Diabetes & metabolism最新文献

{"title":"BedBiopsy: Diagnostic performance of bedside ultrasound-guided bone biopsies for the management of diabetic foot infection","authors":"Nolan Hassold ,&nbsp;Hélène Bihan ,&nbsp;Yolène Pambo Moumba ,&nbsp;Isabelle Poilane ,&nbsp;Frédéric Méchaï ,&nbsp;Nabil Assad ,&nbsp;Véronique Labbe-Gentils ,&nbsp;Meriem Sal ,&nbsp;Omar Nouhou Koutcha ,&nbsp;Antoine Martin ,&nbsp;Dana Radu ,&nbsp;Emmanuel Martinod ,&nbsp;Hugues Cordel ,&nbsp;Nicolas Vignier ,&nbsp;Sopio Tatulashvili ,&nbsp;Narimane Berkane ,&nbsp;Etienne Carbonnelle ,&nbsp;Olivier Bouchaud ,&nbsp;Emmanuel Cosson","doi":"10.1016/j.diabet.2024.101525","DOIUrl":"10.1016/j.diabet.2024.101525","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to assess the feasibility and diagnostic performance of ultrasound-guided bone biopsies at the bedside of diabetic patients admitted for suspected foot osteitis not requiring surgery.</p></div><div><h3>Research Design and Methods</h3><p>In this retrospective monocentric study, we compared the performance of ultrasound-guided (<em>n</em> = 29 consecutive patients, Dec.2020-Oct.2022) versus surgical (<em>n</em> = 24 consecutive patients, Jan.2018-Nov.2020) bone biopsies at confirming or ruling out diabetic foot osteitis (primary outcome).</p></div><div><h3>Results</h3><p>Patient characteristics were similar in the two intervention groups, including arteritis prevalence (62.3 %), SINBAD score, and wound location (phalanges 36 %, metatarsus 43 %, and calcaneus 21 %). However, the ultrasound-guided group was older (67 ± 11 versus 60 ± 13 years respectively, <em>P</em> = 0.047) and had more type 2 diabetes (97 % versus 75 %, <em>P</em> = 0.038). Diagnostic performance (i.e., capacity to confirm or rule out suspected osteitis) was similar for ultrasound-guided (28/29 cases: 25 confirmations, 3 invalidations) and surgical (24 confirmations/24) biopsies, <em>P</em> = 0.358. No biopsy-related side effect or complication was observed for either intervention, even for patients on antiaggregation and/or anticoagulation therapy. The mean (± standard deviation) time necessary to perform the biopsy was shorter in the ultrasound-guided group (2.6 ± 3.0 versus 7.2 ± 5.8 days, respectively, <em>P</em> &lt; 0.001) and wound evolution at three months was more favorable (83.3 versus 41.2 %, <em>P</em> = 0.005) (94.4 % versus 66.7 %, respectively, patients with new surgical procedure within six months excluded; <em>P</em> = 0.055). Even though not statistically significant, healing rates in terms of wound and osteitis at six months were also better in the ultrasound-guided group (wound: 40.9 % versus 36.8 %; <em>P</em> = 0.790, and osteitis: 81.8 vs 55.6 % <em>P</em> = 0.071).</p></div><div><h3>Conclusion</h3><p>In diabetic patients with suspected foot osteitis not requiring surgery, bedside ultrasound-guided bone biopsies may constitute a promising alternative to surgical biopsies. This intervention provided excellent tolerance and microbiological documentation, short lead-times, and more favorable wound prognosis.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101525"},"PeriodicalIF":7.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S126236362400017X/pdfft?md5=9cd9269cb51ef1e69ce6f23096a21c4b&pid=1-s2.0-S126236362400017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study","authors":"Fadi Alkhami,&nbsp;Gauthier Borderie,&nbsp;Ninon Foussard,&nbsp;Alice Larroumet,&nbsp;Laurence Blanco,&nbsp;Marie-Amélie Barbet-Massin,&nbsp;Amandine Ferriere,&nbsp;Claire Ducos,&nbsp;Kamel Mohammedi,&nbsp;Sami Fawaz,&nbsp;Thierry Couffinhal,&nbsp;Vincent Rigalleau","doi":"10.1016/j.diabet.2024.101524","DOIUrl":"10.1016/j.diabet.2024.101524","url":null,"abstract":"<div><h3>Background</h3><p>Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM.</p></div><div><h3>Research design and methods</h3><p>We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death). The relationship between SAF and CVE was analyzed by multivariable Cox regression. Log-rank curves were used to compare CVE-free survival in patients whose SAF at admission was above versus below the whole-population median. The analysis was repeated in subjects without/with macroangiopathy (defined as myocardial infarction, stroke, peripheral revascularization) at baseline.