Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/3844f
F. Budak, E. Aydin, A. Koçkaya, B. Ozkara
Midbrain infarction rarely causes partial fascicular oculomotor palsy, which is characterised by bilateral midriasis and loss of vertical gaze movements. We describe a patient with acute ischemic infarcts involving both uppermost part of the midbrain, presenting with marked vertical gaze palsy and mydriasis bilaterally as the only neurological abnormality. These features are suggestive of partial fascicular oculomotor palsies involving the pupil, inferior rectus, superior rectus, inferior oblique muscles and sparing medial rectus, levator palpebrae muscles. These neuro-ophthalmological and radiological findings in our case support the model that the fibers to medial rectus and levator palpebrae muscles might be located in the more caudal portion of the oculomotor fascicles.
{"title":"Study on Isolated Vertical Ophtalmoplegia and Mydriasis Due to Bilateral Midbrain Infarction","authors":"F. Budak, E. Aydin, A. Koçkaya, B. Ozkara","doi":"10.9734/bpi/nfmmr/v10/3844f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/3844f","url":null,"abstract":"Midbrain infarction rarely causes partial fascicular oculomotor palsy, which is characterised by bilateral midriasis and loss of vertical gaze movements. We describe a patient with acute ischemic infarcts involving both uppermost part of the midbrain, presenting with marked vertical gaze palsy and mydriasis bilaterally as the only neurological abnormality. These features are suggestive of partial fascicular oculomotor palsies involving the pupil, inferior rectus, superior rectus, inferior oblique muscles and sparing medial rectus, levator palpebrae muscles. These neuro-ophthalmological and radiological findings in our case support the model that the fibers to medial rectus and levator palpebrae muscles might be located in the more caudal portion of the oculomotor fascicles.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129761138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/4013f
O. Amira, Alfaifi Abdullah, Z. Mohammed, M. Abeer, Samadi Abdelmohsin, A. Omar
Gama-aminobutyric (GABA) transaminase deficiency is a rare disorder with only few cases described in the literature. We present here a neonate who presented early with an epileptic encephalopathy. The recently described diagnostic criteria and gene sequencing are now the backbone for diagnosing this severe rare metabolic encephalopathy and has helped in understanding its metabolic effects and the pathophysiology. Affected families can benefit from genetic counseling for their future pregnancies. The variant in this baby (p.Gly106Ser) has not been described before.
{"title":"Gaba Transaminase Deficiency Presenting as Neonatal Encephalopathy","authors":"O. Amira, Alfaifi Abdullah, Z. Mohammed, M. Abeer, Samadi Abdelmohsin, A. Omar","doi":"10.9734/bpi/nfmmr/v10/4013f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/4013f","url":null,"abstract":"Gama-aminobutyric (GABA) transaminase deficiency is a rare disorder with only few cases described in the literature. We present here a neonate who presented early with an epileptic encephalopathy. The recently described diagnostic criteria and gene sequencing are now the backbone for diagnosing this severe rare metabolic encephalopathy and has helped in understanding its metabolic effects and the pathophysiology. Affected families can benefit from genetic counseling for their future pregnancies. The variant in this baby (p.Gly106Ser) has not been described before.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"14 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123756201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/4106f
A. Manov, A. Hatharasinghe, S. Acaralp
Testosterone replacement therapy is the mainstay treatment for both primary and secondary hypogonadism. Clinical benefits of testosterone include improvement of the muscle mass, libido, and bone density. However, there are potential risks associated with it, including hypercoagulability, prostate cancer, worsening sleep apnea, cardiovascular disease etc. There are contraindications for treatment as per current guidelines of AACE/. Therefore, initiating testosterone should be done with caution and after excluding breast, prostatic cancers, PSA above 4ng/ml or above 3ng/ml in high risk patients-AfricanAmerican or having first degree relative with prostatic cancer, untreated Congestive heart failure, untreated severe sleep apnea, thrombophilia, Stroke, Transient ischemic attack (TIA) and myocardial Infarction (MI) within 6 months, Hematocrit (HCT) above 50% or if the patient seeks fertility. Given the high prevalence of cardiovascular disease worldwide testosterone replacement therapy may not be an option for every patient. We are describing a case regarding a patient successfully treated with the SERM- Clomiphene citrate a SERM with improvement of Testosterone to normal ranges, improvement of erectile dysfunction and morning erections and libido without the side effects of testosterone injections like polycythemia.
