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[The significance of breast radiography for the surgeon]. 【乳腺x线摄影对外科医生的意义】。
Der Krebsarzt
Pub Date : 1969-01-01
J Strobl
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引用次数: 0
[Permanent cure of a bone sarcoma following x-ray irradiation]. 【x射线照射后骨肉瘤的永久治愈】。
Der Krebsarzt
Pub Date : 1969-01-01
G Fuchs
{"title":"[Permanent cure of a bone sarcoma following x-ray irradiation].","authors":"G Fuchs","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11337,"journal":{"name":"Der Krebsarzt","volume":"24 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"1969-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16860643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress observations in patients with inoperable lung tumors during treatment with a combined internal therapy (alkylating agent and endogenous polypeptid)]. [不能手术的肺肿瘤患者联合内源性多肽(烷基化剂)治疗的进展观察]。
Der Krebsarzt
Pub Date : 1969-01-01
G Klose, R Below
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引用次数: 0
[Therapy of breast cancer]. [乳腺癌的治疗]。
Der Krebsarzt
Pub Date : 1969-01-01
E Rappert

Report about 97 patients with 103 operations of cancer of breast. I used always restricted methods: 23 segment resections, 20 simple mastectomies, 60 enlarged mastectomies. The axillary glands were not extirpated. All patients got after operation an energy radiotherapy. If there were still production of estrogen hormone, the ovaries were treated by x-rays or by extirpation. The 5 year survival rate for all cases is 69.5%, the 10 year rate 39.6%. The 5 year survival rate of patients of stage I and II (Steinthal) is 81.8%, the 10 year rate 54.8%. Steinthal III-patients have a five year rate of 33% and a 10 year rate of 6%.

报告97例乳腺癌手术103例。我总是使用限制性的方法:23个节段切除术，20个单纯乳房切除术，60个扩大乳房切除术。腋腺未被切除。所有患者术后均行能量放疗。如果卵巢仍能产生雌激素，则用x光或切除卵巢进行治疗。5年生存率为69.5%，10年生存率为39.6%。I期和II期患者(Steinthal) 5年生存率为81.8%，10年生存率为54.8%。Steinthal iii型患者的5年生存率为33%，10年生存率为6%。
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引用次数: 0
[Results of a statistical survey of survivor and death rates of pensioners and occupations among 6389 patients with malignant disease undergoing metaphylactic care]. [6389例接受变态治疗的恶性疾病患者中养老金领取者和职业的生存率和死亡率统计调查结果]。
Der Krebsarzt
Pub Date : 1969-01-01
C L Trüb
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引用次数: 0
[New amino acid derivatives with oncolytic action]. [具有溶瘤作用的新型氨基酸衍生物]。
Der Krebsarzt
Pub Date : 1969-01-01
J Zangger

A total of 27 new derivatives have been obtained by substitution on seven amino acids and betaines, respectively. The present experimental study examines the oncolytic and oncostatic action of four new amino acid compounds. Under experimental conditions in vitro the following remarkable properties of the chemical preparations can be ascertained on Ehrlich's tumor cells of the white mouse: 1. The oncolysis detected by micromorphology only occurs after an incubation of 4-6 hours, the transplantability of the tumor cells is lost much earlier. 2. The anaerobic glycolysis is in no case limited, the cell respiration is stimulated under the influence of amino acid compounds. 3. The Crabtree effect on Ehrlich ascites tumor cells is inhibited by the test substances. The irreversible damage caused by the new amino acid compounds to the Ehrlich tumor cells and observed in vitro only occurs with large excess of the substances. The mechanism of action may be due to a substrate-like excess inhibition, a disturbance of the amino acid sequence within the cell proteins being discussed. Therapeutic inhibition tests on experimental animal tumors have shown that an effect may only be expected after the application of high doses and prolonged administration. The extremely low general toxicity and the lack of any disturbance of the hematopoietic system permit a long-time application of the amino acid compounds.

通过对7种氨基酸和甜菜碱的取代，共得到27个新的衍生物。本实验研究考察了四种新的氨基酸化合物的溶瘤和抑瘤作用。在体外实验条件下，该化学制剂对小鼠埃利希氏瘤细胞有以下显著的作用:微形态学检测到的肿瘤溶解仅在4-6小时后发生，肿瘤细胞的可移植性更早丧失。2. 厌氧糖酵解在任何情况下都不受限制，在氨基酸化合物的影响下刺激细胞呼吸。3.实验物质对埃利希腹水肿瘤细胞有抑制作用。新氨基酸化合物对体外观察到的埃利希肿瘤细胞的不可逆损伤，只有在物质大量过量时才会发生。作用机制可能是由于底物样的过度抑制，即正在讨论的细胞蛋白质内氨基酸序列的干扰。实验性动物肿瘤的治疗抑制试验表明，只有在应用高剂量和长时间给药后才能预期产生效果。极低的一般毒性和对造血系统没有任何干扰，允许氨基酸化合物的长期应用。
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引用次数: 0
[Heat incubation of plasma according to Gross. A contribution to the practical evaluation of separation methods of tumor and inflammation caused sedimentation rate]. [格罗斯说的等离子体热培养。[对肿瘤和炎症引起的沉降率分离方法的实用评价]。
Der Krebsarzt
Pub Date : 1969-01-01
H Bartolmäs
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引用次数: 0
[On the observation of a fourfold cancer]. [根据对四重癌症的观察]。
Der Krebsarzt
Pub Date : 1969-01-01
G Zimmermann
{"title":"[On the observation of a fourfold cancer].","authors":"G Zimmermann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11337,"journal":{"name":"Der Krebsarzt","volume":"24 2","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"1969-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15987138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Initial clinical experiences with the administration of new amino acid derivatives in the treatment of malignant tumors]. 【新氨基酸衍生物治疗恶性肿瘤的初步临床经验】。
Der Krebsarzt
Pub Date : 1969-01-01
J Eder, J Zangger

A report is given on the first clinical experience made with the application of new amino acid compounds in the therapy of malignant tumors. The established good compatibility of the substances allows long-termed treatments with great variability of individual dosage. The regressions of tumors observed and the frequent improvement of the general status, even in advanced stages of tumors, should give rise to a broad investigation of the available tumor inhibitors.

本文报道了新型氨基酸化合物在恶性肿瘤治疗中的首次临床应用。所建立的物质的良好相容性允许长期治疗与个体剂量的巨大变化。观察到肿瘤的消退和一般状态的频繁改善，甚至在肿瘤的晚期，应该引起对可用肿瘤抑制剂的广泛研究。
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引用次数: 0
[New ways of the chemotherapy of cancer]. [癌症化疗的新方法]。
Der Krebsarzt
Pub Date : 1969-01-01
C G Schmidt
{"title":"[New ways of the chemotherapy of cancer].","authors":"C G Schmidt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11337,"journal":{"name":"Der Krebsarzt","volume":"24 3","pages":"129-49"},"PeriodicalIF":0.0,"publicationDate":"1969-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16885231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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