</p></div><div><h3>Findings</h3><p>During 54 months of follow-up, 69 (13.7%) patients had a CVE. Baseline SAF was significantly higher in patients with T2DM who later experienced a CVE (2.89 ± 0.70 arbitrary units versus 2.64 ± 0.62 in others, <em>P</em> = 0.002). This relationship was significant after adjusting for age, sex, conventional risk factors (diabetes duration, HbA1c, arterial hypertension, dyslipidemia, smoking, body mass index), vascular complications, C-reactive protein, and treatments for diabetes. The CVE-free survival curves differed between subjects whose SAF was above the whole-population median (log-rank: <em>P</em> = 0.002) and those whose SAF was above the macroangiopathy-free sub-population median (log-rank: <em>P</em> = 0.016).</p></div><div><h3>Conclusion</h3><p>SAF of advanced glycation end-products was related to a higher incidence of later CVE in patients with T2DM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101524"},"PeriodicalIF":7.2,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between blood urea nitrogen-to-creatinine ratio and insulin sensitivity","authors":"JaeHyuck Lee ,&nbsp;In Cheol Hwang ,&nbsp;Hong Yup Ahn","doi":"10.1016/j.diabet.2024.101521","DOIUrl":"10.1016/j.diabet.2024.101521","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101521"},"PeriodicalIF":7.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High serum total bilirubin as a potential protective factor for gestational diabetes mellitus: A retrospective cohort study of 92,885 Chinese pregnant women","authors":"Yan Zhao ,&nbsp;Wenyu Zhu ,&nbsp;Miao Wang ,&nbsp;Luyi Cai ,&nbsp;Xueying Zheng ,&nbsp;Liping Jin","doi":"10.1016/j.diabet.2024.101523","DOIUrl":"10.1016/j.diabet.2024.101523","url":null,"abstract":"<div><h3>Aims</h3><p>Identifying physiological factors that could reduce pregnant women's risk for developing gestational diabetes mellitus (GDM) is crucial for early prevention and intervention. We aimed to examine whether higher serum levels of total bilirubin (TBIL) were associated with a decreased risk of GDM.</p></div><div><h3>Methods</h3><p>We conducted a retrospective cohort study in a tertiary care hospital in Shanghai, China. A total of 92,885 pregnant women were included. Serum TBIL levels were determined during the first antenatal visit before 24 weeks of gestation and GDM was diagnosed with a 75-g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation.</p></div><div><h3>Results</h3><p>A total of 13,037 GDM cases were identified, a prevalence of 14.0 % (13,037/92,885). These women had a higher median TBIL concentration 7.9 versus 7.6 mmol/l (<em>P</em> &lt; 0.001). For the 91,051 women with TBIL within the physiologically normal range (≤ 17.1 μmol/l), a one interquartile range increase in TBIL (3.4 μmol/l) was associated with a decreased risk of GDM: adjusted odds ratio (OR)=0.89 [95 % CI 0.87;0.92]. For these women, the adjusted ORs for GDM across TBIL quartiles were: 0.92 [0.88;0.97] for the second, 0.85 [0.81;0.90] for the third, and 0.78 [0.74;0.83] for the fourth quartile in comparison with the first quartile.</p></div><div><h3>Conclusion</h3><p>Our study demonstrated that elevated serum TBIL levels were associated with decreased risk of GDM and supported its potential role in the prevention and early intervention of GDM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101523"},"PeriodicalIF":7.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of rotator cuff tear and rotator cuff repair surgery comparison between sodium-glucose cotransporter 2 inhibitors and glucagon like peptide-1 receptor agonists: A real-world study","authors":"Yu-Chi Su ,&nbsp;Pei-Chun Hsieh ,&nbsp;Edward Chia-Cheng Lai ,&nbsp;Yu-Ching Lin","doi":"10.1016/j.diabet.2024.101522","DOIUrl":"10.1016/j.diabet.2024.101522","url":null,"abstract":"<div><h3>Aim</h3><p>Theoretically, sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce the risk of rotator cuff tear through an anti-inflammatory mechanism. To clarify this association, in this study, we compared SGLT2is users and glucagon-like peptide-1 receptor agonists (GLP-1RAs) users in terms of the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery.</p></div><div><h3>Methods</h3><p>A retrospective cohort analysis was conducted using data from the TriNetX platform. A target trial design was adopted to identify patients with type 2 diabetes mellitus who started receiving SGLT2is or GLP-1RAs. Propensity score matching was used to form two homogeneous groups. The study outcomes were the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated within the TriNetX platform.