{"title":"Effective Treatment of Secondary Hypogonadism with Clomiphene Citrate in a Male Patient with Secondary Polycythemia and History of Transient Ischemic Attack: A Case Report","authors":"A. Manov, A. Hatharasinghe, S. Acaralp","doi":"10.9734/bpi/nfmmr/v10/4106f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/4106f","url":null,"abstract":"Testosterone replacement therapy is the mainstay treatment for both primary and secondary hypogonadism. Clinical benefits of testosterone include improvement of the muscle mass, libido, and bone density. However, there are potential risks associated with it, including hypercoagulability, prostate cancer, worsening sleep apnea, cardiovascular disease etc. There are contraindications for treatment as per current guidelines of AACE/. Therefore, initiating testosterone should be done with caution and after excluding breast, prostatic cancers, PSA above 4ng/ml or above 3ng/ml in high risk patients-AfricanAmerican or having first degree relative with prostatic cancer, untreated Congestive heart failure, untreated severe sleep apnea, thrombophilia, Stroke, Transient ischemic attack (TIA) and myocardial Infarction (MI) within 6 months, Hematocrit (HCT) above 50% or if the patient seeks fertility. Given the high prevalence of cardiovascular disease worldwide testosterone replacement therapy may not be an option for every patient. We are describing a case regarding a patient successfully treated with the SERM- Clomiphene citrate a SERM with improvement of Testosterone to normal ranges, improvement of erectile dysfunction and morning erections and libido without the side effects of testosterone injections like polycythemia.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"26 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131801885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/4105f
A. Manov, A. Hatharasinghe, Katrina Equinox Lopez
Diabetes mellitus type 2/ DM2/ - is increasing in incidence in United States and throughout the world mostly due to increasing Obesity epidemy- around 40 % of adult people in USA. Two are the major defects of the disease- insulin resistance which sets up the stage 4-7 years before DM type 2 is diagnosed and relative to the increased resistance insulin deficiency. After the diagnosis of DM type 2 the Insulin resistance stays usually constant while the Insulin deficiency progresses necessitating the intensification of the therapy and eventually the need of Insulin . Initially the insulin is started usually as a basal and eventually as the DM type 2- progresses we add bolus rapid acting insulin to major meal- basal plus regimen/BP/ and eventually to every meal- basal- bolus /BB/ insulin. This intensification of the therapy is frequently able to control DM type 2, but leads to significant 3-4 kg weight gain with risk of hypoglycemia. Other option of intensification of the therapy of DM type 2 is to add to the oral anti - diabetic medications only basal Insulin and GLP1- RAs. GLP1-RAs decrease post prandial blood sugar as the rapid acting insulin does and the long acting GLP1-RAs also decrease fasting blood sugar. GLP1- RAs suppress the appetite and theoretically might lead to weight loss and less incidence of hypoglycemia compare to BP/BB Insulin regimens, because they act on glucose dependent manner- increase the endogenous insulin production only if the blood sugar is elevated. In our meta- analysis our objective was to look at the effect on the blood sugar as well as into looking at the side effect of GLP 1- RAs and basal- Insulin combination compare to BP/BB insulin combination like weight loss/gain, incidence of hypoglycemia, adverse events- mainly the gastrointestinal ones. Our secondary end point was the change in HbA1c between GLP1-RAs and basal insulin group compare to BP/BB insulin group in patients with HbA1c 7-11%. This is the first meta- analysis as far as we now comparing those 2- combinations – BB/BP insulin to GLP1-RAs and basal insulin in the terms of looking as a primary end point at the side effects of those combinations.
