong>The A1012G heterozygous VDR polymorphism exhibited a lower odds ratio (OR) for juvenile AD onset (OR: 0.046, 95% CI 0.004-0.51, p=0.012). In contrast, the presence of ≥2 homozygous VDR polymorphisms were significantly associated with positive skin prick test (SPT) (10/20, 50%) vs. negative SPT (1/23, 4.3%; p=0.0003). The most highly expressed TJ proteins in lesions of AD patients were claudin-1 and zonulin-1 (ZO-1), while VDR and occludin were less prevalent. A significant correlation was observed between ZO-1 expression and a body mass index ≥30 kg/m<sup>2</sup> (OR: 12.1, 95% CI 1.06-137.9, p=0.045). Claudin-1 expression was associated with a positive SPT (OR: 8.23, 95% CI 1.04-65.5, p=0.046) and serum 25(OH)D levels were negatively correlated with ZO-1 expression (rho= -0.43, p=0.0058).</p><p><strong>Conclusion: </strong>This study provides novel insights into the relationship between VDR gene polymorphisms, VDR, TJ protein expression, and clinical features in adult AD patients, highlighting a significant role of vitamin D in the pathophysiology of this disease.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Piccolo, Ramon Grimalt, Julia Nowowiejska, Mario Cutrone
{"title":"Bilateral Facial Hair Whorls in a Child.","authors":"Vincenzo Piccolo, Ramon Grimalt, Julia Nowowiejska, Mario Cutrone","doi":"10.5826/dpc.1403a136","DOIUrl":"10.5826/dpc.1403a136","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Gnesotto, Bianca Maria Piraccini, Michela Starace, Luigi Naldi, Guido Mioso, Andrea Sechi
Introduction: Oral antifungals are the treatment choice for onychomycosis, and topical therapies are favored in cases of limited nail involvement. Recently, carbon dioxide (CO2) laser treatment has emerged as an option to enhance the effectiveness of topical therapies.
Objectives: Our objective was to compare the efficacy of fractional ablative and fully ablative CO2 laser treatments for distolateral subungual onychomycosis affecting a single toenail and caused by dermatophytes.
Methods: The records of 10 patients treated with a single fully ablative CO2 session were matched with those of 10 patients who underwent a single CO2 fractional treatment. All had previously failed topical antifungal lacquers and were discharged with the prescription of topical ciclopirox nail lacquer (8%) for 3 months.
Results: The clinical response rates were 80% for the fully ablative group and 60% for the fractional group. Additionally, the mean reduction in Onychomycosis Severity Index from baseline to 8.6±1.6 weeks after treatment completion was 6.9±5.4 in the fully ablative group and 3.6±6.6 in the fractional group. The relapse rate among responders was 12.5% in the fully ablative and 33.3% in the fractional group after a mean follow-up time of 29.4±2.3 weeks.
Conclusions: Fractional and fully ablative CO2 laser in combination with ciclopirox lacquer could increase the response rate in onychomycosis resistant to topical antifungals when systemic therapy is contraindicated or not yet pursued. Fully ablative mode therapy is significantly more effective than fractional (P < 0.05). Further studies are needed to identify prognostic response factors and assess the long-term effectiveness of CO2 laser treatment.
