Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2058
D. Soller, C. Lenivy, J. DallaRosa, G. Murali
{"title":"Mediastinal Lymphadenopathy: An IrregG4ular Cause","authors":"D. Soller, C. Lenivy, J. DallaRosa, G. Murali","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2058","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2058","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133241777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2032
A. Thota, L. Ramírez, U. Naqvi, A. Mahgoub, A. Abdelrahman
{"title":"An Unusual Presentation of IgA Vasculitis","authors":"A. Thota, L. Ramírez, U. Naqvi, A. Mahgoub, A. Abdelrahman","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2032","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2032","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130759479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2033
M. Ondeck, S. Gayen, B. Gupta, M. Patel, P. Desai
{"title":"Diagnostic Dilemma: EGPA Without Vasculitis on Biopsy?","authors":"M. Ondeck, S. Gayen, B. Gupta, M. Patel, P. Desai","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2033","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2033","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115186501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2054
J. Mathew, H. García
{"title":"An Atypical Presentation of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids Syndrome: A Case Report","authors":"J. Mathew, H. García","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2054","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2054","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128677039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2065
L.V. Bocanegra English, L. Hinkle
{"title":"Non-Bronchiectatic Suppurative Airway Disease (Bronchiolitis): A Rare Extraintestinal Manifestation of Crohn's Disease","authors":"L.V. Bocanegra English, L. Hinkle","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2065","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2065","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131095471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2066
S. Chalmers, M. Baqir
{"title":"Multiple Tumor-Like Lesions in a Patient with Hearing Loss, Fatigue, Night Sweats, and Weight Loss","authors":"S. Chalmers, M. Baqir","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2066","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2066","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130644546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2044
J. Selickman, H. Desai, K. Pendleton
{"title":"Novel Treatment for Diffuse Alveolar Hemorrhage","authors":"J. Selickman, H. Desai, K. Pendleton","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2044","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2044","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127138607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2055
A. Kears, K. Musco, D. Soller, A. Ahluwalia
{"title":"The Undetected Myopathy: Anti-PL-12 Induced Antisynthetase Syndrome","authors":"A. Kears, K. Musco, D. Soller, A. Ahluwalia","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2055","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2055","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116612645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2039
A. Yuen, J. Betancourt, K. Eng
Introduction The presence of antibodies against melanoma differentiation-associated gene 5 (MDA-5) is an ominous marker that is associated with rapidly progressive interstitial lung disease (ILD) associated with clinically amyopathic dermatomyositis (CADM). Early identification along with consideration of aggressive immunomodulation with monitoring for referral for lung transplantation evaluation is critical for patient outcomes. Here, we describe the diagnostic evaluation for a patient presenting with productive cough and progressive dyspnea on exertion, eventually found to have MDA-5 positive dermatomyositis-related ILD. Description of the case A 37-year-old male with history of THC vape exposure presented with an acute febrile respiratory illness prior to the COVID pandemic. He was found on high-resolution CT imaging of his chest to have peripheral predominant bilateral ground glass opacities and underwent bronchoscopy with transbronchial biopsy of the right lower lobe, with pathology demonstrating organizing pneumonia. Infectious studies from a subsequent bronchalveolar lavage demonstrated no evidence of infection, and the patient was initiated on pulse steroids for progressive hypoxemic respiratory failure requiring ICU admission and high flow nasal cannula. Initial concern at this juncture was for e-cigarette or vaping use-associated lung injury (EVALI) because his initial infectious and autoimmune panels were negative, with concern for early progression to fibrosis. However, a subsequent extended myositis panel revealed positivity for MDA-5 antibodies. Upon completion of his pulse steroids, he was transitioned to mycophenolate mofetil with intermittent intravenous immunoglobulins targeting for cutaneous dermatomyositis manifestation in coordination with rheumatology. With titration of his immunosuppression, he was able to wean off supplemental oxygen therapy. He remains closely monitored by pulmonary function tests, 6-minute walk tests, and imaging. Discussion of the novelty and importance of the case This case demonstrates the complexity of diagnosis of rapidly progressive interstitial lung diseases, with the need for multidisciplinary management for aggressive disease phenotypes. Early, aggressive immunomodulation in coordination with rheumatology achieved disease stability for this patient and has successfully delayed need for lung transplantation evaluation.
{"title":"Gasping for a Diagnosis - A Case of MDA-5 Positive Dermatomyositis-Related Interstitial Lung Disease","authors":"A. Yuen, J. Betancourt, K. Eng","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2039","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2039","url":null,"abstract":"Introduction The presence of antibodies against melanoma differentiation-associated gene 5 (MDA-5) is an ominous marker that is associated with rapidly progressive interstitial lung disease (ILD) associated with clinically amyopathic dermatomyositis (CADM). Early identification along with consideration of aggressive immunomodulation with monitoring for referral for lung transplantation evaluation is critical for patient outcomes. Here, we describe the diagnostic evaluation for a patient presenting with productive cough and progressive dyspnea on exertion, eventually found to have MDA-5 positive dermatomyositis-related ILD. Description of the case A 37-year-old male with history of THC vape exposure presented with an acute febrile respiratory illness prior to the COVID pandemic. He was found on high-resolution CT imaging of his chest to have peripheral predominant bilateral ground glass opacities and underwent bronchoscopy with transbronchial biopsy of the right lower lobe, with pathology demonstrating organizing pneumonia. Infectious studies from a subsequent bronchalveolar lavage demonstrated no evidence of infection, and the patient was initiated on pulse steroids for progressive hypoxemic respiratory failure requiring ICU admission and high flow nasal cannula. Initial concern at this juncture was for e-cigarette or vaping use-associated lung injury (EVALI) because his initial infectious and autoimmune panels were negative, with concern for early progression to fibrosis. However, a subsequent extended myositis panel revealed positivity for MDA-5 antibodies. Upon completion of his pulse steroids, he was transitioned to mycophenolate mofetil with intermittent intravenous immunoglobulins targeting for cutaneous dermatomyositis manifestation in coordination with rheumatology. With titration of his immunosuppression, he was able to wean off supplemental oxygen therapy. He remains closely monitored by pulmonary function tests, 6-minute walk tests, and imaging. Discussion of the novelty and importance of the case This case demonstrates the complexity of diagnosis of rapidly progressive interstitial lung diseases, with the need for multidisciplinary management for aggressive disease phenotypes. Early, aggressive immunomodulation in coordination with rheumatology achieved disease stability for this patient and has successfully delayed need for lung transplantation evaluation.","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"677 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133267776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2035
E. T. Stone, A. Deitchman, N. Das
{"title":"Its Not Easy as ILD","authors":"E. T. Stone, A. Deitchman, N. Das","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2035","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2035","url":null,"abstract":"","PeriodicalId":114116,"journal":{"name":"TP33. TP033 CASE REPORTS IN AUTOIMMUNE LUNG DISEASE","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122510685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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