{"title":"Comparison of the effect on Hyperglycemia and the Adverse Effects among Different GLP-1 Receptor Agonists Added to Basal Insulin and between GLP-1 Receptor Agonists and Basal Insulin Versus Basal-Plus or Basal-Bolus Insulin in Type 2 Diabetes: A Meta-Analysis","authors":"A. Manov, A. Hatharasinghe, Katrina Equinox Lopez","doi":"10.9734/bpi/nfmmr/v10/4105f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/4105f","url":null,"abstract":"Diabetes mellitus type 2/ DM2/ - is increasing in incidence in United States and throughout the world mostly due to increasing Obesity epidemy- around 40 % of adult people in USA. Two are the major defects of the disease- insulin resistance which sets up the stage 4-7 years before DM type 2 is diagnosed and relative to the increased resistance insulin deficiency. After the diagnosis of DM type 2 the Insulin resistance stays usually constant while the Insulin deficiency progresses necessitating the intensification of the therapy and eventually the need of Insulin . Initially the insulin is started usually as a basal and eventually as the DM type 2- progresses we add bolus rapid acting insulin to major meal- basal plus regimen/BP/ and eventually to every meal- basal- bolus /BB/ insulin. This intensification of the therapy is frequently able to control DM type 2, but leads to significant 3-4 kg weight gain with risk of hypoglycemia. \u0000Other option of intensification of the therapy of DM type 2 is to add to the oral anti - diabetic medications only basal Insulin and GLP1- RAs. GLP1-RAs decrease post prandial blood sugar as the rapid acting insulin does and the long acting GLP1-RAs also decrease fasting blood sugar. GLP1- RAs suppress the appetite and theoretically might lead to weight loss and less incidence of hypoglycemia compare to BP/BB Insulin regimens, because they act on glucose dependent manner- increase the endogenous insulin production only if the blood sugar is elevated. \u0000In our meta- analysis our objective was to look at the effect on the blood sugar as well as into looking at the side effect of GLP 1- RAs and basal- Insulin combination compare to BP/BB insulin combination like weight loss/gain, incidence of hypoglycemia, adverse events- mainly the gastrointestinal ones. \u0000Our secondary end point was the change in HbA1c between GLP1-RAs and basal insulin group compare to BP/BB insulin group in patients with HbA1c 7-11%. \u0000This is the first meta- analysis as far as we now comparing those 2- combinations – BB/BP insulin to GLP1-RAs and basal insulin in the terms of looking as a primary end point at the side effects of those combinations.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129563599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/4034f
Vaneeta Bhardwar, Neha Batra, S. Goyal, K. Masih
Malignancy of small intestine is a very rare entity. Duodenum is the most common site for intestinal malignancy. The lesions present with stricture mostly. Most common cause of small intestine stricture in India is tubercular pathology. Tumors make up a very small percentage of causes of small intestinal obstruction.Small intestinal strictures distal to the duodenum are relatively inaccessible by endoscopy. This leads to difficulty in definitive preoperative diagnosis. The symptoms in case of jejunal malignancy are very nonspecific and a high index of suspicion is required for diagnosis. The objective of this case report is to highlight a case of Primary adenocarcinoma in Jejunum with good outcome after surgical resection.