{"title":"Efficacy of Fractional Versus Fully Ablative CO<sub>2</sub> Laser for Distolateral Onychomycosis: Experience With 20 Patients.","authors":"Laura Gnesotto, Bianca Maria Piraccini, Michela Starace, Luigi Naldi, Guido Mioso, Andrea Sechi","doi":"10.5826/dpc.1403a121","DOIUrl":"10.5826/dpc.1403a121","url":null,"abstract":"<p><strong>Introduction: </strong>Oral antifungals are the treatment choice for onychomycosis, and topical therapies are favored in cases of limited nail involvement. Recently, carbon dioxide (CO<sub>2</sub>) laser treatment has emerged as an option to enhance the effectiveness of topical therapies.</p><p><strong>Objectives: </strong>Our objective was to compare the efficacy of fractional ablative and fully ablative CO<sub>2</sub> laser treatments for distolateral subungual onychomycosis affecting a single toenail and caused by dermatophytes.</p><p><strong>Methods: </strong>The records of 10 patients treated with a single fully ablative CO<sub>2</sub> session were matched with those of 10 patients who underwent a single CO<sub>2</sub> fractional treatment. All had previously failed topical antifungal lacquers and were discharged with the prescription of topical ciclopirox nail lacquer (8%) for 3 months.</p><p><strong>Results: </strong>The clinical response rates were 80% for the fully ablative group and 60% for the fractional group. Additionally, the mean reduction in Onychomycosis Severity Index from baseline to 8.6±1.6 weeks after treatment completion was 6.9±5.4 in the fully ablative group and 3.6±6.6 in the fractional group. The relapse rate among responders was 12.5% in the fully ablative and 33.3% in the fractional group after a mean follow-up time of 29.4±2.3 weeks.</p><p><strong>Conclusions: </strong>Fractional and fully ablative CO<sub>2</sub> laser in combination with ciclopirox lacquer could increase the response rate in onychomycosis resistant to topical antifungals when systemic therapy is contraindicated or not yet pursued. Fully ablative mode therapy is significantly more effective than fractional (P < 0.05). Further studies are needed to identify prognostic response factors and assess the long-term effectiveness of CO<sub>2</sub> laser treatment.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Alopecia areata is a type of non-scarring alopecia which is thought to be associated with T-cell mediated immune response.
Objective: This study aimed to compare the levels of serum inflammatory markers before and after treatment in patients with alopecia areata. The study explored the utility of the systemic immune-inflammation index (SII) in assessing the severity and treatment response in alopecia areata patients.
Methods: The study included 60 alopecia areata patients and 40 control patients diagnosed with tinea unguium, aged between 18 and 65 years. Sociodemographic characteristics such as age, sex, and medical history were recorded for both groups. For alopecia areata patients, serum inflammatory markers were recorded before and at the third month of treatment. Serum inflammatory markers for the control group were also recorded. Furthermore, the Severity of Alopecia Tool (SALT) score was calculated for alopecia areata patients before and at the third month of treatment.
Results: The alopecia areata group had a significantly higher neutrophil-lymphocyte ratio, mean platelet volume, and SII values compared to the control group, while high-density lipoprotein (HDL) values were significantly lower. Serum inflammatory markers, assessed at the third month of treatment in the alopecia areata group, were lower, and HDL values were significantly higher compared to pre-treatment levels. A statistically significant correlation was observed between disease severity and the SII.
Conclusion: The SII is a cost-effective marker that can be utilized in assessing the severity of alopecia areata and treatment response.
简介:斑秃是一种非瘢痕性脱发,被认为与 T 细胞介导的免疫反应有关:斑秃是一种非瘢痕性脱发,被认为与 T 细胞介导的免疫反应有关:本研究旨在比较斑秃患者治疗前后的血清炎症指标水平。该研究探讨了全身免疫炎症指数(SII)在评估斑秃患者病情严重程度和治疗反应方面的实用性:研究对象包括 60 名斑秃患者和 40 名对照组患者,年龄在 18 岁至 65 岁之间。两组患者的年龄、性别和病史等社会人口学特征均有记录。在治疗前和治疗的第三个月,记录了斑秃患者的血清炎症指标。同时还记录了对照组的血清炎症指标。此外,还计算了治疗前和治疗第三个月时斑秃患者的脱发严重程度工具(SALT)评分:结果:与对照组相比,斑秃组的中性粒细胞-淋巴细胞比率、平均血小板体积和SII值明显较高,而高密度脂蛋白(HDL)值则明显较低。与治疗前的水平相比,斑秃组在治疗第三个月时评估的血清炎症标志物更低,高密度脂蛋白值明显更高。从统计学角度看,疾病严重程度与 SII 之间存在明显的相关性:SII是一种经济有效的指标,可用于评估斑秃的严重程度和治疗反应。