</p></div><div><h3>Results</h3><p>Initially, 351,800 SGLT2is users and 387,616 GLP-1RAs users were identified. After propensity score matching, each group comprised 274,026 patients. The mean age was 59.5 years in both groups; the proportions of women in the SGLT2is and GLP-1RAs groups were 46.9 % and 46.7 %, respectively. Compared with the GLP-1RAs group, the SGLT2is group had significantly reduced risks of rotator cuff tear (HR 0.812 [0.761;0.867]) and rotator cuff repair surgery (HR 0.900 [0.815;0.994]).</p></div><div><h3>Conclusion</h3><p>SGLT2is appear to reduce the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery in patients with type 2 diabetes mellitus. Further prospective studies are needed to validate our findings.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101522"},"PeriodicalIF":7.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic Risk Index (GRI) variability in type 1 diabetes adults with HbA1c ≤ 7%: Insights for clinical evaluation and intervention","authors":"Philippe Oriot ,&nbsp;Michel P Hermans ,&nbsp;Antoine Vandelaer ,&nbsp;Jean Christophe Philips ,&nbsp;Gaëtan Prévost","doi":"10.1016/j.diabet.2024.101520","DOIUrl":"10.1016/j.diabet.2024.101520","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101520"},"PeriodicalIF":7.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of type 2 diabetes and the risk of migraine in Chinese populations","authors":"Jielong Wu ,&nbsp;Jie Fang ,&nbsp;Xiaodong Yuan ,&nbsp;Lingshan Ma ,&nbsp;Liangcheng Zheng ,&nbsp;Qing Lin ,&nbsp;Xingkai An ,&nbsp;Zhanxiang Wang ,&nbsp;Qilin Ma","doi":"10.1016/j.diabet.2024.101518","DOIUrl":"10.1016/j.diabet.2024.101518","url":null,"abstract":"<div><h3>Aim</h3><p>We aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM.</p></div><div><h3>Methods</h3><p><span><span>Data on the study cohort of 9873 individuals were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The incidence rate of migraine from 2015 to 2018 was assessed. The Cox </span>proportional hazards model was used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) for the relationship between T2DM and the incidence of migraine. In addition, a cross-sectional study including 168 migraine patients was conducted in Xiamen, China. Migraine patients were grouped according to their T2DM status. Multivariable </span>linear regression models were used to estimate βs and their 95% CIs for the relationship between migraine characteristics and T2DM.</p></div><div><h3>Results</h3><p>The cumulative incidence rate of migraine from 2015 to 2018 in the T2DM group and control group was 7.26% [6.04%.8.65%] and 8.91% [8.27%.9.58%], respectively. The risk of migraine in patients with T2DM was reduced by 21% (HR 0.79 [0.65;0.95]) compared to patients with no T2DM after adjustment for confounders. The cross-sectional study showed that the presence of T2DM significantly reduced migraine frequency and relieved migraine intensity.</p></div><div><h3>Conclusion</h3><p>This was the first study to validate that T2DM reduced the risk of migraine in a Chinese population cohort. Patients with migraine and T2DM may experience significant relief from their headache symptoms. Carrying out relevant mechanistic research may help to identify new targets for migraine treatment<span> and contribute to further understanding the impact of T2DM or related metabolic disorders on an individual's health.</span></p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101518"},"PeriodicalIF":7.2,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139560147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social isolation, loneliness, and the risk of incident type 2 diabetes mellitus by glycemic status","authors":"Yanjun Zhang ,&nbsp;Mengyi Liu ,&nbsp;Chun Zhou ,&nbsp;Ziliang Ye ,&nbsp;Yuanyuan Zhang ,&nbsp;Sisi Yang ,&nbsp;Panpan He ,&nbsp;Xiaoqin Gan ,&nbsp;Xianhui Qin","doi":"10.1016/j.diabet.2024.101517","DOIUrl":"10.1016/j.diabet.2024.101517","url":null,"abstract":"<div><h3>Aim</h3><p>The modifying effect of prediabetic status on the association of social isolation and loneliness with the risk of type 2 diabetes mellitus (T2DM) remains uncertain. We aimed to explore whether prediabetic status modifies the association of social isolation and loneliness with incident T2DM.