{"title":"A Case Report on Primary Adenocarcinoma of Jejunum","authors":"Vaneeta Bhardwar, Neha Batra, S. Goyal, K. Masih","doi":"10.9734/bpi/nfmmr/v10/4034f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/4034f","url":null,"abstract":"Malignancy of small intestine is a very rare entity. Duodenum is the most common site for intestinal malignancy. The lesions present with stricture mostly. Most common cause of small intestine stricture in India is tubercular pathology. Tumors make up a very small percentage of causes of small intestinal obstruction.Small intestinal strictures distal to the duodenum are relatively inaccessible by endoscopy. This leads to difficulty in definitive preoperative diagnosis. The symptoms in case of jejunal malignancy are very nonspecific and a high index of suspicion is required for diagnosis. The objective of this case report is to highlight a case of Primary adenocarcinoma in Jejunum with good outcome after surgical resection.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128841267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/12321d
Gitana Diana Stukaite
Background: Currently, there is paucity of published evidence on the Virtual Fracture Clinic (VFC) model. There are limited resources from which conclusions could be drawn relating to the management of orthopaedic conditions, cost effectiveness, quality and safety, patient satisfaction rates and management when using the VFC model. Objectives: This narrative review of current published evidence aims to reveal how cost effective the VFC model is in relation to the orthopaedic management of both children and adults in the United Kingdom (UK). The review also seeks to identify gaps in current available literature and make recommendations for further research into the VFC model. Methods: This narrative review is secondary research of the evidence available on the VFC using a systematic approach. Seven electronic databases were searched to identify relevant peer-reviewed studies published since January 2010. The literature review identified 678 initial articles produced by undertaking key word searches (see appendix II). A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram was used to assist in illustrating the process of filtering and applying the inclusion and exclusion criteria to the search retrieval which subsequently led to 32 articles [1]. In total 14 relevant papers were selected following deduplication. Seven studies of various study types were selected and subjected to critical analysis using a systematic approach [2]. The main themes that have been selected are identified in Table 2. Results: No Randomised Controlled Trials (RCTs) or systematic reviews were found regarding VFCs. Seven articles were identified and reviewed following an in-depth databases search, these consisted of clinical audits, simulation study, comparison study, perspective analysis and retrospective research. All studies were from the UK only. One paper focused on paediatric fractures, two dedicated their research to Webber B ankle breaks and fifth metatarsal, including Jones fractures. The other four research articles consisted of mainly cost comparison and service redesign studies. All studies but one, by White et al. [3] reported positive findings. Overall, cost effectiveness of VFCs ranged from £13.91 per patient to £122. Individual study trusts estimated variable cost savings, ranging from £81,920 to £212,705, also Nationally approximate projections confirmed sums reaching £1,1 million per year. Conclusion: This narrative review shows that there are potential cost savings to be made when using the VFC model. Current financial projections cannot be taken for granted at this present time. Further robust evidence such as RCTs or systematic reviews with meta-analysis are required before final conclusions can be drawn regarding cost effectiveness when using the VFC model throughout the UK.
{"title":"The Narrative Review of Published Evidence on Cost Analysis and Sustainability of the Virtual Fracture Clinic Model: A Report Based Study","authors":"Gitana Diana Stukaite","doi":"10.9734/bpi/nfmmr/v10/12321d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/12321d","url":null,"abstract":"Background: Currently, there is paucity of published evidence on the Virtual Fracture Clinic (VFC) model. There are limited resources from which conclusions could be drawn relating to the management of orthopaedic conditions, cost effectiveness, quality and safety, patient satisfaction rates and management when using the VFC model. \u0000Objectives: This narrative review of current published evidence aims to reveal how cost effective the VFC model is in relation to the orthopaedic management of both children and adults in the United Kingdom (UK). The review also seeks to identify gaps in current available literature and make recommendations for further research into the VFC model. \u0000Methods: This narrative review is secondary research of the evidence available on the VFC using a systematic approach. Seven electronic databases were searched to identify relevant peer-reviewed studies published since January 2010. The literature review identified 678 initial articles produced by undertaking key word searches (see appendix II). A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram was used to assist in illustrating the process of filtering and applying the inclusion and exclusion criteria to the search retrieval which subsequently led to 32 articles [1]. In total 14 relevant papers were selected following deduplication. Seven studies of