{"title":"Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients.","authors":"Icim Komurcugil, Nermin Karaosmanoglu","doi":"10.5826/dpc.1403a193","DOIUrl":"10.5826/dpc.1403a193","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata is a type of non-scarring alopecia which is thought to be associated with T-cell mediated immune response.</p><p><strong>Objective: </strong>This study aimed to compare the levels of serum inflammatory markers before and after treatment in patients with alopecia areata. The study explored the utility of the systemic immune-inflammation index (SII) in assessing the severity and treatment response in alopecia areata patients.</p><p><strong>Methods: </strong>The study included 60 alopecia areata patients and 40 control patients diagnosed with tinea unguium, aged between 18 and 65 years. Sociodemographic characteristics such as age, sex, and medical history were recorded for both groups. For alopecia areata patients, serum inflammatory markers were recorded before and at the third month of treatment. Serum inflammatory markers for the control group were also recorded. Furthermore, the Severity of Alopecia Tool (SALT) score was calculated for alopecia areata patients before and at the third month of treatment.</p><p><strong>Results: </strong>The alopecia areata group had a significantly higher neutrophil-lymphocyte ratio, mean platelet volume, and SII values compared to the control group, while high-density lipoprotein (HDL) values were significantly lower. Serum inflammatory markers, assessed at the third month of treatment in the alopecia areata group, were lower, and HDL values were significantly higher compared to pre-treatment levels. A statistically significant correlation was observed between disease severity and the SII.</p><p><strong>Conclusion: </strong>The SII is a cost-effective marker that can be utilized in assessing the severity of alopecia areata and treatment response.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandro Borghi, Giulia Odorici, Federico Bardazzi, Federica Filippi, Laura Bigi, Claudia Lasagni, Marco Manfredini, Vito Di Lernia, Francesca Peccerillo, Andrea Conti, Rossana Tiberio, Francesca Satolli, Carolina Fantini, Miriam Rovesti, Massimo Gasperini, Michela Tabanelli, Simone D'Adamio, Maria Elena Flacco, Monica Corazza
{"title":"Real Life Comparative Effectiveness of IL-23 Inhibitors in the Treatment of Moderate to Severe Psoriasis: A Multicenter Experience.","authors":"Alessandro Borghi, Giulia Odorici, Federico Bardazzi, Federica Filippi, Laura Bigi, Claudia Lasagni, Marco Manfredini, Vito Di Lernia, Francesca Peccerillo, Andrea Conti, Rossana Tiberio, Francesca Satolli, Carolina Fantini, Miriam Rovesti, Massimo Gasperini, Michela Tabanelli, Simone D'Adamio, Maria Elena Flacco, Monica Corazza","doi":"10.5826/dpc.1403a179","DOIUrl":"10.5826/dpc.1403a179","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Real-World Experience of Upadacitinib Dosing Reduction in Patients with Moderate Atopic Dermatitis: A Case Series Study in Taiwan.","authors":"Yang-Yi Chen, Chieh-Hsun Chen, Cheng-Che Eric Lan","doi":"10.5826/dpc.1403a186","DOIUrl":"10.5826/dpc.1403a186","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Telogen effluvium (TE) is a common type of non-cicatricial alopecia, and it is reported frequently in patients with SARS-CoV-2 infection.
Objectives: Herein, we aimed to examine the demographic, dermoscopic, and laboratory features of the patients with SARS-CoV-2 associated TE (CATE) and compare them with TE due to other causes (TEDOC) according to these features.
Methods: In this retrospective case-control study we evaluated the patients who were diagnosed with TE and were above 18 years of age between April and June 2022. The patients were divided into two groups based on their medical history and SARS-CoV-2 PCR positivity. The first group included patients with CATE and positive SARS-CoV-2 PCR test results in the last 3 months. The second group consisted of patients with TEDOC. Patients gender, age, disease duration, additional systemic disease, dermoscopic findings, and laboratory results were recorded.