</p></div><div><h3>Methods</h3><p><span>358,951 participants with random blood glucose &lt; 11.1 mmol/l, </span>hemoglobin A1c<span><span> &lt; 6.5 % and without diagnosis of diabetes from the UK Biobank were included. </span>Prediabetes was defined by hemoglobin A1c level at 5.7–6.4 %. Social isolation and loneliness were assessed using self-reported questionnaires. The study outcome was incident T2DM.</span></p></div><div><h3>Results</h3><p>During a median follow-up of 12.5 years, 13,213 (3.7 %) incident T2DM cases were documented. Social isolation and loneliness in subjects with normoglycemia (adjusted HR [95 %CI]: social isolation: 1.14 [1.07;1.23]; loneliness: 1.33 [1.20;1.47]) were more strongly associated with increased risk of T2DM than in those with prediabetes (adjusted HR [95 %CI]: social isolation: 0.97 [0.91;1.03]; loneliness: 1.04 [0.95;1.13]) (Both <em>P</em><span> for interaction &lt; 0.001). Among individuals with prediabetes, alcoholic consumption (30.9 %), household income (23.3 %), healthy sleep (17.1 %), loneliness (14.9 %), and physical activity (12.6 %) mediated most of the variance in the association between social isolation and incident T2DM, while body mass index (17.9 %) and healthy sleep (17.6 %) mediated most of the variance in the association between loneliness and incident T2DM.</span></p></div><div><h3>Conclusion</h3><p>Social isolation and loneliness were independently associated with a higher risk of T2DM among individuals without prediabetes. Among those with prediabetes, the association of social isolation and loneliness with incident T2DM were mainly mediated by some socioeconomic and lifestyle factors.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101517"},"PeriodicalIF":7.2,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139507803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hope, hype and present limitations of hybrid closed loop systems for persons with type 1 diabetes","authors":"Charles Thivolet","doi":"10.1016/j.diabet.2024.101510","DOIUrl":"10.1016/j.diabet.2024.101510","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101510"},"PeriodicalIF":7.2,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eleven-year trends in socioeconomic inequalities in the prevalence and incidence of pharmacologically treated type 2 diabetes in France, 2010–2020","authors":"Marie Guion ,&nbsp;Laurence Mandereau-Bruno ,&nbsp;Sarah Goria ,&nbsp;Emmanuel Cosson ,&nbsp;Sandrine Fosse-Edorh","doi":"10.1016/j.diabet.2024.101509","DOIUrl":"10.1016/j.diabet.2024.101509","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to describe the association between socioeconomic inequalities and the prevalence and incidence of pharmacologically-treated type 2 diabetes in European France over the 2010–2020 period.</p></div><div><h3>Methods</h3><p>Diabetes cases were identified using a validated algorithm from the French National Health Data System. Analysis was restricted to adults aged 45 years and older to focus on type 2 diabetes. Socioeconomic inequalities were measured for all years in European France using the French deprivation index (FDep, 2015 version), which is an area-based deprivation indicator using population-weighted quintiles (Q1 corresponds to the least deprived municipalities). The relative risks of diabetes prevalence and incidence associated with FDep quintiles (Q1 as the reference) were estimated by sex using a log-linear Poisson model adjusted for year, age and French department. The study population was the French health consumers aged 45 years and over (from 24,228,526 in 2010 to 29,772,928 in 2020).</p></div><div><h3>Results</h3><p>A positive gradient was observed in the relative risks of type 2 diabetes prevalence and incidence by FDep quintiles over the study period. The strength of the estimated associations increased over the last decade for prevalence among men and women and for incidence among men in the two most deprived quintiles.</p></div><div><h3>Conclusion</h3><p>Thus, type 2 diabetes prevention should include a proportionate universalism approach, proposing actions of greater intensity in the most deprived areas.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101509"},"PeriodicalIF":7.2,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139411692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}