various study types were selected and subjected to critical analysis using a systematic approach [2]. The main themes that have been selected are identified in Table 2. \u0000Results: No Randomised Controlled Trials (RCTs) or systematic reviews were found regarding VFCs. Seven articles were identified and reviewed following an in-depth databases search, these consisted of clinical audits, simulation study, comparison study, perspective analysis and retrospective research. All studies were from the UK only. One paper focused on paediatric fractures, two dedicated their research to Webber B ankle breaks and fifth metatarsal, including Jones fractures. The other four research articles consisted of mainly cost comparison and service redesign studies. All studies but one, by White et al. [3] reported positive findings. Overall, cost effectiveness of VFCs ranged from £13.91 per patient to £122. Individual study trusts estimated variable cost savings, ranging from £81,920 to £212,705, also Nationally approximate projections confirmed sums reaching £1,1 million per year. \u0000Conclusion: This narrative review shows that there are potential cost savings to be made when using the VFC model. Current financial projections cannot be taken for granted at this present time. Further robust evidence such as RCTs or systematic reviews with meta-analysis are required before final conclusions can be drawn regarding cost effectiveness when using the VFC model throughout the UK.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128429145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/12114d
S. Ramesh, S. Sundari
Background: Seizures are a prevalent condition seen in Pediatric emergency departments all around the world. Objective: The aim of this study was to investigate the etiology of convulsions in children aged 1 month to 14 years. Methods: Between June 2014 and May 2015, 120 children admitted to a tertiary care hospital's paediatric department with convulsions were studied in this cross-sectional study.All of the children had a complete blood count, blood sugar, serum calcium, magnesium, and electrolytes checked. Depending on the clinical circumstances, Mantoux, chest X-ray, liver biopsy, Electroencephalography, lumbar puncture and cerebrospinal fluid analysis, ultrasonography cranium, computed tomography brain, or magnetic resonance imaging brain was performed. Results: We discovered that 46.7% of the children had febrile seizures, 19.2% had a seizure disorder, 15% had cerebral palsy, 5.8% had viral encephalitis, 3.3% had pyogenic meningitis, 1.7% had neurocysticercosis, 0.8% had metabolic disorders, and 0.8% had a traumatic brain injury, with the cause of seizures unknown in 6.6% of the children. Conclusion: Seizures in children require a thorough examination to determine the underlying pathology that is causing the seizures.
{"title":"Study on Etiological Evaluation of Convulsions in Children from 1 Month to 14 Years of Age","authors":"S. Ramesh, S. Sundari","doi":"10.9734/bpi/nfmmr/v10/12114d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/12114d","url":null,"abstract":"Background: Seizures are a prevalent condition seen in Pediatric emergency departments all around the world. \u0000Objective: The aim of this study was to investigate the etiology of convulsions in children aged 1 month to 14 years. \u0000Methods: Between June 2014 and May 2015, 120 children admitted to a tertiary care hospital's paediatric department with convulsions were studied in this cross-sectional study.All of the children had a complete blood count, blood sugar, serum calcium, magnesium, and electrolytes checked. Depending on the clinical circumstances, Mantoux, chest X-ray, liver biopsy, Electroencephalography, lumbar puncture and cerebrospinal fluid analysis, ultrasonography cranium, computed tomography brain, or magnetic resonance imaging brain was performed. \u0000Results: We discovered that 46.7% of the children had febrile seizures, 19.2% had a seizure disorder, 15% had cerebral palsy, 5.8% had viral encephalitis, 3.3% had pyogenic meningitis, 1.7% had neurocysticercosis, 0.8% had metabolic disorders, and 0.8% had a traumatic brain injury, with the cause of seizures unknown in 6.6% of the children. \u0000Conclusion: Seizures in children require a thorough examination to determine the underlying pathology that is causing the seizures.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125460973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/11957d
Rohan S. Kulkarni
This paper provides a comprehensive overview of COVID-19 related deaths within India over the first eight months of 2020 for two different Kaggle data sets. Analyzing first data set provided by the Kaggle for the period included Indian Nationality, states, and counts for total cases, deaths, and cured demonstrated that the states are statistically significant in a regression model. Furthermore, the second Kaggle data set provided by the Kaggle for the period for age, gender, nationality, and all states in the country, I drew conclusions concerning correlations between COVID-19 deaths and the four factor categories and found that the overall logistics regression model was statistically significant. The studyconcluded that within the first eight months of 2020, the both sexes are affected equally by the virus while age and states of residence play important roles in life and death due to the virus. Higher urban populated states with higher GDP creation have seen highest virus related deaths and may explain the forced avoidance of social distancing effect.