Results: A total of 92 patients, 86 (93.5%) females, and 6 (6.5%) males, were included in the study. CATE was detected in 52 (56.5%) patients whereas 40 (44.5%) patients had TEDOC. The mean time between the onset of SARS-CoV-2 infection and hair loss complaint was calculated as 64.8 + 25.6 days, and this time was significantly shorter than patients with TEDOC (P = 0.003). The dermoscopic evaluation showed that empty follicular openings and yellow dots were statistically higher in patients with CATE, whereas short regrowing hair were markedly higher in patients with TEDOC (P = 0.001, P = 0.001,and P = 0.001, respectively) CONCLUSIONS: CATE is characterized by excessive hair-shedding that begins sooner after infection than classic TE. Dermoscopic findings can assist clinicians in diagnosis.
{"title":"The Difference Between SARS-CoV-2 Associated Telogen Effluvium and Telogen Effluvium Due to Other Causes.","authors":"Didem Kazan, Defne Özkoca, Nazlı Dizen Namdar","doi":"10.5826/dpc.1403a170","DOIUrl":"10.5826/dpc.1403a170","url":null,"abstract":"<p><strong>Introduction: </strong>Telogen effluvium (TE) is a common type of non-cicatricial alopecia, and it is reported frequently in patients with SARS-CoV-2 infection.</p><p><strong>Objectives: </strong>Herein, we aimed to examine the demographic, dermoscopic, and laboratory features of the patients with SARS-CoV-2 associated TE (CATE) and compare them with TE due to other causes (TEDOC) according to these features.</p><p><strong>Methods: </strong>In this retrospective case-control study we evaluated the patients who were diagnosed with TE and were above 18 years of age between April and June 2022. The patients were divided into two groups based on their medical history and SARS-CoV-2 PCR positivity. The first group included patients with CATE and positive SARS-CoV-2 PCR test results in the last 3 months. The second group consisted of patients with TEDOC. Patients gender, age, disease duration, additional systemic disease, dermoscopic findings, and laboratory results were recorded.</p><p><strong>Results: </strong>A total of 92 patients, 86 (93.5%) females, and 6 (6.5%) males, were included in the study. CATE was detected in 52 (56.5%) patients whereas 40 (44.5%) patients had TEDOC. The mean time between the onset of SARS-CoV-2 infection and hair loss complaint was calculated as 64.8 + 25.6 days, and this time was significantly shorter than patients with TEDOC (P = 0.003). The dermoscopic evaluation showed that empty follicular openings and yellow dots were statistically higher in patients with CATE, whereas short regrowing hair were markedly higher in patients with TEDOC (P = 0.001, P = 0.001,and P = 0.001, respectively) CONCLUSIONS: CATE is characterized by excessive hair-shedding that begins sooner after infection than classic TE. Dermoscopic findings can assist clinicians in diagnosis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Data regarding quality of life (QoL) of oncologic patients experiencing dermatologic immune-related adverse events (dirAEs) and their course after dermatologic intervention are scarce.
Objectives: To assess the impact of dirAEs on patients QoL and to investigate the correlation between dermatologic and oncologic indexes used for estimating QoL.
Methods: We enrolled oncologic patients with dirAEs managed in two supportive onco-dermatology outpatient clinics in Greece. Patient-reported outcomes included DLQI, EORTC-QLQ-C30 and Numerical Rating Scale for pruritus (pNRS).
Results: Overall, 110 patients were enrolled in the study. Mean (standard deviation) DLQI and pNRS scores were 15.54 (5.44) and 7.25 (2.95), correspondingly, while functional, symptom and summary scores of EORTC-C30 were 79.17 (2.11), 17.66 (3.60) and 80.67 (3.08), respectively. After therapeutic interventions, there was a statistically significant decrease in DLQI scores after first intervention compared to baseline, and second intervention compared to first (mean decrease 4.38 (2.91), P < 0.001 and 5.16 (3.99), P < 0.001, respectively). DLQI showed no correlation with global health status/QoLs (rho 0.01, P = 0.90) of EORTC-C30.
Conclusions: DirAEs negatively affect QoL. Dermatologic intervention improves patients QoL, facilitating an unimpaired oncologic treatment. Poor correlation between DLQI and EORTC-QLQ-30 highlights the need for adapted QoL measurement tools in the context of immune checkpoint inhibitors treatment.
