Diagnostic Cytopathology最新文献

Solitary fibrous tumors (SFT) are a rare neoplasm of mesenchymal origin. SFT was previously described primarily in the pleura and meninges; however, extrapleural and extra-meningeal SFT have been reported in almost every anatomic site and account for up to 40% of cases. The most significant histologic findings of SFT include spindle cell proliferation in a “pattern-less pattern”, dilated and branching “staghorn”-like vasculature, and ropey collagen deposition. However, these findings are not consistently present in every case of SFT and may also be seen in other diseases. SFT has a characteristic NAB2::STAT6 gene fusion and nuclear overexpression of STAT6. The rarity of the disease, broad range of differential diagnoses, and wide spectrum of cytomorphological and histologic findings make the diagnosis of extrapleural SFT, especially on a fine needle aspiration (FNA) specimen, challenging. Recognizing and including this entity in the differential is necessary before the final diagnosis may be achieved through proper immunohistochemical and molecular workup. In this paper, we present two cases of extrapleural SFT with unusual locations: the first is a primary SFT present in a parotid gland and the second is a metastatic SFT present as two solid pancreatic masses.

Mentorship has been a cornerstone of my professional development in cytopathology, shaping both my diagnostic acumen and academic identity. Under the guidance of Dr. Claire Michael during residency and fellowship, I was introduced to a culture of intellectual rigor, systems thinking, and continuous improvement. Her mentorship on diagnostic refinement and molecular innovation laid the foundation for my scholarly growth in cytopathology. Later, as I transitioned into faculty life, Dr. Jonas Heymann became a peer mentor whose collegial support and shared inquiry helped me navigate independent practice. Together, we explored diagnostic reproducibility and quality assurance in thyroid cytology with an innovative approach. This narrative reflects the transformative power of mentorship across career stages and its enduring impact on professional growth.

Male breast cancer (MBC) is a rare disease accounting for less than 1% of breast cancers and for 0.11% of all male malignancies. Despite the fact that the epidemiologic, clinical, and therapeutic literature regarding female breast cancer is well documented, little is known about the features of male breast cancer. Here, we present a case of cytological pleural metastasis from ductal breast carcinoma in a 55-year-old man. Immunohistochemical staining showed that the tumor cells were positive for BerEp4, GATA-3, AE1/AE3, CAM5.2, ER (70%), AR (10%), PR (10%), and ki67 (10%). In our experience, effusion cytology remains an accurate tool for the diagnosis of metastatic carcinomas.

Cribriform Morular Thyroid Carcinoma (CM-TC) is a rare thyroid malignancy characterized by distinctive histomorphologic and genetic features, primarily driven by continuous activation of the WNT/β-catenin signaling pathway. However, diagnosis can be challenging on fine needle aspiration biopsy due to its rarity and overlapping cytomorphologic features with other thyroid tumors. We present a unique case of CM-TC displaying long papillary fronds and intracytoplasmic globules, reminiscent of solid pseudopapillary tumor of the pancreas. These two cytologic features have not been previously described in the literature. Molecular analysis (ThyroSeq) revealed an activating CTNNB1 (beta-catenin) exon 3 mutation in this case, which is also commonly observed in solid pseudopapillary tumors of the pancreas. We propose that morphologic similarity may be a consequence of a similar mutation. Recognizing these novel characteristics may aid in distinguishing CM-TC from other thyroid tumors, improving diagnostic accuracy and patient management.