{"title":"The First Wave of COVID-19 in India: Demographic and Economic Analysis","authors":"Rohan S. Kulkarni","doi":"10.9734/bpi/nfmmr/v10/11957d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/11957d","url":null,"abstract":"This paper provides a comprehensive overview of COVID-19 related deaths within India over the first eight months of 2020 for two different Kaggle data sets. Analyzing first data set provided by the Kaggle for the period included Indian Nationality, states, and counts for total cases, deaths, and cured demonstrated that the states are statistically significant in a regression model. \u0000Furthermore, the second Kaggle data set provided by the Kaggle for the period for age, gender, nationality, and all states in the country, I drew conclusions concerning correlations between COVID-19 deaths and the four factor categories and found that the overall logistics regression model was statistically significant. The studyconcluded that within the first eight months of 2020, the both sexes are affected equally by the virus while age and states of residence play important roles in life and death due to the virus. Higher urban populated states with higher GDP creation have seen highest virus related deaths and may explain the forced avoidance of social distancing effect.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132652328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/12413d
M. Shkilna, K. Shtokailo, O. Ivakhiv, Roksolana Humenna, M. Huk, A. Petruk, Z. Smahlii
Localized scleroderma (morphea) is a long-term progressive chronic disease characterised by a connective tissue lesion in the skin with a predominance of fibro-sclerotic and vascular problems. The present studies based on 40 patients, which conducted a questionnaire and laboratory examination. The age of tested persons ranged from 18–74years. Because of the skin thickness, the index of the severity of localised scleroderma associated with Lyme disease was lower than in responders alone with morphea. As a result, the topic of our research demands more attention from dermatologists not only from Ukraine, but from all around the world.
{"title":"Study on Localized Scleroderma, Associated with Lyme Disease","authors":"M. Shkilna, K. Shtokailo, O. Ivakhiv, Roksolana Humenna, M. Huk, A. Petruk, Z. Smahlii","doi":"10.9734/bpi/nfmmr/v10/12413d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v10/12413d","url":null,"abstract":"Localized scleroderma (morphea) is a long-term progressive chronic disease characterised by a connective tissue lesion in the skin with a predominance of fibro-sclerotic and vascular problems. The present studies based on 40 patients, which conducted a questionnaire and laboratory examination. The age of tested persons ranged from 18–74years. Because of the skin thickness, the index of the severity of localised scleroderma associated with Lyme disease was lower than in responders alone with morphea. As a result, the topic of our research demands more attention from dermatologists not only from Ukraine, but from all around the world.","PeriodicalId":113195,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 10","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116302686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.9734/bpi/nfmmr/v10/12377d
G. Odoh, J. Uwakwe, J. Edah, J. Ojobi, E. Chuhwak
The Metabolic Syndrome (MetS) is a grouping of cardiovascular risk factors that includes obesity (typically central), hypertension, dyslipidemia, glucose intolerance, prothrombotic state, and inflammation. MetS is a factor in the development of type 2 diabetes and cardiovascular disease. Jean Vague in the 1940s and early 1950s related the presence of male type (android form) of adiposity to the development of diabetes mellitus and cardiovascular diseases which are all important factors of the MetS. MetS is defined based on a variety of criteria, such as the National Cholesterol Education Program Adult Treatment Pane lIII (NCEP-ATPIII), World Health Organization (WHO) and International Diabetes Federation (IDF). Central obesity is an important component of MetS in these definitions. This is largely due to the key role played by the adipocyte in the development of the syndrome. The contents of this article were drawn from an extensive online search of literature covering the subject matter, and aims to review the pathophysiological role of central obesity in the development of the components of the metabolic syndrome. We advocate for early detection of central obesity, by simple measures such as the use measuring tape to assess the waist circumference.
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