简介:有关肿瘤患者皮肤科免疫相关不良事件(dirAEs)的生活质量(QoL)及其在皮肤科干预后的过程的数据很少:有关发生皮肤免疫相关不良事件(dirAEs)的肿瘤患者的生活质量(QoL)及其在皮肤病干预后的病程的数据很少:评估 dirAEs 对患者 QoL 的影响,并研究用于估算 QoL 的皮肤科和肿瘤科指标之间的相关性:我们招募了在希腊两家支持性皮肤病门诊接受治疗的dirAEs肿瘤患者。患者报告的结果包括 DLQI、EORTC-QQLQ-C30 和瘙痒症数字评定量表(pNRS):结果:共有 110 名患者参与研究。DLQI和pNRS的平均分(标准差)分别为15.54(5.44)和7.25(2.95),而EORTC-C30的功能分、症状分和总分分别为79.17(2.11)、17.66(3.60)和80.67(3.08)。经过治疗干预后,与基线相比,第一次干预后的 DLQI 分数有显著下降,与第一次干预相比,第二次干预后的 DLQI 分数有显著下降(分别为平均下降 4.38 (2.91),P < 0.001 和 5.16 (3.99),P < 0.001)。DLQI 与 EORTC-C30 的总体健康状况/QoLs 没有相关性(rho 0.01,P = 0.90):结论:DirAEs 对 QoL 有负面影响。结论:DirAEs 对 QoL 有负面影响,皮肤科干预可改善患者的 QoL,促进肿瘤治疗的顺利进行。DLQI与EORTC-QLQ-30之间的相关性较差,这凸显了在免疫检查点抑制剂治疗中对QoL测量工具进行调整的必要性。
{"title":"The Impact of Immune Checkpoint Inhibitors-Induced Skin Toxicity on Patients Quality of Life and the Role of Dermatologic Intervention.","authors":"Christina Kemanetzi, Konstantinos Lallas, Elizavet Lazaridou, Chrysoula Papageorgiou, Aimilios Lallas, Alexandros Stratigos, Eleni Timotheadou, George Lazaridis, Dimitrios Dionysopoulos, Kalliopi Kalaitzi, Antonios Tsimpidakis, Myrto Trakatelli, Aikaterini Patsatsi, Vasiliki Nikolao, Zoe Apalla","doi":"10.5826/dpc.1403a118","DOIUrl":"10.5826/dpc.1403a118","url":null,"abstract":"<p><strong>Introduction: </strong>Data regarding quality of life (QoL) of oncologic patients experiencing dermatologic immune-related adverse events (dirAEs) and their course after dermatologic intervention are scarce.</p><p><strong>Objectives: </strong>To assess the impact of dirAEs on patients QoL and to investigate the correlation between dermatologic and oncologic indexes used for estimating QoL.</p><p><strong>Methods: </strong>We enrolled oncologic patients with dirAEs managed in two supportive onco-dermatology outpatient clinics in Greece. Patient-reported outcomes included DLQI, EORTC-QLQ-C30 and Numerical Rating Scale for pruritus (pNRS).</p><p><strong>Results: </strong>Overall, 110 patients were enrolled in the study. Mean (standard deviation) DLQI and pNRS scores were 15.54 (5.44) and 7.25 (2.95), correspondingly, while functional, symptom and summary scores of EORTC-C30 were 79.17 (2.11), 17.66 (3.60) and 80.67 (3.08), respectively. After therapeutic interventions, there was a statistically significant decrease in DLQI scores after first intervention compared to baseline, and second intervention compared to first (mean decrease 4.38 (2.91), P < 0.001 and 5.16 (3.99), P < 0.001, respectively). DLQI showed no correlation with global health status/QoLs (rho 0.01, P = 0.90) of EORTC-C30.</p><p><strong>Conclusions: </strong>DirAEs negatively affect QoL. Dermatologic intervention improves patients QoL, facilitating an unimpaired oncologic treatment. Poor correlation between DLQI and EORTC-QLQ-30 highlights the need for adapted QoL measurement tools in the context of immune checkpoint inhibitors treatment.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}